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The map label for this gene is nox [H]

Identifier: 116491852

GI number: 116491852

Start: 31840

End: 33201

Strand: Reverse

Name: nox [H]

Synonym: PEPE_0034

Alternate gene names: 116491852

Gene position: 33201-31840 (Counterclockwise)

Preceding gene: 116491854

Following gene: 116491846

Centisome position: 1.81

GC content: 39.79

Gene sequence:

>1362_bases
ATGACAGAAAAAATAATCGTCGTTGGTTGTACCCATGCTGGTATTGCAGCGGTCAATGAAATCTTGAAATACCACCCACA
AGCGGACGTTACTGTTTTCGAACGACACGATACAATTTCATACTTATCATGCGCCACTTACTTAACATTAGGAAAAACAA
TATCTAATCTTGATGAAGCGATGTATGCTGATCCCGACTACTACCGGGCTCAGGGGATAGACATGCGTCTACGCCACGAT
GTGATTGATATTAATGTCGAAGAACATACCGTCTTTGCTCAAGACTTAGAGACTAAAGAATTCACTACCGAATCTTTCGA
TAAGTTAATCATGGCTACTGGTTCACTCACGTCTATTCCTACTATTCAAGGCGTTGAAAATCCCAAAGTAAAGCTATGCA
AGACTTATGAAGAAGCTCGTGACTTATGTGACGAAGCCCAAAATGATGAACGAATCGCTATTATTGGCGGTGGCTATATT
GGTGTTGAATTAGCTGAAGGTTACAATAAATCTAACCACGAGGTTATTCTTTTCCATAAAAAAGAGACTCCACTAGACCG
TCATATCGAACCTGAAATTGCTGACAAAATTACCAATCTTTTAGAAGATAAAGGCATTCAGGTCAAAACTGGTACGATTG
TTAAATCCTTCGAAGATGGCGCTAACGATACCTTAATCGTAAAAACCGCCGACGAAGCGTTTGAAGTAGATATGGCTGTA
ATTTGTACTGGCTTACTTCCTCAAGCTGATTTATTACAAGGTAAAGTAGATCAACTAACTAATGGAGCAATCGTCGTTAA
TGATTATATGGAAACATCTAACCCTGATATCTTTGCTGCTGGAGATGCTGCTTCAGTTAAACATAATGGTTTGCAAACCG
ATGTTTACATGCCATTAGCATCACAAGCCGTTCGCCAAGGGGCCTTGGCTGGTATTAATGTGTTAGATAAACGCCTCCGT
TCAATTGGTACCCAATCAACAACTGGAATGCTAATCTTCGGACGCACTTTAGCTTGTAGTGGTGTGACCTTAGCCATGGC
TTTGGATGCTGGAATTAACGCTACTAAAGTGGCGTATAAAGGTAGCTACCGTCCAGACTTTATGCCTAATGCTCACAAAG
TTGAAATCGAATTAGTTTACGATCGTAACTCCCGTAAGGTTCTGGGAGTACAACTATGGAGCAAACATGATGTTTCTCAA
GCTGCGGATACAATCTCAGCCTTAATGCATTATCACGGCACGATTGACGAATTATCCTTTATAGATATGCTATTTTCTCC
AAACTTTGATCAACCTTTCAATTACTTAAATCTAGTTGGTCAATTAGCTGTTAAACAAGAAAATGGTTACTTACGAACAT
AA

Upstream 100 bases:

>100_bases
ATTAATCATATACTATACTATGTATAACGTTTAAGTTATAGTATACTATATAAATACTATAATTCATAATTCATACCATA
AAAAAGAGGTGTCATTACAG

Downstream 100 bases:

>100_bases
TAATAATAACAAATAAACTACGACAAAAGGTAATGAATCCTTCGAAGTACGAAATTCACTTCGAAAATTACCTAAAGTCG
TAGTTTTTTAATATTCTACA

Product: NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTEKIIVVGCTHAGIAAVNEILKYHPQADVTVFERHDTISYLSCATYLTLGKTISNLDEAMYADPDYYRAQGIDMRLRHD
VIDINVEEHTVFAQDLETKEFTTESFDKLIMATGSLTSIPTIQGVENPKVKLCKTYEEARDLCDEAQNDERIAIIGGGYI
GVELAEGYNKSNHEVILFHKKETPLDRHIEPEIADKITNLLEDKGIQVKTGTIVKSFEDGANDTLIVKTADEAFEVDMAV
ICTGLLPQADLLQGKVDQLTNGAIVVNDYMETSNPDIFAAGDAASVKHNGLQTDVYMPLASQAVRQGALAGINVLDKRLR
SIGTQSTTGMLIFGRTLACSGVTLAMALDAGINATKVAYKGSYRPDFMPNAHKVEIELVYDRNSRKVLGVQLWSKHDVSQ
AADTISALMHYHGTIDELSFIDMLFSPNFDQPFNYLNLVGQLAVKQENGYLRT

Sequences:

>Translated_453_residues
MTEKIIVVGCTHAGIAAVNEILKYHPQADVTVFERHDTISYLSCATYLTLGKTISNLDEAMYADPDYYRAQGIDMRLRHD
VIDINVEEHTVFAQDLETKEFTTESFDKLIMATGSLTSIPTIQGVENPKVKLCKTYEEARDLCDEAQNDERIAIIGGGYI
GVELAEGYNKSNHEVILFHKKETPLDRHIEPEIADKITNLLEDKGIQVKTGTIVKSFEDGANDTLIVKTADEAFEVDMAV
ICTGLLPQADLLQGKVDQLTNGAIVVNDYMETSNPDIFAAGDAASVKHNGLQTDVYMPLASQAVRQGALAGINVLDKRLR
SIGTQSTTGMLIFGRTLACSGVTLAMALDAGINATKVAYKGSYRPDFMPNAHKVEIELVYDRNSRKVLGVQLWSKHDVSQ
AADTISALMHYHGTIDELSFIDMLFSPNFDQPFNYLNLVGQLAVKQENGYLRT
>Mature_452_residues
TEKIIVVGCTHAGIAAVNEILKYHPQADVTVFERHDTISYLSCATYLTLGKTISNLDEAMYADPDYYRAQGIDMRLRHDV
IDINVEEHTVFAQDLETKEFTTESFDKLIMATGSLTSIPTIQGVENPKVKLCKTYEEARDLCDEAQNDERIAIIGGGYIG
VELAEGYNKSNHEVILFHKKETPLDRHIEPEIADKITNLLEDKGIQVKTGTIVKSFEDGANDTLIVKTADEAFEVDMAVI
CTGLLPQADLLQGKVDQLTNGAIVVNDYMETSNPDIFAAGDAASVKHNGLQTDVYMPLASQAVRQGALAGINVLDKRLRS
IGTQSTTGMLIFGRTLACSGVTLAMALDAGINATKVAYKGSYRPDFMPNAHKVEIELVYDRNSRKVLGVQLWSKHDVSQA
ADTISALMHYHGTIDELSFIDMLFSPNFDQPFNYLNLVGQLAVKQENGYLRT

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=348, Percent_Identity=24.7126436781609, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI65787454, Length=348, Percent_Identity=24.7126436781609, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226437568, Length=348, Percent_Identity=24.7126436781609, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789065, Length=208, Percent_Identity=28.3653846153846, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789765, Length=262, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789915, Length=206, Percent_Identity=30.5825242718447, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24639257, Length=345, Percent_Identity=22.6086956521739, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281359715, Length=345, Percent_Identity=22.6086956521739, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281359713, Length=345, Percent_Identity=22.6086956521739, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24639250, Length=345, Percent_Identity=22.6086956521739, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI18543267, Length=345, Percent_Identity=22.6086956521739, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24639252, Length=345, Percent_Identity=22.6086956521739, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24585130, Length=281, Percent_Identity=22.7758007117438, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49936; Mature: 49805

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKIIVVGCTHAGIAAVNEILKYHPQADVTVFERHDTISYLSCATYLTLGKTISNLDEA
CCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
MYADPDYYRAQGIDMRLRHDVIDINVEEHTVFAQDLETKEFTTESFDKLIMATGSLTSIP
HCCCCCHHHHCCCCEEEECEEEEEECHHHEEEHHCCCCHHCCHHHHHHHHEECCCCCCCC
TIQGVENPKVKLCKTYEEARDLCDEAQNDERIAIIGGGYIGVELAEGYNKSNHEVILFHK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCCCCCCCEEEEEEC
KETPLDRHIEPEIADKITNLLEDKGIQVKTGTIVKSFEDGANDTLIVKTADEAFEVDMAV
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCCEEEEEECCHHHHCCHHH
ICTGLLPQADLLQGKVDQLTNGAIVVNDYMETSNPDIFAAGDAASVKHNGLQTDVYMPLA
HHHCCCCCHHHHCCCHHHHCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEECCHH
SQAVRQGALAGINVLDKRLRSIGTQSTTGMLIFGRTLACSGVTLAMALDAGINATKVAYK
HHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECEECCCCEEEEEEECCCCCEEEEEEC
GSYRPDFMPNAHKVEIELVYDRNSRKVLGVQLWSKHDVSQAADTISALMHYHGTIDELSF
CCCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHH
IDMLFSPNFDQPFNYLNLVGQLAVKQENGYLRT
HHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCC
>Mature Secondary Structure 
TEKIIVVGCTHAGIAAVNEILKYHPQADVTVFERHDTISYLSCATYLTLGKTISNLDEA
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
MYADPDYYRAQGIDMRLRHDVIDINVEEHTVFAQDLETKEFTTESFDKLIMATGSLTSIP
HCCCCCHHHHCCCCEEEECEEEEEECHHHEEEHHCCCCHHCCHHHHHHHHEECCCCCCCC
TIQGVENPKVKLCKTYEEARDLCDEAQNDERIAIIGGGYIGVELAEGYNKSNHEVILFHK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCCCCCCCEEEEEEC
KETPLDRHIEPEIADKITNLLEDKGIQVKTGTIVKSFEDGANDTLIVKTADEAFEVDMAV
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCCEEEEEECCHHHHCCHHH
ICTGLLPQADLLQGKVDQLTNGAIVVNDYMETSNPDIFAAGDAASVKHNGLQTDVYMPLA
HHHCCCCCHHHHCCCHHHHCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEECCHH
SQAVRQGALAGINVLDKRLRSIGTQSTTGMLIFGRTLACSGVTLAMALDAGINATKVAYK
HHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECEECCCCEEEEEEECCCCCEEEEEEC
GSYRPDFMPNAHKVEIELVYDRNSRKVLGVQLWSKHDVSQAADTISALMHYHGTIDELSF
CCCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHH
IDMLFSPNFDQPFNYLNLVGQLAVKQENGYLRT
HHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]