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The map label for this gene is cobQ

Identifier: 110679454

GI number: 110679454

Start: 2078032

End: 2079477

Strand: Reverse

Name: cobQ

Synonym: RD1_2180

Alternate gene names: 110679454

Gene position: 2079477-2078032 (Counterclockwise)

Preceding gene: 110679455

Following gene: 110679453

Centisome position: 50.31

GC content: 59.27

Gene sequence:

>1446_bases
ATGGGCCGCGCGATCATGCTGCAGGGCACAGGCTCTGATGTCGGCAAGTCACTTTTGGTGGCAGGGCTTTGCCGCGCTGC
CAAGCGTCGCGGCATATCTGTCGCGCCGTTCAAGCCGCAAAACATGTCCAACAACGCGGCAGCCACGACGAACGGGGGCG
AGATCGGCCGCGCGCAGGCGTTGCAGGCTTTTGCCTGCGGGCTAGACCCAACGGTGGACATGAACCCGATCCTGCTCAAG
CCTGAAACCGAAACAGGCTCGCAGGTGATCGTTCAGGGCCAGCGCATGACCTCCGTTGCAGCGGGCGATTATGCAAAGCT
GAAACCGACATTGCTCGGCCCTGTGCTCGACAGTTTCAACCGGCTCAAGGCGCAGTATGATCTGATCATCGTCGAAGGCG
CCGGCAGCCCGGCAGAGGTAAACCTGCGCAGCAATGACATCGCCAATATGGGCTTTGCTGAGGCGGCGCAGGTTCCCGTG
CTACTTTGTGGGGACATCAACCGAGGCGGTGTGATCGCGCAGGTCGTGGGCACGCAAGCAGTCATATCACCCGCTGATGC
AGGCATGATAAAGGGCTTCCTTATCAACAAGTTTCGCGGCGATCCTAAACTTTTTGATGAAGGCTATGAGATCATAAAAA
ACCATACTGGTTGGCCCGGATTTGGCGTGCTGCCGTGGTTTACTGATGCCTGGAAGCTCCCGGCTGAAGACGCCTATGAT
ATCAAAACGCCACCCCGCAAGGGTGGTCTGCACATTGTGTGTCTGCACCTGTCTCGCATCGCAAATTTCGACGATATGGA
CCCGCTGAGCCATGAACCCGGCGTGCAGATGACCATGTTGCGCGCAGGCGAGGTTTTGCCTGCGGATGCGGATATCGTGA
TCTTGCCGGGCAGCAAATCAACGCGGGGTGATCTGGCCTTCCTGCGTGCGCAAGGATGGGACATTGATCTGGCCGCGCAT
CTGCGCCGTGGCGGCCATGTGCTGGGCTTGTGCGGTGGGTATCAGATGCTGGGGCAGTCCATTGCCGACCCTGATGGCAT
AGAAGGCCCCCCCGGCACGACGGAGGGTTTGGGGTTTCTGGACATCACCACGGTCATGACGCCGCAAAAACGGGTCGCCC
GGATCACAGCGAAACACGCGCAGAGCGGTGCGATGTTCCCCGCCTATGAAATTCACGTTGGTCGCACAGACGGGCCCGAT
TGCGCCCGCCCTTTTGCCTATGTTCACGGGCAACCCGATGGTGCGATCAGTCAGAACGCGCAGGTCACGGGCACCTATCT
GCACGGTATGTTCACGGATGATGCGTTCAGGGCGCAATGGCTTGCACAGTTCGATGTCACGCAGAACGCATCCTACACGG
CGACGGTTGAAACCACCCTTGATGCTCTGGCGACGCATCTTGAAGCTCATGCGGATGTTGACGGTATACTGGCGCTGGCG
CGTTAG

Upstream 100 bases:

>100_bases
ATTGAGGCCGCCGATCTCGTGACCGAGATGACCTTGGTGAAACACCCGTTCAAAGACGGTGTCGTTGCCCAAAAAGGCAT
CGAGTTTTAGGGTAACGCGC

Downstream 100 bases:

>100_bases
ACAGGGCCATTCAAGACCAGCACGGTATCACTGGAAACACAACCACCCCGATTGACTCCGCGCGCGTCAGGCCACAGACC
TTGGCACAACGACCAAACCG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MGRAIMLQGTGSDVGKSLLVAGLCRAAKRRGISVAPFKPQNMSNNAAATTNGGEIGRAQALQAFACGLDPTVDMNPILLK
PETETGSQVIVQGQRMTSVAAGDYAKLKPTLLGPVLDSFNRLKAQYDLIIVEGAGSPAEVNLRSNDIANMGFAEAAQVPV
LLCGDINRGGVIAQVVGTQAVISPADAGMIKGFLINKFRGDPKLFDEGYEIIKNHTGWPGFGVLPWFTDAWKLPAEDAYD
IKTPPRKGGLHIVCLHLSRIANFDDMDPLSHEPGVQMTMLRAGEVLPADADIVILPGSKSTRGDLAFLRAQGWDIDLAAH
LRRGGHVLGLCGGYQMLGQSIADPDGIEGPPGTTEGLGFLDITTVMTPQKRVARITAKHAQSGAMFPAYEIHVGRTDGPD
CARPFAYVHGQPDGAISQNAQVTGTYLHGMFTDDAFRAQWLAQFDVTQNASYTATVETTLDALATHLEAHADVDGILALA
R

Sequences:

>Translated_481_residues
MGRAIMLQGTGSDVGKSLLVAGLCRAAKRRGISVAPFKPQNMSNNAAATTNGGEIGRAQALQAFACGLDPTVDMNPILLK
PETETGSQVIVQGQRMTSVAAGDYAKLKPTLLGPVLDSFNRLKAQYDLIIVEGAGSPAEVNLRSNDIANMGFAEAAQVPV
LLCGDINRGGVIAQVVGTQAVISPADAGMIKGFLINKFRGDPKLFDEGYEIIKNHTGWPGFGVLPWFTDAWKLPAEDAYD
IKTPPRKGGLHIVCLHLSRIANFDDMDPLSHEPGVQMTMLRAGEVLPADADIVILPGSKSTRGDLAFLRAQGWDIDLAAH
LRRGGHVLGLCGGYQMLGQSIADPDGIEGPPGTTEGLGFLDITTVMTPQKRVARITAKHAQSGAMFPAYEIHVGRTDGPD
CARPFAYVHGQPDGAISQNAQVTGTYLHGMFTDDAFRAQWLAQFDVTQNASYTATVETTLDALATHLEAHADVDGILALA
R
>Mature_480_residues
GRAIMLQGTGSDVGKSLLVAGLCRAAKRRGISVAPFKPQNMSNNAAATTNGGEIGRAQALQAFACGLDPTVDMNPILLKP
ETETGSQVIVQGQRMTSVAAGDYAKLKPTLLGPVLDSFNRLKAQYDLIIVEGAGSPAEVNLRSNDIANMGFAEAAQVPVL
LCGDINRGGVIAQVVGTQAVISPADAGMIKGFLINKFRGDPKLFDEGYEIIKNHTGWPGFGVLPWFTDAWKLPAEDAYDI
KTPPRKGGLHIVCLHLSRIANFDDMDPLSHEPGVQMTMLRAGEVLPADADIVILPGSKSTRGDLAFLRAQGWDIDLAAHL
RRGGHVLGLCGGYQMLGQSIADPDGIEGPPGTTEGLGFLDITTVMTPQKRVARITAKHAQSGAMFPAYEIHVGRTDGPDC
ARPFAYVHGQPDGAISQNAQVTGTYLHGMFTDDAFRAQWLAQFDVTQNASYTATVETTLDALATHLEAHADVDGILALAR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_ROSDO (Q167R8)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682461.1
- ProteinModelPortal:   Q167R8
- SMR:   Q167R8
- STRING:   Q167R8
- GeneID:   4196566
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2180
- NMPDR:   fig|375451.6.peg.2034
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- BioCyc:   RDEN375451:RD1_2180-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 51075; Mature: 50944

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 331-331 ACT_SITE 428-428

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRAIMLQGTGSDVGKSLLVAGLCRAAKRRGISVAPFKPQNMSNNAAATTNGGEIGRAQA
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEECCCCCCCHHHH
LQAFACGLDPTVDMNPILLKPETETGSQVIVQGQRMTSVAAGDYAKLKPTLLGPVLDSFN
HHHHHCCCCCCCCCCCEEEECCCCCCCEEEEECCCEEEECCCCCHHCCHHHHHHHHHHHH
RLKAQYDLIIVEGAGSPAEVNLRSNDIANMGFAEAAQVPVLLCGDINRGGVIAQVVGTQA
HHCEEEEEEEEECCCCCEEEEECCCCCCCCCCHHHCCCCEEEECCCCCCCEEEEEECCCE
VISPADAGMIKGFLINKFRGDPKLFDEGYEIIKNHTGWPGFGVLPWFTDAWKLPAEDAYD
EECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
IKTPPRKGGLHIVCLHLSRIANFDDMDPLSHEPGVQMTMLRAGEVLPADADIVILPGSKS
CCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCC
TRGDLAFLRAQGWDIDLAAHLRRGGHVLGLCGGYQMLGQSIADPDGIEGPPGTTEGLGFL
CCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
DITTVMTPQKRVARITAKHAQSGAMFPAYEIHVGRTDGPDCARPFAYVHGQPDGAISQNA
EEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHCCCEEEECCCCCCCCCCC
QVTGTYLHGMFTDDAFRAQWLAQFDVTQNASYTATVETTLDALATHLEAHADVDGILALA
EEEEEEEEEEECCCHHHHHHHEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEC
R
C
>Mature Secondary Structure 
GRAIMLQGTGSDVGKSLLVAGLCRAAKRRGISVAPFKPQNMSNNAAATTNGGEIGRAQA
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEECCCCCCCHHHH
LQAFACGLDPTVDMNPILLKPETETGSQVIVQGQRMTSVAAGDYAKLKPTLLGPVLDSFN
HHHHHCCCCCCCCCCCEEEECCCCCCCEEEEECCCEEEECCCCCHHCCHHHHHHHHHHHH
RLKAQYDLIIVEGAGSPAEVNLRSNDIANMGFAEAAQVPVLLCGDINRGGVIAQVVGTQA
HHCEEEEEEEEECCCCCEEEEECCCCCCCCCCHHHCCCCEEEECCCCCCCEEEEEECCCE
VISPADAGMIKGFLINKFRGDPKLFDEGYEIIKNHTGWPGFGVLPWFTDAWKLPAEDAYD
EECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
IKTPPRKGGLHIVCLHLSRIANFDDMDPLSHEPGVQMTMLRAGEVLPADADIVILPGSKS
CCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCC
TRGDLAFLRAQGWDIDLAAHLRRGGHVLGLCGGYQMLGQSIADPDGIEGPPGTTEGLGFL
CCCCEEEEEECCCCCHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
DITTVMTPQKRVARITAKHAQSGAMFPAYEIHVGRTDGPDCARPFAYVHGQPDGAISQNA
EEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHCCCEEEECCCCCCCCCCC
QVTGTYLHGMFTDDAFRAQWLAQFDVTQNASYTATVETTLDALATHLEAHADVDGILALA
EEEEEEEEEEECCCHHHHHHHEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA