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The map label for this gene is hisD [H]

Identifier: 116688449

GI number: 116688449

Start: 474887

End: 476203

Strand: Direct

Name: hisD [H]

Synonym: Bcen2424_0425

Alternate gene names: 116688449

Gene position: 474887-476203 (Clockwise)

Preceding gene: 116688448

Following gene: 116688450

Centisome position: 13.63

GC content: 69.63

Gene sequence:

>1317_bases
ATGTCCATCACCATCCGCAAGCTCGATTCGACGAACGAAGGCTTCGGCGCCGCGCTGCGCGCCGTGCTCGCGTTCGAGGC
GAGCGAAGACGAAGCGATCGAGCAATCGGTCGCGAAGATCCTCGCCGACGTGAAGTCGCGCGGCGACGCCGCGGTGCTCG
AGTACACGAACCGTTTCGACCGGCTGAGCGCGAACAGCGTCGCCGCGCTCGAACTGCCGCAGGACGCGCTGCAGACGGCG
CTCGACGGCCTCGCGCCGAAGGCGCGCGCGGCGCTGGAAGCGGCCGCGGCGCGGGTGCGCGCGTACCACGAGAAGCAGAA
GATCGAATGCGGCACGCATAGCTGGCAGTACACGGAAAGCGACGGCACGGTGCTCGGCCAGAAGGTCACGCCGCTTGACC
GCGTCGGCCTGTACGTGCCGGGCGGCAAGGCCGCGTATCCGTCGTCGGTGCTGATGAACGCGATTCCGGCGCGCGTCGCG
GGCGTCGGCGAGATCGTGATGGTCGTGCCGACCCCGGACGGCGTGAAGAACGACCTCGTGCTGGCGGCGGCGCTGCTCGG
CGGCGTCGATCGCGTGTTCACGATCGGCGGCGCGCAGGCGGTCGGCGCGCTCGCGTACGGCACCGAGACGGTGCCGGCCG
TCGACAAGATCTGCGGCCCCGGCAACGCGTACGTCGCGTCGGCGAAGCGCCGCGTGTTCGGCACGGTCGGCATCGACATG
ATCGCCGGGCCGTCGGAAATCCTCGTGCTGTGCGACGGGACGACCGATCCGAACTGGGTCGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAACTCGCGCAGTCGATCCTGCTGTGCCCGGACGCTGCATTCCTCGATCGCGTCGAGAAGGCGATCG
GCGAGCTGCTGCCGACGATGCCGCGCCAGGACGTGATCCGCGCGTCGCTCGAAGGCCGCGGCGCGCTGATCAAGGTGCGC
GACATGGCCGAGGCATGCCGGATCGCGAACGACATCGCGCCGGAACACCTCGAAATCTCGGCGCTGGAGCCGCAGCAATG
GGGCCAGCAGATCCGCCACGCGGGCGCGATCTTCCTCGGCCGCTATACGAGCGAGAGCCTCGGCGACTACTGCGCGGGCC
CGAACCACGTGCTGCCGACGTCGCGCACCGCGCGTTTCTCGTCGCCGCTCGGCGTGTACGACTTCATCAAGCGCTCGAGC
CTGATCGAGGTCAGCGCGGAAGGCGCGCAGACGCTCGGCGAGATCGCATCCGAGCTCGCCTACGGCGAAGGGCTGCAGGC
GCACGCGAGGAGCGCCGAGTTCCGGATGAAGGGCTGA

Upstream 100 bases:

>100_bases
CGCGCTGAAACTGAAGCGCGCGGCGCTCAAGCCGATCCTCGACGCGTTCGAACGCGCGTCGCAGAATGGCGGTTGAGCGC
ATCACCGTAACGGAACTCCC

Downstream 100 bases:

>100_bases
CCGCGCATCGTGCGCGGGGCCGGGCGGGCGCCGAGGCGCCGGCACCGGCGGCACCCGGAGCGGGGCAGGAGACGAGCGCA
GGGCGGCAGCCGCCGCCTTG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSITIRKLDSTNEGFGAALRAVLAFEASEDEAIEQSVAKILADVKSRGDAAVLEYTNRFDRLSANSVAALELPQDALQTA
LDGLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDAAFLDRVEKAIGELLPTMPRQDVIRASLEGRGALIKVR
DMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSAEGAQTLGEIASELAYGEGLQAHARSAEFRMKG

Sequences:

>Translated_438_residues
MSITIRKLDSTNEGFGAALRAVLAFEASEDEAIEQSVAKILADVKSRGDAAVLEYTNRFDRLSANSVAALELPQDALQTA
LDGLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDAAFLDRVEKAIGELLPTMPRQDVIRASLEGRGALIKVR
DMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSAEGAQTLGEIASELAYGEGLQAHARSAEFRMKG
>Mature_437_residues
SITIRKLDSTNEGFGAALRAVLAFEASEDEAIEQSVAKILADVKSRGDAAVLEYTNRFDRLSANSVAALELPQDALQTAL
DGLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTESDGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAG
VGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDAAFLDRVEKAIGELLPTMPRQDVIRASLEGRGALIKVRD
MAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSL
IEVSAEGAQTLGEIASELAYGEGLQAHARSAEFRMKG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=41.2048192771084, Blast_Score=283, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=409, Percent_Identity=35.4523227383863, Blast_Score=236, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46430; Mature: 46299

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIRKLDSTNEGFGAALRAVLAFEASEDEAIEQSVAKILADVKSRGDAAVLEYTNRFD
CCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RLSANSVAALELPQDALQTALDGLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTES
CCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDAAFLDRVEKAIGELLPTM
ECCCCEEEEEECCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PRQDVIRASLEGRGALIKVRDMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAQTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHH
YGEGLQAHARSAEFRMKG
HCCCCHHHHCCCCEEECC
>Mature Secondary Structure 
SITIRKLDSTNEGFGAALRAVLAFEASEDEAIEQSVAKILADVKSRGDAAVLEYTNRFD
CEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RLSANSVAALELPQDALQTALDGLAPKARAALEAAAARVRAYHEKQKIECGTHSWQYTES
CCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTETVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPNWVAMDLFSQAEHDELAQSILLCPDAAFLDRVEKAIGELLPTM
ECCCCEEEEEECCCCCCCEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PRQDVIRASLEGRGALIKVRDMAEACRIANDIAPEHLEISALEPQQWGQQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAQTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHH
YGEGLQAHARSAEFRMKG
HCCCCHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA