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The map label for this gene is hisB [H]

Identifier: 119775079

GI number: 119775079

Start: 2372250

End: 2373317

Strand: Direct

Name: hisB [H]

Synonym: Sama_1944

Alternate gene names: 119775079

Gene position: 2372250-2373317 (Clockwise)

Preceding gene: 119775078

Following gene: 119775080

Centisome position: 55.09

GC content: 55.06

Gene sequence:

>1068_bases
ATGCCCCAGAAAATGCTTTTTATCGACCGCGATGGCACCCTGATTGAGGAGCCGGTAACAGATAAGCAGGTCGACAGTCT
CAGCAAGCTGGTGTTTGAACCAACCGCCATTCCCGCGCTGCTGCGGCTGCAAAAAGCCGGTTACCGCCTGATTATGGTCA
GTAATCAGGATGGCCTCGGCACCCCATCTTTCCCTCAGGAAGACTTTGACGCCCCCCACAACCTGATGATGCAGGTTTTT
GAAAGTCAGGGCGTTAAGTTTGATGAGGTGCTGATTTGCCCGCACTTCAACGATGAAAACTGCAGCTGCCGGAAGCCCAA
ACTCGGTCTGGTAAAATCCTTCCTGACCCAAGGTCTGGTGGATTTTACCGCCTCAGCAGTGATTGGCGATCGCGACACCG
ATGTCGAACTTGGCAACGCCATGGGCATCAAGAGCTTTAAGTATCAGCGTGAAACCCTCGGCTGGAACGCCATTGCCGAT
TCGCTGCTCGCCAAAGGCCGCTGCGCCACCGTTGTGCGCACGACCCGCGAAACCGACATTAGGGTCACGGTGGATTTAGA
CACCCCGGGCAACAATCAAATCGACACCGGCATCGGCTTTTTTGACCATATGCTTGATCAAATCGCCACCCACGGTAATT
TCAGCCTCAAGCTTAACGTCGATGGCGACCTTGAGATTGACGATCACCACAGTGTGGAAGACACAGCATTGGCCTTGGGT
GATGCCCTGCGTCAGGCCCTTGGAGATAAGCGCGGCATCGGCCGTTTCGGCTTTGCCCTGCCGATGGATGAAGCCTCGGG
CCAGTGTTTGATGGATATCTCAGGTCGGCCTTTTATCAAGTTTGAGGCGAGCTTTAGCCGCGATAAAGTGGGCGAAATGG
CCACCGAAATGGTGCCGCACTTCTTTCGCTCCTTCGCCGATGGTCTGCGCTGCACCTTACACATCGGCTGCGATGGCGAT
AACGATCACCACAAGGTAGAAGCCCTGTTCAAGGTGCTTGGCCGCACCCTACGCCAGGCCATTGCCATCGAAGGTGATGC
CCTGCCATCGTCAAAAGGAGTGCTTTGA

Upstream 100 bases:

>100_bases
GATGCCATTCGCATCAGCTATGCCAGCGAACAACAAACGGATTCCATTATCGAGGCCATCGGCCGTATCGACAGCAAATA
ATCACAAGGACAGAGTACCC

Downstream 100 bases:

>100_bases
TGAGTGAGGAGGCTATTCCCAACGCTGAGACCGAGAAATCGGCGCCCGAACTGGTCATCATCGACACCGGCTGCGCCAAT
TTAAGCTCGGTGAAGTTTGC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MPQKMLFIDRDGTLIEEPVTDKQVDSLSKLVFEPTAIPALLRLQKAGYRLIMVSNQDGLGTPSFPQEDFDAPHNLMMQVF
ESQGVKFDEVLICPHFNDENCSCRKPKLGLVKSFLTQGLVDFTASAVIGDRDTDVELGNAMGIKSFKYQRETLGWNAIAD
SLLAKGRCATVVRTTRETDIRVTVDLDTPGNNQIDTGIGFFDHMLDQIATHGNFSLKLNVDGDLEIDDHHSVEDTALALG
DALRQALGDKRGIGRFGFALPMDEASGQCLMDISGRPFIKFEASFSRDKVGEMATEMVPHFFRSFADGLRCTLHIGCDGD
NDHHKVEALFKVLGRTLRQAIAIEGDALPSSKGVL

Sequences:

>Translated_355_residues
MPQKMLFIDRDGTLIEEPVTDKQVDSLSKLVFEPTAIPALLRLQKAGYRLIMVSNQDGLGTPSFPQEDFDAPHNLMMQVF
ESQGVKFDEVLICPHFNDENCSCRKPKLGLVKSFLTQGLVDFTASAVIGDRDTDVELGNAMGIKSFKYQRETLGWNAIAD
SLLAKGRCATVVRTTRETDIRVTVDLDTPGNNQIDTGIGFFDHMLDQIATHGNFSLKLNVDGDLEIDDHHSVEDTALALG
DALRQALGDKRGIGRFGFALPMDEASGQCLMDISGRPFIKFEASFSRDKVGEMATEMVPHFFRSFADGLRCTLHIGCDGD
NDHHKVEALFKVLGRTLRQAIAIEGDALPSSKGVL
>Mature_354_residues
PQKMLFIDRDGTLIEEPVTDKQVDSLSKLVFEPTAIPALLRLQKAGYRLIMVSNQDGLGTPSFPQEDFDAPHNLMMQVFE
SQGVKFDEVLICPHFNDENCSCRKPKLGLVKSFLTQGLVDFTASAVIGDRDTDVELGNAMGIKSFKYQRETLGWNAIADS
LLAKGRCATVVRTTRETDIRVTVDLDTPGNNQIDTGIGFFDHMLDQIATHGNFSLKLNVDGDLEIDDHHSVEDTALALGD
ALRQALGDKRGIGRFGFALPMDEASGQCLMDISGRPFIKFEASFSRDKVGEMATEMVPHFFRSFADGLRCTLHIGCDGDN
DHHKVEALFKVLGRTLRQAIAIEGDALPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=62.2535211267606, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786399, Length=145, Percent_Identity=28.2758620689655, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=47.2727272727273, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39081; Mature: 38950

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQKMLFIDRDGTLIEEPVTDKQVDSLSKLVFEPTAIPALLRLQKAGYRLIMVSNQDGLG
CCCCEEEEECCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCC
TPSFPQEDFDAPHNLMMQVFESQGVKFDEVLICPHFNDENCSCRKPKLGLVKSFLTQGLV
CCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
DFTASAVIGDRDTDVELGNAMGIKSFKYQRETLGWNAIADSLLAKGRCATVVRTTRETDI
HHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEE
RVTVDLDTPGNNQIDTGIGFFDHMLDQIATHGNFSLKLNVDGDLEIDDHHSVEDTALALG
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCHHHHHHHHH
DALRQALGDKRGIGRFGFALPMDEASGQCLMDISGRPFIKFEASFSRDKVGEMATEMVPH
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
FFRSFADGLRCTLHIGCDGDNDHHKVEALFKVLGRTLRQAIAIEGDALPSSKGVL
HHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PQKMLFIDRDGTLIEEPVTDKQVDSLSKLVFEPTAIPALLRLQKAGYRLIMVSNQDGLG
CCCEEEEECCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCC
TPSFPQEDFDAPHNLMMQVFESQGVKFDEVLICPHFNDENCSCRKPKLGLVKSFLTQGLV
CCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
DFTASAVIGDRDTDVELGNAMGIKSFKYQRETLGWNAIADSLLAKGRCATVVRTTRETDI
HHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEE
RVTVDLDTPGNNQIDTGIGFFDHMLDQIATHGNFSLKLNVDGDLEIDDHHSVEDTALALG
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCHHHHHHHHH
DALRQALGDKRGIGRFGFALPMDEASGQCLMDISGRPFIKFEASFSRDKVGEMATEMVPH
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
FFRSFADGLRCTLHIGCDGDNDHHKVEALFKVLGRTLRQAIAIEGDALPSSKGVL
HHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]