Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 116688450

GI number: 116688450

Start: 476347

End: 477420

Strand: Direct

Name: hisC [H]

Synonym: Bcen2424_0426

Alternate gene names: 116688450

Gene position: 476347-477420 (Clockwise)

Preceding gene: 116688449

Following gene: 116688451

Centisome position: 13.67

GC content: 69.18

Gene sequence:

>1074_bases
ATGACGACGCCACAAGACATCATCCGCCGCGACGTGCTCGCGATGACCAGCTATCCGGTGCCGGACGCGAGCGGGTTCGT
GAAGCTCGACGCGATGGAGAACCCGTACCCGCTGCCGGCGCCGCTCGCCGCGGCGCTCGGCGAGCGGCTCGCGCAGGTCG
CGCTGAACCGCTACCCGGCGCCGCGCCCGGCCGCGCTGCTCGACAAGCTGCGCCACGCGATGCGCGTGCCGGCCGGCTGC
GACGTGCTGCTCGGCAACGGTTCCGACGAAATCATCAGCATGATCTCGGTCGCGTGCGCGCAGCCGGGCGCGAAGGTGCT
CGCACCGGTGCCGGGCTTCGTGATGTACGAACTCTCGGCGAAGTTCGCGCAGCTCGAATTCGTCGGCGTGCCGCTGAAGG
CGGACCTGACGCTCGACGTCGACGCGATGCTCGCGGCGATCGCCGAGCACCGGCCGGCGATCGTCTATCTCGCGTACCCG
AACAACCCGACCGGCACGCTGTACGACGATGCCGACGTCGAGCGGATCGTCGCGGCCGCGCGGCACAGCCTGATCGTGAT
CGACGAGGCGTACCAGCCGTTCGCCGAGCGTTCGTGGCTGCCGCGCGCCGCCGAGTTCGACAACGTCGTCGTGATGCGCA
CGGTGTCGAAGCTCGGCCTCGCGGGCATCCGCCTCGGCTACCTCGTCGGCTTGCCGGCGTGGCTGAACGAATTCGACAAG
GTGCGCCCGCCGTACAACATCAACGTGCTGACCCAGGCGACCGCCGATTTCCTGCTCGATCACCTCGACGTGCTCGACGC
GCAGGCGGCCGAATTGCGCGCGGAACGCACCCGCCTCGCGCAGGCGGTGGCCGCGCTGCCGGGCGCGACGGTGTTCCCGA
GCGCCGGCAATTTCCTGCTGGTGCGCGTGCCGGACGCGGCAGCCGTGTTCGACGCGCTGCTCACCGAGCGGGTGCTGGTC
AAAAACGTGAGTAAAATGCATCCATTACTGGCCGAATGCGTGCGGCTGACCGTCGGTTCTCCCGACGAAAACGCCCGCCT
GCTGGCCGCCTTGAAACTCGCGCTGCCCGGTTGA

Upstream 100 bases:

>100_bases
ACCGGCGGCACCCGGAGCGGGGCAGGAGACGAGCGCAGGGCGGCAGCCGCCGCCTTGCCGACCCATTTGACGCCGGCGCG
ACGCACGCCGGCTTGAGACC

Downstream 100 bases:

>100_bases
GCCCAGGGCGCGGCGGCGCGCGACGATCAATCCCCATTTACATCAGACTCAATCAAGGAATTGCCATGCGTGTGGCGGAA
GTCGTTCGCAATACCAGCGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPAPLAAALGERLAQVALNRYPAPRPAALLDKLRHAMRVPAGC
DVLLGNGSDEIISMISVACAQPGAKVLAPVPGFVMYELSAKFAQLEFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYP
NNPTGTLYDDADVERIVAAARHSLIVIDEAYQPFAERSWLPRAAEFDNVVVMRTVSKLGLAGIRLGYLVGLPAWLNEFDK
VRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERTRLAQAVAALPGATVFPSAGNFLLVRVPDAAAVFDALLTERVLV
KNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPG

Sequences:

>Translated_357_residues
MTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPAPLAAALGERLAQVALNRYPAPRPAALLDKLRHAMRVPAGC
DVLLGNGSDEIISMISVACAQPGAKVLAPVPGFVMYELSAKFAQLEFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYP
NNPTGTLYDDADVERIVAAARHSLIVIDEAYQPFAERSWLPRAAEFDNVVVMRTVSKLGLAGIRLGYLVGLPAWLNEFDK
VRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERTRLAQAVAALPGATVFPSAGNFLLVRVPDAAAVFDALLTERVLV
KNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPG
>Mature_356_residues
TTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPAPLAAALGERLAQVALNRYPAPRPAALLDKLRHAMRVPAGCD
VLLGNGSDEIISMISVACAQPGAKVLAPVPGFVMYELSAKFAQLEFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYPN
NPTGTLYDDADVERIVAAARHSLIVIDEAYQPFAERSWLPRAAEFDNVVVMRTVSKLGLAGIRLGYLVGLPAWLNEFDKV
RPPYNINVLTQATADFLLDHLDVLDAQAAELRAERTRLAQAVAALPGATVFPSAGNFLLVRVPDAAAVFDALLTERVLVK
NVSKMHPLLAECVRLTVGSPDENARLLAALKLALPG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=367, Percent_Identity=31.0626702997275, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=28.4931506849315, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38396; Mature: 38265

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPAPLAAALGERLAQVALNRYPA
CCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
PRPAALLDKLRHAMRVPAGCDVLLGNGSDEIISMISVACAQPGAKVLAPVPGFVMYELSA
CCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCCCEEEHHHH
KFAQLEFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYPNNPTGTLYDDADVERIVAAA
HHEEEEEEECCEECCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
RHSLIVIDEAYQPFAERSWLPRAAEFDNVVVMRTVSKLGLAGIRLGYLVGLPAWLNEFDK
HCCEEEEECHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERTRLAQAVAALPGATVFPSAGNFLL
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEE
VRVPDAAAVFDALLTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPAPLAAALGERLAQVALNRYPA
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
PRPAALLDKLRHAMRVPAGCDVLLGNGSDEIISMISVACAQPGAKVLAPVPGFVMYELSA
CCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEECCCCCCEEEHHHH
KFAQLEFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYPNNPTGTLYDDADVERIVAAA
HHEEEEEEECCEECCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
RHSLIVIDEAYQPFAERSWLPRAAEFDNVVVMRTVSKLGLAGIRLGYLVGLPAWLNEFDK
HCCEEEEECHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERTRLAQAVAALPGATVFPSAGNFLL
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEE
VRVPDAAAVFDALLTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12754231 [H]