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The map label for this gene is pbpC [H]

Identifier: 110833761

GI number: 110833761

Start: 1003490

End: 1005775

Strand: Direct

Name: pbpC [H]

Synonym: ABO_0900

Alternate gene names: 110833761

Gene position: 1003490-1005775 (Clockwise)

Preceding gene: 110833760

Following gene: 110833762

Centisome position: 32.16

GC content: 64.04

Gene sequence:

>2286_bases
ATGGTGGTCGCGTTGCAGTTCTGGCCATTGCCCGAGCGGCTAACCCACACTCCGTACGCCACCCTGATGCTGGACCGCAA
TGATCGCTTGCTCGGGGCGCGTATTGCCGCAGATGAGCAGTGGCGCTTCGTTCCGGTGGAGGTGTTGCCGGACAAATACC
GCCGCGCCTTGCTGAGTTACGAAGACAAGCGCTTCTTCGCTCACCCCGGGGTCGATCCGCTGGCGATTGCTCGGGCTGCC
TGGCTCAATGCCCGTGCCGGCCGCGTGGTTAGCGGTGGCTCCACGCTGACCATGCAGCTGGCCCGGCTGCTGCGTGATGA
CCCGCCCAGAACACTGCCAGAGAAGGCCCGCGAGGCGCTGTTGGCGCTGCAGCTGGAATGGCACTTCAGCAAGGATGAGC
TGCTAATCCAGTACGCTAGCCGGGCTCCCTTTGGGGGCAATATTGTGGGGTTACGCGCCGCCGCTTGGCGTTACTTTGGC
CGGGAACCGGCGGCGTTGAGCTGGGCGGAAGCGGCGTTGTTGGCGGTGCTGCCCAATGCCCCCTCATTGATCCACCCGGG
GCGAAACCGGGAACGATTACGGGCCAAGCGCAATGGGTTGCTCAATGACCTGCACGAGAGCGGAGCACTGCCGGCCAGGG
ACCTGCAACTGGCACTGCTGGAACCTTTGCCCGCTGCCCCCAAGGCGTTGCCCGCTAACGCCAACCACCTGCTGAACTCT
CTCACCGTCAGTAGCGAACAACACCTGTTCCGCACTACTTTGGATGCAGACCTGCAGCACCGGGTGCGCGAGCTGGCGCG
CCGGCATGGTCGGCGCTTAGCCGGGGAGGGCGTGCATAATGTGGCGGTGGTGGTGATTGATCACATCGAGTTGGCCACCC
GCGCCTACGTGGGCAACATGACCCACGGCGATGCCCGCGAATACGGTGCCGCCGTGGATATCGCCAGTGCGCCGCGCTCC
ACGGGCAGCGTACTCAAGCCCTTGTTATATGGCCTGATGCTGGACGATGGGTTGTTGCTGCCCGATACGCTGGTGCCGGA
TTTGCCTACCAATTATGGCGGCTTCAGCCCGGAAAATTTCGACCATGGCTACCGGGGCGCTGTCCCTGCCCATCAGGCGC
TCAGTCAGTCCCTGAACATTCCCGCCGTGCGCATGCTGCGCGAATACGGGGTGGGGCGTTTCCATAACCAGCTGCAGCGC
ATGGGTATGACCACCCTGTTTCGTAACGCTGAAGATTACGGCCTCACCCTGGTGCTGGGTGGAGCAGAGGGGGCGCTTAA
CGAACTCACGGGTATTTACGCACGGCTGTTTGCTAGCGCCCGGCAGGCACCGGCTTACCCCGTGGCGGTGTTGCAATCCT
CCCTTGCCAATAGAGAGCCCGGCAGGGCGCAGCCCAGCCCTGTTCTTAGCCCCGGCGCTGCTTGGTTAACCCTGGATGCC
CTGCGCCAGGTGGCACGGCCCGGCACCGCCCGGCAATGGCGGTTGTTCAGCTCCAGCCAAGCCATCGCCTGGAAAACCGG
TACCAGCTATGGCCTGCGCGATGCCTGGGCTATCGGCAGTAATGGCCGCTACACCGTGGGCGTGTGGGCGGGCAACGGCA
ACGGTGAGCCGGCTCCTAGCCTGGGCGGCGCGGCCACTGCAGCGCCGTTGATGTTGGACGCGTTCAGCCTGCTGGGGCCG
GCTCGCTGGCCAGAGGCGCCCTTGGCTGATTTGAAAACCGTGCATGTGTGCAGTGACGACGGTTATCTGGCCGGGGGGCG
TTGCCCCACGGTGGAGCGGCAGGCGCCGCTGCACAGCCATTTCGAAACCGTCACGCCGTACCATGTGCGGGTGCATTTGG
ATAACAATGGCCAGCGGGTGCATAGCCAGTGCGAGCCGGTAAGCGCCATGCGTCATCGCGATTGGTTTGTGCTGCCTCCC
GGTCAGGCCTGGTTCTACCAGCGCCGCCACCCGCACTACCGGCCGTTGCCCAGCTGGCGGGAGGATTGCTTAGCGGGGGC
TCGGGCCATGGATAGCGAGCCGCCCATGGCACTGATCTACCCCCATGCGGGCACCGCCATTTATATTCCGGTGGAGCTGA
ATGGTCGGCTGGGCCGGGCGGTGTTGCGCGCGGTGCACCAGCGCGCCGATGCCACCCTGTATTGGCACCTGGATGCCACT
TACTTAGGGGAAACCCGCCATTTTCACGAATGGGCGCTCATCGCCGAGCCCGGCTGGCATACCCTCACGTTGGTGGATGA
TCAGGGGTTTCGGTTAAAGCAGCGCTTCAAGGTGTTGGGCAAATAA

Upstream 100 bases:

>100_bases
GGCGTAGCCGTAACCCGATACAGGCTTTTGCAACCGGCCCCCACCCGCGATGAAATTTCTGCGCCGTTCAATTCTTACCC
TGCTGATTATCGCTGTGCCT

Downstream 100 bases:

>100_bases
ATCACCTTTACTGCCAGATTACGCCTTTTCAGGTCCTCGGAGCCCTTGGGTACATTCCGCCGATAAAACCCTATATTCAC
CGCGCCTTTTCTTCGCGAAT

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MVVALQFWPLPERLTHTPYATLMLDRNDRLLGARIAADEQWRFVPVEVLPDKYRRALLSYEDKRFFAHPGVDPLAIARAA
WLNARAGRVVSGGSTLTMQLARLLRDDPPRTLPEKAREALLALQLEWHFSKDELLIQYASRAPFGGNIVGLRAAAWRYFG
REPAALSWAEAALLAVLPNAPSLIHPGRNRERLRAKRNGLLNDLHESGALPARDLQLALLEPLPAAPKALPANANHLLNS
LTVSSEQHLFRTTLDADLQHRVRELARRHGRRLAGEGVHNVAVVVIDHIELATRAYVGNMTHGDAREYGAAVDIASAPRS
TGSVLKPLLYGLMLDDGLLLPDTLVPDLPTNYGGFSPENFDHGYRGAVPAHQALSQSLNIPAVRMLREYGVGRFHNQLQR
MGMTTLFRNAEDYGLTLVLGGAEGALNELTGIYARLFASARQAPAYPVAVLQSSLANREPGRAQPSPVLSPGAAWLTLDA
LRQVARPGTARQWRLFSSSQAIAWKTGTSYGLRDAWAIGSNGRYTVGVWAGNGNGEPAPSLGGAATAAPLMLDAFSLLGP
ARWPEAPLADLKTVHVCSDDGYLAGGRCPTVERQAPLHSHFETVTPYHVRVHLDNNGQRVHSQCEPVSAMRHRDWFVLPP
GQAWFYQRRHPHYRPLPSWREDCLAGARAMDSEPPMALIYPHAGTAIYIPVELNGRLGRAVLRAVHQRADATLYWHLDAT
YLGETRHFHEWALIAEPGWHTLTLVDDQGFRLKQRFKVLGK

Sequences:

>Translated_761_residues
MVVALQFWPLPERLTHTPYATLMLDRNDRLLGARIAADEQWRFVPVEVLPDKYRRALLSYEDKRFFAHPGVDPLAIARAA
WLNARAGRVVSGGSTLTMQLARLLRDDPPRTLPEKAREALLALQLEWHFSKDELLIQYASRAPFGGNIVGLRAAAWRYFG
REPAALSWAEAALLAVLPNAPSLIHPGRNRERLRAKRNGLLNDLHESGALPARDLQLALLEPLPAAPKALPANANHLLNS
LTVSSEQHLFRTTLDADLQHRVRELARRHGRRLAGEGVHNVAVVVIDHIELATRAYVGNMTHGDAREYGAAVDIASAPRS
TGSVLKPLLYGLMLDDGLLLPDTLVPDLPTNYGGFSPENFDHGYRGAVPAHQALSQSLNIPAVRMLREYGVGRFHNQLQR
MGMTTLFRNAEDYGLTLVLGGAEGALNELTGIYARLFASARQAPAYPVAVLQSSLANREPGRAQPSPVLSPGAAWLTLDA
LRQVARPGTARQWRLFSSSQAIAWKTGTSYGLRDAWAIGSNGRYTVGVWAGNGNGEPAPSLGGAATAAPLMLDAFSLLGP
ARWPEAPLADLKTVHVCSDDGYLAGGRCPTVERQAPLHSHFETVTPYHVRVHLDNNGQRVHSQCEPVSAMRHRDWFVLPP
GQAWFYQRRHPHYRPLPSWREDCLAGARAMDSEPPMALIYPHAGTAIYIPVELNGRLGRAVLRAVHQRADATLYWHLDAT
YLGETRHFHEWALIAEPGWHTLTLVDDQGFRLKQRFKVLGK
>Mature_761_residues
MVVALQFWPLPERLTHTPYATLMLDRNDRLLGARIAADEQWRFVPVEVLPDKYRRALLSYEDKRFFAHPGVDPLAIARAA
WLNARAGRVVSGGSTLTMQLARLLRDDPPRTLPEKAREALLALQLEWHFSKDELLIQYASRAPFGGNIVGLRAAAWRYFG
REPAALSWAEAALLAVLPNAPSLIHPGRNRERLRAKRNGLLNDLHESGALPARDLQLALLEPLPAAPKALPANANHLLNS
LTVSSEQHLFRTTLDADLQHRVRELARRHGRRLAGEGVHNVAVVVIDHIELATRAYVGNMTHGDAREYGAAVDIASAPRS
TGSVLKPLLYGLMLDDGLLLPDTLVPDLPTNYGGFSPENFDHGYRGAVPAHQALSQSLNIPAVRMLREYGVGRFHNQLQR
MGMTTLFRNAEDYGLTLVLGGAEGALNELTGIYARLFASARQAPAYPVAVLQSSLANREPGRAQPSPVLSPGAAWLTLDA
LRQVARPGTARQWRLFSSSQAIAWKTGTSYGLRDAWAIGSNGRYTVGVWAGNGNGEPAPSLGGAATAAPLMLDAFSLLGP
ARWPEAPLADLKTVHVCSDDGYLAGGRCPTVERQAPLHSHFETVTPYHVRVHLDNNGQRVHSQCEPVSAMRHRDWFVLPP
GQAWFYQRRHPHYRPLPSWREDCLAGARAMDSEPPMALIYPHAGTAIYIPVELNGRLGRAVLRAVHQRADATLYWHLDAT
YLGETRHFHEWALIAEPGWHTLTLVDDQGFRLKQRFKVLGK

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=791, Percent_Identity=34.7661188369153, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786343, Length=593, Percent_Identity=27.318718381113, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI87082258, Length=196, Percent_Identity=35.7142857142857, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1789601, Length=199, Percent_Identity=30.6532663316583, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 84081; Mature: 84081

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVALQFWPLPERLTHTPYATLMLDRNDRLLGARIAADEQWRFVPVEVLPDKYRRALLSY
CEEEEEECCCCHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEHEECCHHHHHHHHCC
EDKRFFAHPGVDPLAIARAAWLNARAGRVVSGGSTLTMQLARLLRDDPPRTLPEKAREAL
CCCEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHH
LALQLEWHFSKDELLIQYASRAPFGGNIVGLRAAAWRYFGREPAALSWAEAALLAVLPNA
EEEEEEECCCCCHHHHEEHHCCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHEECCCC
PSLIHPGRNRERLRAKRNGLLNDLHESGALPARDLQLALLEPLPAAPKALPANANHLLNS
CCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHCCHHEEECCCCCCCCCCCCCHHHHHHH
LTVSSEQHLFRTTLDADLQHRVRELARRHGRRLAGEGVHNVAVVVIDHIELATRAYVGNM
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHCCC
THGDAREYGAAVDIASAPRSTGSVLKPLLYGLMLDDGLLLPDTLVPDLPTNYGGFSPENF
CCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCC
DHGYRGAVPAHQALSQSLNIPAVRMLREYGVGRFHNQLQRMGMTTLFRNAEDYGLTLVLG
CCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCHHHHHCCCCCCCEEEEEE
GAEGALNELTGIYARLFASARQAPAYPVAVLQSSLANREPGRAQPSPVLSPGAAWLTLDA
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LRQVARPGTARQWRLFSSSQAIAWKTGTSYGLRDAWAIGSNGRYTVGVWAGNGNGEPAPS
HHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCC
LGGAATAAPLMLDAFSLLGPARWPEAPLADLKTVHVCSDDGYLAGGRCPTVERQAPLHSH
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCHHH
FETVTPYHVRVHLDNNGQRVHSQCEPVSAMRHRDWFVLPPGQAWFYQRRHPHYRPLPSWR
HCCCCCEEEEEEECCCCHHHHHHCCHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCCHH
EDCLAGARAMDSEPPMALIYPHAGTAIYIPVELNGRLGRAVLRAVHQRADATLYWHLDAT
HHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEEE
YLGETRHFHEWALIAEPGWHTLTLVDDQGFRLKQRFKVLGK
EECCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MVVALQFWPLPERLTHTPYATLMLDRNDRLLGARIAADEQWRFVPVEVLPDKYRRALLSY
CEEEEEECCCCHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEHEECCHHHHHHHHCC
EDKRFFAHPGVDPLAIARAAWLNARAGRVVSGGSTLTMQLARLLRDDPPRTLPEKAREAL
CCCEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHH
LALQLEWHFSKDELLIQYASRAPFGGNIVGLRAAAWRYFGREPAALSWAEAALLAVLPNA
EEEEEEECCCCCHHHHEEHHCCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHEECCCC
PSLIHPGRNRERLRAKRNGLLNDLHESGALPARDLQLALLEPLPAAPKALPANANHLLNS
CCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHCCHHEEECCCCCCCCCCCCCHHHHHHH
LTVSSEQHLFRTTLDADLQHRVRELARRHGRRLAGEGVHNVAVVVIDHIELATRAYVGNM
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHCCC
THGDAREYGAAVDIASAPRSTGSVLKPLLYGLMLDDGLLLPDTLVPDLPTNYGGFSPENF
CCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCC
DHGYRGAVPAHQALSQSLNIPAVRMLREYGVGRFHNQLQRMGMTTLFRNAEDYGLTLVLG
CCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCHHHHHCCCCCCCEEEEEE
GAEGALNELTGIYARLFASARQAPAYPVAVLQSSLANREPGRAQPSPVLSPGAAWLTLDA
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LRQVARPGTARQWRLFSSSQAIAWKTGTSYGLRDAWAIGSNGRYTVGVWAGNGNGEPAPS
HHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCC
LGGAATAAPLMLDAFSLLGPARWPEAPLADLKTVHVCSDDGYLAGGRCPTVERQAPLHSH
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCHHH
FETVTPYHVRVHLDNNGQRVHSQCEPVSAMRHRDWFVLPPGQAWFYQRRHPHYRPLPSWR
HCCCCCEEEEEEECCCCHHHHHHCCHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCCHH
EDCLAGARAMDSEPPMALIYPHAGTAIYIPVELNGRLGRAVLRAVHQRADATLYWHLDAT
HHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEEE
YLGETRHFHEWALIAEPGWHTLTLVDDQGFRLKQRFKVLGK
EECCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]