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The map label for this gene is apt

Identifier: 119716618

GI number: 119716618

Start: 2546455

End: 2547012

Strand: Direct

Name: apt

Synonym: Noca_2391

Alternate gene names: 119716618

Gene position: 2546455-2547012 (Clockwise)

Preceding gene: 119716617

Following gene: 119716619

Centisome position: 51.07

GC content: 73.84

Gene sequence:

>558_bases
GTGACGCTGCCCGGGCCGGAGGCACCGGGGCTCTCCGAGGCGCTCGCCCTGATCGCCGACGTCCCCGACTTCCCCCAGCC
CGGGATCCTCTTCAAGGACATCACGCCGCTGCTGGCCGAGCACGCGGCGCTCGAGGCGGTCGTCGCGGCCCTCGCCGCAC
CCGGGCGCGATCAGACCGGTGCCCCGGTCGTCGACAAGGTGCTGGGGATGGAGTCGCGCGGCTTCATCCTGGGCGCGCCG
GTCGCGCTGGCCCTCGGCGTGGGGTTCGTCCCGGTCCGCAAGGCCGGCAAGCTGCCGCGAGCGACGTACGCCGTCTCCTA
CGCGCTGGAGTACGGCGAGGCCACGCTCGAGGTGCACCAGGACGCACTCGAGCCGGGGGACCGGGTGCTGCTCGTCGACG
ACGTGCTCGCCACCGGCGGGACCGCGCGGGCGACGATCGACCTGGTCGAGAAGTGCGGTGCCAGCGTGCACGCCGTCGCG
ATCCTCATGGAGCTCGGCTTCCTGCCCGGCCGCGAGGCGCTCGGTACGGTGCCCCTGACCACGCTCCTCACCGTCTGA

Upstream 100 bases:

>100_bases
GGGGCCGGATCGCCCCCCAGGGTCACGGCCCGGTCCGGCCCTCCAGCGCCGCCGGCCGCCAGCAGCCGACCCGCCAGCCC
CGCTCCAAGCGGGGCAAGAA

Downstream 100 bases:

>100_bases
GAGATACGTAGACTGGCCGGGTGACCGAGGAACGCACCGCCCCGCCCACGCAGGAGCGGCGCGCCTCGGAGCCGGCACCG
TCCACGCGCAGCATGCGCGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MTLPGPEAPGLSEALALIADVPDFPQPGILFKDITPLLAEHAALEAVVAALAAPGRDQTGAPVVDKVLGMESRGFILGAP
VALALGVGFVPVRKAGKLPRATYAVSYALEYGEATLEVHQDALEPGDRVLLVDDVLATGGTARATIDLVEKCGASVHAVA
ILMELGFLPGREALGTVPLTTLLTV

Sequences:

>Translated_185_residues
MTLPGPEAPGLSEALALIADVPDFPQPGILFKDITPLLAEHAALEAVVAALAAPGRDQTGAPVVDKVLGMESRGFILGAP
VALALGVGFVPVRKAGKLPRATYAVSYALEYGEATLEVHQDALEPGDRVLLVDDVLATGGTARATIDLVEKCGASVHAVA
ILMELGFLPGREALGTVPLTTLLTV
>Mature_184_residues
TLPGPEAPGLSEALALIADVPDFPQPGILFKDITPLLAEHAALEAVVAALAAPGRDQTGAPVVDKVLGMESRGFILGAPV
ALALGVGFVPVRKAGKLPRATYAVSYALEYGEATLEVHQDALEPGDRVLLVDDVLATGGTARATIDLVEKCGASVHAVAI
LMELGFLPGREALGTVPLTTLLTV

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=46.7065868263473, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI71773201, Length=122, Percent_Identity=49.1803278688525, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=47.5609756097561, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=167, Percent_Identity=47.9041916167665, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=41.3173652694611, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=35.4037267080745, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136334, Length=157, Percent_Identity=40.1273885350318, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_NOCSJ (A1SJB1)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923583.1
- ProteinModelPortal:   A1SJB1
- SMR:   A1SJB1
- STRING:   A1SJB1
- GeneID:   4599491
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2391
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A1SJB1
- ProtClustDB:   CLSK2783557
- BioCyc:   NSP35761:NOCA_2391-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18964; Mature: 18833

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPGPEAPGLSEALALIADVPDFPQPGILFKDITPLLAEHAALEAVVAALAAPGRDQTG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
APVVDKVLGMESRGFILGAPVALALGVGFVPVRKAGKLPRATYAVSYALEYGEATLEVHQ
CHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHH
DALEPGDRVLLVDDVLATGGTARATIDLVEKCGASVHAVAILMELGFLPGREALGTVPLT
HHCCCCCEEEEEEHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCHH
TLLTV
HHHCC
>Mature Secondary Structure 
TLPGPEAPGLSEALALIADVPDFPQPGILFKDITPLLAEHAALEAVVAALAAPGRDQTG
CCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
APVVDKVLGMESRGFILGAPVALALGVGFVPVRKAGKLPRATYAVSYALEYGEATLEVHQ
CHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHH
DALEPGDRVLLVDDVLATGGTARATIDLVEKCGASVHAVAILMELGFLPGREALGTVPLT
HHCCCCCEEEEEEHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCHH
TLLTV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA