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The map label for this gene is hisI

Identifier: 103487025

GI number: 103487025

Start: 1607054

End: 1607434

Strand: Reverse

Name: hisI

Synonym: Sala_1540

Alternate gene names: 103487025

Gene position: 1607434-1607054 (Counterclockwise)

Preceding gene: 103487029

Following gene: 103487024

Centisome position: 48.05

GC content: 68.24

Gene sequence:

>381_bases
ATGGATGAGCAGCGCGATACGACCGACCGATTTCTCCCGCGTTTCGATGCCGCCGGGCTGGTGACGGCGATCGTCGTCGA
CGCCGACACGCAGGCGCTGTTGATGGTCGCACATATGAATGCGGATGCGATCGAGGCGACGCGCGCGACGGGGCAGGCGC
ATTTCTGGTCGCGTTCGCGCTCTGCGCTGTGGCGCAAGGGCGAGACGTCGGGCAACGGGCTGACGCTGGTCGAGATGCGC
GTCGATTGCGATCAGGACGCGCTGCTGCTGCGCGTGAAGCCCGCGGGGCCCGCCTGTCACACCGGGCGCCGGTCGTGCTT
CTATCGCCGCGTCGAGGCCGACGGCGGCCTGACCTTCCTTGCGGACGATGCGCAGGGTTAG

Upstream 100 bases:

>100_bases
GAGGGCAAAGGCGATTGTCGCCCCCCTAATCACGATATTGTCACATCGGCGGTCACGCGCGGGGTGACAGCGGCTTCGAT
CCTGCTCTAAAGCGGCGGGC

Downstream 100 bases:

>100_bases
CGTTGCCCTCGCGCTGGCGGCGCTGCTGCTCGCGGCGTGCGAGCGCGGGGCGAACGGCGAGGAGGCGATCGACGCCGGAA
ATCCGCTGGAGATTGCGGCG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MDEQRDTTDRFLPRFDAAGLVTAIVVDADTQALLMVAHMNADAIEATRATGQAHFWSRSRSALWRKGETSGNGLTLVEMR
VDCDQDALLLRVKPAGPACHTGRRSCFYRRVEADGGLTFLADDAQG

Sequences:

>Translated_126_residues
MDEQRDTTDRFLPRFDAAGLVTAIVVDADTQALLMVAHMNADAIEATRATGQAHFWSRSRSALWRKGETSGNGLTLVEMR
VDCDQDALLLRVKPAGPACHTGRRSCFYRRVEADGGLTFLADDAQG
>Mature_126_residues
MDEQRDTTDRFLPRFDAAGLVTAIVVDADTQALLMVAHMNADAIEATRATGQAHFWSRSRSALWRKGETSGNGLTLVEMR
VDCDQDALLLRVKPAGPACHTGRRSCFYRRVEADGGLTFLADDAQG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=46.0674157303371, Blast_Score=93, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6319819, Length=90, Percent_Identity=40, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_SPHAL (Q1GSW9)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616586.1
- ProteinModelPortal:   Q1GSW9
- SMR:   Q1GSW9
- GeneID:   4082439
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1540
- NMPDR:   fig|317655.9.peg.1472
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- BioCyc:   SALA317655:SALA_1540-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13798; Mature: 13798

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQRDTTDRFLPRFDAAGLVTAIVVDADTQALLMVAHMNADAIEATRATGQAHFWSRSR
CCCCCCCHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHCCCCCCHHCCCC
SALWRKGETSGNGLTLVEMRVDCDQDALLLRVKPAGPACHTGRRSCFYRRVEADGGLTFL
HHHCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEE
ADDAQG
ECCCCC
>Mature Secondary Structure
MDEQRDTTDRFLPRFDAAGLVTAIVVDADTQALLMVAHMNADAIEATRATGQAHFWSRSR
CCCCCCCHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHCCCCCCHHCCCC
SALWRKGETSGNGLTLVEMRVDCDQDALLLRVKPAGPACHTGRRSCFYRRVEADGGLTFL
HHHCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEE
ADDAQG
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA