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The map label for this gene is pgi

Identifier: 103486703

GI number: 103486703

Start: 1256425

End: 1257930

Strand: Direct

Name: pgi

Synonym: Sala_1215

Alternate gene names: 103486703

Gene position: 1256425-1257930 (Clockwise)

Preceding gene: 103486699

Following gene: 103486704

Centisome position: 37.56

GC content: 66.2

Gene sequence:

>1506_bases
ATGACGATTGCCTCCGACGCCTGGCAGGCCCTTGCCGACTGGCAACCGCAAAAGCTCACCGATCTGGTCGCCGCCGATCC
CGATGCGCGCTTGCAGGCGCTGGTGCGCAATGTCGCCGACATCCGCTTCGACTTTGCCAAGACGCACCTCGACGCCGCCG
CGATCGCCATTCTGGCGAACCTTGCCGAAGCGCAGGATTTCGGCGGGCGGCGCAAGACGCTGTTTTCGGGCGGTATCGCC
AATCCCACGGAGAATCGCGCCGCCGAGCACAGCGCCGAGCGCGGCGATGGAGCACCCGAATCGGTCCATGCTGCGCAGGC
CCTGCACCAAAGAATGCGGATGATGATCGACGCGATCGAAGCGGGGGCGTTCGGCGAGATCCGCCACCTGCTGCACATCG
GCATCGGCGGATCGGCGCTTGGTCCCGATTTGCTCGTCGATGCGCTTGGCCGCCACAGCGACCGCTATGACGTCGCGGTC
GTCTCGAACGTCGATGGCGCCGCACTTGACGAAGCCTTTGCAAAGTTCAGTCCCGAACATACGCTCGTCGCCGTTGCGTC
CAAGACCTTCACGACGACCGAAACCTTGCTGAACGCCAATTCGGCGCTGCAATGGCTTGACGAAGCGGGGGTCGCCGACC
CCGTCGGCCGCTTCATCGCGCTGACCGCCAATCCGGGCCGTGCGATGGAATGGGGGATCGACGAAACGCGCATCCTGCCG
TTCAGCGAGACGGTCGGCGGGCGCTATTCGCTCTGGTCGTCGATCGGCTTCCCCGCGGCGCTCGCGCTCGGCTGGGACGC
CTTCGCCGACCTGCTCGAAGGCGCGGCGGAGATGGACCGCCACTTCCGCCTTGCCGACGGCGCCGACAATATCTGCCTGC
TCGCCGCCTTTGCCGACCAGGTCTATGCAAACCGTCTCGGCTGTCAGACGCGCGCGGTCTTCGCCTATGACGAGCGGCTG
CGCCTGCTTCCCGCCTATCTGCAACAGCTCGAGATGGAATCGAACGGCAAGTCGGTGACGCTGGACGGCGCGCCGCTCGC
GCAGCATAGCGCCCCGGTCACCTGGGGTGGCGTCGGCACCGATGCGCAGCACGCGGTGTTCCAGCTGCTCCATCAGGGCA
CGCACCTGGTGCCGGTCGAGTTCATTGTCGCGCGCGAGCCCGATCATCTGCTCGACGACGCGCATCACGAAACACTCGTT
GCCAATTGCATTGCGCAGGGTGCGGCGCTGATGGCGGGGCGCGCGAGCGACGATCGCGCGCGCGCATATCCCGGCGACCG
GCCCTCGACGACGATTTTGCTCGATCAGGTGAGCCCGCGCAGCCTCGGCGCGCTGATCGCCTTTTACGAGCATCGCGTCT
TTGCCAATGCGGTGCTGCTCGGCGTCAATCCGTTCGACCAGTTCGGCGTCGAGCTGGGCAAGGAGATGGCGAAGGGGCTT
GCCGAAGGGACGGTCGACTTCGATCCAGCGACGCAGGCGCTGATGAAGGCGGCGCTCGGCGATTAG

Upstream 100 bases:

>100_bases
CCGTTCGCATCGGGCGAAGTCGAGGTGGCCATCGCCGTGGTGCCACGCTTCGGGGTGTCTCGACTTCGCTCGACACGAAC
GGAAAACCAAGGAAGATTCA

Downstream 100 bases:

>100_bases
GCTGAACGCAGAAATCGATTGGCATCGCGGCCGCGCGTAACCACATAGGCGCGGGCTGCGAACTGCGGCCTGTCCATAGC
AGGGGTTCTCCATGTCCGAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTIASDAWQALADWQPQKLTDLVAADPDARLQALVRNVADIRFDFAKTHLDAAAIAILANLAEAQDFGGRRKTLFSGGIA
NPTENRAAEHSAERGDGAPESVHAAQALHQRMRMMIDAIEAGAFGEIRHLLHIGIGGSALGPDLLVDALGRHSDRYDVAV
VSNVDGAALDEAFAKFSPEHTLVAVASKTFTTTETLLNANSALQWLDEAGVADPVGRFIALTANPGRAMEWGIDETRILP
FSETVGGRYSLWSSIGFPAALALGWDAFADLLEGAAEMDRHFRLADGADNICLLAAFADQVYANRLGCQTRAVFAYDERL
RLLPAYLQQLEMESNGKSVTLDGAPLAQHSAPVTWGGVGTDAQHAVFQLLHQGTHLVPVEFIVAREPDHLLDDAHHETLV
ANCIAQGAALMAGRASDDRARAYPGDRPSTTILLDQVSPRSLGALIAFYEHRVFANAVLLGVNPFDQFGVELGKEMAKGL
AEGTVDFDPATQALMKAALGD

Sequences:

>Translated_501_residues
MTIASDAWQALADWQPQKLTDLVAADPDARLQALVRNVADIRFDFAKTHLDAAAIAILANLAEAQDFGGRRKTLFSGGIA
NPTENRAAEHSAERGDGAPESVHAAQALHQRMRMMIDAIEAGAFGEIRHLLHIGIGGSALGPDLLVDALGRHSDRYDVAV
VSNVDGAALDEAFAKFSPEHTLVAVASKTFTTTETLLNANSALQWLDEAGVADPVGRFIALTANPGRAMEWGIDETRILP
FSETVGGRYSLWSSIGFPAALALGWDAFADLLEGAAEMDRHFRLADGADNICLLAAFADQVYANRLGCQTRAVFAYDERL
RLLPAYLQQLEMESNGKSVTLDGAPLAQHSAPVTWGGVGTDAQHAVFQLLHQGTHLVPVEFIVAREPDHLLDDAHHETLV
ANCIAQGAALMAGRASDDRARAYPGDRPSTTILLDQVSPRSLGALIAFYEHRVFANAVLLGVNPFDQFGVELGKEMAKGL
AEGTVDFDPATQALMKAALGD
>Mature_500_residues
TIASDAWQALADWQPQKLTDLVAADPDARLQALVRNVADIRFDFAKTHLDAAAIAILANLAEAQDFGGRRKTLFSGGIAN
PTENRAAEHSAERGDGAPESVHAAQALHQRMRMMIDAIEAGAFGEIRHLLHIGIGGSALGPDLLVDALGRHSDRYDVAVV
SNVDGAALDEAFAKFSPEHTLVAVASKTFTTTETLLNANSALQWLDEAGVADPVGRFIALTANPGRAMEWGIDETRILPF
SETVGGRYSLWSSIGFPAALALGWDAFADLLEGAAEMDRHFRLADGADNICLLAAFADQVYANRLGCQTRAVFAYDERLR
LLPAYLQQLEMESNGKSVTLDGAPLAQHSAPVTWGGVGTDAQHAVFQLLHQGTHLVPVEFIVAREPDHLLDDAHHETLVA
NCIAQGAALMAGRASDDRARAYPGDRPSTTILLDQVSPRSLGALIAFYEHRVFANAVLLGVNPFDQFGVELGKEMAKGLA
EGTVDFDPATQALMKAALGD

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=484, Percent_Identity=36.7768595041322, Blast_Score=314, Evalue=2e-85,
Organism=Homo sapiens, GI296080693, Length=472, Percent_Identity=35.5932203389831, Blast_Score=295, Evalue=6e-80,
Organism=Escherichia coli, GI1790457, Length=513, Percent_Identity=38.7914230019493, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71996708, Length=505, Percent_Identity=37.4257425742574, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71996703, Length=505, Percent_Identity=37.4257425742574, Blast_Score=316, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319673, Length=471, Percent_Identity=38.4288747346072, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24651916, Length=517, Percent_Identity=36.5570599613153, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24651914, Length=517, Percent_Identity=36.5570599613153, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17737445, Length=517, Percent_Identity=36.5570599613153, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SPHAL (Q1GTU1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616264.1
- ProteinModelPortal:   Q1GTU1
- SMR:   Q1GTU1
- GeneID:   4080439
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1215
- NMPDR:   fig|317655.9.peg.1149
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- ProtClustDB:   PRK00179
- BioCyc:   SALA317655:SALA_1215-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 53611; Mature: 53480

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 333-333 ACT_SITE 364-364 ACT_SITE 474-474

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIASDAWQALADWQPQKLTDLVAADPDARLQALVRNVADIRFDFAKTHLDAAAIAILAN
CCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAEAQDFGGRRKTLFSGGIANPTENRAAEHSAERGDGAPESVHAAQALHQRMRMMIDAIE
HHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGAFGEIRHLLHIGIGGSALGPDLLVDALGRHSDRYDVAVVSNVDGAALDEAFAKFSPEH
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
TLVAVASKTFTTTETLLNANSALQWLDEAGVADPVGRFIALTANPGRAMEWGIDETRILP
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEECCCCCCEEEC
FSETVGGRYSLWSSIGFPAALALGWDAFADLLEGAAEMDRHFRLADGADNICLLAAFADQ
CHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCEEEHHHHHHH
VYANRLGCQTRAVFAYDERLRLLPAYLQQLEMESNGKSVTLDGAPLAQHSAPVTWGGVGT
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEECCCCC
DAQHAVFQLLHQGTHLVPVEFIVAREPDHLLDDAHHETLVANCIAQGAALMAGRASDDRA
CHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RAYPGDRPSTTILLDQVSPRSLGALIAFYEHRVFANAVLLGVNPFDQFGVELGKEMAKGL
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHH
AEGTVDFDPATQALMKAALGD
HCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TIASDAWQALADWQPQKLTDLVAADPDARLQALVRNVADIRFDFAKTHLDAAAIAILAN
CCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAEAQDFGGRRKTLFSGGIANPTENRAAEHSAERGDGAPESVHAAQALHQRMRMMIDAIE
HHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGAFGEIRHLLHIGIGGSALGPDLLVDALGRHSDRYDVAVVSNVDGAALDEAFAKFSPEH
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCC
TLVAVASKTFTTTETLLNANSALQWLDEAGVADPVGRFIALTANPGRAMEWGIDETRILP
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEECCCCCCEEEC
FSETVGGRYSLWSSIGFPAALALGWDAFADLLEGAAEMDRHFRLADGADNICLLAAFADQ
CHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCEEEHHHHHHH
VYANRLGCQTRAVFAYDERLRLLPAYLQQLEMESNGKSVTLDGAPLAQHSAPVTWGGVGT
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEECCCCC
DAQHAVFQLLHQGTHLVPVEFIVAREPDHLLDDAHHETLVANCIAQGAALMAGRASDDRA
CHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RAYPGDRPSTTILLDQVSPRSLGALIAFYEHRVFANAVLLGVNPFDQFGVELGKEMAKGL
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHH
AEGTVDFDPATQALMKAALGD
HCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA