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The map label for this gene is mrpD [H]

Identifier: 239616967

GI number: 239616967

Start: 613797

End: 615275

Strand: Reverse

Name: mrpD [H]

Synonym: Kole_0565

Alternate gene names: 239616967

Gene position: 615275-613797 (Counterclockwise)

Preceding gene: 239616968

Following gene: 239616966

Centisome position: 26.73

GC content: 43.88

Gene sequence:

>1479_bases
GTGATAATACCTTATCTGGTTATCATACCTTTGGCTGCAGGTTTCTTGATTGTTCTATTAGGGAGGAAGAATAAGGTTCT
GCCAGAACTGATTGCTTTGACGGCCACTTTCTCTCTTTTAGCGATTTCTCTCCTGCTCTTTCCTATGATTGAAAGCGAAG
GAGGAGCGATTCTTTACGAACTTTCCGGATGGAAAATACCGTATACCATATCCTTTGTAATCGATTATTTATCAGCCTTT
TTGGTTACCATGGTCTCCGCGTTGGCTGTACTGAGTACGATTTATTCCGTCGGATATATGAGAAAATTTTCTGGTATATG
GAACTACTACGCGCTTTTAATGCTGATGATTACCGGCCTTAACGGTGTGGCGATTACCGGTGACCTCTTCAACCTCTTTG
TCTTTATGGAGATCGCGCTTATAGCTACTTACGCTCTTGTAGCTTTTCATGGTGAGGCGGAACATTATGAAGCGGCCTTC
AAGTACGCGATCATGAGTTCGTTATCCTCAAGCCTTGTGCTCTTTGGGATAGGTTGCGTGTACAGTATGACCTCGTCTTT
GACCCTGATGCAGATTTCAAATAAGATGATTGGGGTAGGTGAGACTAACCTTGTTTACGCTCTATTCCTGACGGGGTTTG
GATTGAAAGCGGCGATGTTTCCATTTCATTCGTGGTTACCAGATGCACATCCTTCAGCTCCATCACCTGTATCGGCTATG
CTTTCCGGGGTACTGATAAAAGTTCTGGGAGCTTACACACTCATTAGGGTTTTCTACATGGTATTCGGGGTTTCAGAACT
GGTGAAGGAATTGTTTCTTATATTTGGGACGCTTTCCATGGTAATAGGCGCTCTTGTAGCTGTTATGCAGAAAGATATCA
AGAGAATGCTGGGTTTCAGCAGTGTCAGCCAGATGGGATACATCATCTTCGCTCTCGGTATTGGAACACCCCTTGGGGTG
CTTGGTGCGATTTATCACATGTTGAACCATGCTGTACTGAAAGGATTGCTTTTCATGGATGCTGGAGCAGTGGAACTGAT
TGAAGGCACGAGAGATATGGAAGAGATGAAAGGTGTAAGTGACAGAACCACTTACGTAACATCTCTTATGGCTTCTTTAG
GAATTTCCGGTGTACCTCCTTTCGGTGGATTCTTCAGCAAGCTGATTATAATTACCGCCGCAATATATACCGGAAAATTT
ATCTATGCGATTATTGCCCTCGCGGTAAGCGTGATAACTCTTGGATATTATCTTGGAATGCTCAAGAAGGCTTTCAGAAA
GAGGAATAAAGAGGTTAACGATAAAGGATCTCTACCCGCATCACTGAAGATTCCCATGATAATCCTTGCGGTTCTCACAC
TTGCAACCGCTTTGTTTTACGTTCCTGTTGTACGGGAAAACATTCTGGAAAAGGTTGTTTCCTGTATAACGGACAGAACG
GCCTACATCGCTTTGTTTACGGCAGGTGGTGGACGATGA

Upstream 100 bases:

>100_bases
TTATCGAGCTCGGTGTGACCGCATTGTTGATAACGCTGGCTATAAATATTCATCGTAAATACGGAACATTTGACCTGAGG
AAGATAAGGAGGCTCAGGGA

Downstream 100 bases:

>100_bases
AACTTTCCACGAAAAGTAAAATTACGGTTTTTACATTATCCTTTTTTGTCTGGATACTTATAACAGCTATCACAGATGTT
CAGGAGATTATTGCCGGTCT

Product: NADH/Ubiquinone/plastoquinone (complex I)

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MIIPYLVIIPLAAGFLIVLLGRKNKVLPELIALTATFSLLAISLLLFPMIESEGGAILYELSGWKIPYTISFVIDYLSAF
LVTMVSALAVLSTIYSVGYMRKFSGIWNYYALLMLMITGLNGVAITGDLFNLFVFMEIALIATYALVAFHGEAEHYEAAF
KYAIMSSLSSSLVLFGIGCVYSMTSSLTLMQISNKMIGVGETNLVYALFLTGFGLKAAMFPFHSWLPDAHPSAPSPVSAM
LSGVLIKVLGAYTLIRVFYMVFGVSELVKELFLIFGTLSMVIGALVAVMQKDIKRMLGFSSVSQMGYIIFALGIGTPLGV
LGAIYHMLNHAVLKGLLFMDAGAVELIEGTRDMEEMKGVSDRTTYVTSLMASLGISGVPPFGGFFSKLIIITAAIYTGKF
IYAIIALAVSVITLGYYLGMLKKAFRKRNKEVNDKGSLPASLKIPMIILAVLTLATALFYVPVVRENILEKVVSCITDRT
AYIALFTAGGGR

Sequences:

>Translated_492_residues
MIIPYLVIIPLAAGFLIVLLGRKNKVLPELIALTATFSLLAISLLLFPMIESEGGAILYELSGWKIPYTISFVIDYLSAF
LVTMVSALAVLSTIYSVGYMRKFSGIWNYYALLMLMITGLNGVAITGDLFNLFVFMEIALIATYALVAFHGEAEHYEAAF
KYAIMSSLSSSLVLFGIGCVYSMTSSLTLMQISNKMIGVGETNLVYALFLTGFGLKAAMFPFHSWLPDAHPSAPSPVSAM
LSGVLIKVLGAYTLIRVFYMVFGVSELVKELFLIFGTLSMVIGALVAVMQKDIKRMLGFSSVSQMGYIIFALGIGTPLGV
LGAIYHMLNHAVLKGLLFMDAGAVELIEGTRDMEEMKGVSDRTTYVTSLMASLGISGVPPFGGFFSKLIIITAAIYTGKF
IYAIIALAVSVITLGYYLGMLKKAFRKRNKEVNDKGSLPASLKIPMIILAVLTLATALFYVPVVRENILEKVVSCITDRT
AYIALFTAGGGR
>Mature_492_residues
MIIPYLVIIPLAAGFLIVLLGRKNKVLPELIALTATFSLLAISLLLFPMIESEGGAILYELSGWKIPYTISFVIDYLSAF
LVTMVSALAVLSTIYSVGYMRKFSGIWNYYALLMLMITGLNGVAITGDLFNLFVFMEIALIATYALVAFHGEAEHYEAAF
KYAIMSSLSSSLVLFGIGCVYSMTSSLTLMQISNKMIGVGETNLVYALFLTGFGLKAAMFPFHSWLPDAHPSAPSPVSAM
LSGVLIKVLGAYTLIRVFYMVFGVSELVKELFLIFGTLSMVIGALVAVMQKDIKRMLGFSSVSQMGYIIFALGIGTPLGV
LGAIYHMLNHAVLKGLLFMDAGAVELIEGTRDMEEMKGVSDRTTYVTSLMASLGISGVPPFGGFFSKLIIITAAIYTGKF
IYAIIALAVSVITLGYYLGMLKKAFRKRNKEVNDKGSLPASLKIPMIILAVLTLATALFYVPVVRENILEKVVSCITDRT
AYIALFTAGGGR

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=354, Percent_Identity=27.1186440677966, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI251831116, Length=225, Percent_Identity=28, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788831, Length=415, Percent_Identity=32.0481927710843, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1788827, Length=420, Percent_Identity=29.2857142857143, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788829, Length=404, Percent_Identity=28.2178217821782, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788613, Length=466, Percent_Identity=28.9699570815451, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788614, Length=405, Percent_Identity=25.1851851851852, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693160, Length=212, Percent_Identity=33.9622641509434, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI2367154, Length=337, Percent_Identity=24.3323442136499, Blast_Score=93, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 53332; Mature: 53332

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPYLVIIPLAAGFLIVLLGRKNKVLPELIALTATFSLLAISLLLFPMIESEGGAILYE
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LSGWKIPYTISFVIDYLSAFLVTMVSALAVLSTIYSVGYMRKFSGIWNYYALLMLMITGL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGVAITGDLFNLFVFMEIALIATYALVAFHGEAEHYEAAFKYAIMSSLSSSLVLFGIGCV
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSMTSSLTLMQISNKMIGVGETNLVYALFLTGFGLKAAMFPFHSWLPDAHPSAPSPVSAM
HHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHH
LSGVLIKVLGAYTLIRVFYMVFGVSELVKELFLIFGTLSMVIGALVAVMQKDIKRMLGFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
SVSQMGYIIFALGIGTPLGVLGAIYHMLNHAVLKGLLFMDAGAVELIEGTRDMEEMKGVS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHCCCC
DRTTYVTSLMASLGISGVPPFGGFFSKLIIITAAIYTGKFIYAIIALAVSVITLGYYLGM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKAFRKRNKEVNDKGSLPASLKIPMIILAVLTLATALFYVPVVRENILEKVVSCITDRT
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYIALFTAGGGR
EEEEEEECCCCC
>Mature Secondary Structure
MIIPYLVIIPLAAGFLIVLLGRKNKVLPELIALTATFSLLAISLLLFPMIESEGGAILYE
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LSGWKIPYTISFVIDYLSAFLVTMVSALAVLSTIYSVGYMRKFSGIWNYYALLMLMITGL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGVAITGDLFNLFVFMEIALIATYALVAFHGEAEHYEAAFKYAIMSSLSSSLVLFGIGCV
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSMTSSLTLMQISNKMIGVGETNLVYALFLTGFGLKAAMFPFHSWLPDAHPSAPSPVSAM
HHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHH
LSGVLIKVLGAYTLIRVFYMVFGVSELVKELFLIFGTLSMVIGALVAVMQKDIKRMLGFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
SVSQMGYIIFALGIGTPLGVLGAIYHMLNHAVLKGLLFMDAGAVELIEGTRDMEEMKGVS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHCCCC
DRTTYVTSLMASLGISGVPPFGGFFSKLIIITAAIYTGKFIYAIIALAVSVITLGYYLGM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKAFRKRNKEVNDKGSLPASLKIPMIILAVLTLATALFYVPVVRENILEKVVSCITDRT
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYIALFTAGGGR
EEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]