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The map label for this gene is uppS [H]

Identifier: 239617980

GI number: 239617980

Start: 1725685

End: 1726380

Strand: Reverse

Name: uppS [H]

Synonym: Kole_1608

Alternate gene names: 239617980

Gene position: 1726380-1725685 (Counterclockwise)

Preceding gene: 239617981

Following gene: 239617979

Centisome position: 74.99

GC content: 41.95

Gene sequence:

>696_bases
ATGAAGATACCTACTCATATTGCTATCATAATGGATGGCAACGGTCGCTGGGCCAAACAAAGAGGATTACGGAGAACGGA
AGGGCATAAAAAAGGTGCTGAGGTCGCAGACAGTGTTGCCCGATGGGCAGCGGAACTCGGGATTCGTTATCTTACTCTGT
ACGCTTTCTCCACGGAAAACTGGAAACGCCCGAAAGAGGAGGTTGAATTTCTTTTCAATTTGCTCGTTCGTTACATCAAC
AACCGCTTGAACGAGATCATTAACGAAGGTATAAAACTGAAATTTCTCGGGCGAATTCAACAACTGCCAGGAAATATACG
CAGATTTTGTGAGAATATAGAACAGAAAACCGCAAAAAACGACCGCCTGAATTTGATCATTGCCTTAAACTATGGAGGAC
GTGCTGAGATCATAGACGCTGTAAACAAAATCCTCGCTGCCAAGCTCAAAAAAGTAGATGAACATATCTTTGAACGTTAC
CTTTATCTCCCCGAAATGCCGGAGCCGGATCTAATAATCAGAACTTCCGGAGAAAAAAGGCTAAGTAATTTTCTAATGTG
GGAAAGTGCTTATTCAGAGCTGTATTTCTGTGAAAAGCTCTGGCCTGAGTTTACGAAAGATGATTTTTTACAGGCGATTG
AAGATTATTCCAGAAGAAAGAGAAAATTTGGTGCGGTGATAAAGGATGAAGAGTAA

Upstream 100 bases:

>100_bases
GATTTGAGGAAGAGCTCCAAAAGTTGACCGACAAATACGTTGAAGAAATGGATAAGCTTTTTGAGAAAAAGAAAAAGGAA
ATCATGGAGTTTTAAAGCAG

Downstream 100 bases:

>100_bases
ATCGGATGTTTTCACAAGAATATTAACTGCATTGACCATTAGCCCATTTGTTGTACTGTGTTTTGTGAGTTACAAATCTC
TGGTGGGATTGGTAGCGACT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKIPTHIAIIMDGNGRWAKQRGLRRTEGHKKGAEVADSVARWAAELGIRYLTLYAFSTENWKRPKEEVEFLFNLLVRYIN
NRLNEIINEGIKLKFLGRIQQLPGNIRRFCENIEQKTAKNDRLNLIIALNYGGRAEIIDAVNKILAAKLKKVDEHIFERY
LYLPEMPEPDLIIRTSGEKRLSNFLMWESAYSELYFCEKLWPEFTKDDFLQAIEDYSRRKRKFGAVIKDEE

Sequences:

>Translated_231_residues
MKIPTHIAIIMDGNGRWAKQRGLRRTEGHKKGAEVADSVARWAAELGIRYLTLYAFSTENWKRPKEEVEFLFNLLVRYIN
NRLNEIINEGIKLKFLGRIQQLPGNIRRFCENIEQKTAKNDRLNLIIALNYGGRAEIIDAVNKILAAKLKKVDEHIFERY
LYLPEMPEPDLIIRTSGEKRLSNFLMWESAYSELYFCEKLWPEFTKDDFLQAIEDYSRRKRKFGAVIKDEE
>Mature_231_residues
MKIPTHIAIIMDGNGRWAKQRGLRRTEGHKKGAEVADSVARWAAELGIRYLTLYAFSTENWKRPKEEVEFLFNLLVRYIN
NRLNEIINEGIKLKFLGRIQQLPGNIRRFCENIEQKTAKNDRLNLIIALNYGGRAEIIDAVNKILAAKLKKVDEHIFERY
LYLPEMPEPDLIIRTSGEKRLSNFLMWESAYSELYFCEKLWPEFTKDDFLQAIEDYSRRKRKFGAVIKDEE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=220, Percent_Identity=35.9090909090909, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI45580742, Length=220, Percent_Identity=35.9090909090909, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1786371, Length=241, Percent_Identity=40.2489626556017, Blast_Score=186, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=233, Percent_Identity=33.9055793991416, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=211, Percent_Identity=35.0710900473934, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=241, Percent_Identity=29.4605809128631, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=39.7321428571429, Blast_Score=166, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27201; Mature: 27201

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIPTHIAIIMDGNGRWAKQRGLRRTEGHKKGAEVADSVARWAAELGIRYLTLYAFSTEN
CCCCCEEEEEECCCCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
WKRPKEEVEFLFNLLVRYINNRLNEIINEGIKLKFLGRIQQLPGNIRRFCENIEQKTAKN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCHHHHHHHHHHHHHHCCC
DRLNLIIALNYGGRAEIIDAVNKILAAKLKKVDEHIFERYLYLPEMPEPDLIIRTSGEKR
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
LSNFLMWESAYSELYFCEKLWPEFTKDDFLQAIEDYSRRKRKFGAVIKDEE
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIPTHIAIIMDGNGRWAKQRGLRRTEGHKKGAEVADSVARWAAELGIRYLTLYAFSTEN
CCCCCEEEEEECCCCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
WKRPKEEVEFLFNLLVRYINNRLNEIINEGIKLKFLGRIQQLPGNIRRFCENIEQKTAKN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCHHHHHHHHHHHHHHCCC
DRLNLIIALNYGGRAEIIDAVNKILAAKLKKVDEHIFERYLYLPEMPEPDLIIRTSGEKR
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
LSNFLMWESAYSELYFCEKLWPEFTKDDFLQAIEDYSRRKRKFGAVIKDEE
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]