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The map label for this gene is fdhA [H]

Identifier: 110833762

GI number: 110833762

Start: 1005917

End: 1008136

Strand: Direct

Name: fdhA [H]

Synonym: ABO_0901

Alternate gene names: 110833762

Gene position: 1005917-1008136 (Clockwise)

Preceding gene: 110833761

Following gene: 110833764

Centisome position: 32.24

GC content: 60.18

Gene sequence:

>2220_bases
ATGACACACCTTCACTACCACACCTGTAATTTATGCGAAGCCATGTGCGGTATCGAGGTAGAGCACAACGGAGATGACAT
ACACGCTATCCGTGGTGACAAGGCCGACCCGTTCAGCCGTGGGCATATCTGCCCTAAGGCCGTGGCGTTGCAAGATCTGC
ATAACGACCCAGACCGCCTGCGCCACCCGGTGAAGCGCACCGCCGATGGCTGGGTGCCGATTAGCTGGGATGAAGCCCTG
GATGAAACCGCCCAGCGGCTCCACGACATTCAGCGCGCGCACGGCAACAATGCGGTATCGCTGTACTTGGGCAACCCCAC
GGCACACAACCACGGAGCCCTGTTTATGTTGTTGCCGTTTACCTGGGCGCTGAATACCCGCCAGCGCTTCAGCGCCACCT
CAACGGACCAGTTGCCCCATCAGCTTGCTACTTACCAGCTGTTTGGCCACCAGGCCCTGTTCCCGATTCCGGATATCGAC
CGTACCGATTACTTCATGATCATTGGCGGTAACCCATTGGTTTCCAACGGTTCCATCATGACCGTCCCCGACGTGAAAAA
TCGCCTCAAGGCGCTGCAAAGCCGCGGGGGCAAACTGGTGGTGGTGGACCCGCGTCGTACCGAAACCGCCCAGCTGGCAA
ACGAGCATCATTTCGTGCGCCCGGGCACCGATGTGTACCTGCTGCTGGCGCTAGTGCAGGTGCTGTATGCGGAATTATTG
GTGGCGCCGGGCCGTATCGATGGCTTGCTTGATGGCAAGCAAACCCTAGAGAAGCTGGTGGCGCCCTGGACCCCGGAAAA
AGTGGCTGAGGCGGTGGGCATACCCGCCGAGACTATCCGCACGCTGGCTCGCGATATTGCTAACGCGCCCAGCGCGGCGG
TGTACTCCCGCGTGGGGGTAACCACCAGCGCCCACGGCAGCCTCAGCGCCTGGCTGGTCTATGTGATTAACATCCTCACC
GGCAATCTGGACCGCCAAGGGGGCGTCATGTTCACCAACCCGGCTTTTGATGTTGTCAGCATGAGTGGCCTGAGTGGCGA
TACCGGCAGCTTCGACGCTTATCGCAGCCGGGTGAACGGCTACCCGGAGTTCGGCGGTGAATTTCCGGTCACGGCCATGG
CCGATGAAATGCTGACGCCGGGGCGCGGCCAGATAAAAGCCTTTATTTCTCATGCCGGCAACCCGGTGTTGTCGTGCCCA
GATGGCAACAAGCTGGATCGTGCGCTCAGTGGCCTGGATTTCATGGTCAGCATCGATTTTTACATCAATGAAACCACCCG
CCATGCGGACATTATTCTGCCGCCCACCGGCCAGCTCGAACACGGCCAGTTCGACCCTATTTTTCAGGCGGTGGCGGTGC
GCAATGTGGTGAAATACACGCCACCGTTGGTGCCTCGCCCGGAAGGCATGTTGCACGATTGGGAAATCCTGCTTGGGCTC
ACCTCACGGTTGAACCGGCTTAACGCCCGCAGTCGCCGCAACCGCTTGAAGTTTGCCGCCACCGATCGTTTTATCCGCAC
GCTGGGCGACCGGGGCATTATCGATTTGGGCCTGCGCCTGGGGCCCTATGGTAGTGGCGGCAAGGCCCTAGCCGAGCTGA
GGGAAAAGGGCTTGCATACCCTGCCTAAAGTGGCTTGGCGTTTGCTGCGTGGCAACAGCGGTGGGTTAACGTTAAAGCGC
TTGGAAGCCGCTCCCCATGGCATTGATTTAGGGCCGCTGGTGCCCATGCTGCCGCAACGCCTTTACACCCCCAATCAACG
GATCAATCTGGTTCCCGCCCTCTATAACCGGGCACTGCAAGGGTTGCCGGTGCCGGATGCCCCGCAAGGCAATCAGCTGT
TGATGATTGGCCGCCGTCATCTGCGCAGCAATAACTCCTGGATGCACAACAGCCAACGGCTAATCAAAGGCAAAGGCCGT
TTCAACGCCATGCTCCACCCTGTGGATGCAGAACGGTTGGGGGTGCAAGAGGGCGCAGATGTGCTCATTAGCGGCAGTGC
CGGCAGCATAACGCTACCGGCCACCCTCAGTGACGACATCATGCCCGGTGTGGTCAGCGTGCCCCATGGTTGGGGCCATG
ATCGCGCGGGCGTTCAGTTGGGCATTGCCCGGAGTACAGCGGGCAGCAGCATCAACGATGTGCTGGGCACCGAGCGGGTG
GAAGCGGTAACGGCCATGGCGCAGCTCAATGGCATTCCCGTTACGCTGGCCCCAGCATGA

Upstream 100 bases:

>100_bases
GCCCTTGGGTACATTCCGCCGATAAAACCCTATATTCACCGCGCCTTTTCTTCGCGAATCTGATAAACAAGAACTCTTCG
CGCAACCAACGGGGCTACCG

Downstream 100 bases:

>100_bases
GAACACTGACCATAGGCCGGCAGAGGTGGCTACCCCGTTAGCCGGCGCGCGCCAGCAACAAACATCACCACAGCTGGGGT
ACTTTTTGCAGCTTGTTCAG

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MTHLHYHTCNLCEAMCGIEVEHNGDDIHAIRGDKADPFSRGHICPKAVALQDLHNDPDRLRHPVKRTADGWVPISWDEAL
DETAQRLHDIQRAHGNNAVSLYLGNPTAHNHGALFMLLPFTWALNTRQRFSATSTDQLPHQLATYQLFGHQALFPIPDID
RTDYFMIIGGNPLVSNGSIMTVPDVKNRLKALQSRGGKLVVVDPRRTETAQLANEHHFVRPGTDVYLLLALVQVLYAELL
VAPGRIDGLLDGKQTLEKLVAPWTPEKVAEAVGIPAETIRTLARDIANAPSAAVYSRVGVTTSAHGSLSAWLVYVINILT
GNLDRQGGVMFTNPAFDVVSMSGLSGDTGSFDAYRSRVNGYPEFGGEFPVTAMADEMLTPGRGQIKAFISHAGNPVLSCP
DGNKLDRALSGLDFMVSIDFYINETTRHADIILPPTGQLEHGQFDPIFQAVAVRNVVKYTPPLVPRPEGMLHDWEILLGL
TSRLNRLNARSRRNRLKFAATDRFIRTLGDRGIIDLGLRLGPYGSGGKALAELREKGLHTLPKVAWRLLRGNSGGLTLKR
LEAAPHGIDLGPLVPMLPQRLYTPNQRINLVPALYNRALQGLPVPDAPQGNQLLMIGRRHLRSNNSWMHNSQRLIKGKGR
FNAMLHPVDAERLGVQEGADVLISGSAGSITLPATLSDDIMPGVVSVPHGWGHDRAGVQLGIARSTAGSSINDVLGTERV
EAVTAMAQLNGIPVTLAPA

Sequences:

>Translated_739_residues
MTHLHYHTCNLCEAMCGIEVEHNGDDIHAIRGDKADPFSRGHICPKAVALQDLHNDPDRLRHPVKRTADGWVPISWDEAL
DETAQRLHDIQRAHGNNAVSLYLGNPTAHNHGALFMLLPFTWALNTRQRFSATSTDQLPHQLATYQLFGHQALFPIPDID
RTDYFMIIGGNPLVSNGSIMTVPDVKNRLKALQSRGGKLVVVDPRRTETAQLANEHHFVRPGTDVYLLLALVQVLYAELL
VAPGRIDGLLDGKQTLEKLVAPWTPEKVAEAVGIPAETIRTLARDIANAPSAAVYSRVGVTTSAHGSLSAWLVYVINILT
GNLDRQGGVMFTNPAFDVVSMSGLSGDTGSFDAYRSRVNGYPEFGGEFPVTAMADEMLTPGRGQIKAFISHAGNPVLSCP
DGNKLDRALSGLDFMVSIDFYINETTRHADIILPPTGQLEHGQFDPIFQAVAVRNVVKYTPPLVPRPEGMLHDWEILLGL
TSRLNRLNARSRRNRLKFAATDRFIRTLGDRGIIDLGLRLGPYGSGGKALAELREKGLHTLPKVAWRLLRGNSGGLTLKR
LEAAPHGIDLGPLVPMLPQRLYTPNQRINLVPALYNRALQGLPVPDAPQGNQLLMIGRRHLRSNNSWMHNSQRLIKGKGR
FNAMLHPVDAERLGVQEGADVLISGSAGSITLPATLSDDIMPGVVSVPHGWGHDRAGVQLGIARSTAGSSINDVLGTERV
EAVTAMAQLNGIPVTLAPA
>Mature_738_residues
THLHYHTCNLCEAMCGIEVEHNGDDIHAIRGDKADPFSRGHICPKAVALQDLHNDPDRLRHPVKRTADGWVPISWDEALD
ETAQRLHDIQRAHGNNAVSLYLGNPTAHNHGALFMLLPFTWALNTRQRFSATSTDQLPHQLATYQLFGHQALFPIPDIDR
TDYFMIIGGNPLVSNGSIMTVPDVKNRLKALQSRGGKLVVVDPRRTETAQLANEHHFVRPGTDVYLLLALVQVLYAELLV
APGRIDGLLDGKQTLEKLVAPWTPEKVAEAVGIPAETIRTLARDIANAPSAAVYSRVGVTTSAHGSLSAWLVYVINILTG
NLDRQGGVMFTNPAFDVVSMSGLSGDTGSFDAYRSRVNGYPEFGGEFPVTAMADEMLTPGRGQIKAFISHAGNPVLSCPD
GNKLDRALSGLDFMVSIDFYINETTRHADIILPPTGQLEHGQFDPIFQAVAVRNVVKYTPPLVPRPEGMLHDWEILLGLT
SRLNRLNARSRRNRLKFAATDRFIRTLGDRGIIDLGLRLGPYGSGGKALAELREKGLHTLPKVAWRLLRGNSGGLTLKRL
EAAPHGIDLGPLVPMLPQRLYTPNQRINLVPALYNRALQGLPVPDAPQGNQLLMIGRRHLRSNNSWMHNSQRLIKGKGRF
NAMLHPVDAERLGVQEGADVLISGSAGSITLPATLSDDIMPGVVSVPHGWGHDRAGVQLGIARSTAGSSINDVLGTERVE
AVTAMAQLNGIPVTLAPA

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=500, Percent_Identity=27, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI1787870, Length=491, Percent_Identity=24.2362525458248, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1787231, Length=515, Percent_Identity=25.631067961165, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI171474008, Length=498, Percent_Identity=24.8995983935743, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI145693196, Length=799, Percent_Identity=22.4030037546934, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI3868720, Length=398, Percent_Identity=23.8693467336683, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787778, Length=438, Percent_Identity=23.7442922374429, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 80518; Mature: 80387

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLHYHTCNLCEAMCGIEVEHNGDDIHAIRGDKADPFSRGHICPKAVALQDLHNDPDRL
CCEEEECHHHHHHHHHCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
RHPVKRTADGWVPISWDEALDETAQRLHDIQRAHGNNAVSLYLGNPTAHNHGALFMLLPF
HHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEH
TWALNTRQRFSATSTDQLPHQLATYQLFGHQALFPIPDIDRTDYFMIIGGNPLVSNGSIM
HHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCEEECCCCEE
TVPDVKNRLKALQSRGGKLVVVDPRRTETAQLANEHHFVRPGTDVYLLLALVQVLYAELL
ECCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHH
VAPGRIDGLLDGKQTLEKLVAPWTPEKVAEAVGIPAETIRTLARDIANAPSAAVYSRVGV
HCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCC
TTSAHGSLSAWLVYVINILTGNLDRQGGVMFTNPAFDVVSMSGLSGDTGSFDAYRSRVNG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCCCCHHHHHHHCCC
YPEFGGEFPVTAMADEMLTPGRGQIKAFISHAGNPVLSCPDGNKLDRALSGLDFMVSIDF
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHCCCEEEEEEEE
YINETTRHADIILPPTGQLEHGQFDPIFQAVAVRNVVKYTPPLVPRPEGMLHDWEILLGL
EECCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
TSRLNRLNARSRRNRLKFAATDRFIRTLGDRGIIDLGLRLGPYGSGGKALAELREKGLHT
HHHHHHHHHHHHHCCEEHHHHHHHHHHHCCCCEEEECCEECCCCCCHHHHHHHHHCCCHH
LPKVAWRLLRGNSGGLTLKRLEAAPHGIDLGPLVPMLPQRLYTPNQRINLVPALYNRALQ
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHC
GLPVPDAPQGNQLLMIGRRHLRSNNSWMHNSQRLIKGKGRFNAMLHPVDAERLGVQEGAD
CCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCHHEECCCCCCEEECCCCHHHHCCCCCCC
VLISGSAGSITLPATLSDDIMPGVVSVPHGWGHDRAGVQLGIARSTAGSSINDVLGTERV
EEEECCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
EAVTAMAQLNGIPVTLAPA
HHHHHHHHHCCCCEEECCC
>Mature Secondary Structure 
THLHYHTCNLCEAMCGIEVEHNGDDIHAIRGDKADPFSRGHICPKAVALQDLHNDPDRL
CEEEECHHHHHHHHHCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
RHPVKRTADGWVPISWDEALDETAQRLHDIQRAHGNNAVSLYLGNPTAHNHGALFMLLPF
HHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEH
TWALNTRQRFSATSTDQLPHQLATYQLFGHQALFPIPDIDRTDYFMIIGGNPLVSNGSIM
HHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCEEECCCCEE
TVPDVKNRLKALQSRGGKLVVVDPRRTETAQLANEHHFVRPGTDVYLLLALVQVLYAELL
ECCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHH
VAPGRIDGLLDGKQTLEKLVAPWTPEKVAEAVGIPAETIRTLARDIANAPSAAVYSRVGV
HCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCC
TTSAHGSLSAWLVYVINILTGNLDRQGGVMFTNPAFDVVSMSGLSGDTGSFDAYRSRVNG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCCCCHHHHHHHCCC
YPEFGGEFPVTAMADEMLTPGRGQIKAFISHAGNPVLSCPDGNKLDRALSGLDFMVSIDF
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHCCCEEEEEEEE
YINETTRHADIILPPTGQLEHGQFDPIFQAVAVRNVVKYTPPLVPRPEGMLHDWEILLGL
EECCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
TSRLNRLNARSRRNRLKFAATDRFIRTLGDRGIIDLGLRLGPYGSGGKALAELREKGLHT
HHHHHHHHHHHHHCCEEHHHHHHHHHHHCCCCEEEECCEECCCCCCHHHHHHHHHCCCHH
LPKVAWRLLRGNSGGLTLKRLEAAPHGIDLGPLVPMLPQRLYTPNQRINLVPALYNRALQ
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHC
GLPVPDAPQGNQLLMIGRRHLRSNNSWMHNSQRLIKGKGRFNAMLHPVDAERLGVQEGAD
CCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCHHEECCCCCCEEECCCCHHHHCCCCCCC
VLISGSAGSITLPATLSDDIMPGVVSVPHGWGHDRAGVQLGIARSTAGSSINDVLGTERV
EEEECCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
EAVTAMAQLNGIPVTLAPA
HHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]