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The map label for this gene is norM [H]

Identifier: 239617149

GI number: 239617149

Start: 806081

End: 807484

Strand: Reverse

Name: norM [H]

Synonym: Kole_0754

Alternate gene names: 239617149

Gene position: 807484-806081 (Counterclockwise)

Preceding gene: 239617150

Following gene: 239617148

Centisome position: 35.08

GC content: 43.09

Gene sequence:

>1404_bases
ATGGTGATGTCAATGAAGTATAGCCTGCTAAGAAGTTATCTTTCTCACGAAGAAGCTGCTGAAATAAGAAAAAAATTAAT
TGTTATTGCTCTTCCAGCGATGGGTGAGAACATCCTCCAGATGCTTCTCGGTATTGCGGATACCGCATTTCTTGGGCATT
ATGATTGGCGGGTTATGAGCGGCGTTGGGGTAGCGAACCAGATGGTTTTTATACTTCAGGTGATTCTTATAGCAGTATCT
ACCGGGACAATGGTTTATATTTCAAATGGGCTTGGCGCGAAAAATCAAAGGCTTGTAAATAGAGTAAGCTGGCATTCGAT
TTATCTTGCAGCGGCTGTTGGAATAGCGATGACTCTTTTGGCTTTTTTCTCTGATAGTTTTATAGAGTGGTTTTTCCCGA
AGGCTGAACCCATTGTTCAGCAAGCCGCACAGGATTATTTAGCCATTATCCTTCTTGGTGCGACAGGGTTCAGCTTTATG
ATCGTTCTTGGATCCGTTCTGAGAGGGGCAGGAGATACCAAATCCCCGATGATAACCGTGGCAATATCCAATGCGATAAA
CATTTTTCTCGATTATGCACTCATTTTTGGAAGGTTCGGATTCCCCGAATTGGGAGCAAGAGGTGCAGCGACAGCTACAA
TTATTTCAAGGTTTGTTGGTGCAACTATTTTGCTTTATCTTCTTTTCAGGAATAAGAGAATAGCAATGGGACCAAAACCG
TGCAGATTTTCTTCGAGAGTAACGAGAAATATATTTTCAGTTGGTCTGCCAACGGCTTTTGATAATCTATCTTTTTCGGT
GGGAATTATGGTTTTTGCTAATATACTGCTTTTAGCTGGTGCCAGGGTGTATGCGGCGCATAGAATAGGTATAAACGTTG
AGTCGATTTCCTTCATGCCTGCCTGGGGGTTGGGTGTTTCCATTACGGCTCTTGTCGGTATGTATAATGGAGCAGGACAG
ATAAACAAGGTTATCGGGACCTTGCGACAGGGCTGGATTATCTCAATGTGTTTTTCCTCTATTATCGGCATTTTGATCTT
TCTGTTTCCGCGTGCTTTTATAATGATCTTCACAAACGACGCTGAGATAATTCAGATGGCGAGCCTGCCAGTCAGGATAA
TCGGGTTGTTTCAAATCATCCTCGGGACAGATTTTGCTTTTACCGGTGCGCTGCGCGGGCTGGGAGATACACGGTTTCCT
ATGATTGCCTCTATGATCGCTATGTGGCTTGTCAGGATACCTGTGGGTTTTGTTCTGGTAAAATATTTCGGTATGGGACT
TATGGGGGCATGGATAGGTATGATGATTGATATGATCCTCAGAATGTCCCTTAAAGTATTCAGATTACTTTCAGGTAACT
GGGAAAAAACTGCCGATAAGGTTCGTAAAAAAGCCGGTGCATAA

Upstream 100 bases:

>100_bases
TTCGGAGCGCACCCGTGCGTAGTGTGCTTACCCTAATTTTCACACTTTCATCATAGAGAATAAATCTTAAAAAACTAAAA
TAGTTAGGAATCCTAACGAT

Downstream 100 bases:

>100_bases
AGGCATAACGGTGCGAAAATAGGGAGTCAGCAGCTTTTTCGTGAGTAGGGATCGATACTCATGGTGTTGATGGTGGGCTA
AGCAAGGATTTTCTTCCAGG

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MVMSMKYSLLRSYLSHEEAAEIRKKLIVIALPAMGENILQMLLGIADTAFLGHYDWRVMSGVGVANQMVFILQVILIAVS
TGTMVYISNGLGAKNQRLVNRVSWHSIYLAAAVGIAMTLLAFFSDSFIEWFFPKAEPIVQQAAQDYLAIILLGATGFSFM
IVLGSVLRGAGDTKSPMITVAISNAINIFLDYALIFGRFGFPELGARGAATATIISRFVGATILLYLLFRNKRIAMGPKP
CRFSSRVTRNIFSVGLPTAFDNLSFSVGIMVFANILLLAGARVYAAHRIGINVESISFMPAWGLGVSITALVGMYNGAGQ
INKVIGTLRQGWIISMCFSSIIGILIFLFPRAFIMIFTNDAEIIQMASLPVRIIGLFQIILGTDFAFTGALRGLGDTRFP
MIASMIAMWLVRIPVGFVLVKYFGMGLMGAWIGMMIDMILRMSLKVFRLLSGNWEKTADKVRKKAGA

Sequences:

>Translated_467_residues
MVMSMKYSLLRSYLSHEEAAEIRKKLIVIALPAMGENILQMLLGIADTAFLGHYDWRVMSGVGVANQMVFILQVILIAVS
TGTMVYISNGLGAKNQRLVNRVSWHSIYLAAAVGIAMTLLAFFSDSFIEWFFPKAEPIVQQAAQDYLAIILLGATGFSFM
IVLGSVLRGAGDTKSPMITVAISNAINIFLDYALIFGRFGFPELGARGAATATIISRFVGATILLYLLFRNKRIAMGPKP
CRFSSRVTRNIFSVGLPTAFDNLSFSVGIMVFANILLLAGARVYAAHRIGINVESISFMPAWGLGVSITALVGMYNGAGQ
INKVIGTLRQGWIISMCFSSIIGILIFLFPRAFIMIFTNDAEIIQMASLPVRIIGLFQIILGTDFAFTGALRGLGDTRFP
MIASMIAMWLVRIPVGFVLVKYFGMGLMGAWIGMMIDMILRMSLKVFRLLSGNWEKTADKVRKKAGA
>Mature_467_residues
MVMSMKYSLLRSYLSHEEAAEIRKKLIVIALPAMGENILQMLLGIADTAFLGHYDWRVMSGVGVANQMVFILQVILIAVS
TGTMVYISNGLGAKNQRLVNRVSWHSIYLAAAVGIAMTLLAFFSDSFIEWFFPKAEPIVQQAAQDYLAIILLGATGFSFM
IVLGSVLRGAGDTKSPMITVAISNAINIFLDYALIFGRFGFPELGARGAATATIISRFVGATILLYLLFRNKRIAMGPKP
CRFSSRVTRNIFSVGLPTAFDNLSFSVGIMVFANILLLAGARVYAAHRIGINVESISFMPAWGLGVSITALVGMYNGAGQ
INKVIGTLRQGWIISMCFSSIIGILIFLFPRAFIMIFTNDAEIIQMASLPVRIIGLFQIILGTDFAFTGALRGLGDTRFP
MIASMIAMWLVRIPVGFVLVKYFGMGLMGAWIGMMIDMILRMSLKVFRLLSGNWEKTADKVRKKAGA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=444, Percent_Identity=23.1981981981982, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI38261960, Length=480, Percent_Identity=22.2916666666667, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI226510954, Length=453, Percent_Identity=26.4900662251656, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994890, Length=445, Percent_Identity=25.1685393258427, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51108; Mature: 51108

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMSMKYSLLRSYLSHEEAAEIRKKLIVIALPAMGENILQMLLGIADTAFLGHYDWRVMS
CCCCHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GVGVANQMVFILQVILIAVSTGTMVYISNGLGAKNQRLVNRVSWHSIYLAAAVGIAMTLL
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFFSDSFIEWFFPKAEPIVQQAAQDYLAIILLGATGFSFMIVLGSVLRGAGDTKSPMITV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEE
AISNAINIFLDYALIFGRFGFPELGARGAATATIISRFVGATILLYLLFRNKRIAMGPKP
EEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
CRFSSRVTRNIFSVGLPTAFDNLSFSVGIMVFANILLLAGARVYAAHRIGINVESISFMP
CCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHEECCEEEEEEECC
AWGLGVSITALVGMYNGAGQINKVIGTLRQGWIISMCFSSIIGILIFLFPRAFIMIFTND
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC
AEIIQMASLPVRIIGLFQIILGTDFAFTGALRGLGDTRFPMIASMIAMWLVRIPVGFVLV
HHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KYFGMGLMGAWIGMMIDMILRMSLKVFRLLSGNWEKTADKVRKKAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MVMSMKYSLLRSYLSHEEAAEIRKKLIVIALPAMGENILQMLLGIADTAFLGHYDWRVMS
CCCCHHHHHHHHHHCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GVGVANQMVFILQVILIAVSTGTMVYISNGLGAKNQRLVNRVSWHSIYLAAAVGIAMTLL
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AFFSDSFIEWFFPKAEPIVQQAAQDYLAIILLGATGFSFMIVLGSVLRGAGDTKSPMITV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEE
AISNAINIFLDYALIFGRFGFPELGARGAATATIISRFVGATILLYLLFRNKRIAMGPKP
EEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
CRFSSRVTRNIFSVGLPTAFDNLSFSVGIMVFANILLLAGARVYAAHRIGINVESISFMP
CCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHEECCEEEEEEECC
AWGLGVSITALVGMYNGAGQINKVIGTLRQGWIISMCFSSIIGILIFLFPRAFIMIFTND
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC
AEIIQMASLPVRIIGLFQIILGTDFAFTGALRGLGDTRFPMIASMIAMWLVRIPVGFVLV
HHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KYFGMGLMGAWIGMMIDMILRMSLKVFRLLSGNWEKTADKVRKKAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]