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The map label for this gene is hisG

Identifier: 110833422

GI number: 110833422

Start: 618397

End: 619041

Strand: Direct

Name: hisG

Synonym: ABO_0561

Alternate gene names: 110833422

Gene position: 618397-619041 (Clockwise)

Preceding gene: 110833421

Following gene: 110833423

Centisome position: 19.82

GC content: 54.57

Gene sequence:

>645_bases
ATGAGTAAGCCATTGACCATCGCCCTTTCTAAAGGGCGCATTCTCAAGGAAACCCTGCCGCTGCTGAAAGCCGCAGGCAT
TGAGCTGCTGGAAGACCCGGCAGCGTCGCGCAAGCTGATTTTTGACACCACCCGAGACGATGTAAAAATTATCATCATTC
GCGCCACGGACGTCCCCCCCTATGTGCAGCATGGTGCGGCGGATATTGGTGTGGCCGGAAAAGACGTGCTCATGGAGCAT
GGCGGTGACGGGGTGTTTGAGCCAGTGGATCTGGATATTGCTCGCTGCAAATTGATGGTGGCAGCTATGAAGGATGCTCC
GGAAACCGGTAGCCGGCTGCGCGTAGCCACTAAATTTGTAAACGTGGCCAAAGCCTACTACGCCCAGCAGGGCAAGCAGG
CGGAAGTGATTAAGCTATACGGCGCGATGGAACTGGCCCCGTTAGTGGGGCTGGCGGACCGCATTGTGGATATCGTTGAT
ACCGGCAACACGTTGCGTGCTAATGGGCTAGAACCCACAGAGCTAATTGCCCATATTTCTACCCGGGTGATTGTTAATCG
CGCCAGCATGAAAACTCGCCATAGTGATATCCAAACGATTTTGGACAAGCTGGTAGAGGCGGTAGCCTCTCGCAAGGCAG
GTTAA

Upstream 100 bases:

>100_bases
TTTACCATATTGATCGCGGTTATGAGTGTATCGAAGAGAAACTGCAATCGCTGGGCGCGATCATCCGTCGCGTACCACGC
TGACCGGATCGGGACCTGTG

Downstream 100 bases:

>100_bases
AGGCCTTTCATCATAGATCGCATAGCGTAAACAGCTAAAAATATACCTGTTTGATGTGATGTTGAGCGAGAGGTTTTGCT
TATCTTTGCGATAGAAAAAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSKPLTIALSKGRILKETLPLLKAAGIELLEDPAASRKLIFDTTRDDVKIIIIRATDVPPYVQHGAADIGVAGKDVLMEH
GGDGVFEPVDLDIARCKLMVAAMKDAPETGSRLRVATKFVNVAKAYYAQQGKQAEVIKLYGAMELAPLVGLADRIVDIVD
TGNTLRANGLEPTELIAHISTRVIVNRASMKTRHSDIQTILDKLVEAVASRKAG

Sequences:

>Translated_214_residues
MSKPLTIALSKGRILKETLPLLKAAGIELLEDPAASRKLIFDTTRDDVKIIIIRATDVPPYVQHGAADIGVAGKDVLMEH
GGDGVFEPVDLDIARCKLMVAAMKDAPETGSRLRVATKFVNVAKAYYAQQGKQAEVIKLYGAMELAPLVGLADRIVDIVD
TGNTLRANGLEPTELIAHISTRVIVNRASMKTRHSDIQTILDKLVEAVASRKAG
>Mature_213_residues
SKPLTIALSKGRILKETLPLLKAAGIELLEDPAASRKLIFDTTRDDVKIIIIRATDVPPYVQHGAADIGVAGKDVLMEHG
GDGVFEPVDLDIARCKLMVAAMKDAPETGSRLRVATKFVNVAKAYYAQQGKQAEVIKLYGAMELAPLVGLADRIVDIVDT
GNTLRANGLEPTELIAHISTRVIVNRASMKTRHSDIQTILDKLVEAVASRKAG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=214, Percent_Identity=32.2429906542056, Blast_Score=85, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=170, Percent_Identity=30.5882352941176, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ALCBS (Q0VS39)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692281.1
- ProteinModelPortal:   Q0VS39
- SMR:   Q0VS39
- STRING:   Q0VS39
- GeneID:   4212797
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0561
- NMPDR:   fig|393595.12.peg.559
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   ABOR393595:ABO_0561-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23061; Mature: 22930

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLTIALSKGRILKETLPLLKAAGIELLEDPAASRKLIFDTTRDDVKIIIIRATDVPP
CCCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVQHGAADIGVAGKDVLMEHGGDGVFEPVDLDIARCKLMVAAMKDAPETGSRLRVATKFV
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
NVAKAYYAQQGKQAEVIKLYGAMELAPLVGLADRIVDIVDTGNTLRANGLEPTELIAHIS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
TRVIVNRASMKTRHSDIQTILDKLVEAVASRKAG
HHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKPLTIALSKGRILKETLPLLKAAGIELLEDPAASRKLIFDTTRDDVKIIIIRATDVPP
CCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVQHGAADIGVAGKDVLMEHGGDGVFEPVDLDIARCKLMVAAMKDAPETGSRLRVATKFV
HHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
NVAKAYYAQQGKQAEVIKLYGAMELAPLVGLADRIVDIVDTGNTLRANGLEPTELIAHIS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
TRVIVNRASMKTRHSDIQTILDKLVEAVASRKAG
HHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA