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The map label for this gene is hisD [H]

Identifier: 110833423

GI number: 110833423

Start: 619215

End: 620516

Strand: Direct

Name: hisD [H]

Synonym: ABO_0562

Alternate gene names: 110833423

Gene position: 619215-620516 (Clockwise)

Preceding gene: 110833422

Following gene: 110833424

Centisome position: 19.85

GC content: 58.37

Gene sequence:

>1302_bases
ATGGAAACCACCTGGCTTAACGCCCAAGATGCGGATTTCGATGCCAAGCTCGCCGCGCTAACCGCCTGGTCGGAAGAGCG
TGACGAAGAGGTGGCGCATCGTGTGCGCGGCATCCTCAAGGGTGTGGCCCAGCGTGGCGACGTGGCACTGGTGGAGTACA
CCAACCGCTTTGACCGTCGTGATGTGTCGGCCATGGATGAGCTGGTAGTGGATCAGGCTCAGTTGCAGGCCGCGCTGGCG
CGTATTCCCGCTGAACAACGCGAAGCCCTGGAGGCGGCCGCTGATCGTGTGCGTCGCTACCATGAAAAGCAGAAACAGGA
TTCCTGGCACTACCGGGAAGCGGACGGCACCTTGCTGGGCCAGCAGGTGACGCCTTTGGATCGGGCCGGTATTTATGTGC
CCGGCGGTAAAGCCGCGTACCCCAGCTCAGTATTAATGAATGCGCTACCGGCAAAGGTGGCGGGTGTCGGCGAGATCATA
ATGGTATCGCCTGCCCCAGAGGGCATCATCAATGACATGGTGCTGGCGGCGGCGGCTATTGCGGGTGTCGACAAGCTCTT
TACTCTGGGCGGCGGGCAAGCGGTGGCCGCTTTGGCCTACGGTACAGAGACGGTGCCGGCGGTGGATAAAATTGTCGGCC
CCGGCAATATCTATGTGGCCGAAGCCAAACGGCAGGTGTTTGGCAAAGTAGGCATCGACATGATTGCCGGCCCTTCGGAA
ATTTTGGTGGTCTGTGACGGCAAGACCAACCCGGACTGGATTGCCATGGATCTGTTTTCTCAGGCTGAGCATGATGAGGA
AGCTCAGGCCATTTTGGTGTCACCGGACGCCGATTTTTTGAAGCAGGTTGCGCAGTCCATGGAAACCTTGGCCGCGACTC
TGGAGCGGGAAACCATTATTCGCACGTCCATGAAGCACCGGGGGGCGTTGATTCAGGTGAAGGATCTGGATCAGGCCATC
GAAATCGCCAACCGCATTGCTTCTGAGCATCTGGAATTATCCATTGATGACGCGGAGCAATGGGCGAAAAAAGTTCGCCA
TGCCGGTGCGATTTTTCTGGGTCGCCACACTCCCGAAGCGTTGGGTGATTACTGCGCCGGGCCGAACCACGTGCTGCCTA
CGAGTGCCACCGCCCGCTTTTCTTCGCCATTGGGTGTGTACGATTTTCAGAAACGCAGTTCGCTGATTGGCTGCTCCCCG
GAAGGGGCTAGCAGTCTTGCAAAAATTGCCTCTCCGCTTGCCCGTGGCGAAAGCCTCACGGCCCATGCCCGCAGTGCGGA
ATATAGAATCAAGAAACGCTAA

Upstream 100 bases:

>100_bases
TTTTGCTTATCTTTGCGATAGAAAAAGCGTCGCTTTTTTTCCGTGAACCCTGAGCCCTCTGTGGTAAAAATAGATTCTGA
CTTTTAAAACGGTGCCAACC

Downstream 100 bases:

>100_bases
CACGCCTCACGCATCACGTTTCCACGGGTGATGCGTGTTGCCTGATGCATGCAGGCGGAATACGTATGAGTAAATATTGG
AGCGACTTCGTTCACCATTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
METTWLNAQDADFDAKLAALTAWSEERDEEVAHRVRGILKGVAQRGDVALVEYTNRFDRRDVSAMDELVVDQAQLQAALA
RIPAEQREALEAAADRVRRYHEKQKQDSWHYREADGTLLGQQVTPLDRAGIYVPGGKAAYPSSVLMNALPAKVAGVGEII
MVSPAPEGIINDMVLAAAAIAGVDKLFTLGGGQAVAALAYGTETVPAVDKIVGPGNIYVAEAKRQVFGKVGIDMIAGPSE
ILVVCDGKTNPDWIAMDLFSQAEHDEEAQAILVSPDADFLKQVAQSMETLAATLERETIIRTSMKHRGALIQVKDLDQAI
EIANRIASEHLELSIDDAEQWAKKVRHAGAIFLGRHTPEALGDYCAGPNHVLPTSATARFSSPLGVYDFQKRSSLIGCSP
EGASSLAKIASPLARGESLTAHARSAEYRIKKR

Sequences:

>Translated_433_residues
METTWLNAQDADFDAKLAALTAWSEERDEEVAHRVRGILKGVAQRGDVALVEYTNRFDRRDVSAMDELVVDQAQLQAALA
RIPAEQREALEAAADRVRRYHEKQKQDSWHYREADGTLLGQQVTPLDRAGIYVPGGKAAYPSSVLMNALPAKVAGVGEII
MVSPAPEGIINDMVLAAAAIAGVDKLFTLGGGQAVAALAYGTETVPAVDKIVGPGNIYVAEAKRQVFGKVGIDMIAGPSE
ILVVCDGKTNPDWIAMDLFSQAEHDEEAQAILVSPDADFLKQVAQSMETLAATLERETIIRTSMKHRGALIQVKDLDQAI
EIANRIASEHLELSIDDAEQWAKKVRHAGAIFLGRHTPEALGDYCAGPNHVLPTSATARFSSPLGVYDFQKRSSLIGCSP
EGASSLAKIASPLARGESLTAHARSAEYRIKKR
>Mature_433_residues
METTWLNAQDADFDAKLAALTAWSEERDEEVAHRVRGILKGVAQRGDVALVEYTNRFDRRDVSAMDELVVDQAQLQAALA
RIPAEQREALEAAADRVRRYHEKQKQDSWHYREADGTLLGQQVTPLDRAGIYVPGGKAAYPSSVLMNALPAKVAGVGEII
MVSPAPEGIINDMVLAAAAIAGVDKLFTLGGGQAVAALAYGTETVPAVDKIVGPGNIYVAEAKRQVFGKVGIDMIAGPSE
ILVVCDGKTNPDWIAMDLFSQAEHDEEAQAILVSPDADFLKQVAQSMETLAATLERETIIRTSMKHRGALIQVKDLDQAI
EIANRIASEHLELSIDDAEQWAKKVRHAGAIFLGRHTPEALGDYCAGPNHVLPTSATARFSSPLGVYDFQKRSSLIGCSP
EGASSLAKIASPLARGESLTAHARSAEYRIKKR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=406, Percent_Identity=41.6256157635468, Blast_Score=304, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=416, Percent_Identity=35.5769230769231, Blast_Score=255, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46740; Mature: 46740

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTWLNAQDADFDAKLAALTAWSEERDEEVAHRVRGILKGVAQRGDVALVEYTNRFDRR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCC
DVSAMDELVVDQAQLQAALARIPAEQREALEAAADRVRRYHEKQKQDSWHYREADGTLLG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEC
QQVTPLDRAGIYVPGGKAAYPSSVLMNALPAKVAGVGEIIMVSPAPEGIINDMVLAAAAI
CCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
AGVDKLFTLGGGQAVAALAYGTETVPAVDKIVGPGNIYVAEAKRQVFGKVGIDMIAGPSE
HHHHHHHCCCCCCEEEHHHCCCCCCHHHHHHCCCCCEEEEHHHHHHHHHCCCCEECCCCE
ILVVCDGKTNPDWIAMDLFSQAEHDEEAQAILVSPDADFLKQVAQSMETLAATLERETII
EEEEECCCCCCCEEHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RTSMKHRGALIQVKDLDQAIEIANRIASEHLELSIDDAEQWAKKVRHAGAIFLGRHTPEA
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCEEEEECCCHHH
LGDYCAGPNHVLPTSATARFSSPLGVYDFQKRSSLIGCSPEGASSLAKIASPLARGESLT
HHHHCCCCCCCCCCCCCHHCCCCCCCCCHHHCCCEECCCCCCHHHHHHHHHHHHCCCCCC
AHARSAEYRIKKR
HHHCCCCEEECCC
>Mature Secondary Structure
METTWLNAQDADFDAKLAALTAWSEERDEEVAHRVRGILKGVAQRGDVALVEYTNRFDRR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCC
DVSAMDELVVDQAQLQAALARIPAEQREALEAAADRVRRYHEKQKQDSWHYREADGTLLG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEC
QQVTPLDRAGIYVPGGKAAYPSSVLMNALPAKVAGVGEIIMVSPAPEGIINDMVLAAAAI
CCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
AGVDKLFTLGGGQAVAALAYGTETVPAVDKIVGPGNIYVAEAKRQVFGKVGIDMIAGPSE
HHHHHHHCCCCCCEEEHHHCCCCCCHHHHHHCCCCCEEEEHHHHHHHHHCCCCEECCCCE
ILVVCDGKTNPDWIAMDLFSQAEHDEEAQAILVSPDADFLKQVAQSMETLAATLERETII
EEEEECCCCCCCEEHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RTSMKHRGALIQVKDLDQAIEIANRIASEHLELSIDDAEQWAKKVRHAGAIFLGRHTPEA
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCEEEEECCCHHH
LGDYCAGPNHVLPTSATARFSSPLGVYDFQKRSSLIGCSPEGASSLAKIASPLARGESLT
HHHHCCCCCCCCCCCCCHHCCCCCCCCCHHHCCCEECCCCCCHHHHHHHHHHHHCCCCCC
AHARSAEYRIKKR
HHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]