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The map label for this gene is ltrA [H]

Identifier: 238925037

GI number: 238925037

Start: 2566112

End: 2567776

Strand: Direct

Name: ltrA [H]

Synonym: EUBREC_2688

Alternate gene names: 238925037

Gene position: 2566112-2567776 (Clockwise)

Preceding gene: 238925036

Following gene: 238925038

Centisome position: 74.39

GC content: 46.13

Gene sequence:

>1665_bases
ATGAACAGGAAACTGTGTGCGCCTGCTGACAGGGCACAAAGCTGGGAATCCATTGATTGGAAGAAGGCGGAGGCCTATGT
TAAAAAGCTGCAAATGCGTATCGTAAAGGCTCAAAAAGACGGTCATTACAACAAGGTGAAAACCCTGCAATGGCTGTTGA
CGCACTCTTTCTATGCCAAGGCATTGGCGGTAAAGCGTGTGACAAGTAATAAAGGCAAAAACACTGCTGGTGTAGACCAT
GAATTATGGAAAACGCCAAAGGGCAAATTCGAGGCGATTGAAAAACTCAAACGCCGGGGCTATAAGCCCCAACCTCTCAG
ACGGGTGTACATCCCGAAGAAAAACGGAAAATTACGCCCGCTGAGTATTCCGACGATGACAGACCGCGCCATGCAGACAT
TATATAAGTTTGCATTGGAACCATTGGCAGAAACTCTAGCAGACCCGAACTCCTACGGTTTTAGAATTGGAAGAAGCACA
CACGACGCTATCGGGCAATGCTTCAACGATTTATGCAGAGCCGGTTCTCCACAATGGATTTTGGAAGGAGATATTAAAGG
GTGCTTCGACCACATCAGCCATAACTGGCTGTTGGCAAACATTCCAATGGATAAGAAAATGCTCGGGAAATGGCTGAAAT
GCGGTTTTGTGGAAACCAAAAAGCTCTTTCCAACAGAGGAAGGAACCCCACAGGGCGGCACAATATCGCCAGTCTTGATG
AACATGACCTTAGACGGTCTGGAGCGGATTCTAAAAGAAAGATTCCCTATGAGACGGACGGTGGCAGGTAAAACTGTTTA
CGACCAGATTAACTTCGTGCGATATGCCGACGACTTTATCGTTACCGGAAAAAGCCCGGAAACTCTACGTAACGAGGTTA
TGCCGCTCATCAAGGACTTTCTGGCGGAACGCGGCCTGCAACTCTCCGAGGAAAAAACGGTAATCACACATATCAGCGAC
GGTTTTGATTTTCTTGGGCAGAACGTTCGGAAATACAACGGAAAATTGCTCATTAAGCCGTCAAAGAATGCGATAAAATC
CTTCCTCAAAAAAGTGCGGACTATCGTTAGGGAGAACAAAACAGCCACACAGGACTTGCTCATTCGCAAGTTAAATCCTG
TCATTCGTGGTTGGGTCAACTACCATCGCTATGTAGTTTCTGCGGATATTTTTGGATTGGTTGACCACAGGATTTTCGAG
TGCCTATGGAGGTGGGCTTGCCGCAGACACAAGCGAAAAGGTAGGAAATGGATTGCCAACAAATACTGGCACCATATTGA
TAACCGAACGTGGACGTTTGCAACAGAGCCTGCTTTCCGCAGTAAAGATTTCGATGAAAAATACCTCAAGCTGGAATACG
CGGCAAATACTAAAATCATCCGATTCAGGAAAATCGCCGCCGAAGCTAACCCATTCGATGAAAAATGGACGGGATATTAT
GAGGAACGTGACGGAGAAAGAATGCTGAACAGTACCAAAGGACGGGAAAAACTCGTTAAAATCTGGAACAACCAGAAACG
GTGCTGCCCTGTATGCGGAGAAAGAATTACATCCGAAACAGGATTCAAGACGCATTTTAACACCGAAAACAACAGGAAAT
GGCCCGCTATTATGGTACATCCCTGGTGTCATCGAAATCTGCATGAGCCAAACTACTTGATTTGA

Upstream 100 bases:

>100_bases
GATAGGGATTGAAACAGTATTCCACGCGAAAGCGGGCTGACTTCCAGCAGGTCTATCTTTACGAGAGAATTTACAGAACT
TTTGAGAGGAGGAATTGCAA

Downstream 100 bases:

>100_bases
GCCGGGTTTCGTTTTACACGAGGCCTTACGATAGGCTTGAGCCGTATGACGGGAAACTGTCACGTACGGTTCTTAGGGGA
GGGGCTGGCAGCAATACCAG

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MNRKLCAPADRAQSWESIDWKKAEAYVKKLQMRIVKAQKDGHYNKVKTLQWLLTHSFYAKALAVKRVTSNKGKNTAGVDH
ELWKTPKGKFEAIEKLKRRGYKPQPLRRVYIPKKNGKLRPLSIPTMTDRAMQTLYKFALEPLAETLADPNSYGFRIGRST
HDAIGQCFNDLCRAGSPQWILEGDIKGCFDHISHNWLLANIPMDKKMLGKWLKCGFVETKKLFPTEEGTPQGGTISPVLM
NMTLDGLERILKERFPMRRTVAGKTVYDQINFVRYADDFIVTGKSPETLRNEVMPLIKDFLAERGLQLSEEKTVITHISD
GFDFLGQNVRKYNGKLLIKPSKNAIKSFLKKVRTIVRENKTATQDLLIRKLNPVIRGWVNYHRYVVSADIFGLVDHRIFE
CLWRWACRRHKRKGRKWIANKYWHHIDNRTWTFATEPAFRSKDFDEKYLKLEYAANTKIIRFRKIAAEANPFDEKWTGYY
EERDGERMLNSTKGREKLVKIWNNQKRCCPVCGERITSETGFKTHFNTENNRKWPAIMVHPWCHRNLHEPNYLI

Sequences:

>Translated_554_residues
MNRKLCAPADRAQSWESIDWKKAEAYVKKLQMRIVKAQKDGHYNKVKTLQWLLTHSFYAKALAVKRVTSNKGKNTAGVDH
ELWKTPKGKFEAIEKLKRRGYKPQPLRRVYIPKKNGKLRPLSIPTMTDRAMQTLYKFALEPLAETLADPNSYGFRIGRST
HDAIGQCFNDLCRAGSPQWILEGDIKGCFDHISHNWLLANIPMDKKMLGKWLKCGFVETKKLFPTEEGTPQGGTISPVLM
NMTLDGLERILKERFPMRRTVAGKTVYDQINFVRYADDFIVTGKSPETLRNEVMPLIKDFLAERGLQLSEEKTVITHISD
GFDFLGQNVRKYNGKLLIKPSKNAIKSFLKKVRTIVRENKTATQDLLIRKLNPVIRGWVNYHRYVVSADIFGLVDHRIFE
CLWRWACRRHKRKGRKWIANKYWHHIDNRTWTFATEPAFRSKDFDEKYLKLEYAANTKIIRFRKIAAEANPFDEKWTGYY
EERDGERMLNSTKGREKLVKIWNNQKRCCPVCGERITSETGFKTHFNTENNRKWPAIMVHPWCHRNLHEPNYLI
>Mature_554_residues
MNRKLCAPADRAQSWESIDWKKAEAYVKKLQMRIVKAQKDGHYNKVKTLQWLLTHSFYAKALAVKRVTSNKGKNTAGVDH
ELWKTPKGKFEAIEKLKRRGYKPQPLRRVYIPKKNGKLRPLSIPTMTDRAMQTLYKFALEPLAETLADPNSYGFRIGRST
HDAIGQCFNDLCRAGSPQWILEGDIKGCFDHISHNWLLANIPMDKKMLGKWLKCGFVETKKLFPTEEGTPQGGTISPVLM
NMTLDGLERILKERFPMRRTVAGKTVYDQINFVRYADDFIVTGKSPETLRNEVMPLIKDFLAERGLQLSEEKTVITHISD
GFDFLGQNVRKYNGKLLIKPSKNAIKSFLKKVRTIVRENKTATQDLLIRKLNPVIRGWVNYHRYVVSADIFGLVDHRIFE
CLWRWACRRHKRKGRKWIANKYWHHIDNRTWTFATEPAFRSKDFDEKYLKLEYAANTKIIRFRKIAAEANPFDEKWTGYY
EERDGERMLNSTKGREKLVKIWNNQKRCCPVCGERITSETGFKTHFNTENNRKWPAIMVHPWCHRNLHEPNYLI

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=281, Percent_Identity=28.1138790035587, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6226520, Length=317, Percent_Identity=27.7602523659306, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 64826; Mature: 64826

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKLCAPADRAQSWESIDWKKAEAYVKKLQMRIVKAQKDGHYNKVKTLQWLLTHSFYAK
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ALAVKRVTSNKGKNTAGVDHELWKTPKGKFEAIEKLKRRGYKPQPLRRVYIPKKNGKLRP
HHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
LSIPTMTDRAMQTLYKFALEPLAETLADPNSYGFRIGRSTHDAIGQCFNDLCRAGSPQWI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEE
LEGDIKGCFDHISHNWLLANIPMDKKMLGKWLKCGFVETKKLFPTEEGTPQGGTISPVLM
EECCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHH
NMTLDGLERILKERFPMRRTVAGKTVYDQINFVRYADDFIVTGKSPETLRNEVMPLIKDF
HHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHEEEECCEEEECCCHHHHHHHHHHHHHHH
LAERGLQLSEEKTVITHISDGFDFLGQNVRKYNGKLLIKPSKNAIKSFLKKVRTIVRENK
HHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCC
TATQDLLIRKLNPVIRGWVNYHRYVVSADIFGLVDHRIFECLWRWACRRHKRKGRKWIAN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYWHHIDNRTWTFATEPAFRSKDFDEKYLKLEYAANTKIIRFRKIAAEANPFDEKWTGYY
HHHHHCCCCEEEEECCCCCCCCCCCCHHEEEEECCCCEEEEEEHHHHCCCCCCHHHCCCH
EERDGERMLNSTKGREKLVKIWNNQKRCCPVCGERITSETGFKTHFNTENNRKWPAIMVH
HHCCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCEEEEC
PWCHRNLHEPNYLI
HHHHCCCCCCCCCC
>Mature Secondary Structure
MNRKLCAPADRAQSWESIDWKKAEAYVKKLQMRIVKAQKDGHYNKVKTLQWLLTHSFYAK
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ALAVKRVTSNKGKNTAGVDHELWKTPKGKFEAIEKLKRRGYKPQPLRRVYIPKKNGKLRP
HHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
LSIPTMTDRAMQTLYKFALEPLAETLADPNSYGFRIGRSTHDAIGQCFNDLCRAGSPQWI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEE
LEGDIKGCFDHISHNWLLANIPMDKKMLGKWLKCGFVETKKLFPTEEGTPQGGTISPVLM
EECCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHH
NMTLDGLERILKERFPMRRTVAGKTVYDQINFVRYADDFIVTGKSPETLRNEVMPLIKDF
HHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHEEEECCEEEECCCHHHHHHHHHHHHHHH
LAERGLQLSEEKTVITHISDGFDFLGQNVRKYNGKLLIKPSKNAIKSFLKKVRTIVRENK
HHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCC
TATQDLLIRKLNPVIRGWVNYHRYVVSADIFGLVDHRIFECLWRWACRRHKRKGRKWIAN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYWHHIDNRTWTFATEPAFRSKDFDEKYLKLEYAANTKIIRFRKIAAEANPFDEKWTGYY
HHHHHCCCCEEEEECCCCCCCCCCCCHHEEEEECCCCEEEEEEHHHHCCCCCCHHHCCCH
EERDGERMLNSTKGREKLVKIWNNQKRCCPVCGERITSETGFKTHFNTENNRKWPAIMVH
HHCCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCEEEEC
PWCHRNLHEPNYLI
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]