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The map label for this gene is relA [H]

Identifier: 119716619

GI number: 119716619

Start: 2547105

End: 2549336

Strand: Direct

Name: relA [H]

Synonym: Noca_2392

Alternate gene names: 119716619

Gene position: 2547105-2549336 (Clockwise)

Preceding gene: 119716618

Following gene: 119716620

Centisome position: 51.09

GC content: 69.27

Gene sequence:

>2232_bases
ATGCGCGCGCGGTTCGCGCGGATGGGCGCCCGCAACCAAGGCGCGAACCCGGTCCTGGAGCCGCTGTTCCGCTCGGTGCG
GGCCAACCACCCGAAGGCCGACCTGGCCCTGCTGGAACGCGCGTACACCACCGCGGAGCGGATGCACGGGACCCAGACCC
GCAAGAGCGGTGACCCGTACATCACCCACCCGCTCGCGGTGACGACGATCCTCGCCGACATCGGCATGACCGAGCCGACG
CTCGCCGCGGCCCTGCTGCACGACACGGTGGAGGACACGCCGTACACCCTCGAGCAGGTGCGTCAGGACTTCGGCGAGGA
GATCGCCCAGCTGGTCGACGGCGTGACCAAGCTCGACAAGGTGAAGTACGGCGACTCCGCGCAGGCCGAGACGATCCGGA
AGATGATCGTCGCGATGTCGCGCGACATCCGGGTCCTGGTCATCAAGCTCGCCGACCGGCTGCACAACATGCGGACCCTG
CGCTACGTGCGGCAGGAGACCCAGGAGCGGGTCGCCCGCGAGACGCTCGACATCTACGCGCCCCTGGCCCACCGGCTGGG
CATGAACACGATCAAGTGGGAGCTCGAGGACCTGGCGTTCGCGACCCTGCACCCCAAGATCTACGACGAGATCGTCCGGA
TGGTCGCGGAGCGGGCGCCGTCACGGGACCAGTTCCTGGCCGAGGTGATCGCCCAGGTGGAGGCCGACCTGCGCGAGGCG
AAGGTGAAGGCGTCGGTCACCGGACGGCCCAAGCACTACTACTCGATCTACCAGAAGATGATCGTGGGCGGCCGGGAGTT
CTCGGACATCTACGACCTGGTCGGCATCCGCGTCCTGGTCGAGAACGACCGGGACTGCTACACCGTCCTCGGAGTGCTCC
ACTCGCGCTGGAACCCGGTGCTGGGGCGGTTCAAGGACTACGTCGCGATGCCGAAGTTCAACATGTACCAGTCGCTGCAC
ACGACGGTCATCGGCCCGCAGGGCAAGCCCGTCGAGCTGCAGATCCGGACCTTCGCGATGCACCGGCGCGCGGAGTACGG
CGTGGCCGCGCACTGGAAGTACAAGGAGGACGGCCGCGCCGGCGTCGACACCGACCGGTCGGGCGACCTCGACGACATGA
CCTGGGTGCGCCAGCTCCTCGACTGGCAGAACGAGATGGAGGACCCCGGGGAGTTCCTGGAGTCGCTGCGCTTCGAGATC
AACCGCGCCGAGGTCTACGTCTTCACCCCGCGCGGCGACGTGATCGCGCTGCCGACCGGTGCGACCCCGGTCGACTTCGC
GTACGCCGTGCACACCGAGGTCGGCCACCACACGATCGGCGCCCGGGTGAACGGGCGCCTGGTGCCCCTGGAGTCCGGCC
TCGAGAACGGCGACGTCGTCGAGGTCTTCACCTCCAAGGCCCCCACCGCGGGCCCGTCGCGCGACTGGCTCGGGTTCGTG
AAGTCCCAGCGCGCCCGCTCCAAGATCCGCCAGTGGTTCACCAAGGAGCGTCGCGAGGAGGCGATCGACCGCGGCAAGGA
GCAGATCGCCAAGCTGATGCGCAAGGAGGGGCTGCCGCTCAAGCGGCTGCTGTCCCACGAGTCGCTCACGTTGGCGGCGG
GCCACTTCAAGCTGGCGGACGTCTCCGCCCTGTACGCCGCCGTGGGTGAGGGCAACCTGTCGGCGCAGTCGGTCGTCCGC
CGCGTCATCGACGTCCACGGCGGGGACGGTGGCGCCGCCGAGGACCTCGCCGAGGGCGTGACGATCACCGGGCGACGCGG
CCGGGCCAAGGCCCAGCCGGGTGGCGACGCCGGCGTGATCGTCAAGGGCGCCCCGGACGTGTGGGTCAAGCTCGCGAAGT
GCTGCACCCCAGTGCCGCCGGACCCGATCCTCGGCTTCGTCACGAAGGGTGGGGGAGTCTCGGTGCACCGCCAGAACTGC
ACCAACGCCGCCAGCCTGCAGGCCCAGCCGGAGCGGCTCCTCGACGTCGAGTGGGCCCCCACCGGACAGTCCAGCTTCCT
GGTCAACATCCAGGTCGAGGCACTGGACCGGGCCCGGCTGCTCTCGGACATCACGATGGCGCTCTCCGACGCGCACGTGG
ACATCCTCAGCGCCAACCTCTCGACCACCCGCGACCGGGTCGCCAAGAGCCGGTTCACCTTCGAGATGGCCGAGGCCAAG
CACCTCGACAACGTGCTCAAGGCGGTCCGTTCGGTACCCGGCGTCTTCGACGCCTACCGCGTCACGCAATAG

Upstream 100 bases:

>100_bases
CCGTCTGAGAGATACGTAGACTGGCCGGGTGACCGAGGAACGCACCGCCCCGCCCACGCAGGAGCGGCGCGCCTCGGAGC
CGGCACCGTCCACGCGCAGC

Downstream 100 bases:

>100_bases
CGCTACGGAGCGTCCGCGGCGTTGCCGGCACTCGACGACCCGCTTCGCTCGGCGGTCGCCTTCGCGCCGGCGCCTTGCGG
CCGCACGCGTAGCGCTACCG

Product: RelA/SpoT family protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 743; Mature: 743

Protein sequence:

>743_residues
MRARFARMGARNQGANPVLEPLFRSVRANHPKADLALLERAYTTAERMHGTQTRKSGDPYITHPLAVTTILADIGMTEPT
LAAALLHDTVEDTPYTLEQVRQDFGEEIAQLVDGVTKLDKVKYGDSAQAETIRKMIVAMSRDIRVLVIKLADRLHNMRTL
RYVRQETQERVARETLDIYAPLAHRLGMNTIKWELEDLAFATLHPKIYDEIVRMVAERAPSRDQFLAEVIAQVEADLREA
KVKASVTGRPKHYYSIYQKMIVGGREFSDIYDLVGIRVLVENDRDCYTVLGVLHSRWNPVLGRFKDYVAMPKFNMYQSLH
TTVIGPQGKPVELQIRTFAMHRRAEYGVAAHWKYKEDGRAGVDTDRSGDLDDMTWVRQLLDWQNEMEDPGEFLESLRFEI
NRAEVYVFTPRGDVIALPTGATPVDFAYAVHTEVGHHTIGARVNGRLVPLESGLENGDVVEVFTSKAPTAGPSRDWLGFV
KSQRARSKIRQWFTKERREEAIDRGKEQIAKLMRKEGLPLKRLLSHESLTLAAGHFKLADVSALYAAVGEGNLSAQSVVR
RVIDVHGGDGGAAEDLAEGVTITGRRGRAKAQPGGDAGVIVKGAPDVWVKLAKCCTPVPPDPILGFVTKGGGVSVHRQNC
TNAASLQAQPERLLDVEWAPTGQSSFLVNIQVEALDRARLLSDITMALSDAHVDILSANLSTTRDRVAKSRFTFEMAEAK
HLDNVLKAVRSVPGVFDAYRVTQ

Sequences:

>Translated_743_residues
MRARFARMGARNQGANPVLEPLFRSVRANHPKADLALLERAYTTAERMHGTQTRKSGDPYITHPLAVTTILADIGMTEPT
LAAALLHDTVEDTPYTLEQVRQDFGEEIAQLVDGVTKLDKVKYGDSAQAETIRKMIVAMSRDIRVLVIKLADRLHNMRTL
RYVRQETQERVARETLDIYAPLAHRLGMNTIKWELEDLAFATLHPKIYDEIVRMVAERAPSRDQFLAEVIAQVEADLREA
KVKASVTGRPKHYYSIYQKMIVGGREFSDIYDLVGIRVLVENDRDCYTVLGVLHSRWNPVLGRFKDYVAMPKFNMYQSLH
TTVIGPQGKPVELQIRTFAMHRRAEYGVAAHWKYKEDGRAGVDTDRSGDLDDMTWVRQLLDWQNEMEDPGEFLESLRFEI
NRAEVYVFTPRGDVIALPTGATPVDFAYAVHTEVGHHTIGARVNGRLVPLESGLENGDVVEVFTSKAPTAGPSRDWLGFV
KSQRARSKIRQWFTKERREEAIDRGKEQIAKLMRKEGLPLKRLLSHESLTLAAGHFKLADVSALYAAVGEGNLSAQSVVR
RVIDVHGGDGGAAEDLAEGVTITGRRGRAKAQPGGDAGVIVKGAPDVWVKLAKCCTPVPPDPILGFVTKGGGVSVHRQNC
TNAASLQAQPERLLDVEWAPTGQSSFLVNIQVEALDRARLLSDITMALSDAHVDILSANLSTTRDRVAKSRFTFEMAEAK
HLDNVLKAVRSVPGVFDAYRVTQ
>Mature_743_residues
MRARFARMGARNQGANPVLEPLFRSVRANHPKADLALLERAYTTAERMHGTQTRKSGDPYITHPLAVTTILADIGMTEPT
LAAALLHDTVEDTPYTLEQVRQDFGEEIAQLVDGVTKLDKVKYGDSAQAETIRKMIVAMSRDIRVLVIKLADRLHNMRTL
RYVRQETQERVARETLDIYAPLAHRLGMNTIKWELEDLAFATLHPKIYDEIVRMVAERAPSRDQFLAEVIAQVEADLREA
KVKASVTGRPKHYYSIYQKMIVGGREFSDIYDLVGIRVLVENDRDCYTVLGVLHSRWNPVLGRFKDYVAMPKFNMYQSLH
TTVIGPQGKPVELQIRTFAMHRRAEYGVAAHWKYKEDGRAGVDTDRSGDLDDMTWVRQLLDWQNEMEDPGEFLESLRFEI
NRAEVYVFTPRGDVIALPTGATPVDFAYAVHTEVGHHTIGARVNGRLVPLESGLENGDVVEVFTSKAPTAGPSRDWLGFV
KSQRARSKIRQWFTKERREEAIDRGKEQIAKLMRKEGLPLKRLLSHESLTLAAGHFKLADVSALYAAVGEGNLSAQSVVR
RVIDVHGGDGGAAEDLAEGVTITGRRGRAKAQPGGDAGVIVKGAPDVWVKLAKCCTPVPPDPILGFVTKGGGVSVHRQNC
TNAASLQAQPERLLDVEWAPTGQSSFLVNIQVEALDRARLLSDITMALSDAHVDILSANLSTTRDRVAKSRFTFEMAEAK
HLDNVLKAVRSVPGVFDAYRVTQ

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=730, Percent_Identity=41.0958904109589, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=715, Percent_Identity=37.0629370629371, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI25143118, Length=132, Percent_Identity=40.1515151515151, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82768; Mature: 82768

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARFARMGARNQGANPVLEPLFRSVRANHPKADLALLERAYTTAERMHGTQTRKSGDPY
CCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
ITHPLAVTTILADIGMTEPTLAAALLHDTVEDTPYTLEQVRQDFGEEIAQLVDGVTKLDK
EECHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VKYGDSAQAETIRKMIVAMSRDIRVLVIKLADRLHNMRTLRYVRQETQERVARETLDIYA
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLAHRLGMNTIKWELEDLAFATLHPKIYDEIVRMVAERAPSRDQFLAEVIAQVEADLREA
HHHHHCCCCHHEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KVKASVTGRPKHYYSIYQKMIVGGREFSDIYDLVGIRVLVENDRDCYTVLGVLHSRWNPV
HHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHH
LGRFKDYVAMPKFNMYQSLHTTVIGPQGKPVELQIRTFAMHRRAEYGVAAHWKYKEDGRA
HHHHHHHHCCCCHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCC
GVDTDRSGDLDDMTWVRQLLDWQNEMEDPGEFLESLRFEINRAEVYVFTPRGDVIALPTG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEEEEEECCCCCEEEECCC
ATPVDFAYAVHTEVGHHTIGARVNGRLVPLESGLENGDVVEVFTSKAPTAGPSRDWLGFV
CCCCHHHEEEHHHCCCEEECCEECCEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
KSQRARSKIRQWFTKERREEAIDRGKEQIAKLMRKEGLPLKRLLSHESLTLAAGHFKLAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCEEHHH
VSALYAAVGEGNLSAQSVVRRVIDVHGGDGGAAEDLAEGVTITGRRGRAKAQPGGDAGVI
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCEEE
VKGAPDVWVKLAKCCTPVPPDPILGFVTKGGGVSVHRQNCTNAASLQAQPERLLDVEWAP
EECCHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCCCHHCCCCCHHHEEEEECC
TGQSSFLVNIQVEALDRARLLSDITMALSDAHVDILSANLSTTRDRVAKSRFTFEMAEAK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCHHEEEECCCHHHHHHHHHHHHHHHHHHHH
HLDNVLKAVRSVPGVFDAYRVTQ
HHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MRARFARMGARNQGANPVLEPLFRSVRANHPKADLALLERAYTTAERMHGTQTRKSGDPY
CCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
ITHPLAVTTILADIGMTEPTLAAALLHDTVEDTPYTLEQVRQDFGEEIAQLVDGVTKLDK
EECHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VKYGDSAQAETIRKMIVAMSRDIRVLVIKLADRLHNMRTLRYVRQETQERVARETLDIYA
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLAHRLGMNTIKWELEDLAFATLHPKIYDEIVRMVAERAPSRDQFLAEVIAQVEADLREA
HHHHHCCCCHHEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KVKASVTGRPKHYYSIYQKMIVGGREFSDIYDLVGIRVLVENDRDCYTVLGVLHSRWNPV
HHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHH
LGRFKDYVAMPKFNMYQSLHTTVIGPQGKPVELQIRTFAMHRRAEYGVAAHWKYKEDGRA
HHHHHHHHCCCCHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCC
GVDTDRSGDLDDMTWVRQLLDWQNEMEDPGEFLESLRFEINRAEVYVFTPRGDVIALPTG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEEEEEECCCCCEEEECCC
ATPVDFAYAVHTEVGHHTIGARVNGRLVPLESGLENGDVVEVFTSKAPTAGPSRDWLGFV
CCCCHHHEEEHHHCCCEEECCEECCEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
KSQRARSKIRQWFTKERREEAIDRGKEQIAKLMRKEGLPLKRLLSHESLTLAAGHFKLAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCEEHHH
VSALYAAVGEGNLSAQSVVRRVIDVHGGDGGAAEDLAEGVTITGRRGRAKAQPGGDAGVI
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCEEE
VKGAPDVWVKLAKCCTPVPPDPILGFVTKGGGVSVHRQNCTNAASLQAQPERLLDVEWAP
EECCHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCCCHHCCCCCHHHEEEEECC
TGQSSFLVNIQVEALDRARLLSDITMALSDAHVDILSANLSTTRDRVAKSRFTFEMAEAK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCHHEEEECCCHHHHHHHHHHHHHHHHHHHH
HLDNVLKAVRSVPGVFDAYRVTQ
HHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8825780; 8631867; 12000953 [H]