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The map label for this gene is uxaA [H]

Identifier: 238896616

GI number: 238896616

Start: 4598440

End: 4599927

Strand: Reverse

Name: uxaA [H]

Synonym: KP1_4817

Alternate gene names: 238896616

Gene position: 4599927-4598440 (Counterclockwise)

Preceding gene: 238896617

Following gene: 238896615

Centisome position: 87.64

GC content: 58.27

Gene sequence:

>1488_bases
ATGCAATACATCAAAATCCATTCGCAGGATAACGTCGCGGTCGCGCTGACGGATATCGCTGCCGGTAGCGTGGTGACGAT
TGATAATGACTCGGTCACCCTCGGCCAGGATATCGTTCGCGGCCACAAGTTTGCACTGCGCGCTATCGCGAAAGGGGAAA
ACGTCGTTAAGTACGGGTTGCCGATTGGCCATGCGCTGGCGGATATCGCGCCGGGAGAGCATGTTCATGCGCACAATACG
CGCACCAATCTCAGCGACCTTGACGCGTATCGCTATCAACCGGACCTGGTTGCCCAACCGCCACAGCCTGCGGATCGCGA
AGTACAGATTTATCGTCGCGCCAACGGTGACGTCGGCGTGCGCAATGAGCTGTGGATCCTGCCGACCGTCGGCTGCGTCA
ACGCGATGGCCAGACAAATGCAGAACCGTTTCCTGAAAGAGACGTATGGCGCTGAGGATATCGATGGGGTACATCTCTTC
AGCCACACCTATGGCTGCTCGCAGCTTGGGGACGATCACATCAACACTCGCACCATGCTGCAAAATATGGTTCGTCACCC
GAACGCCGGGGCGGTGCTGGTGGTTGGCCTTGGCTGTGAAAACAACCAGGTGGAGGCCTTTCGCGAGACGCTGGGCGAGT
TTGACCCGCAGCGCGTGCACTTTATGGTTTGCCAGCATCAGGACGATGAAGTGGAGGCGGGGGTTGAGCATCTGCATCAG
CTGTATGAAGTGATGCGTCAGGATAAACGCCAGCCGGGCAAGCTCAGCGAGCTGAAGTTTGGCCTCGAGTGCGGGGGATC
GGACGGCCTGTCGGGCATTACCGCTAATCCGATGCTGGGCCGCTTCTCAGACTATGTGATCGCCAACGGCGGCACTACCG
TGCTGACCGAAGTGCCGGAGATGTTCGGCGCTGAACAGTTGCTGATGAGCCACTGCCGCGACGAAGCGACCTTCGACAAG
CTGGTGACCATGGTCAATGACTTTAAGCAGTACTTTATTGCTCACGACCAGCCTATTTACGAAAACCCCTCGCCGGGTAA
TAAGGCCGGAGGGATCACTACCCTCGAAGATAAGTCGCTGGGCTGTACTCAGAAAGCGGGCTCCAGCCAGGTGGTGGATG
TTCTGCGCTACGGCGAGCGCCTGAAGGTTCATGGTCTGAATTTACTGAGCGCGCCGGGCAACGACGCGGTCGCCACCAGC
GCGCTGGCCGGCGCCGGCTGCCATATGGTGCTGTTCAGCACCGGTCGCGGCACGCCGTACGGCGGCTTTGTGCCAACGGT
GAAGATCGCCACCAATAGCGAGCTGGCGGCGAAGAAAAAGCACTGGATCGACTTTGATGCCGGGCAGCTGCTCCACGGCA
AAACGATGCCGCAGCTGCTGGAAGAGTTTGTGGATGCCATTGTAGCCTTCGCCAACGGTAAACCGACCTGTAATGAGCAG
AATGACTTCCGCGAGCTGGCCATCTTTAAAAGCGGTGTTACCCTGTAA

Upstream 100 bases:

>100_bases
GGATATCGCGCTGCTGGGCGAGATGGTGAAAAACATTTGCTTTAACAATGCGCGTGACTATTTCGCCATTGAACTGAACT
AAGGCCAGAGGTCGGTTGAT

Downstream 100 bases:

>100_bases
AGGCGTATTTGCGTTGGCGCCCAGAGGCTTGGTTTGTGTATCGGCCTGATAGCGTAGCGCCATCGGGCTCGTAACAGCGG
CGTTTCAGCCAGTGAAGCGC

Product: altronate hydrolase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MQYIKIHSQDNVAVALTDIAAGSVVTIDNDSVTLGQDIVRGHKFALRAIAKGENVVKYGLPIGHALADIAPGEHVHAHNT
RTNLSDLDAYRYQPDLVAQPPQPADREVQIYRRANGDVGVRNELWILPTVGCVNAMARQMQNRFLKETYGAEDIDGVHLF
SHTYGCSQLGDDHINTRTMLQNMVRHPNAGAVLVVGLGCENNQVEAFRETLGEFDPQRVHFMVCQHQDDEVEAGVEHLHQ
LYEVMRQDKRQPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPEMFGAEQLLMSHCRDEATFDK
LVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSLGCTQKAGSSQVVDVLRYGERLKVHGLNLLSAPGNDAVATS
ALAGAGCHMVLFSTGRGTPYGGFVPTVKIATNSELAAKKKHWIDFDAGQLLHGKTMPQLLEEFVDAIVAFANGKPTCNEQ
NDFRELAIFKSGVTL

Sequences:

>Translated_495_residues
MQYIKIHSQDNVAVALTDIAAGSVVTIDNDSVTLGQDIVRGHKFALRAIAKGENVVKYGLPIGHALADIAPGEHVHAHNT
RTNLSDLDAYRYQPDLVAQPPQPADREVQIYRRANGDVGVRNELWILPTVGCVNAMARQMQNRFLKETYGAEDIDGVHLF
SHTYGCSQLGDDHINTRTMLQNMVRHPNAGAVLVVGLGCENNQVEAFRETLGEFDPQRVHFMVCQHQDDEVEAGVEHLHQ
LYEVMRQDKRQPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPEMFGAEQLLMSHCRDEATFDK
LVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSLGCTQKAGSSQVVDVLRYGERLKVHGLNLLSAPGNDAVATS
ALAGAGCHMVLFSTGRGTPYGGFVPTVKIATNSELAAKKKHWIDFDAGQLLHGKTMPQLLEEFVDAIVAFANGKPTCNEQ
NDFRELAIFKSGVTL
>Mature_495_residues
MQYIKIHSQDNVAVALTDIAAGSVVTIDNDSVTLGQDIVRGHKFALRAIAKGENVVKYGLPIGHALADIAPGEHVHAHNT
RTNLSDLDAYRYQPDLVAQPPQPADREVQIYRRANGDVGVRNELWILPTVGCVNAMARQMQNRFLKETYGAEDIDGVHLF
SHTYGCSQLGDDHINTRTMLQNMVRHPNAGAVLVVGLGCENNQVEAFRETLGEFDPQRVHFMVCQHQDDEVEAGVEHLHQ
LYEVMRQDKRQPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPEMFGAEQLLMSHCRDEATFDK
LVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSLGCTQKAGSSQVVDVLRYGERLKVHGLNLLSAPGNDAVATS
ALAGAGCHMVLFSTGRGTPYGGFVPTVKIATNSELAAKKKHWIDFDAGQLLHGKTMPQLLEEFVDAIVAFANGKPTCNEQ
NDFRELAIFKSGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=495, Percent_Identity=87.8787878787879, Blast_Score=915, Evalue=0.0,
Organism=Escherichia coli, GI1789516, Length=514, Percent_Identity=32.4902723735409, Blast_Score=209, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 54067; Mature: 54067

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYIKIHSQDNVAVALTDIAAGSVVTIDNDSVTLGQDIVRGHKFALRAIAKGENVVKYGL
CCEEEEECCCCEEEEEEEECCCCEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECC
PIGHALADIAPGEHVHAHNTRTNLSDLDAYRYQPDLVAQPPQPADREVQIYRRANGDVGV
CHHHHHHHCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCC
RNELWILPTVGCVNAMARQMQNRFLKETYGAEDIDGVHLFSHTYGCSQLGDDHINTRTML
CCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCHHHHHH
QNMVRHPNAGAVLVVGLGCENNQVEAFRETLGEFDPQRVHFMVCQHQDDEVEAGVEHLHQ
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHH
LYEVMRQDKRQPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPE
HHHHHHHHCCCCCCHHHEEECCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCHHHHHHH
MFGAEQLLMSHCRDEATFDKLVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSL
HHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCC
GCTQKAGSSQVVDVLRYGERLKVHGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTPY
CCCCCCCCHHHHHHHHCCCEEEEECCEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCC
GGFVPTVKIATNSELAAKKKHWIDFDAGQLLHGKTMPQLLEEFVDAIVAFANGKPTCNEQ
CCCCCEEEEECCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
NDFRELAIFKSGVTL
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MQYIKIHSQDNVAVALTDIAAGSVVTIDNDSVTLGQDIVRGHKFALRAIAKGENVVKYGL
CCEEEEECCCCEEEEEEEECCCCEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECC
PIGHALADIAPGEHVHAHNTRTNLSDLDAYRYQPDLVAQPPQPADREVQIYRRANGDVGV
CHHHHHHHCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCC
RNELWILPTVGCVNAMARQMQNRFLKETYGAEDIDGVHLFSHTYGCSQLGDDHINTRTML
CCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCHHHHHH
QNMVRHPNAGAVLVVGLGCENNQVEAFRETLGEFDPQRVHFMVCQHQDDEVEAGVEHLHQ
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHH
LYEVMRQDKRQPGKLSELKFGLECGGSDGLSGITANPMLGRFSDYVIANGGTTVLTEVPE
HHHHHHHHCCCCCCHHHEEECCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCHHHHHHH
MFGAEQLLMSHCRDEATFDKLVTMVNDFKQYFIAHDQPIYENPSPGNKAGGITTLEDKSL
HHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCC
GCTQKAGSSQVVDVLRYGERLKVHGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTPY
CCCCCCCCHHHHHHHHCCCEEEEECCEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCC
GGFVPTVKIATNSELAAKKKHWIDFDAGQLLHGKTMPQLLEEFVDAIVAFANGKPTCNEQ
CCCCCEEEEECCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
NDFRELAIFKSGVTL
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3038546 [H]