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The map label for this gene is hisD [H]

Identifier: 119775077

GI number: 119775077

Start: 2369838

End: 2371145

Strand: Direct

Name: hisD [H]

Synonym: Sama_1942

Alternate gene names: 119775077

Gene position: 2369838-2371145 (Clockwise)

Preceding gene: 119775076

Following gene: 119775078

Centisome position: 55.03

GC content: 57.72

Gene sequence:

>1308_bases
ATGGAAACCTTGGTCTGGAACACCTTAAGCGAGGATGCCAAGCGCCAGGCGCTGTCCCGCTCACCTCTGGTGGGGGATGA
TAGTCTGGCGACATCCGTCAGTGACATTCTTTGCAATGTGAAGCGTCGCGGCGACAGCACCCTGATTGAATACGCGGCGC
GCTTCGATAAAGCCGAAATCGATACGCTGGCGCTGAGTGCGGACGAAATCGCAGCAGCCTGCGAGCGTGTAAGCCCTGAG
CTTAAAGACGCCATCAACGCCGCCCGCACCAACATTGCCCGTTTTCATAGCGCCCAGCAGTTCAGCGAAATCAGCCTGGA
GACCCAACCGGGAGTTCGCTGCGAGCTTAAAAGTGAGGCCATTGAAAAGGTGGGGCTTTATATTCCGGGCGGTAGTGCCC
CCCTTATCAGCACAGTGTTGATGTTGGCCGTGCCTGCCGCTATCGCTGGTTGTACCAAGCGGGTACTGGTAAGCCCACCG
CCCATTGATGACGCCATTCTTTATGCTGCCAGCGTGTGCGGCATTACCGATGTGTTCCAGATAGGCGGCGCCCAGGCCAT
TGCGGCGCTCGCCTACGGCACTGAGAGCGTACCAAAAGTGGACAAGATTTTTGGGCCCGGCAATCGTTACGTGACCGAAG
CCAAGGCCCAGGTGGCAAGGGATACCCAGGCTGCCGTCACCATCGACATGCCAGCCGGTCCTTCCGAAGTGCTGGTGATT
GCCGATGATGCCGCCAACCCCGAGTTTATCGCAGCAGACCTCTTGTCTCAGGCCGAGCACGGCAGTGACTCACAGGTGAT
TTTTGTCACCGACTCCCGCACCCAGGCAAACGCGGTTGAAGCGGCCCTTGAGCGCCAGCTCACCCTGCTGCCCAGAAGAG
AAACTGCAGAAGGGGCGCTGTCATGCAGCCGTATTATCATTACTGCCACCCTGGATGAGGCGGCAATCGTGTCTAACCTC
TATGCCCCTGAGCACCTCATTATTCAAACCAGAGAGCCAAGGGCGCTGCTGCCACGTATTCGTGCGGCTGGGTCCGTATT
TTTAGGCGCCTATACGCCGGAATCGGTTGGCGACTATGCCTCCGGCACCAACCACGTGCTGCCCACTTACGGTTACAGTA
AGACCGTCTCCAGTTTGTCGCTGGCCGATTTTTGCCGCCGCTTTACCGTGCAGGAGTTGAGTGCAGAAGGACTGAAGGGA
CTCGGTCAAACCGTGATGACTCTGGCTGCGGCCGAGTCGCTGGATGCCCACAAAAATGCAGTAAAAGTCAGGCTTGATGC
CATCGCACGTGAGGAGAATCGTCAATGA

Upstream 100 bases:

>100_bases
CAGCACCGAAGACTTGTTCTGGGACACCATGGAAGAACTGACGGCCCTCGGTGCCAGCTCGATTCTGGTGATGCCAATCG
AAAAAATGATGGGGTAAGCG

Downstream 100 bases:

>100_bases
CATCTCAGGTAAACGCAGTGCCAACGGATAGCCTGGCAGCCCGCCTCGCCCGCCCTGAGCTTTTAAGCCTTGAGCCCTAC
CAGAGCGCCCGGCGCATCGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
METLVWNTLSEDAKRQALSRSPLVGDDSLATSVSDILCNVKRRGDSTLIEYAARFDKAEIDTLALSADEIAAACERVSPE
LKDAINAARTNIARFHSAQQFSEISLETQPGVRCELKSEAIEKVGLYIPGGSAPLISTVLMLAVPAAIAGCTKRVLVSPP
PIDDAILYAASVCGITDVFQIGGAQAIAALAYGTESVPKVDKIFGPGNRYVTEAKAQVARDTQAAVTIDMPAGPSEVLVI
ADDAANPEFIAADLLSQAEHGSDSQVIFVTDSRTQANAVEAALERQLTLLPRRETAEGALSCSRIIITATLDEAAIVSNL
YAPEHLIIQTREPRALLPRIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFCRRFTVQELSAEGLKG
LGQTVMTLAAAESLDAHKNAVKVRLDAIAREENRQ

Sequences:

>Translated_435_residues
METLVWNTLSEDAKRQALSRSPLVGDDSLATSVSDILCNVKRRGDSTLIEYAARFDKAEIDTLALSADEIAAACERVSPE
LKDAINAARTNIARFHSAQQFSEISLETQPGVRCELKSEAIEKVGLYIPGGSAPLISTVLMLAVPAAIAGCTKRVLVSPP
PIDDAILYAASVCGITDVFQIGGAQAIAALAYGTESVPKVDKIFGPGNRYVTEAKAQVARDTQAAVTIDMPAGPSEVLVI
ADDAANPEFIAADLLSQAEHGSDSQVIFVTDSRTQANAVEAALERQLTLLPRRETAEGALSCSRIIITATLDEAAIVSNL
YAPEHLIIQTREPRALLPRIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFCRRFTVQELSAEGLKG
LGQTVMTLAAAESLDAHKNAVKVRLDAIAREENRQ
>Mature_435_residues
METLVWNTLSEDAKRQALSRSPLVGDDSLATSVSDILCNVKRRGDSTLIEYAARFDKAEIDTLALSADEIAAACERVSPE
LKDAINAARTNIARFHSAQQFSEISLETQPGVRCELKSEAIEKVGLYIPGGSAPLISTVLMLAVPAAIAGCTKRVLVSPP
PIDDAILYAASVCGITDVFQIGGAQAIAALAYGTESVPKVDKIFGPGNRYVTEAKAQVARDTQAAVTIDMPAGPSEVLVI
ADDAANPEFIAADLLSQAEHGSDSQVIFVTDSRTQANAVEAALERQLTLLPRRETAEGALSCSRIIITATLDEAAIVSNL
YAPEHLIIQTREPRALLPRIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFCRRFTVQELSAEGLKG
LGQTVMTLAAAESLDAHKNAVKVRLDAIAREENRQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=61.2676056338028, Blast_Score=521, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=46.4114832535885, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46240; Mature: 46240

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLVWNTLSEDAKRQALSRSPLVGDDSLATSVSDILCNVKRRGDSTLIEYAARFDKAEI
CCCEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHH
DTLALSADEIAAACERVSPELKDAINAARTNIARFHSAQQFSEISLETQPGVRCELKSEA
HHHEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHH
IEKVGLYIPGGSAPLISTVLMLAVPAAIAGCTKRVLVSPPPIDDAILYAASVCGITDVFQ
HHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCHHHHHH
IGGAQAIAALAYGTESVPKVDKIFGPGNRYVTEAKAQVARDTQAAVTIDMPAGPSEVLVI
HCCHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEE
ADDAANPEFIAADLLSQAEHGSDSQVIFVTDSRTQANAVEAALERQLTLLPRRETAEGAL
ECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
SCSRIIITATLDEAAIVSNLYAPEHLIIQTREPRALLPRIRAAGSVFLGAYTPESVGDYA
CCCEEEEEEECCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEECCCCHHHCCCC
SGTNHVLPTYGYSKTVSSLSLADFCRRFTVQELSAEGLKGLGQTVMTLAAAESLDAHKNA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKVRLDAIAREENRQ
HEEHHHHHHHHCCCC
>Mature Secondary Structure
METLVWNTLSEDAKRQALSRSPLVGDDSLATSVSDILCNVKRRGDSTLIEYAARFDKAEI
CCCEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHH
DTLALSADEIAAACERVSPELKDAINAARTNIARFHSAQQFSEISLETQPGVRCELKSEA
HHHEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHH
IEKVGLYIPGGSAPLISTVLMLAVPAAIAGCTKRVLVSPPPIDDAILYAASVCGITDVFQ
HHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCHHHHHH
IGGAQAIAALAYGTESVPKVDKIFGPGNRYVTEAKAQVARDTQAAVTIDMPAGPSEVLVI
HCCHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEE
ADDAANPEFIAADLLSQAEHGSDSQVIFVTDSRTQANAVEAALERQLTLLPRRETAEGAL
ECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHH
SCSRIIITATLDEAAIVSNLYAPEHLIIQTREPRALLPRIRAAGSVFLGAYTPESVGDYA
CCCEEEEEEECCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEECCCCHHHCCCC
SGTNHVLPTYGYSKTVSSLSLADFCRRFTVQELSAEGLKGLGQTVMTLAAAESLDAHKNA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKVRLDAIAREENRQ
HEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]