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The map label for this gene is xanQ [H]

Identifier: 238921376

GI number: 238921376

Start: 3413865

End: 3415283

Strand: Reverse

Name: xanQ [H]

Synonym: NT01EI_3520

Alternate gene names: 238921376

Gene position: 3415283-3413865 (Counterclockwise)

Preceding gene: 238921377

Following gene: 238921375

Centisome position: 89.59

GC content: 58.07

Gene sequence:

>1419_bases
ATGTCTGATATACCGCGTGCTGGATCCGATCTTATTTATCAACTCGAGGATAAACCGCCATTTCACCAGCTCATGGTGGG
TGCGGTGACTCACCTGCTGGCGATTTTTGTCCCCATGGTGGCACCGGCGCTGATTGTCGGTACCGCGCTGGGCCTTTCCA
CCGAAATCACCGCCTATCTGGTCTCCATGGCGATGATTGCCTCCGGCGTTGGCACCTGGCTGCAGGTCAACCGCTATGGC
TGCGTCGGCTCTGGCCTGCTGTCTATCCAATCGGTCAATTTCTCCTTTGTTACCGTGATGATAGCTCTGGGCGGCGCGAT
GAAACACGATGGCCTGCATGAGGAGCTGATCGTGTCGACTCTGCTGGGGGTCTCCTTTGTCGGTGCCTTCCTGGTGGTGG
GCGCCTCGTTTATCCTGCCTTACCTGCGCCGGGTGATCACCCCGACGGTGAGCGGGGTGGTGGTACTGATGATCGGCCTG
AGCCTGATCAAGGTTGGCATCATCGATTTCGGCGGTGGCTTTGCCGCCAAGAGCAGTGGCACCTATGGTAATTATGAAAA
CATCGGCGTCGGCCTGCTGGTACTGCTGGTGGTTATCGGCTTTAACTGTGCGCGTCATCCCTTACTGCGGATGGGCGGCA
TCGCCATCGGGCTTATCGTCGGCTATATCATGGCGCTGTGTCTGGGCATGGTGGATTTCAGCGCCCTGCGCGACCTGCCA
CTGGTTACCGTTCCGGTTCCCTTTAAATATGGTTTTACCTTTGACATGCACGCTTTCCTGGTGGCTGGCACCATCTATCT
GCTCAGCGTGCTGGAGGCGGTGGGAGATATCACCGCGACGGCGATGGTCTCGAATCGCCCCATCGAAGGGCCTGAGTATC
AGTCGCGTCTGAGCGGTGGCGTGCTGGCCGATGGGCTGGTGTCGGTCATTGCTTCTGCCCTGGGCTCATTGCCGCTGACC
ACCTTTGCCCAGAATAACGGGGTGATCCAGATGACCGGCGTGGCCTCACGCTATGTCGGTCGGGCTATCGCCGGGATGCT
GGTACTGCTGGGGCTGTTTCCGGTCATCGGGCGCTTTTTTACCACCATTCCGGCTCCGGTATTGGGCGGCGCGATGACGC
TAATGTTCTCCATGATCGCTATCGCCGGGATCCGCATCATTATTTCCAACGGATTGCGTCGCCGCGAGACCATCATCGTC
GCCACCTCCCTTGGGCTGGGGCTGGGTGTCTCGTACGATCCGGCCGTGTTCCGGGTATTGCCAGATTCGCTGTACGTATT
GGTAGAGAATCCCATTTGTGCCGGTGGTCTGACGGCAATCATCCTCAACTTACTGATTCCGATGCGCAAGAAAGCGGAGG
TCCGTCGGGAAGAGGATGAACCGACAGGCACATTGTCTGCAGAAGAAGAGATGGACTGA

Upstream 100 bases:

>100_bases
AAACACTCTCAGGGGCGTCCCTTGCCGCGCGGCGGGAAAATGGGTAGGCGGATATTTATTAATTGGATCAGATGATCAAA
TTTACCAGGGGAGTAAAGGG

Downstream 100 bases:

>100_bases
GTCGATGTCTTGGCTGATTAGGAGTTAATCATGGTTTGTGAACATACCCTCAAGGCAGTCCGCGGTAGCATTCTGGATGT
CACCCGTACGGTGACCGATC

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSDIPRAGSDLIYQLEDKPPFHQLMVGAVTHLLAIFVPMVAPALIVGTALGLSTEITAYLVSMAMIASGVGTWLQVNRYG
CVGSGLLSIQSVNFSFVTVMIALGGAMKHDGLHEELIVSTLLGVSFVGAFLVVGASFILPYLRRVITPTVSGVVVLMIGL
SLIKVGIIDFGGGFAAKSSGTYGNYENIGVGLLVLLVVIGFNCARHPLLRMGGIAIGLIVGYIMALCLGMVDFSALRDLP
LVTVPVPFKYGFTFDMHAFLVAGTIYLLSVLEAVGDITATAMVSNRPIEGPEYQSRLSGGVLADGLVSVIASALGSLPLT
TFAQNNGVIQMTGVASRYVGRAIAGMLVLLGLFPVIGRFFTTIPAPVLGGAMTLMFSMIAIAGIRIIISNGLRRRETIIV
ATSLGLGLGVSYDPAVFRVLPDSLYVLVENPICAGGLTAIILNLLIPMRKKAEVRREEDEPTGTLSAEEEMD

Sequences:

>Translated_472_residues
MSDIPRAGSDLIYQLEDKPPFHQLMVGAVTHLLAIFVPMVAPALIVGTALGLSTEITAYLVSMAMIASGVGTWLQVNRYG
CVGSGLLSIQSVNFSFVTVMIALGGAMKHDGLHEELIVSTLLGVSFVGAFLVVGASFILPYLRRVITPTVSGVVVLMIGL
SLIKVGIIDFGGGFAAKSSGTYGNYENIGVGLLVLLVVIGFNCARHPLLRMGGIAIGLIVGYIMALCLGMVDFSALRDLP
LVTVPVPFKYGFTFDMHAFLVAGTIYLLSVLEAVGDITATAMVSNRPIEGPEYQSRLSGGVLADGLVSVIASALGSLPLT
TFAQNNGVIQMTGVASRYVGRAIAGMLVLLGLFPVIGRFFTTIPAPVLGGAMTLMFSMIAIAGIRIIISNGLRRRETIIV
ATSLGLGLGVSYDPAVFRVLPDSLYVLVENPICAGGLTAIILNLLIPMRKKAEVRREEDEPTGTLSAEEEMD
>Mature_471_residues
SDIPRAGSDLIYQLEDKPPFHQLMVGAVTHLLAIFVPMVAPALIVGTALGLSTEITAYLVSMAMIASGVGTWLQVNRYGC
VGSGLLSIQSVNFSFVTVMIALGGAMKHDGLHEELIVSTLLGVSFVGAFLVVGASFILPYLRRVITPTVSGVVVLMIGLS
LIKVGIIDFGGGFAAKSSGTYGNYENIGVGLLVLLVVIGFNCARHPLLRMGGIAIGLIVGYIMALCLGMVDFSALRDLPL
VTVPVPFKYGFTFDMHAFLVAGTIYLLSVLEAVGDITATAMVSNRPIEGPEYQSRLSGGVLADGLVSVIASALGSLPLTT
FAQNNGVIQMTGVASRYVGRAIAGMLVLLGLFPVIGRFFTTIPAPVLGGAMTLMFSMIAIAGIRIIISNGLRRRETIIVA
TSLGLGLGVSYDPAVFRVLPDSLYVLVENPICAGGLTAIILNLLIPMRKKAEVRREEDEPTGTLSAEEEMD

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=506, Percent_Identity=24.3083003952569, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI40316845, Length=506, Percent_Identity=24.3083003952569, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI44680145, Length=433, Percent_Identity=24.0184757505774, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI44680143, Length=437, Percent_Identity=23.3409610983982, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082178, Length=472, Percent_Identity=82.2033898305085, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI1790087, Length=445, Percent_Identity=44.2696629213483, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI87082181, Length=446, Percent_Identity=28.47533632287, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081818, Length=409, Percent_Identity=27.3838630806846, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788843, Length=274, Percent_Identity=27.3722627737226, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=227, Percent_Identity=32.5991189427313, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541904, Length=281, Percent_Identity=25.2669039145907, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49696; Mature: 49565

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIPRAGSDLIYQLEDKPPFHQLMVGAVTHLLAIFVPMVAPALIVGTALGLSTEITAYL
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VSMAMIASGVGTWLQVNRYGCVGSGLLSIQSVNFSFVTVMIALGGAMKHDGLHEELIVST
HHHHHHHHCCCHHEEEECCCCCCCCHHEEEECCHHHHHHHHHHCCHHHCCCCHHHHHHHH
LLGVSFVGAFLVVGASFILPYLRRVITPTVSGVVVLMIGLSLIKVGIIDFGGGFAAKSSG
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TYGNYENIGVGLLVLLVVIGFNCARHPLLRMGGIAIGLIVGYIMALCLGMVDFSALRDLP
CCCCCCHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LVTVPVPFKYGFTFDMHAFLVAGTIYLLSVLEAVGDITATAMVSNRPIEGPEYQSRLSGG
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCC
VLADGLVSVIASALGSLPLTTFAQNNGVIQMTGVASRYVGRAIAGMLVLLGLFPVIGRFF
HHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTIPAPVLGGAMTLMFSMIAIAGIRIIISNGLRRRETIIVATSLGLGLGVSYDPAVFRVL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHEEC
PDSLYVLVENPICAGGLTAIILNLLIPMRKKAEVRREEDEPTGTLSAEEEMD
CCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
SDIPRAGSDLIYQLEDKPPFHQLMVGAVTHLLAIFVPMVAPALIVGTALGLSTEITAYL
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH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CCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]