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The map label for this gene is gor [H]

Identifier: 103486704

GI number: 103486704

Start: 1258022

End: 1259368

Strand: Direct

Name: gor [H]

Synonym: Sala_1216

Alternate gene names: 103486704

Gene position: 1258022-1259368 (Clockwise)

Preceding gene: 103486703

Following gene: 103486706

Centisome position: 37.61

GC content: 64.29

Gene sequence:

>1347_bases
ATGTCCGATTTCGACTTCGACCTGTTTGTCATCGGCGCCGGTTCGGGCGGCGTGCGCGCATCGCGCATCGCGGCGTCGCA
CGGCGCGCGCGTCGCGGTGGCGGAGGAGCACCGGGTCGGCGGGACCTGCGTCATCCGCGGCTGCGTACCGAAGAAGCTGC
TCGTCTATGGCGCGCATTTCGCCGAGGATCTGAAAGACGCGCGCAAGTTCGGCTGGGAGGTGCCCGACTGCCGCTTCGAC
TGGGACGTGCTACGCGACAATGTGCTCGCCGAGGTCGACCGGCTCGAAGGCCTTTATGGGCAGACGCTCGATAACCACAA
GGTCAGGGTCTTCAAGACCCGCGCCACCGTCGTCGCGCCGCAAACGGTGCGCCTTGCCGACGGGCAGGAGCTGACCGCCG
AGCGCATCCTGATCGCGACTGGCGGATGGCCGCATGTGCCGGATTTTCCGGGCAGCGAACACGCGATCACCTCGAATGAG
GTTTTTCACCTCGAAACGCTGCCGAGGCGCGTCGTGATCGCGGGCGGAGGCTATATCGCCAATGAGTTCGCGGGCATTTT
CAACGAATTCGGCAGCAAGGTCACGATCGTCAACCGCGGCGACACGATCCTGCGCGGCTATGACGAGCAGATCCGCGACC
GGCTGCTCCAGATTTCGATGACCAAGGGCATCGATTTCAAGTTCAACGCGCCGTTCGAGAAGATCGAGAAAAACGACGAC
GGAACGTTGACGATCTATCTCGGCGGTTGCGAACCGATCGTTGCCGACGCGGTGCTGGTCGCGACCGGGCGCGTGCCCAA
CACCAAGGGGCTGGGTCTCGATGAGGTCGGAGTCGATCTCGACCCAACGGGTGCGATCAGGGTCGATGAGCACAACCAGT
CGTCGGTGCCCAGCATCTATGGGGTCGGCGACGTCACCAACCGCATCCAGCTGACTCCGGTGGCGATCCGCGAGGGGCAG
GCGTTTGCCGACTCGGTGTTCGGCGGCCATCCGACGGTGGTGGATTATGCCAATGTCCCGAGCGCGGTGTTCAGCCACCC
GCCGATCGGCGCGGTCGGGATGACCGAGGCGGAGGCGCGCAACAAGCTTGGTTCGGTCCGCGTCTACACCAGCGATTTTC
GCGCGATGAAAAATGTCCTCGCGGGACGCAACGAGCGCGCGCTCTACAAGATGATCGTCAATGCCGCGACCGACCAGGTC
GTCGGGCTGCACATGATCGGCCCGGACGCGCCGGAGATACTTCAGGCGGCGGCCATCGCGGTGAAGGCGGGGCTGACCAA
GGCCGATTTCGACGCGACGGTCGCGCTGCATCCGAGCATGGCCGAAGAGCTGGTGTTGTTGAAATAG

Upstream 100 bases:

>100_bases
GGCGATTAGGCTGAACGCAGAAATCGATTGGCATCGCGGCCGCGCGTAACCACATAGGCGCGGGCTGCGAACTGCGGCCT
GTCCATAGCAGGGGTTCTCC

Downstream 100 bases:

>100_bases
TGTTACAACGTCGCCCCCGCGCAGGCGGGGGCGACGCCAATCGTCATCCAATCCGGTACGGCACCACATCGCGCCGATCG
GGATCGACCAAAATCGGCCG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSDFDFDLFVIGAGSGGVRASRIAASHGARVAVAEEHRVGGTCVIRGCVPKKLLVYGAHFAEDLKDARKFGWEVPDCRFD
WDVLRDNVLAEVDRLEGLYGQTLDNHKVRVFKTRATVVAPQTVRLADGQELTAERILIATGGWPHVPDFPGSEHAITSNE
VFHLETLPRRVVIAGGGYIANEFAGIFNEFGSKVTIVNRGDTILRGYDEQIRDRLLQISMTKGIDFKFNAPFEKIEKNDD
GTLTIYLGGCEPIVADAVLVATGRVPNTKGLGLDEVGVDLDPTGAIRVDEHNQSSVPSIYGVGDVTNRIQLTPVAIREGQ
AFADSVFGGHPTVVDYANVPSAVFSHPPIGAVGMTEAEARNKLGSVRVYTSDFRAMKNVLAGRNERALYKMIVNAATDQV
VGLHMIGPDAPEILQAAAIAVKAGLTKADFDATVALHPSMAEELVLLK

Sequences:

>Translated_448_residues
MSDFDFDLFVIGAGSGGVRASRIAASHGARVAVAEEHRVGGTCVIRGCVPKKLLVYGAHFAEDLKDARKFGWEVPDCRFD
WDVLRDNVLAEVDRLEGLYGQTLDNHKVRVFKTRATVVAPQTVRLADGQELTAERILIATGGWPHVPDFPGSEHAITSNE
VFHLETLPRRVVIAGGGYIANEFAGIFNEFGSKVTIVNRGDTILRGYDEQIRDRLLQISMTKGIDFKFNAPFEKIEKNDD
GTLTIYLGGCEPIVADAVLVATGRVPNTKGLGLDEVGVDLDPTGAIRVDEHNQSSVPSIYGVGDVTNRIQLTPVAIREGQ
AFADSVFGGHPTVVDYANVPSAVFSHPPIGAVGMTEAEARNKLGSVRVYTSDFRAMKNVLAGRNERALYKMIVNAATDQV
VGLHMIGPDAPEILQAAAIAVKAGLTKADFDATVALHPSMAEELVLLK
>Mature_447_residues
SDFDFDLFVIGAGSGGVRASRIAASHGARVAVAEEHRVGGTCVIRGCVPKKLLVYGAHFAEDLKDARKFGWEVPDCRFDW
DVLRDNVLAEVDRLEGLYGQTLDNHKVRVFKTRATVVAPQTVRLADGQELTAERILIATGGWPHVPDFPGSEHAITSNEV
FHLETLPRRVVIAGGGYIANEFAGIFNEFGSKVTIVNRGDTILRGYDEQIRDRLLQISMTKGIDFKFNAPFEKIEKNDDG
TLTIYLGGCEPIVADAVLVATGRVPNTKGLGLDEVGVDLDPTGAIRVDEHNQSSVPSIYGVGDVTNRIQLTPVAIREGQA
FADSVFGGHPTVVDYANVPSAVFSHPPIGAVGMTEAEARNKLGSVRVYTSDFRAMKNVLAGRNERALYKMIVNAATDQVV
GLHMIGPDAPEILQAAAIAVKAGLTKADFDATVALHPSMAEELVLLK

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=40.0871459694989, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=35.8811040339703, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=34.3157894736842, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=34.3157894736842, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=34.3157894736842, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=34.3157894736842, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=34.3157894736842, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI291045266, Length=430, Percent_Identity=33.7209302325581, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=30.4824561403509, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI291045268, Length=428, Percent_Identity=31.0747663551402, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=37.995337995338, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081717, Length=445, Percent_Identity=29.8876404494382, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=30.5494505494506, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=27.8867102396514, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789065, Length=183, Percent_Identity=30.6010928961749, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71983429, Length=449, Percent_Identity=39.6436525612472, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71983419, Length=449, Percent_Identity=39.6436525612472, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=33.8983050847458, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=30.0207039337474, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=30.7017543859649, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.3101952277657, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321091, Length=459, Percent_Identity=28.7581699346405, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=485, Percent_Identity=28.8659793814433, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=33.5443037974684, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=33.0490405117271, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=33.0490405117271, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=32.9787234042553, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=30.6521739130435, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48313; Mature: 48181

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFDFDLFVIGAGSGGVRASRIAASHGARVAVAEEHRVGGTCVIRGCVPKKLLVYGAHF
CCCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCHHEECHHH
AEDLKDARKFGWEVPDCRFDWDVLRDNVLAEVDRLEGLYGQTLDNHKVRVFKTRATVVAP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEEEEEEEECC
QTVRLADGQELTAERILIATGGWPHVPDFPGSEHAITSNEVFHLETLPRRVVIAGGGYIA
CEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCEEEEECCCCEEEEECCCCHH
NEFAGIFNEFGSKVTIVNRGDTILRGYDEQIRDRLLQISMTKGIDFKFNAPFEKIEKNDD
HHHHHHHHHHCCEEEEEECCCCEECCCCHHHHHHHHEEEECCCCCEEECCCHHHHCCCCC
GTLTIYLGGCEPIVADAVLVATGRVPNTKGLGLDEVGVDLDPTGAIRVDEHNQSSVPSIY
CEEEEEECCCCHHHHCEEEEEECCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCEE
GVGDVTNRIQLTPVAIREGQAFADSVFGGHPTVVDYANVPSAVFSHPPIGAVGMTEAEAR
ECCCCCCEEEEEEEEEECCCHHHHHHCCCCCCEEECCCCCHHHHCCCCCCCCCCCHHHHH
NKLGSVRVYTSDFRAMKNVLAGRNERALYKMIVNAATDQVVGLHMIGPDAPEILQAAAIA
HCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHH
VKAGLTKADFDATVALHPSMAEELVLLK
HHCCCCCCCCCEEEEECCCCCCCEEECC
>Mature Secondary Structure 
SDFDFDLFVIGAGSGGVRASRIAASHGARVAVAEEHRVGGTCVIRGCVPKKLLVYGAHF
CCCCEEEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCHHEECHHH
AEDLKDARKFGWEVPDCRFDWDVLRDNVLAEVDRLEGLYGQTLDNHKVRVFKTRATVVAP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEEEEEEEECC
QTVRLADGQELTAERILIATGGWPHVPDFPGSEHAITSNEVFHLETLPRRVVIAGGGYIA
CEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCEEEEECCCCEEEEECCCCHH
NEFAGIFNEFGSKVTIVNRGDTILRGYDEQIRDRLLQISMTKGIDFKFNAPFEKIEKNDD
HHHHHHHHHHCCEEEEEECCCCEECCCCHHHHHHHHEEEECCCCCEEECCCHHHHCCCCC
GTLTIYLGGCEPIVADAVLVATGRVPNTKGLGLDEVGVDLDPTGAIRVDEHNQSSVPSIY
CEEEEEECCCCHHHHCEEEEEECCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCEE
GVGDVTNRIQLTPVAIREGQAFADSVFGGHPTVVDYANVPSAVFSHPPIGAVGMTEAEAR
ECCCCCCEEEEEEEEEECCCHHHHHHCCCCCCEEECCCCCHHHHCCCCCCCCCCCHHHHH
NKLGSVRVYTSDFRAMKNVLAGRNERALYKMIVNAATDQVVGLHMIGPDAPEILQAAAIA
HCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHH
VKAGLTKADFDATVALHPSMAEELVLLK
HHCCCCCCCCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]