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The map label for this gene is dhaT [H]

Identifier: 239617138

GI number: 239617138

Start: 794117

End: 795325

Strand: Reverse

Name: dhaT [H]

Synonym: Kole_0742

Alternate gene names: 239617138

Gene position: 795325-794117 (Counterclockwise)

Preceding gene: 239617139

Following gene: 239617135

Centisome position: 34.55

GC content: 44.25

Gene sequence:

>1209_bases
ATGTGGGAAAGCAAAATGGACATTTACAACGTTTTTGAACTCAGAGGAAGAACATTGTGCTACTTTGGCGTTGGCGCCAT
AAAAAAGATAAAAGACATTGCTGAAGCCCTCAAAAAGCAAGGAATAAATAAGGTTATTGTGGTTACCGATGAAGTTGCTT
ACAAAGTTACCGGTGCCTGGGATGTTATAGAACCTGCCCTTAAAGAGGTCGGAATCGATAGTATAATGTACACGGGCGTA
ACACCCAATCCAACGGTAGAACAGATTGACGAAGCCACAGCAATGGGAAAAGAATTCGGGGCTCAGGCCGTCATCGGAAT
AGGTGGAGGAAGTCCCATCGATTCAGCAAAGAGCGTAGCAATACTCCTGGAATACACTGACAAAACTGCCAGCGAACTGT
ACGAACAGAAATTTATTCCGGAAAAAGCCAAACCAATCATCGCTGTAAACACCACTCATGGAACTGGTACCGAAGTTGAC
AGGTTTGCTGTTGCTTCTATCCTTGACAAAGAATATAAACCCGCTCTTGCATACGATTGTATTTACCCGACCTACGCTAT
TGATGACCCCGCTCTTATGAAAACGCTACCTCCAAACCAGACAAAATTCACATCGATTGACGCTATTAACCACGTAACAG
AAGCTGCAACCACTATCGTTGCCAGCCCGTATTCAATACTTCTCGCCAAGGAAACAATCAGACTCATTACAAGATACCTA
CCTCAGGCTCTTTCACACCCAGAAGATCTTGTAGCAAGATATTACCTGCTCTACGCTTCAGCCATAGCCGGTATATCCTT
CGACAACGGTTTGCTCCATTTCACACATGCACTTGAACACCCACTAAGTGCTATAAAACCTGAACTTCCACACGGTCTTG
GTCTCGCGATGCTCCTCCCGGCGGTTGTTAAACACATATATCCGGCTGTTCCTGAAGTGTTGGCTGACATTTATGAACCA
ATTGTTCCCGGTCTAAAGGGTGTTCCGGGCGAGGCAGAAAAGATCGCTGCTGGTATTGAAAAATGGTTGTTCAGCCTTGG
TATCACAGAAAAACTCGAAGATATGGGCTTTACAAAAGACGATATTCCAAAACTCGTTGAACTTGCAACAACACCTTCCC
TTGATCTCTTACTGAGCCTTGCTCCTATTAAGGCAACAAAAGAGGTTATTGCTAAGATCTACGAAGATTCTCTGAAACCA
TTGAGCTAA

Upstream 100 bases:

>100_bases
TCACATAATCGTTCTGATCAAGTTACCTTATCTTCGCAGGAATTACATAATAGTAGTGGTAAAATATAAGTGAAAAAATT
CACAAGCAGGAGGTGAAATT

Downstream 100 bases:

>100_bases
AATAGAAAGTAAAAGAAAAGGCTGGTTTTCACCAGCCTTTTCTTTTTTGTTTGTTATTATTTTTGAGAGTCTATTAATTT
CAATAAAGCTTTAGCTGCCT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MWESKMDIYNVFELRGRTLCYFGVGAIKKIKDIAEALKKQGINKVIVVTDEVAYKVTGAWDVIEPALKEVGIDSIMYTGV
TPNPTVEQIDEATAMGKEFGAQAVIGIGGGSPIDSAKSVAILLEYTDKTASELYEQKFIPEKAKPIIAVNTTHGTGTEVD
RFAVASILDKEYKPALAYDCIYPTYAIDDPALMKTLPPNQTKFTSIDAINHVTEAATTIVASPYSILLAKETIRLITRYL
PQALSHPEDLVARYYLLYASAIAGISFDNGLLHFTHALEHPLSAIKPELPHGLGLAMLLPAVVKHIYPAVPEVLADIYEP
IVPGLKGVPGEAEKIAAGIEKWLFSLGITEKLEDMGFTKDDIPKLVELATTPSLDLLLSLAPIKATKEVIAKIYEDSLKP
LS

Sequences:

>Translated_402_residues
MWESKMDIYNVFELRGRTLCYFGVGAIKKIKDIAEALKKQGINKVIVVTDEVAYKVTGAWDVIEPALKEVGIDSIMYTGV
TPNPTVEQIDEATAMGKEFGAQAVIGIGGGSPIDSAKSVAILLEYTDKTASELYEQKFIPEKAKPIIAVNTTHGTGTEVD
RFAVASILDKEYKPALAYDCIYPTYAIDDPALMKTLPPNQTKFTSIDAINHVTEAATTIVASPYSILLAKETIRLITRYL
PQALSHPEDLVARYYLLYASAIAGISFDNGLLHFTHALEHPLSAIKPELPHGLGLAMLLPAVVKHIYPAVPEVLADIYEP
IVPGLKGVPGEAEKIAAGIEKWLFSLGITEKLEDMGFTKDDIPKLVELATTPSLDLLLSLAPIKATKEVIAKIYEDSLKP
LS
>Mature_402_residues
MWESKMDIYNVFELRGRTLCYFGVGAIKKIKDIAEALKKQGINKVIVVTDEVAYKVTGAWDVIEPALKEVGIDSIMYTGV
TPNPTVEQIDEATAMGKEFGAQAVIGIGGGSPIDSAKSVAILLEYTDKTASELYEQKFIPEKAKPIIAVNTTHGTGTEVD
RFAVASILDKEYKPALAYDCIYPTYAIDDPALMKTLPPNQTKFTSIDAINHVTEAATTIVASPYSILLAKETIRLITRYL
PQALSHPEDLVARYYLLYASAIAGISFDNGLLHFTHALEHPLSAIKPELPHGLGLAMLLPAVVKHIYPAVPEVLADIYEP
IVPGLKGVPGEAEKIAAGIEKWLFSLGITEKLEDMGFTKDDIPKLVELATTPSLDLLLSLAPIKATKEVIAKIYEDSLKP
LS

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=412, Percent_Identity=26.6990291262136, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=30.5851063829787, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87082107, Length=380, Percent_Identity=29.7368421052632, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789163, Length=386, Percent_Identity=29.7927461139896, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787493, Length=364, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789386, Length=399, Percent_Identity=27.8195488721804, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=426, Percent_Identity=26.7605633802817, Blast_Score=134, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=382, Percent_Identity=29.8429319371728, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24657991, Length=432, Percent_Identity=27.7777777777778, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 43723; Mature: 43723

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWESKMDIYNVFELRGRTLCYFGVGAIKKIKDIAEALKKQGINKVIVVTDEVAYKVTGAW
CCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCH
DVIEPALKEVGIDSIMYTGVTPNPTVEQIDEATAMGKEFGAQAVIGIGGGSPIDSAKSVA
HHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEE
ILLEYTDKTASELYEQKFIPEKAKPIIAVNTTHGTGTEVDRFAVASILDKEYKPALAYDC
EEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHC
IYPTYAIDDPALMKTLPPNQTKFTSIDAINHVTEAATTIVASPYSILLAKETIRLITRYL
CCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
PQALSHPEDLVARYYLLYASAIAGISFDNGLLHFTHALEHPLSAIKPELPHGLGLAMLLP
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCHHHHHH
AVVKHIYPAVPEVLADIYEPIVPGLKGVPGEAEKIAAGIEKWLFSLGITEKLEDMGFTKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHH
DIPKLVELATTPSLDLLLSLAPIKATKEVIAKIYEDSLKPLS
HHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MWESKMDIYNVFELRGRTLCYFGVGAIKKIKDIAEALKKQGINKVIVVTDEVAYKVTGAW
CCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCH
DVIEPALKEVGIDSIMYTGVTPNPTVEQIDEATAMGKEFGAQAVIGIGGGSPIDSAKSVA
HHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEE
ILLEYTDKTASELYEQKFIPEKAKPIIAVNTTHGTGTEVDRFAVASILDKEYKPALAYDC
EEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHC
IYPTYAIDDPALMKTLPPNQTKFTSIDAINHVTEAATTIVASPYSILLAKETIRLITRYL
CCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
PQALSHPEDLVARYYLLYASAIAGISFDNGLLHFTHALEHPLSAIKPELPHGLGLAMLLP
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCHHHHHH
AVVKHIYPAVPEVLADIYEPIVPGLKGVPGEAEKIAAGIEKWLFSLGITEKLEDMGFTKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHH
DIPKLVELATTPSLDLLLSLAPIKATKEVIAKIYEDSLKPLS
HHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]