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The map label for this gene is mecR1 [H]

Identifier: 238925639

GI number: 238925639

Start: 3131836

End: 3133557

Strand: Reverse

Name: mecR1 [H]

Synonym: EUBREC_3296

Alternate gene names: 238925639

Gene position: 3133557-3131836 (Counterclockwise)

Preceding gene: 238925640

Following gene: 238925638

Centisome position: 90.84

GC content: 42.33

Gene sequence:

>1722_bases
ATGAGTTCATTCTTTTTGAAAATTGTAAATATGAGTATCGCCGCATCTTGGCTGATCCTTGCGGTCGTACTTTTGCGTGT
GGTTTTGAAAAAGGCACCTAAGTGGATCAATGTCCTACTGTGGGGTATCGTAGCTTTTCGATTGATTTGCCCATTCAGTT
TTGAAAGCGCATTGAGCTTGATTCCAAGTGCCGAGACCATCAGTCCTGAAATCATGATGGACTGGACACCAGAAATCTCC
ACAGGCGTAAGCTCTATCGACAAGGTAGTGAATCCAATTATTACGGACACCTTTGCTCCAGAGCCAATTGCAAGCGCAAA
TCCACTTCAGCTTTTGATTCCTGTGCTGGCAATCGGATGGGCAATAGGCATCATAGCCATGCTCGTTTATGCTGCCGTCA
GCTATTTCCGCTTGCAAAAGAAAGTCGGTGCATCCCTTTCTGTGCGGGACAACATTTGGATTTGTGACGATATACAAACA
CCTTTTATTCTTGGTTTCTTCAAACCGAGCATCTACATTCCCTCCGGGACAGATGAAGCACAGTTGCCCTATATTATTGC
CCATGAGAATGCTCATCTGAAACGCTGTGACCATTGGTGGAAACCGTTGGGGTATTTAGTGTTGGCAATCCATTGGTTCA
ATCCTCTTGTATGGATTGCGTATATTTTACTTTGCCGAGATATTGAACTTGCCTGCGATGAAAAAGTTATTCGTGGACTG
AATCAAAACGAGTCTATTTCTTATTCAGAAGCTCTGCTTTCTTGTAGCGTGAATAGAAGAACAGTTATGGTTTGTCCACT
TGCCTTTGGAGAGGTTGGCGTCAAAGAAAGGGTGAAAAATGTGCTGAATTACAAGAAACCTGCATTTTGGATTGTTGCTA
TTGCTGTGGTTTCAAGTATTGTTCTTGGGGTATGTTTCCTGACAAATCCGAGTTCATTCCCAGTGAAACTTGATTCTGTT
CAAATTTCCAAAGCAAGCACCATGGACTTTAGAACAAATATCGGACCGACCACATTCCAATTATCCGCAGCGGAAATTGA
CGAGTTGAGCAGTCGTATTAAAAACTTAAAGATTGGTCACAAAGACCAATCTTTGCAAGGTCATACACCTTTCTATTCCC
TTCATGTGGATACCAAGGAAAACGACAGAATCACATTCAGCGGTTTTGATTCCAACGGAAATCAAGCAGCAATTCTGTAT
GAGAATGTGTATTACCGAATAACTGACTCTGACTTTATCAGCTATTTACAACGCATCTGTGCCGGGGAAACCAGAACAGA
ATCGATTAACGAAACCAATGTTGATACAGCAATCCATAATGCAATCATGGAACATAACAGCGATAGATACTACAAAGGTG
TTTTTGCCTGCGAAAGCCATACTGTATTGGCTACAGAAGCCGGTGGGGCTGCAAACTCTGAGGAGAATGAGACATTGACC
GTATATGTTCTCACTCTTTATGAGGAATATAATTTGTCCGAAGAAGGGATTGAAAGTGTCGGTGGAGGTTGTGGTCCTGT
TGCCCTAACTTTCAATGTGACAGAGAATGGATATGAACTATCTGAATATTGGGAGCCGGGAGATGGCAGCCAATACTCTG
ATGATATTCGTAAAAAGTTCCCGGAGGATATATTAGATGAAGTCTGGAATCCTCAGGATTATGTGGATGCAATGACAGCA
GAAAATGAACAAAAGGCACTCGAATTTTCGGCACAAAAGTGA

Upstream 100 bases:

>100_bases
TGCTTTCATTGCGGCTTTTACACAAAGGAAGGGTATTTCTCAACAGGAAGCTGCGGAGATTCGACGCATGATTGATGCAG
CCGCCGGAAAGGAGTAATCT

Downstream 100 bases:

>100_bases
GATTTCAAAGATTGATAATGAACGCAGTGTTTTAGGGAATAAAGTCAAAAAAATAAAATGTTATTAATCTAAAATCATGC
ATAAAGTAGAAATAGTGTAA

Product: methicillin-resistance MecR1 regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MSSFFLKIVNMSIAASWLILAVVLLRVVLKKAPKWINVLLWGIVAFRLICPFSFESALSLIPSAETISPEIMMDWTPEIS
TGVSSIDKVVNPIITDTFAPEPIASANPLQLLIPVLAIGWAIGIIAMLVYAAVSYFRLQKKVGASLSVRDNIWICDDIQT
PFILGFFKPSIYIPSGTDEAQLPYIIAHENAHLKRCDHWWKPLGYLVLAIHWFNPLVWIAYILLCRDIELACDEKVIRGL
NQNESISYSEALLSCSVNRRTVMVCPLAFGEVGVKERVKNVLNYKKPAFWIVAIAVVSSIVLGVCFLTNPSSFPVKLDSV
QISKASTMDFRTNIGPTTFQLSAAEIDELSSRIKNLKIGHKDQSLQGHTPFYSLHVDTKENDRITFSGFDSNGNQAAILY
ENVYYRITDSDFISYLQRICAGETRTESINETNVDTAIHNAIMEHNSDRYYKGVFACESHTVLATEAGGAANSEENETLT
VYVLTLYEEYNLSEEGIESVGGGCGPVALTFNVTENGYELSEYWEPGDGSQYSDDIRKKFPEDILDEVWNPQDYVDAMTA
ENEQKALEFSAQK

Sequences:

>Translated_573_residues
MSSFFLKIVNMSIAASWLILAVVLLRVVLKKAPKWINVLLWGIVAFRLICPFSFESALSLIPSAETISPEIMMDWTPEIS
TGVSSIDKVVNPIITDTFAPEPIASANPLQLLIPVLAIGWAIGIIAMLVYAAVSYFRLQKKVGASLSVRDNIWICDDIQT
PFILGFFKPSIYIPSGTDEAQLPYIIAHENAHLKRCDHWWKPLGYLVLAIHWFNPLVWIAYILLCRDIELACDEKVIRGL
NQNESISYSEALLSCSVNRRTVMVCPLAFGEVGVKERVKNVLNYKKPAFWIVAIAVVSSIVLGVCFLTNPSSFPVKLDSV
QISKASTMDFRTNIGPTTFQLSAAEIDELSSRIKNLKIGHKDQSLQGHTPFYSLHVDTKENDRITFSGFDSNGNQAAILY
ENVYYRITDSDFISYLQRICAGETRTESINETNVDTAIHNAIMEHNSDRYYKGVFACESHTVLATEAGGAANSEENETLT
VYVLTLYEEYNLSEEGIESVGGGCGPVALTFNVTENGYELSEYWEPGDGSQYSDDIRKKFPEDILDEVWNPQDYVDAMTA
ENEQKALEFSAQK
>Mature_572_residues
SSFFLKIVNMSIAASWLILAVVLLRVVLKKAPKWINVLLWGIVAFRLICPFSFESALSLIPSAETISPEIMMDWTPEIST
GVSSIDKVVNPIITDTFAPEPIASANPLQLLIPVLAIGWAIGIIAMLVYAAVSYFRLQKKVGASLSVRDNIWICDDIQTP
FILGFFKPSIYIPSGTDEAQLPYIIAHENAHLKRCDHWWKPLGYLVLAIHWFNPLVWIAYILLCRDIELACDEKVIRGLN
QNESISYSEALLSCSVNRRTVMVCPLAFGEVGVKERVKNVLNYKKPAFWIVAIAVVSSIVLGVCFLTNPSSFPVKLDSVQ
ISKASTMDFRTNIGPTTFQLSAAEIDELSSRIKNLKIGHKDQSLQGHTPFYSLHVDTKENDRITFSGFDSNGNQAAILYE
NVYYRITDSDFISYLQRICAGETRTESINETNVDTAIHNAIMEHNSDRYYKGVFACESHTVLATEAGGAANSEENETLTV
YVLTLYEEYNLSEEGIESVGGGCGPVALTFNVTENGYELSEYWEPGDGSQYSDDIRKKFPEDILDEVWNPQDYVDAMTAE
NEQKALEFSAQK

Specific function: Penicillin-interactive protein and potential antirepressor [H]

COG id: COG4219

COG function: function code KT; Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M56 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460
- InterPro:   IPR008756 [H]

Pfam domain/function: PF05569 Peptidase_M56; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63979; Mature: 63847

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00334 MYB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFFLKIVNMSIAASWLILAVVLLRVVLKKAPKWINVLLWGIVAFRLICPFSFESALSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
IPSAETISPEIMMDWTPEISTGVSSIDKVVNPIITDTFAPEPIASANPLQLLIPVLAIGW
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AIGIIAMLVYAAVSYFRLQKKVGASLSVRDNIWICDDIQTPFILGFFKPSIYIPSGTDEA
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCEEEEEECCEEECCCCCCCC
QLPYIIAHENAHLKRCDHWWKPLGYLVLAIHWFNPLVWIAYILLCRDIELACDEKVIRGL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHCCC
NQNESISYSEALLSCSVNRRTVMVCPLAFGEVGVKERVKNVLNYKKPAFWIVAIAVVSSI
CCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
VLGVCFLTNPSSFPVKLDSVQISKASTMDFRTNIGPTTFQLSAAEIDELSSRIKNLKIGH
HHHHHHCCCCCCCCEEECCEEECCCCCCCEECCCCCCEEEEEHHHHHHHHHHHHHCCCCC
KDQSLQGHTPFYSLHVDTKENDRITFSGFDSNGNQAAILYENVYYRITDSDFISYLQRIC
CCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEEEEEEEEECCHHHHHHHHHHH
AGETRTESINETNVDTAIHNAIMEHNSDRYYKGVFACESHTVLATEAGGAANSEENETLT
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCEEE
VYVLTLYEEYNLSEEGIESVGGGCGPVALTFNVTENGYELSEYWEPGDGSQYSDDIRKKF
EEEEEEEHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHC
PEDILDEVWNPQDYVDAMTAENEQKALEFSAQK
CHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCC
>Mature Secondary Structure 
SSFFLKIVNMSIAASWLILAVVLLRVVLKKAPKWINVLLWGIVAFRLICPFSFESALSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
IPSAETISPEIMMDWTPEISTGVSSIDKVVNPIITDTFAPEPIASANPLQLLIPVLAIGW
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AIGIIAMLVYAAVSYFRLQKKVGASLSVRDNIWICDDIQTPFILGFFKPSIYIPSGTDEA
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCEEEEEECCEEECCCCCCCC
QLPYIIAHENAHLKRCDHWWKPLGYLVLAIHWFNPLVWIAYILLCRDIELACDEKVIRGL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHCCC
NQNESISYSEALLSCSVNRRTVMVCPLAFGEVGVKERVKNVLNYKKPAFWIVAIAVVSSI
CCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
VLGVCFLTNPSSFPVKLDSVQISKASTMDFRTNIGPTTFQLSAAEIDELSSRIKNLKIGH
HHHHHHCCCCCCCCEEECCEEECCCCCCCEECCCCCCEEEEEHHHHHHHHHHHHHCCCCC
KDQSLQGHTPFYSLHVDTKENDRITFSGFDSNGNQAAILYENVYYRITDSDFISYLQRIC
CCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEEEEEEEEECCHHHHHHHHHHH
AGETRTESINETNVDTAIHNAIMEHNSDRYYKGVFACESHTVLATEAGGAANSEENETLT
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCCCCCCCCCCEEE
VYVLTLYEEYNLSEEGIESVGGGCGPVALTFNVTENGYELSEYWEPGDGSQYSDDIRKKF
EEEEEEEHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHC
PEDILDEVWNPQDYVDAMTAENEQKALEFSAQK
CHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA