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The map label for this gene is arsB [C]

Identifier: 239617970

GI number: 239617970

Start: 1713461

End: 1714744

Strand: Reverse

Name: arsB [C]

Synonym: Kole_1598

Alternate gene names: 239617970

Gene position: 1714744-1713461 (Counterclockwise)

Preceding gene: 239617972

Following gene: 239617969

Centisome position: 74.49

GC content: 42.91

Gene sequence:

>1284_bases
TTGGAAAAGATCTTCGTCTCAGTAGTATTTGTCGTAACTTATCTTTTAATTATTCAGGGAAAATTCAAACGCTCCATCGT
AGCTTTTGCCGCGGGCATGATCATAATCCTTTCAAAGGTAATTGAAAGCTTCAATACAACTGATGTAGGTCAGTATATTG
ATTTCAACACCATCGGTCTTCTCATTGGAATGATGATAATCATAGCTATACTTCGAACCACAGGCTTTTTCGAGTACGTT
GCTATACTCGTTGTGAGGCTTTCGAAAGGAAATATCCGACTTCTTTTCTATTTTTTCATGGTTACGATAGCTGTGTTTTC
CGCTTTCCTGGACAACGTTACCACCATTCTCCTTTTTTCTCCCATCCTTTTTCTTGTTGCTGATTCTCTGGGGGTTTCTC
CTGTCTCTTTTTTAATCATGGGAGTTATATCCGCAAATGTCGGGGGCACCGCTACCCTTATCGGTGACCCACCAAATATA
CTGATAGGCTCAGCAAGTGGAAATGGATTCCTCGACTTTATCATTAATCTGGGGCCGCTTGTTCTGGTAACTCTCGGTAT
TCTTCTTTTGTACATGGATCTCACCGTCTTCAGAAAGTACTCGGGTTTATCCCGAAAGTTAAAAAAACTTTCAGCTGTGG
ACGCTTCTAAGGTAATCAAATCTCAAAAAGAGCTGTACAAATCCCTTGGAATCTTCGTGGCTGTCATCGTTGGCTTCATA
CTTCATGAAACCCTTGATTATGAAACGGCCAGCATCGCATTGACAGGCGCGGCAATCTCTATGTTGCTATCTCAAAAGAG
CGTTGGTGAACTGTCAAGAGATATAGAATGGGATACAATCTTTTTCTTTATGGGATTGTTCATGGTTGCCTCCGCGCTTC
AGGAAGTTGGTATAACCGACCTGATATCCTCCTCCATTGCCGGCCTATATAATCACCCTCTCACCATATTCATGGTCATG
CTGTGGCTCACAGCTATCATGAGCGCTATAATAGGTGCGGTCCCTACGGTGACCGTCATGATACCTATCGTAAAATCTCT
GATAGCTACACACGGATTTCCAGCGGATATCTGGTGGGTTTTATCCATTGGAGCGTGTTTTGGTGGAAATGCCACACTCA
CGGGTGCAGCAGCGAATATGGTAGGAGCTGCCCTGGTTGAGAAGCATACAAGAAAGAAATTTGGATATCTGAATTATTTA
AAACTTTCCATAATACCCACAATGATCTCGCTAGGGCTGGGAACCATCTATGTGCTTGTACAACTTTCGATGGGAGGTAT
GTGA

Upstream 100 bases:

>100_bases
TCCTCTTCATCAACTGTGTGGCAAAAAATTGGGTTCATTTTTTGAGACTTTGCGATTATTCTGATGGTTCAAAAGTGTTA
TACTTATTCGGGGTGATCGC

Downstream 100 bases:

>100_bases
GAATGCTGGTAAAGGATATTTTCAATTCCATAACCCTTGACGCCCCTATTGTTAAAGAGAATGCGGCTATACAGGATATA
GTCAAAGCGCTCCTGGATCA

Product: Citrate transporter

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEKIFVSVVFVVTYLLIIQGKFKRSIVAFAAGMIIILSKVIESFNTTDVGQYIDFNTIGLLIGMMIIIAILRTTGFFEYV
AILVVRLSKGNIRLLFYFFMVTIAVFSAFLDNVTTILLFSPILFLVADSLGVSPVSFLIMGVISANVGGTATLIGDPPNI
LIGSASGNGFLDFIINLGPLVLVTLGILLLYMDLTVFRKYSGLSRKLKKLSAVDASKVIKSQKELYKSLGIFVAVIVGFI
LHETLDYETASIALTGAAISMLLSQKSVGELSRDIEWDTIFFFMGLFMVASALQEVGITDLISSSIAGLYNHPLTIFMVM
LWLTAIMSAIIGAVPTVTVMIPIVKSLIATHGFPADIWWVLSIGACFGGNATLTGAAANMVGAALVEKHTRKKFGYLNYL
KLSIIPTMISLGLGTIYVLVQLSMGGM

Sequences:

>Translated_427_residues
MEKIFVSVVFVVTYLLIIQGKFKRSIVAFAAGMIIILSKVIESFNTTDVGQYIDFNTIGLLIGMMIIIAILRTTGFFEYV
AILVVRLSKGNIRLLFYFFMVTIAVFSAFLDNVTTILLFSPILFLVADSLGVSPVSFLIMGVISANVGGTATLIGDPPNI
LIGSASGNGFLDFIINLGPLVLVTLGILLLYMDLTVFRKYSGLSRKLKKLSAVDASKVIKSQKELYKSLGIFVAVIVGFI
LHETLDYETASIALTGAAISMLLSQKSVGELSRDIEWDTIFFFMGLFMVASALQEVGITDLISSSIAGLYNHPLTIFMVM
LWLTAIMSAIIGAVPTVTVMIPIVKSLIATHGFPADIWWVLSIGACFGGNATLTGAAANMVGAALVEKHTRKKFGYLNYL
KLSIIPTMISLGLGTIYVLVQLSMGGM
>Mature_427_residues
MEKIFVSVVFVVTYLLIIQGKFKRSIVAFAAGMIIILSKVIESFNTTDVGQYIDFNTIGLLIGMMIIIAILRTTGFFEYV
AILVVRLSKGNIRLLFYFFMVTIAVFSAFLDNVTTILLFSPILFLVADSLGVSPVSFLIMGVISANVGGTATLIGDPPNI
LIGSASGNGFLDFIINLGPLVLVTLGILLLYMDLTVFRKYSGLSRKLKKLSAVDASKVIKSQKELYKSLGIFVAVIVGFI
LHETLDYETASIALTGAAISMLLSQKSVGELSRDIEWDTIFFFMGLFMVASALQEVGITDLISSSIAGLYNHPLTIFMVM
LWLTAIMSAIIGAVPTVTVMIPIVKSLIATHGFPADIWWVLSIGACFGGNATLTGAAANMVGAALVEKHTRKKFGYLNYL
KLSIIPTMISLGLGTIYVLVQLSMGGM

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=462, Percent_Identity=30.3030303030303, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI87082277, Length=345, Percent_Identity=25.7971014492754, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19920704, Length=503, Percent_Identity=30.6163021868787, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574683, Length=503, Percent_Identity=30.6163021868787, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574681, Length=503, Percent_Identity=30.6163021868787, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574685, Length=503, Percent_Identity=30.6163021868787, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574678, Length=503, Percent_Identity=30.6163021868787, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24581759, Length=503, Percent_Identity=30.6163021868787, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221472711, Length=499, Percent_Identity=26.6533066132265, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24581764, Length=499, Percent_Identity=26.6533066132265, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45550608, Length=439, Percent_Identity=29.8405466970387, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI85724998, Length=472, Percent_Identity=22.4576271186441, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI62484377, Length=432, Percent_Identity=22.6851851851852, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24656008, Length=400, Percent_Identity=23, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 46132; Mature: 46132

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIFVSVVFVVTYLLIIQGKFKRSIVAFAAGMIIILSKVIESFNTTDVGQYIDFNTIGL
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHH
LIGMMIIIAILRTTGFFEYVAILVVRLSKGNIRLLFYFFMVTIAVFSAFLDNVTTILLFS
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PILFLVADSLGVSPVSFLIMGVISANVGGTATLIGDPPNILIGSASGNGFLDFIINLGPL
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHH
VLVTLGILLLYMDLTVFRKYSGLSRKLKKLSAVDASKVIKSQKELYKSLGIFVAVIVGFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHETLDYETASIALTGAAISMLLSQKSVGELSRDIEWDTIFFFMGLFMVASALQEVGITD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHH
LISSSIAGLYNHPLTIFMVMLWLTAIMSAIIGAVPTVTVMIPIVKSLIATHGFPADIWWV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LSIGACFGGNATLTGAAANMVGAALVEKHTRKKFGYLNYLKLSIIPTMISLGLGTIYVLV
HHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
QLSMGGM
HHHCCCC
>Mature Secondary Structure
MEKIFVSVVFVVTYLLIIQGKFKRSIVAFAAGMIIILSKVIESFNTTDVGQYIDFNTIGL
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHH
LIGMMIIIAILRTTGFFEYVAILVVRLSKGNIRLLFYFFMVTIAVFSAFLDNVTTILLFS
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PILFLVADSLGVSPVSFLIMGVISANVGGTATLIGDPPNILIGSASGNGFLDFIINLGPL
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHH
VLVTLGILLLYMDLTVFRKYSGLSRKLKKLSAVDASKVIKSQKELYKSLGIFVAVIVGFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHETLDYETASIALTGAAISMLLSQKSVGELSRDIEWDTIFFFMGLFMVASALQEVGITD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHH
LISSSIAGLYNHPLTIFMVMLWLTAIMSAIIGAVPTVTVMIPIVKSLIATHGFPADIWWV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LSIGACFGGNATLTGAAANMVGAALVEKHTRKKFGYLNYLKLSIIPTMISLGLGTIYVLV
HHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
QLSMGGM
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]