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The map label for this gene is ggtA [H]

Identifier: 110679453

GI number: 110679453

Start: 2076320

End: 2077915

Strand: Reverse

Name: ggtA [H]

Synonym: RD1_2179

Alternate gene names: 110679453

Gene position: 2077915-2076320 (Counterclockwise)

Preceding gene: 110679454

Following gene: 110679451

Centisome position: 50.28

GC content: 62.47

Gene sequence:

>1596_bases
ATGGAACTCAGCGCACATCACCCCTACCCCTCGCGTCGCTCTGCTGTTGCGGCGGACAACATCGTGTCATCCTCGCATCC
GCTGGCCACGCAAGCCGGGGTGTCCATGATGGCGCGGGGCGGAAATGCGGTGGATGCTGCCCTTGCCACGGCGATCACGC
TGACGGTGGTTGAGCCGACAGGCAATGGTATCGGTTCAGATGCCTTTGCCATTTTGTGGGATGGGCAGGACTTGCATGGG
TTGAACGCATCGGGCCGCGCCCCGGCTGCCTATACGGCTGAGAGGTTTGCCGGGCTTGACCAGATACCAATGCACGGCTG
GGGCTCTGTCACCGTGCCGGGGGCGGTGTCGGCATGGGTGGCGCTGTCGGATCGCTTTGGCAAATTGCCCTTTGCGGCCT
TGTTTGAACCAGCGATCCGCTATGCGGAAAACGGATTTCCTGTCTCACCCGTGATTGCCAAACTATGGCAGCGCGCGGCA
GAGCAACTGGCCGAACAGCCCGGCTTTGCCGATGCTTTCCTTCCCGGTGGCCGCGCCCCGCGCGCAGGCGAATATTTTCG
CAGCACAGGTCACGCGCGTTCGCTGCGACTGATCGCCGAAACCAAGGGCACAGCCTTTTACGAAGGTGTGCTGGCCGAGG
AAATCGCAGCCCATGCGCAGGCCCACGGCGGCGCGCTGACGGTGACCGATCTGGCCGCACACAGGGCAGATTGGTGCGGC
ACGATCGCGCGCGATTTTGACGCGGTCTCGCTGCATGAAATCCCGCCCAATGGTCAGGGGATAGCAGCGCTGATGGGCCT
GGGGATCCTGTCCCGGACCAACATCCGCGATCTTGACCCTGACAGCGCGCAGGCCTTCCATCTACAGATCGAGGCCATGA
AACTTGCCCTGCGCGACGCCGAAGGATTCGTGGCGGATGCGGACCATATGACATCCGTCACCGTGCAGGACTTGCTGGAC
GATGGGTATCTCGCAACGCGGGCGGCGGAAATCAATCTGGACACTGCGAGCGACTTCAAACCCGGCGCGCCGAAACGCGG
CGGCACCGTGTATCTGAGCGCGGCAGATGCCAGCGGGATGATGGTGTCCTTCATTCAATCGAACTATATGGGGTTCGGGT
CCGGCGTGGTTGTGCCAGATACCGGAATATCCATGCAGAACAGGGGTTTCGGATTTTCTCTTGATCCATCACATCAAAAC
CACATCGCCCCCGGCAAACGCCCGTTTCATACGATTATCCCCGGCTTCCTCATGCGCGATGGCGCGCCTCTGATGAGTTT
TGGGGTCATGGGCGGCCCCATGCAGGCGCAAGGGCATGTTCAGATGGTGCTGCGCACGCAACTCTGGGGCCAGGACCCGC
AGATGGCGGTGGATGCCCCCCGCTGGCGCGTGACGCAAGGCCTCGGCGTTGCCTGCGAAACGACCATGGCCCCCGATACG
ATTTCGACCCTGCGCGCGATGGGGCATGACATCACGCTGGAAACCCCGGACAATGCCTTTGGTTTTGGCGGCGCGCAGCT
TATTCACCGCCTGCCGGGGCGCGGGTATGTCGCCGGGTCCGACCCGCGCAAAGACGGCTGCGCAATGGGGTTTTAA

Upstream 100 bases:

>100_bases
CCAGCACGGTATCACTGGAAACACAACCACCCCGATTGACTCCGCGCGCGTCAGGCCACAGACCTTGGCACAACGACCAA
ACCGCAGGACAGACCACCCC

Downstream 100 bases:

>100_bases
ACGCGCTGCGTCAGGTAAATTTGCGGAACAGTTTGGTGCTGTCAAAGATCTCTTCCAGCTCCTGCATGCGCTCTTTGGTC
TCGCCCCAATGCAGCCCCTG

Product: gamma-glutamyltranspeptidase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MELSAHHPYPSRRSAVAADNIVSSSHPLATQAGVSMMARGGNAVDAALATAITLTVVEPTGNGIGSDAFAILWDGQDLHG
LNASGRAPAAYTAERFAGLDQIPMHGWGSVTVPGAVSAWVALSDRFGKLPFAALFEPAIRYAENGFPVSPVIAKLWQRAA
EQLAEQPGFADAFLPGGRAPRAGEYFRSTGHARSLRLIAETKGTAFYEGVLAEEIAAHAQAHGGALTVTDLAAHRADWCG
TIARDFDAVSLHEIPPNGQGIAALMGLGILSRTNIRDLDPDSAQAFHLQIEAMKLALRDAEGFVADADHMTSVTVQDLLD
DGYLATRAAEINLDTASDFKPGAPKRGGTVYLSAADASGMMVSFIQSNYMGFGSGVVVPDTGISMQNRGFGFSLDPSHQN
HIAPGKRPFHTIIPGFLMRDGAPLMSFGVMGGPMQAQGHVQMVLRTQLWGQDPQMAVDAPRWRVTQGLGVACETTMAPDT
ISTLRAMGHDITLETPDNAFGFGGAQLIHRLPGRGYVAGSDPRKDGCAMGF

Sequences:

>Translated_531_residues
MELSAHHPYPSRRSAVAADNIVSSSHPLATQAGVSMMARGGNAVDAALATAITLTVVEPTGNGIGSDAFAILWDGQDLHG
LNASGRAPAAYTAERFAGLDQIPMHGWGSVTVPGAVSAWVALSDRFGKLPFAALFEPAIRYAENGFPVSPVIAKLWQRAA
EQLAEQPGFADAFLPGGRAPRAGEYFRSTGHARSLRLIAETKGTAFYEGVLAEEIAAHAQAHGGALTVTDLAAHRADWCG
TIARDFDAVSLHEIPPNGQGIAALMGLGILSRTNIRDLDPDSAQAFHLQIEAMKLALRDAEGFVADADHMTSVTVQDLLD
DGYLATRAAEINLDTASDFKPGAPKRGGTVYLSAADASGMMVSFIQSNYMGFGSGVVVPDTGISMQNRGFGFSLDPSHQN
HIAPGKRPFHTIIPGFLMRDGAPLMSFGVMGGPMQAQGHVQMVLRTQLWGQDPQMAVDAPRWRVTQGLGVACETTMAPDT
ISTLRAMGHDITLETPDNAFGFGGAQLIHRLPGRGYVAGSDPRKDGCAMGF
>Mature_531_residues
MELSAHHPYPSRRSAVAADNIVSSSHPLATQAGVSMMARGGNAVDAALATAITLTVVEPTGNGIGSDAFAILWDGQDLHG
LNASGRAPAAYTAERFAGLDQIPMHGWGSVTVPGAVSAWVALSDRFGKLPFAALFEPAIRYAENGFPVSPVIAKLWQRAA
EQLAEQPGFADAFLPGGRAPRAGEYFRSTGHARSLRLIAETKGTAFYEGVLAEEIAAHAQAHGGALTVTDLAAHRADWCG
TIARDFDAVSLHEIPPNGQGIAALMGLGILSRTNIRDLDPDSAQAFHLQIEAMKLALRDAEGFVADADHMTSVTVQDLLD
DGYLATRAAEINLDTASDFKPGAPKRGGTVYLSAADASGMMVSFIQSNYMGFGSGVVVPDTGISMQNRGFGFSLDPSHQN
HIAPGKRPFHTIIPGFLMRDGAPLMSFGVMGGPMQAQGHVQMVLRTQLWGQDPQMAVDAPRWRVTQGLGVACETTMAPDT
ISTLRAMGHDITLETPDNAFGFGGAQLIHRLPGRGYVAGSDPRKDGCAMGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=558, Percent_Identity=27.5985663082437, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI73915090, Length=558, Percent_Identity=27.5985663082437, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI73915096, Length=558, Percent_Identity=27.5985663082437, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI73915094, Length=558, Percent_Identity=27.5985663082437, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI113429324, Length=557, Percent_Identity=26.7504488330341, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI113429326, Length=555, Percent_Identity=26.4864864864865, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI109148539, Length=415, Percent_Identity=26.9879518072289, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI153266885, Length=545, Percent_Identity=22.9357798165138, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI153266901, Length=546, Percent_Identity=22.8937728937729, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789856, Length=550, Percent_Identity=28.7272727272727, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=488, Percent_Identity=27.0491803278689, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193208247, Length=503, Percent_Identity=27.6341948310139, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=503, Percent_Identity=27.6341948310139, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=485, Percent_Identity=23.9175257731959, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI212646519, Length=485, Percent_Identity=23.9175257731959, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17542894, Length=483, Percent_Identity=25.2587991718427, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24642670, Length=478, Percent_Identity=26.9874476987448, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24642666, Length=478, Percent_Identity=26.9874476987448, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI161077880, Length=478, Percent_Identity=26.9874476987448, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45551474, Length=478, Percent_Identity=26.9874476987448, Blast_Score=119, Evalue=8e-27,
Organism=Drosophila melanogaster, GI161077878, Length=478, Percent_Identity=26.9874476987448, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI18859893, Length=502, Percent_Identity=25.6972111553785, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI161077496, Length=521, Percent_Identity=24.1842610364683, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18859741, Length=485, Percent_Identity=23.7113402061856, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56010; Mature: 56010

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSAHHPYPSRRSAVAADNIVSSSHPLATQAGVSMMARGGNAVDAALATAITLTVVEPT
CCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHEEEEEEEECCC
GNGIGSDAFAILWDGQDLHGLNASGRAPAAYTAERFAGLDQIPMHGWGSVTVPGAVSAWV
CCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEECCCHHHHHH
ALSDRFGKLPFAALFEPAIRYAENGFPVSPVIAKLWQRAAEQLAEQPGFADAFLPGGRAP
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RAGEYFRSTGHARSLRLIAETKGTAFYEGVLAEEIAAHAQAHGGALTVTDLAAHRADWCG
CCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHH
TIARDFDAVSLHEIPPNGQGIAALMGLGILSRTNIRDLDPDSAQAFHLQIEAMKLALRDA
HHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEHHHHHHCC
EGFVADADHMTSVTVQDLLDDGYLATRAAEINLDTASDFKPGAPKRGGTVYLSAADASGM
CCCEECCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCH
MVSFIQSNYMGFGSGVVVPDTGISMQNRGFGFSLDPSHQNHIAPGKRPFHTIIPGFLMRD
HHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHCCHHHHCC
GAPLMSFGVMGGPMQAQGHVQMVLRTQLWGQDPQMAVDAPRWRVTQGLGVACETTMAPDT
CCCHHHHCCCCCCCCCCCHHEEEEEHHHCCCCCCEEECCCCEEECCCCCEEEECCCCCHH
ISTLRAMGHDITLETPDNAFGFGGAQLIHRLPGRGYVAGSDPRKDGCAMGF
HHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MELSAHHPYPSRRSAVAADNIVSSSHPLATQAGVSMMARGGNAVDAALATAITLTVVEPT
CCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHEEEEEEEECCC
GNGIGSDAFAILWDGQDLHGLNASGRAPAAYTAERFAGLDQIPMHGWGSVTVPGAVSAWV
CCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEECCCHHHHHH
ALSDRFGKLPFAALFEPAIRYAENGFPVSPVIAKLWQRAAEQLAEQPGFADAFLPGGRAP
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RAGEYFRSTGHARSLRLIAETKGTAFYEGVLAEEIAAHAQAHGGALTVTDLAAHRADWCG
CCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHH
TIARDFDAVSLHEIPPNGQGIAALMGLGILSRTNIRDLDPDSAQAFHLQIEAMKLALRDA
HHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEHHHHHHCC
EGFVADADHMTSVTVQDLLDDGYLATRAAEINLDTASDFKPGAPKRGGTVYLSAADASGM
CCCEECCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCH
MVSFIQSNYMGFGSGVVVPDTGISMQNRGFGFSLDPSHQNHIAPGKRPFHTIIPGFLMRD
HHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHCCHHHHCC
GAPLMSFGVMGGPMQAQGHVQMVLRTQLWGQDPQMAVDAPRWRVTQGLGVACETTMAPDT
CCCHHHHCCCCCCCCCCCHHEEEEEHHHCCCCCCEEECCCCEEECCCCCEEEECCCCCHH
ISTLRAMGHDITLETPDNAFGFGGAQLIHRLPGRGYVAGSDPRKDGCAMGF
HHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]