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The map label for this gene is ykoW [H]

Identifier: 238925241

GI number: 238925241

Start: 2771993

End: 2774269

Strand: Reverse

Name: ykoW [H]

Synonym: EUBREC_2895

Alternate gene names: 238925241

Gene position: 2774269-2771993 (Counterclockwise)

Preceding gene: 238925242

Following gene: 238925240

Centisome position: 80.42

GC content: 41.46

Gene sequence:

>2277_bases
ATGAGGATAGTATATGGACTGGGAGTATTGCTGGAAGCAATACTGATTGCACATTGCGCAATCGGTTCCTTTAAAAAACA
TGACAGACTCGGTAAAAGTGTGTGTATATATGAGACGTTGACATTTGCCTGCGCTATAGTCTTTTTTGTTTTTACATTTG
TGCCGGGGCACACTGTTACAGTACTTGCGAAAGGGCTTACTATGGCTCTGTTTGACTGGATGCTCATCGCTCTTATGTTT
TATACACAGTATTATACAGGTGCTGTAAAGACCTTCAAGGGAGTGCAGGCTGCTTCCATGATATTTGCGGTGCTGGACAC
ATATATGCTTATAGAGAACACCTGGACTAATAAGATTTTTGATATAGAATCCATAAAAGCTGAGAATATTAAGGTGGTAT
TCAATAATGACAGCCTATGGTACAGGCTGCATTTTATATTCACATATGCGTTTGTGATTCTGATTATTTTTACATATCTG
TATATGATTATCAAATCATCGCGCATGTACAGGGAGGCATATGGGGCTATAGCGGTAGTTATCTTTATCGGCTTTTCGTT
TGACATTGCTACTATAGGTTCGGACTCCATATATGACCTCACCATGATTATATATGGTGCTATAGCTATTATCATATATT
ACCTGACATACAGATATGTGCCGAATGAGCTTATAGAAAATATGCTCTCTCTTGTGGTCCGCGATATGAACAATGGTATC
ATCTGCTATGACAGAAAGGGCAGGTGCATATATTACAATGACCTGATGGAGGCTATTTACAGGCATGGCGGCAATATGTC
TGTTTATGAAAGTAAATATAGTCAGTGGATTGAAAAGCTGGGAGATGACAGAAGGGACAGTATGACCTTCCAGACAACAG
ATATTGAAATAAACGGTGAAAAGCACTACTTTGAGATTGCCTACAAGCGCATATATGATGAGAGCAATCGCGTTATATGT
GATTATTTTGTATACAATGACCGTACACAGATGTATGAGTCGTGGGAGCAGGAAAAGTACAAGGCATCGCATGACAGTCT
GACCGGACTTTTGAACCGTGACCAGTTCTATGAGGATGTGCACGATATGGTGAACAAGTATCATGACACAACCTTCTACC
TGATTTGCAGCAATATAAAGGATTTCAAATTCATCAATGAGATATTTGGAATGGAGAAGGGCAATCAGGTGCTCTTAAAG
CAGGCGAAGCTCATGTCATCAAATCCATCAGAGAGAACTATTTGTGCAAGGCTTATGAATGACCGCTTTGCGCTGTGTCT
GCCAAGAGAAGAGTTTGATGAAAAAAGAGTGGCAGATTCAATAAAAGAGCTGCAGCGTGAGTTTTCGGGCAATTCTTTCC
ATCTGCATACATACATGGGTGTGTATGAGATAAGAGACAGGGATGAGGCTGTCAGCATTATGGTAGACAAGGCTAATATA
GCGGCAGACACCATAAAGAATAATTACGACTGCTGTGTGGCATACTATGATGAGCATCTGCTTGAGATATCAATAGAGCA
GAGACGTCTGCTCGGTGAATTTGAGCCGGCATTGCAAAATGATGAGTTTGTCATGTACTTACAGCCACAGGTGAAACGTG
ATGGTGCTGCAAAGGGCGCAGAAGCGCTGGTGCGCTGGGTTCATCCATCAAGAGGCATCCTGACACCGTATGCTTTTATT
GATATTTTAGAGAACGCAGGTCTCATTTACAAGCTTGACCTCTATATATGGGAGAAGGCGGCACAAAAGCTTGCAGAGTG
GAAGGAAAAAGGCTATGGAAGCTATCATATATCTGTAAATATATCTACAAAGGACTTTTACATCATAGATATATATGAGA
CCTTTACAGGGCTGATTAATAAATATGGCATAGCAGCGTCCAATCTGCATCTGGAGATTACAGAGACAACGCTGATGACC
GATTTTGAGAAGAATATGAATATTATCCACAAGCTTCAGGACGTAGGCTTCAGGGTGGAGATTGATGATTTCGGAAGCGG
TTACTCATCACTCAACATGCTAAAGGACATCAGTGCCGATGTGCTGAAAATCGATATGGGCTTCCTTCGCAAATCTGAGA
ACGAGGTCAAGGGACAGGATATATTAGAGAGTATCATCACGCTTGCAGGCAAGATAGGCATGGACGTCATCACAGAGGGT
GTGGAGACGAAAAAGCAGCTGGATATGCTTACAATGATGGGATGTCATGAGTTCCAGGGATATTATTTCTCAAAACCGGT
ACCGGTATCTGAGTTTGAAGAAAAGTATCTGGTATAG

Upstream 100 bases:

>100_bases
AGAGGTTGTGACAACCTCTTTTTTGTTTACATTACACATGAAATGAGTTACAATGGCTATATATAGGTTAGTAATATGGT
AATAGAAGACAGGTGGGAAT

Downstream 100 bases:

>100_bases
CTATCATGTATATCTATTATGTATATCCAATATATATTTTAGGTATTGTGCAAAATTTAATACACTGTATATTTGGGGCG
GGTATTGAAATATCCGCCCT

Product: diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MRIVYGLGVLLEAILIAHCAIGSFKKHDRLGKSVCIYETLTFACAIVFFVFTFVPGHTVTVLAKGLTMALFDWMLIALMF
YTQYYTGAVKTFKGVQAASMIFAVLDTYMLIENTWTNKIFDIESIKAENIKVVFNNDSLWYRLHFIFTYAFVILIIFTYL
YMIIKSSRMYREAYGAIAVVIFIGFSFDIATIGSDSIYDLTMIIYGAIAIIIYYLTYRYVPNELIENMLSLVVRDMNNGI
ICYDRKGRCIYYNDLMEAIYRHGGNMSVYESKYSQWIEKLGDDRRDSMTFQTTDIEINGEKHYFEIAYKRIYDESNRVIC
DYFVYNDRTQMYESWEQEKYKASHDSLTGLLNRDQFYEDVHDMVNKYHDTTFYLICSNIKDFKFINEIFGMEKGNQVLLK
QAKLMSSNPSERTICARLMNDRFALCLPREEFDEKRVADSIKELQREFSGNSFHLHTYMGVYEIRDRDEAVSIMVDKANI
AADTIKNNYDCCVAYYDEHLLEISIEQRRLLGEFEPALQNDEFVMYLQPQVKRDGAAKGAEALVRWVHPSRGILTPYAFI
DILENAGLIYKLDLYIWEKAAQKLAEWKEKGYGSYHISVNISTKDFYIIDIYETFTGLINKYGIAASNLHLEITETTLMT
DFEKNMNIIHKLQDVGFRVEIDDFGSGYSSLNMLKDISADVLKIDMGFLRKSENEVKGQDILESIITLAGKIGMDVITEG
VETKKQLDMLTMMGCHEFQGYYFSKPVPVSEFEEKYLV

Sequences:

>Translated_758_residues
MRIVYGLGVLLEAILIAHCAIGSFKKHDRLGKSVCIYETLTFACAIVFFVFTFVPGHTVTVLAKGLTMALFDWMLIALMF
YTQYYTGAVKTFKGVQAASMIFAVLDTYMLIENTWTNKIFDIESIKAENIKVVFNNDSLWYRLHFIFTYAFVILIIFTYL
YMIIKSSRMYREAYGAIAVVIFIGFSFDIATIGSDSIYDLTMIIYGAIAIIIYYLTYRYVPNELIENMLSLVVRDMNNGI
ICYDRKGRCIYYNDLMEAIYRHGGNMSVYESKYSQWIEKLGDDRRDSMTFQTTDIEINGEKHYFEIAYKRIYDESNRVIC
DYFVYNDRTQMYESWEQEKYKASHDSLTGLLNRDQFYEDVHDMVNKYHDTTFYLICSNIKDFKFINEIFGMEKGNQVLLK
QAKLMSSNPSERTICARLMNDRFALCLPREEFDEKRVADSIKELQREFSGNSFHLHTYMGVYEIRDRDEAVSIMVDKANI
AADTIKNNYDCCVAYYDEHLLEISIEQRRLLGEFEPALQNDEFVMYLQPQVKRDGAAKGAEALVRWVHPSRGILTPYAFI
DILENAGLIYKLDLYIWEKAAQKLAEWKEKGYGSYHISVNISTKDFYIIDIYETFTGLINKYGIAASNLHLEITETTLMT
DFEKNMNIIHKLQDVGFRVEIDDFGSGYSSLNMLKDISADVLKIDMGFLRKSENEVKGQDILESIITLAGKIGMDVITEG
VETKKQLDMLTMMGCHEFQGYYFSKPVPVSEFEEKYLV
>Mature_758_residues
MRIVYGLGVLLEAILIAHCAIGSFKKHDRLGKSVCIYETLTFACAIVFFVFTFVPGHTVTVLAKGLTMALFDWMLIALMF
YTQYYTGAVKTFKGVQAASMIFAVLDTYMLIENTWTNKIFDIESIKAENIKVVFNNDSLWYRLHFIFTYAFVILIIFTYL
YMIIKSSRMYREAYGAIAVVIFIGFSFDIATIGSDSIYDLTMIIYGAIAIIIYYLTYRYVPNELIENMLSLVVRDMNNGI
ICYDRKGRCIYYNDLMEAIYRHGGNMSVYESKYSQWIEKLGDDRRDSMTFQTTDIEINGEKHYFEIAYKRIYDESNRVIC
DYFVYNDRTQMYESWEQEKYKASHDSLTGLLNRDQFYEDVHDMVNKYHDTTFYLICSNIKDFKFINEIFGMEKGNQVLLK
QAKLMSSNPSERTICARLMNDRFALCLPREEFDEKRVADSIKELQREFSGNSFHLHTYMGVYEIRDRDEAVSIMVDKANI
AADTIKNNYDCCVAYYDEHLLEISIEQRRLLGEFEPALQNDEFVMYLQPQVKRDGAAKGAEALVRWVHPSRGILTPYAFI
DILENAGLIYKLDLYIWEKAAQKLAEWKEKGYGSYHISVNISTKDFYIIDIYETFTGLINKYGIAASNLHLEITETTLMT
DFEKNMNIIHKLQDVGFRVEIDDFGSGYSSLNMLKDISADVLKIDMGFLRKSENEVKGQDILESIITLAGKIGMDVITEG
VETKKQLDMLTMMGCHEFQGYYFSKPVPVSEFEEKYLV

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=434, Percent_Identity=26.4976958525346, Blast_Score=179, Evalue=7e-46,
Organism=Escherichia coli, GI87081921, Length=430, Percent_Identity=27.2093023255814, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI226510982, Length=470, Percent_Identity=27.6595744680851, Blast_Score=150, Evalue=4e-37,
Organism=Escherichia coli, GI1786507, Length=244, Percent_Identity=33.6065573770492, Blast_Score=142, Evalue=9e-35,
Organism=Escherichia coli, GI87081845, Length=232, Percent_Identity=34.051724137931, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1790496, Length=241, Percent_Identity=31.1203319502075, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI87081743, Length=237, Percent_Identity=31.2236286919831, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1788502, Length=245, Percent_Identity=31.8367346938775, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1787055, Length=420, Percent_Identity=26.1904761904762, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI87082096, Length=248, Percent_Identity=29.8387096774194, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI87081980, Length=242, Percent_Identity=29.3388429752066, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788849, Length=240, Percent_Identity=28.75, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788381, Length=460, Percent_Identity=21.5217391304348, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 87973; Mature: 87973

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVYGLGVLLEAILIAHCAIGSFKKHDRLGKSVCIYETLTFACAIVFFVFTFVPGHTVT
CEEEEHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHH
VLAKGLTMALFDWMLIALMFYTQYYTGAVKTFKGVQAASMIFAVLDTYMLIENTWTNKIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEE
DIESIKAENIKVVFNNDSLWYRLHFIFTYAFVILIIFTYLYMIIKSSRMYREAYGAIAVV
EECCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IFIGFSFDIATIGSDSIYDLTMIIYGAIAIIIYYLTYRYVPNELIENMLSLVVRDMNNGI
HHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCE
ICYDRKGRCIYYNDLMEAIYRHGGNMSVYESKYSQWIEKLGDDRRDSMTFQTTDIEINGE
EEEECCCCEEEHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCC
KHYFEIAYKRIYDESNRVICDYFVYNDRTQMYESWEQEKYKASHDSLTGLLNRDQFYEDV
CHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHH
HDMVNKYHDTTFYLICSNIKDFKFINEIFGMEKGNQVLLKQAKLMSSNPSERTICARLMN
HHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHC
DRFALCLPREEFDEKRVADSIKELQREFSGNSFHLHTYMGVYEIRDRDEAVSIMVDKANI
CCEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECEEEECCCCCEEEEEEECCHH
AADTIKNNYDCCVAYYDEHLLEISIEQRRLLGEFEPALQNDEFVMYLQPQVKRDGAAKGA
HHHHHCCCCCEEEEEECCHHEEEEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHH
EALVRWVHPSRGILTPYAFIDILENAGLIYKLDLYIWEKAAQKLAEWKEKGYGSYHISVN
HHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ISTKDFYIIDIYETFTGLINKYGIAASNLHLEITETTLMTDFEKNMNIIHKLQDVGFRVE
EECCCEEEEEHHHHHHHHHHHCCCEECCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
IDDFGSGYSSLNMLKDISADVLKIDMGFLRKSENEVKGQDILESIITLAGKIGMDVITEG
ECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHC
VETKKQLDMLTMMGCHEFQGYYFSKPVPVSEFEEKYLV
HHHHHHHHHHHHHCHHHHCCEEECCCCCHHHHHHHCCC
>Mature Secondary Structure
MRIVYGLGVLLEAILIAHCAIGSFKKHDRLGKSVCIYETLTFACAIVFFVFTFVPGHTVT
CEEEEHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHH
VLAKGLTMALFDWMLIALMFYTQYYTGAVKTFKGVQAASMIFAVLDTYMLIENTWTNKIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEE
DIESIKAENIKVVFNNDSLWYRLHFIFTYAFVILIIFTYLYMIIKSSRMYREAYGAIAVV
EECCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IFIGFSFDIATIGSDSIYDLTMIIYGAIAIIIYYLTYRYVPNELIENMLSLVVRDMNNGI
HHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCE
ICYDRKGRCIYYNDLMEAIYRHGGNMSVYESKYSQWIEKLGDDRRDSMTFQTTDIEINGE
EEEECCCCEEEHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCC
KHYFEIAYKRIYDESNRVICDYFVYNDRTQMYESWEQEKYKASHDSLTGLLNRDQFYEDV
CHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHH
HDMVNKYHDTTFYLICSNIKDFKFINEIFGMEKGNQVLLKQAKLMSSNPSERTICARLMN
HHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHC
DRFALCLPREEFDEKRVADSIKELQREFSGNSFHLHTYMGVYEIRDRDEAVSIMVDKANI
CCEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECEEEECCCCCEEEEEEECCHH
AADTIKNNYDCCVAYYDEHLLEISIEQRRLLGEFEPALQNDEFVMYLQPQVKRDGAAKGA
HHHHHCCCCCEEEEEECCHHEEEEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHH
EALVRWVHPSRGILTPYAFIDILENAGLIYKLDLYIWEKAAQKLAEWKEKGYGSYHISVN
HHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ISTKDFYIIDIYETFTGLINKYGIAASNLHLEITETTLMTDFEKNMNIIHKLQDVGFRVE
EECCCEEEEEHHHHHHHHHHHCCCEECCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
IDDFGSGYSSLNMLKDISADVLKIDMGFLRKSENEVKGQDILESIITLAGKIGMDVITEG
ECCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHC
VETKKQLDMLTMMGCHEFQGYYFSKPVPVSEFEEKYLV
HHHHHHHHHHHHHCHHHHCCEEECCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]