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The map label for this gene is hisC

Identifier: 119775078

GI number: 119775078

Start: 2371142

End: 2372230

Strand: Direct

Name: hisC

Synonym: Sama_1943

Alternate gene names: 119775078

Gene position: 2371142-2372230 (Clockwise)

Preceding gene: 119775077

Following gene: 119775079

Centisome position: 55.06

GC content: 57.39

Gene sequence:

>1089_bases
ATGACATCTCAGGTAAACGCAGTGCCAACGGATAGCCTGGCAGCCCGCCTCGCCCGCCCTGAGCTTTTAAGCCTTGAGCC
CTACCAGAGCGCCCGGCGCATCGGCGGCAGCGGTGAGATCTGGGTGAATGCCAATGAATCGCCCTTTAACCGCACCGGCA
TCGATGGCGCCAACCGCTATCCGGAGTGCCAGCCACCGGGGCTGATAGCGGCCTACGCGGCTTACGCCGGCGTTGCGGCC
CATGAGCTGGTATGCGGCCGCGGCGCCGACGAAGCCATTGAACTGCTTATTCGCACCTTTTGTGTGCCCGGCCAAGACAG
CATCGGCATTTTCAGCCCTACCTATGGCATGTACGCCATCAGTGCCGCCACCTTTAATGTGGCGGTTAACACCCTGCCGC
TGGCAGAAGATTTCAGCCTGCCTGACGATATCTCGGCCTTAACAGGCAGCAAATTGGTGTTTGTCTGCAACCCCAATAAC
CCAACCGGCACCCTGCTGCCGCTTGGTGAAATCGCGCGGGTGGCGAAAACCTTCCCCAATGCGCTGGTGGTGGTTGATGA
AGCCTACATCGAATTTGCCCACAATGCTGATGGCTCACCCGCCCAAAGCGCCACCAGTTTGATGGCCGAGTTTGAAAATC
TGGTGATTTTGCGCACCCTATCAAAAGCCTTTGGCCTGGCCGGTGCGCGCTGCGGTTTTCTGCTGGCGAAGCCCTCGGTG
TGTGAGTTGGTGATGCGGGTGATTGCACCCTATCCTGTACCTGTTCCCGTATCAGTGATTGCTGAGAAAGCCCTTTCCGT
TATGGGTATCGCTCAAATGCGCGCCGATGTGGTACTTCTTAATAAACAGGGCGCACGACTCGCTCTGGCGCTCACCGAGG
CGGGTCTTAGCGTCCTGCCAAGCGGCGGTAACTATGTACTTGCCTTCAGCAATGATGTGGAAGTACTCGCCAGAGCCCTT
ACCAAGGCTGGCATAGTCGCCAGACGCTACAGCCATCCAAGGCTTAAAGATGCCATTCGCATCAGCTATGCCAGCGAACA
ACAAACGGATTCCATTATCGAGGCCATCGGCCGTATCGACAGCAAATAA

Upstream 100 bases:

>100_bases
GTCAAACCGTGATGACTCTGGCTGCGGCCGAGTCGCTGGATGCCCACAAAAATGCAGTAAAAGTCAGGCTTGATGCCATC
GCACGTGAGGAGAATCGTCA

Downstream 100 bases:

>100_bases
TCACAAGGACAGAGTACCCATGCCCCAGAAAATGCTTTTTATCGACCGCGATGGCACCCTGATTGAGGAGCCGGTAACAG
ATAAGCAGGTCGACAGTCTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTSQVNAVPTDSLAARLARPELLSLEPYQSARRIGGSGEIWVNANESPFNRTGIDGANRYPECQPPGLIAAYAAYAGVAA
HELVCGRGADEAIELLIRTFCVPGQDSIGIFSPTYGMYAISAATFNVAVNTLPLAEDFSLPDDISALTGSKLVFVCNPNN
PTGTLLPLGEIARVAKTFPNALVVVDEAYIEFAHNADGSPAQSATSLMAEFENLVILRTLSKAFGLAGARCGFLLAKPSV
CELVMRVIAPYPVPVPVSVIAEKALSVMGIAQMRADVVLLNKQGARLALALTEAGLSVLPSGGNYVLAFSNDVEVLARAL
TKAGIVARRYSHPRLKDAIRISYASEQQTDSIIEAIGRIDSK

Sequences:

>Translated_362_residues
MTSQVNAVPTDSLAARLARPELLSLEPYQSARRIGGSGEIWVNANESPFNRTGIDGANRYPECQPPGLIAAYAAYAGVAA
HELVCGRGADEAIELLIRTFCVPGQDSIGIFSPTYGMYAISAATFNVAVNTLPLAEDFSLPDDISALTGSKLVFVCNPNN
PTGTLLPLGEIARVAKTFPNALVVVDEAYIEFAHNADGSPAQSATSLMAEFENLVILRTLSKAFGLAGARCGFLLAKPSV
CELVMRVIAPYPVPVPVSVIAEKALSVMGIAQMRADVVLLNKQGARLALALTEAGLSVLPSGGNYVLAFSNDVEVLARAL
TKAGIVARRYSHPRLKDAIRISYASEQQTDSIIEAIGRIDSK
>Mature_361_residues
TSQVNAVPTDSLAARLARPELLSLEPYQSARRIGGSGEIWVNANESPFNRTGIDGANRYPECQPPGLIAAYAAYAGVAAH
ELVCGRGADEAIELLIRTFCVPGQDSIGIFSPTYGMYAISAATFNVAVNTLPLAEDFSLPDDISALTGSKLVFVCNPNNP
TGTLLPLGEIARVAKTFPNALVVVDEAYIEFAHNADGSPAQSATSLMAEFENLVILRTLSKAFGLAGARCGFLLAKPSVC
ELVMRVIAPYPVPVPVSVIAEKALSVMGIAQMRADVVLLNKQGARLALALTEAGLSVLPSGGNYVLAFSNDVEVLARALT
KAGIVARRYSHPRLKDAIRISYASEQQTDSIIEAIGRIDSK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=350, Percent_Identity=45.1428571428571, Blast_Score=268, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6322075, Length=377, Percent_Identity=31.2997347480106, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SHEAM (A1S6Z2)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927818.1
- ProteinModelPortal:   A1S6Z2
- SMR:   A1S6Z2
- STRING:   A1S6Z2
- GeneID:   4604193
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1943
- NMPDR:   fig|326297.7.peg.1825
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   ISHPENI
- PhylomeDB:   A1S6Z2
- ProtClustDB:   PRK04635
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38291; Mature: 38160

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQVNAVPTDSLAARLARPELLSLEPYQSARRIGGSGEIWVNANESPFNRTGIDGANRY
CCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
PECQPPGLIAAYAAYAGVAAHELVCGRGADEAIELLIRTFCVPGQDSIGIFSPTYGMYAI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEE
SAATFNVAVNTLPLAEDFSLPDDISALTGSKLVFVCNPNNPTGTLLPLGEIARVAKTFPN
EEEEEEEEEEEECCCCCCCCCCCHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCC
ALVVVDEAYIEFAHNADGSPAQSATSLMAEFENLVILRTLSKAFGLAGARCGFLLAKPSV
EEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHH
CELVMRVIAPYPVPVPVSVIAEKALSVMGIAQMRADVVLLNKQGARLALALTEAGLSVLP
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCEEEC
SGGNYVLAFSNDVEVLARALTKAGIVARRYSHPRLKDAIRISYASEQQTDSIIEAIGRID
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHHHCC
SK
CC
>Mature Secondary Structure 
TSQVNAVPTDSLAARLARPELLSLEPYQSARRIGGSGEIWVNANESPFNRTGIDGANRY
CCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
PECQPPGLIAAYAAYAGVAAHELVCGRGADEAIELLIRTFCVPGQDSIGIFSPTYGMYAI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEE
SAATFNVAVNTLPLAEDFSLPDDISALTGSKLVFVCNPNNPTGTLLPLGEIARVAKTFPN
EEEEEEEEEEEECCCCCCCCCCCHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCC
ALVVVDEAYIEFAHNADGSPAQSATSLMAEFENLVILRTLSKAFGLAGARCGFLLAKPSV
EEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHH
CELVMRVIAPYPVPVPVSVIAEKALSVMGIAQMRADVVLLNKQGARLALALTEAGLSVLP
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCEEEC
SGGNYVLAFSNDVEVLARALTKAGIVARRYSHPRLKDAIRISYASEQQTDSIIEAIGRID
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHHHCC
SK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA