Click here to switch to the map view.

The map label for this gene is gdh [H]

Identifier: 238925482

GI number: 238925482

Start: 2989305

End: 2990663

Strand: Reverse

Name: gdh [H]

Synonym: EUBREC_3138

Alternate gene names: 238925482

Gene position: 2990663-2989305 (Counterclockwise)

Preceding gene: 238925483

Following gene: 238925479

Centisome position: 86.69

GC content: 44.15

Gene sequence:

>1359_bases
ATGAGCTATGTTGATGAAGTACTCGAAGTAGTAAAGAAGAAAAACGCAGATCAGCCTGAGTTCTTACAGGCAGTAACAGA
GGTTCTTGATTCTTTAAGACCTGTGATCGATGCAAATGAGGAATTATACAGAAAGAATGCGATTCTTGAGAGAATCACAG
AGCCGGATCGTCAGATCATGTTCAGAGTACCATGGGTAGATGACAATGGTCAGGTACAGGTAAACAGAGGTTTCCGTGTA
CAGTTCAATAATTCCATTGGACCATACAAGGGAGGTTTAAGACTTCATCCTTCTGTAAACCTGGGTATTATCAAGTTCTT
AGGTTTCGAGCAGGTATTTAAGAATTCTCTTACAACACTTCCAATCGGTGGTGGTAAAGGTGGTTCTGATTTCGATCCTA
AGGGTAAATCTGACAGAGAGATCATGGCATTCTGCCAGAGCTTCATGACAGAACTTTGCAAATATATCGGAGCAGACGTT
GATGTACCGGCCGGAGATATCGGAACAGGTGCAAGAGAGATTGGCTTCTTATTTGGACAGTATAAGAGAATTCGTGGATC
ATACGAAGGTGTGCTGACTGGTAAGGGTCTTACCTATGGTGGATCTCTTGCACGTACACAGGCTACCGGATATGGTCTGT
TATATCTTACTAACGCATTATGGAAAGATCATGGTATGAGCCTTGAGGGAAAGACAGCAGCAGTTTCCGGATCTGGTAAC
GTTGCTATCTACGCAATCGAGAAGGCACAGCAGCTCGGTGTCAAGGTTGTAACATGTTCTGATTCTACCGGATGGATTTA
TGATCCAAACGGAATTGATGTTGCTCTTCTTAAGGAAGTTAAGGAAGTTAAGCGTGCCCGTCTTACTGAGTATGCAGCTG
CTAAGTCAACTGCTGAGTATCATGCAAAGCAGAACGGTGAGCACGGTGTATGGCAGTACAAGGTAGATCTTGCTCTTCCA
TGTGCGACTCAGAATGAGTTAGACATTGAGGATGCCAAGATGCTCGTTGCTAACGGTGTTACATCTGTAACAGAGGGTGC
TAACATGCCTACAACTCTTGAGGCTACAAAATATCTTCAGGAGAACGGAGTACTCTTCGTAGGTGGTAAAGCTGCCAATG
CAGGTGGTGTTGCTACATCAGCACTTGAGATGAGCCAGAACTCTGAGAGACTTTCATGGACATTCGAAGAGGTTGACGGA
AAGCTCAAGGGTATCATGGAGACAATCTACGCTAACATTAGTGATGCTGCTAAGAGATACAATGCAACAGTTGGTGGAAA
GACTGACTATGTTGCAGGTGCAAATATCGCAGGCTTTGAGAAAGTAGTTGACGCTATGCTTGCTCAGGGTGTTTGCTAA

Upstream 100 bases:

>100_bases
TTTTTATATAAAACTTTCAAAAATTACTTGATTATAGCAATAGATTTATATAAAATAAACTTGTTGATGTGAAAAATAAT
TTTGTAAAGGAGATATAAAA

Downstream 100 bases:

>100_bases
TCTTGTAGGCACTTATTGAATAATGACTATAAAAACCCCTCCCACAGATAGAAGTCTGTGGGAGGGGTTTTGTAATAATA
TTTCAAAGAGAAAACTAATT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSYVDEVLEVVKKKNADQPEFLQAVTEVLDSLRPVIDANEELYRKNAILERITEPDRQIMFRVPWVDDNGQVQVNRGFRV
QFNNSIGPYKGGLRLHPSVNLGIIKFLGFEQVFKNSLTTLPIGGGKGGSDFDPKGKSDREIMAFCQSFMTELCKYIGADV
DVPAGDIGTGAREIGFLFGQYKRIRGSYEGVLTGKGLTYGGSLARTQATGYGLLYLTNALWKDHGMSLEGKTAAVSGSGN
VAIYAIEKAQQLGVKVVTCSDSTGWIYDPNGIDVALLKEVKEVKRARLTEYAAAKSTAEYHAKQNGEHGVWQYKVDLALP
CATQNELDIEDAKMLVANGVTSVTEGANMPTTLEATKYLQENGVLFVGGKAANAGGVATSALEMSQNSERLSWTFEEVDG
KLKGIMETIYANISDAAKRYNATVGGKTDYVAGANIAGFEKVVDAMLAQGVC

Sequences:

>Translated_452_residues
MSYVDEVLEVVKKKNADQPEFLQAVTEVLDSLRPVIDANEELYRKNAILERITEPDRQIMFRVPWVDDNGQVQVNRGFRV
QFNNSIGPYKGGLRLHPSVNLGIIKFLGFEQVFKNSLTTLPIGGGKGGSDFDPKGKSDREIMAFCQSFMTELCKYIGADV
DVPAGDIGTGAREIGFLFGQYKRIRGSYEGVLTGKGLTYGGSLARTQATGYGLLYLTNALWKDHGMSLEGKTAAVSGSGN
VAIYAIEKAQQLGVKVVTCSDSTGWIYDPNGIDVALLKEVKEVKRARLTEYAAAKSTAEYHAKQNGEHGVWQYKVDLALP
CATQNELDIEDAKMLVANGVTSVTEGANMPTTLEATKYLQENGVLFVGGKAANAGGVATSALEMSQNSERLSWTFEEVDG
KLKGIMETIYANISDAAKRYNATVGGKTDYVAGANIAGFEKVVDAMLAQGVC
>Mature_451_residues
SYVDEVLEVVKKKNADQPEFLQAVTEVLDSLRPVIDANEELYRKNAILERITEPDRQIMFRVPWVDDNGQVQVNRGFRVQ
FNNSIGPYKGGLRLHPSVNLGIIKFLGFEQVFKNSLTTLPIGGGKGGSDFDPKGKSDREIMAFCQSFMTELCKYIGADVD
VPAGDIGTGAREIGFLFGQYKRIRGSYEGVLTGKGLTYGGSLARTQATGYGLLYLTNALWKDHGMSLEGKTAAVSGSGNV
AIYAIEKAQQLGVKVVTCSDSTGWIYDPNGIDVALLKEVKEVKRARLTEYAAAKSTAEYHAKQNGEHGVWQYKVDLALPC
ATQNELDIEDAKMLVANGVTSVTEGANMPTTLEATKYLQENGVLFVGGKAANAGGVATSALEMSQNSERLSWTFEEVDGK
LKGIMETIYANISDAAKRYNATVGGKTDYVAGANIAGFEKVVDAMLAQGVC

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=404, Percent_Identity=29.4554455445545, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4885281, Length=404, Percent_Identity=28.7128712871287, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788059, Length=451, Percent_Identity=56.0975609756098, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17544676, Length=429, Percent_Identity=28.2051282051282, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324951, Length=454, Percent_Identity=48.6784140969163, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319256, Length=454, Percent_Identity=48.6784140969163, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24649283, Length=417, Percent_Identity=30.2158273381295, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI45553475, Length=380, Percent_Identity=29.7368421052632, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45549226, Length=380, Percent_Identity=29.7368421052632, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24649460, Length=295, Percent_Identity=31.5254237288136, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 48943; Mature: 48812

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVDEVLEVVKKKNADQPEFLQAVTEVLDSLRPVIDANEELYRKNAILERITEPDRQIM
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEE
FRVPWVDDNGQVQVNRGFRVQFNNSIGPYKGGLRLHPSVNLGIIKFLGFEQVFKNSLTTL
EEECEECCCCEEEECCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHCHHHHHHCCCCEE
PIGGGKGGSDFDPKGKSDREIMAFCQSFMTELCKYIGADVDVPAGDIGTGAREIGFLFGQ
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YKRIRGSYEGVLTGKGLTYGGSLARTQATGYGLLYLTNALWKDHGMSLEGKTAAVSGSGN
HHHHCCCCCEEEECCCCCCCCCCCCHHCCCCCCEEHHHHHHHHCCCCCCCCEEEEECCCC
VAIYAIEKAQQLGVKVVTCSDSTGWIYDPNGIDVALLKEVKEVKRARLTEYAAAKSTAEY
EEEEEECCHHHCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAKQNGEHGVWQYKVDLALPCATQNELDIEDAKMLVANGVTSVTEGANMPTTLEATKYLQ
HHHCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHH
ENGVLFVGGKAANAGGVATSALEMSQNSERLSWTFEEVDGKLKGIMETIYANISDAAKRY
HCCEEEEECCCCCCCCHHHHHHHHCCCCCHHEEEHHHHCHHHHHHHHHHHHCHHHHHHHH
NATVGGKTDYVAGANIAGFEKVVDAMLAQGVC
CCCCCCCCCEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYVDEVLEVVKKKNADQPEFLQAVTEVLDSLRPVIDANEELYRKNAILERITEPDRQIM
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEE
FRVPWVDDNGQVQVNRGFRVQFNNSIGPYKGGLRLHPSVNLGIIKFLGFEQVFKNSLTTL
EEECEECCCCEEEECCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHCHHHHHHCCCCEE
PIGGGKGGSDFDPKGKSDREIMAFCQSFMTELCKYIGADVDVPAGDIGTGAREIGFLFGQ
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YKRIRGSYEGVLTGKGLTYGGSLARTQATGYGLLYLTNALWKDHGMSLEGKTAAVSGSGN
HHHHCCCCCEEEECCCCCCCCCCCCHHCCCCCCEEHHHHHHHHCCCCCCCCEEEEECCCC
VAIYAIEKAQQLGVKVVTCSDSTGWIYDPNGIDVALLKEVKEVKRARLTEYAAAKSTAEY
EEEEEECCHHHCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAKQNGEHGVWQYKVDLALPCATQNELDIEDAKMLVANGVTSVTEGANMPTTLEATKYLQ
HHHCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHH
ENGVLFVGGKAANAGGVATSALEMSQNSERLSWTFEEVDGKLKGIMETIYANISDAAKRY
HCCEEEEECCCCCCCCHHHHHHHHCCCCCHHEEEHHHHCHHHHHHHHHHHHCHHHHHHHH
NATVGGKTDYVAGANIAGFEKVVDAMLAQGVC
CCCCCCCCCEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]