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The map label for this gene is prs [H]

Identifier: 239618101

GI number: 239618101

Start: 1860735

End: 1861685

Strand: Reverse

Name: prs [H]

Synonym: Kole_1733

Alternate gene names: 239618101

Gene position: 1861685-1860735 (Counterclockwise)

Preceding gene: 239618102

Following gene: 239618100

Centisome position: 80.87

GC content: 43.01

Gene sequence:

>951_bases
ATGCCTTTTCAGCCAAATGAAATGAAGGTTTTTTCCGGTTCCTCAAACCGGCAGCTTGCGGAGAAAATTGCGAAATATAT
AGGAATAGACCTCGGAAAATGTGAAGTTGAGAGATTTGCTGACGGGGAAATTAACATAAGGGTAGATGAAACGGTTAGAG
GTCACGACATTTTTATTATCCAGCCAACCTGCCCTCCGGTAAACGAAAATCTGATGGAACTCCTCGTAATGATGGATGCG
TTGAGAAGGGCTTCCGCAAAAAGCATTACAGCTGTGATCCCTTATTATGGTTATGCGCGCCAGGATAGAAAAGCAAGGGG
ACGGGATCCTATAACAGCGAAGCTTGTAGCAAACCTTCTCACCATTTCCGGGGCTTCAAGAATAATGACCATCGATCTGC
ACGCCGAGCAAATACAGGGTTTTTTCGACATTCCCGTGGATAATCTATGGGGGTTCCCGATCTTCAAAAGACACCTCGAA
GAAAAAACGGATATCTCCAAAAATAACTTAGTCGTGGTTTCTCCTGATATCGGTGGAGTAAAACGCGCAAGCAAATTCGC
TGAAAGGCTTGGTGTTCCTCTTGCAATATTGGACAAAAGAAGACCAAAGGACAACATCGCAGAAATCGTTCACGTAATTG
GTGAGGTGGAAAACAGGACAGCTGTAATCTTTGATGATATAATAGACACCGGTCGCTCGTTGGTGGAAGCGGCGAAAATG
ATAAAAAATAAAGGCGCAAACAAGGTTTATGCGTGTGCTACACACGCCGTTTTATCAGGAAAAGCAAAGCAGTTAATCTC
AGATTCACCCATTGAAAAGGTTTTTATAAGCGATACCATTCACCATCCCGAACTCCCTGAAAAGTTTGAAGTGGTTTCTA
TCGCTGGTTTGCTTGGTGAAGCGTTAATGAGAGTAAGAAAGAATCTTTCAGTAAGTATTTTGTTCAGATAG

Upstream 100 bases:

>100_bases
TTATTACCGATGATGTTCCACCATATTCTCTAGCCCTTGGAAGAGGAAGGCAGGTAATCAAAGAAGGTAGATATAAAAAC
AAGGAGAAAGGGGAATAATT

Downstream 100 bases:

>100_bases
AGGAGGGATTCAGATGCACGAAGTAAGGTTACCTGCAGAAAAGCGTGATACTTCTGTCAAAGCAAAGGACCTTTTGAAGA
ACGGTAAGATTCCTGCTGTT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPFQPNEMKVFSGSSNRQLAEKIAKYIGIDLGKCEVERFADGEINIRVDETVRGHDIFIIQPTCPPVNENLMELLVMMDA
LRRASAKSITAVIPYYGYARQDRKARGRDPITAKLVANLLTISGASRIMTIDLHAEQIQGFFDIPVDNLWGFPIFKRHLE
EKTDISKNNLVVVSPDIGGVKRASKFAERLGVPLAILDKRRPKDNIAEIVHVIGEVENRTAVIFDDIIDTGRSLVEAAKM
IKNKGANKVYACATHAVLSGKAKQLISDSPIEKVFISDTIHHPELPEKFEVVSIAGLLGEALMRVRKNLSVSILFR

Sequences:

>Translated_316_residues
MPFQPNEMKVFSGSSNRQLAEKIAKYIGIDLGKCEVERFADGEINIRVDETVRGHDIFIIQPTCPPVNENLMELLVMMDA
LRRASAKSITAVIPYYGYARQDRKARGRDPITAKLVANLLTISGASRIMTIDLHAEQIQGFFDIPVDNLWGFPIFKRHLE
EKTDISKNNLVVVSPDIGGVKRASKFAERLGVPLAILDKRRPKDNIAEIVHVIGEVENRTAVIFDDIIDTGRSLVEAAKM
IKNKGANKVYACATHAVLSGKAKQLISDSPIEKVFISDTIHHPELPEKFEVVSIAGLLGEALMRVRKNLSVSILFR
>Mature_315_residues
PFQPNEMKVFSGSSNRQLAEKIAKYIGIDLGKCEVERFADGEINIRVDETVRGHDIFIIQPTCPPVNENLMELLVMMDAL
RRASAKSITAVIPYYGYARQDRKARGRDPITAKLVANLLTISGASRIMTIDLHAEQIQGFFDIPVDNLWGFPIFKRHLEE
KTDISKNNLVVVSPDIGGVKRASKFAERLGVPLAILDKRRPKDNIAEIVHVIGEVENRTAVIFDDIIDTGRSLVEAAKMI
KNKGANKVYACATHAVLSGKAKQLISDSPIEKVFISDTIHHPELPEKFEVVSIAGLLGEALMRVRKNLSVSILFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=44.2675159235669, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=44.1269841269841, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=43.312101910828, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=42.9022082018927, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=37.2832369942197, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI4506133, Length=340, Percent_Identity=35.8823529411765, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=34.2857142857143, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=34.2857142857143, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=34.2857142857143, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=34.2857142857143, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=49.8412698412698, Blast_Score=314, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=41.7197452229299, Blast_Score=254, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=41.7197452229299, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=41.7197452229299, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=41.4239482200647, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=33.7243401759531, Blast_Score=193, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=39.6825396825397, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=38.4126984126984, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=39.873417721519, Blast_Score=229, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322667, Length=200, Percent_Identity=39.5, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324511, Length=92, Percent_Identity=43.4782608695652, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=43.8095238095238, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=41.1242603550296, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=33.2402234636872, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=33.2402234636872, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI281362873, Length=358, Percent_Identity=33.2402234636872, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24651454, Length=358, Percent_Identity=33.2402234636872, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24651462, Length=204, Percent_Identity=38.2352941176471, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24651464, Length=204, Percent_Identity=38.2352941176471, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI45552010, Length=204, Percent_Identity=38.2352941176471, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35153; Mature: 35022

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFQPNEMKVFSGSSNRQLAEKIAKYIGIDLGKCEVERFADGEINIRVDETVRGHDIFII
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCEECCCEEEEE
QPTCPPVNENLMELLVMMDALRRASAKSITAVIPYYGYARQDRKARGRDPITAKLVANLL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
TISGASRIMTIDLHAEQIQGFFDIPVDNLWGFPIFKRHLEEKTDISKNNLVVVSPDIGGV
HHCCCCEEEEEEEEHHHHCCEECCCHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCH
KRASKFAERLGVPLAILDKRRPKDNIAEIVHVIGEVENRTAVIFDDIIDTGRSLVEAAKM
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHH
IKNKGANKVYACATHAVLSGKAKQLISDSPIEKVFISDTIHHPELPEKFEVVSIAGLLGE
HHHCCCCCEEHHHHHHHHCCHHHHHHCCCCHHEEEECCCCCCCCCCCHHHHHHHHHHHHH
ALMRVRKNLSVSILFR
HHHHHHHCCCEEEEEC
>Mature Secondary Structure 
PFQPNEMKVFSGSSNRQLAEKIAKYIGIDLGKCEVERFADGEINIRVDETVRGHDIFII
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCEECCCEEEEE
QPTCPPVNENLMELLVMMDALRRASAKSITAVIPYYGYARQDRKARGRDPITAKLVANLL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
TISGASRIMTIDLHAEQIQGFFDIPVDNLWGFPIFKRHLEEKTDISKNNLVVVSPDIGGV
HHCCCCEEEEEEEEHHHHCCEECCCHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCH
KRASKFAERLGVPLAILDKRRPKDNIAEIVHVIGEVENRTAVIFDDIIDTGRSLVEAAKM
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHH
IKNKGANKVYACATHAVLSGKAKQLISDSPIEKVFISDTIHHPELPEKFEVVSIAGLLGE
HHHCCCCCEEHHHHHHHHCCHHHHHHCCCCHHEEEECCCCCCCCCCCHHHHHHHHHHHHH
ALMRVRKNLSVSILFR
HHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA