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The map label for this gene is ppiD [H]

Identifier: 238893390

GI number: 238893390

Start: 1230357

End: 1232231

Strand: Direct

Name: ppiD [H]

Synonym: KP1_1274

Alternate gene names: 238893390

Gene position: 1230357-1232231 (Clockwise)

Preceding gene: 238893389

Following gene: 238893391

Centisome position: 23.44

GC content: 57.81

Gene sequence:

>1875_bases
ATGATGGACAACCTACGCACGGCCGCCAACAGCGTCGTGCTCAAGATTATTTTCGGTATCATTATCGTCTCGTTCATTTT
GACCGGGGTGAGTGGTTACCTGATTGGCGGTGGCAAAAACTATGCCGCAAAAGTGAATGGCCAGGAGATTGGCCGTGGGC
AGTTTGAAAACGCCGTCGCCAGCGAACGTAACCGTATGCAGCAGCAGCTTGGCGATCAATTCTCCGAGCTGGCGGCGAAC
GAAAACTACATGAAAACCATGCGCCAGCAGGTGCTGAACCGCCTGATCGATGAGTCGCTTCTGGATCAGTATGCCCGCGA
GCTGGGCCTCAGCATCAGCGATGAGCAGGTGAAGCAGGCGATCTTCCAGACCCAGGCGTTCCAGACGAACGGTAAGTTCG
ACAACCAGCGTTTCAGTGGTATTGTCGCCCAGATGGGGATGACCACCGATCAGTACGCCCAGGCGCTGCGTAACCAGCTG
ACCACGCAGCAGCTGATTAACGCCATTGCGGGTACCGACTTCATGCTGCCGGGCGAGTCCGATCAGCTGGCGGCGCTGGT
ATCTCAACAGCGGGTGGTCCGCGAAGCGACCATCAACGTAAATGCCCTGGCGGCAAAACAGACCGCCAGCGATGAGGAAA
TCAACGCCTTCTGGCAGCAGAATCAGGCCCGTTTTATGGCGCCGGAGCAGTTCCGCGTCAGCTACATCAAAATGGATGCC
GCCAGCATGCAGGAGAGCGCCTCTGACGAAGAGATTCAGTCATGGTACGACCAGCACAAGGATCAGTTCACTCAGCCGCA
GCGCAACCGCTACAGCGTGATTCAGACCAAAACTGAAGCCGATGCGAAAGCGGTACTGGCCGAGCTGCAAAAAGGAGCGG
ACTTCGCCACGCTGGCGAAAGAAAAATCGACCGATATTATCTCTGCCCGCAACGGTGGCGATATGGGGTGGATGGAAGAT
GCCTCTACCGTGCCTGAGCTGAAAGATGCCGGGCTGAAAGAGAAAGGCCAGCTGTCTGGCGTGATCAAATCCTCGGTTGG
CTTCCTGGTAGCTCGTCTGGACGACGTCCAGCCGGCGCAGGTGAAGCCGCTGGCTGACGTGCGTAATGACATTGCGGCGA
AAGTGAAGCAGGAAAAAGCGTTGGATGCTTACTACGCGCTGCAGCAGAAGGTGAGCGATGCGGCCAGCAACGATAATGAA
TCGCTGGCGAGCGCAGCGCAGGTCGCCGGGCTGAAGGTCGTAGAAACCGGCTGGTTTGGCCGCGATAACCTGCCGGAGGA
GCTGAACTTTAAACCGGTCGCTGACGCTATTTTCAACGGCGGTCTGGTGGGTGAGAACGGCGCGCCGGGCAGCAACTCCG
ATATCATTACCGTTGACGGCGATCGCGCTTTTGTTCTGCGCATTAGCGAACACAAAGCCGAGGCGGTGAAGCCGCTGGCC
GAAGTGAAGGCACAGGTTAGCGATATCGTTAAGCACAATAAAGCGGAACAGCAGGCGAAACTGGAGGCCGACAAGCTGCT
GGCGGCGCTGAAAGACGGCAAAGGCGATGAAGCGATGAAGGCGGCTGGCCTGAGCTTTGGCGCGCCGCAGACGCTTTCTC
GTACCGGCCAGGATCCGCTGAGCCAGCTGGCATTTACCCTGCCGCTGCCGCAGCAGGGTAAACCGGTCTACGGCGTGGGC
AGCAATATGCAAGGCGATGTGGTGCTGGTAGCGCTGGATGAGGTGAAAGCCGGCAGCATGCCGGAAGAGCAGAAGAAGGC
CATGGTTCAGGGGATCACCCAGAACAATGCCCAAATCGCTTTCGAAGCGCTGATGAGCAACCTGCGCAAGGCGGCGAAAA
TTAAGCTCGGCGACAGCATCGACCAGCAGCAGTAA

Upstream 100 bases:

>100_bases
ATCACCCTGTTTTCTTGTCAAAATACGTCCTCACGCGCGGCGGCCATCACGTGCTATGCTGCGCGAGCTAAAGTCATCTA
CAGCGGAGCGTTGTTACACC

Downstream 100 bases:

>100_bases
TTTCGCGTCGTCTCGCAAAAATGAGCAACACGATGTAATCCTCAAGGGCCGCTTTCGCGGCCCTTTCCATTTCTGTGATT
TGCCTTTTGTCGACCATCCG

Product: peptidyl-prolyl cis-trans isomerase (rotamase D)

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MMDNLRTAANSVVLKIIFGIIIVSFILTGVSGYLIGGGKNYAAKVNGQEIGRGQFENAVASERNRMQQQLGDQFSELAAN
ENYMKTMRQQVLNRLIDESLLDQYARELGLSISDEQVKQAIFQTQAFQTNGKFDNQRFSGIVAQMGMTTDQYAQALRNQL
TTQQLINAIAGTDFMLPGESDQLAALVSQQRVVREATINVNALAAKQTASDEEINAFWQQNQARFMAPEQFRVSYIKMDA
ASMQESASDEEIQSWYDQHKDQFTQPQRNRYSVIQTKTEADAKAVLAELQKGADFATLAKEKSTDIISARNGGDMGWMED
ASTVPELKDAGLKEKGQLSGVIKSSVGFLVARLDDVQPAQVKPLADVRNDIAAKVKQEKALDAYYALQQKVSDAASNDNE
SLASAAQVAGLKVVETGWFGRDNLPEELNFKPVADAIFNGGLVGENGAPGSNSDIITVDGDRAFVLRISEHKAEAVKPLA
EVKAQVSDIVKHNKAEQQAKLEADKLLAALKDGKGDEAMKAAGLSFGAPQTLSRTGQDPLSQLAFTLPLPQQGKPVYGVG
SNMQGDVVLVALDEVKAGSMPEEQKKAMVQGITQNNAQIAFEALMSNLRKAAKIKLGDSIDQQQ

Sequences:

>Translated_624_residues
MMDNLRTAANSVVLKIIFGIIIVSFILTGVSGYLIGGGKNYAAKVNGQEIGRGQFENAVASERNRMQQQLGDQFSELAAN
ENYMKTMRQQVLNRLIDESLLDQYARELGLSISDEQVKQAIFQTQAFQTNGKFDNQRFSGIVAQMGMTTDQYAQALRNQL
TTQQLINAIAGTDFMLPGESDQLAALVSQQRVVREATINVNALAAKQTASDEEINAFWQQNQARFMAPEQFRVSYIKMDA
ASMQESASDEEIQSWYDQHKDQFTQPQRNRYSVIQTKTEADAKAVLAELQKGADFATLAKEKSTDIISARNGGDMGWMED
ASTVPELKDAGLKEKGQLSGVIKSSVGFLVARLDDVQPAQVKPLADVRNDIAAKVKQEKALDAYYALQQKVSDAASNDNE
SLASAAQVAGLKVVETGWFGRDNLPEELNFKPVADAIFNGGLVGENGAPGSNSDIITVDGDRAFVLRISEHKAEAVKPLA
EVKAQVSDIVKHNKAEQQAKLEADKLLAALKDGKGDEAMKAAGLSFGAPQTLSRTGQDPLSQLAFTLPLPQQGKPVYGVG
SNMQGDVVLVALDEVKAGSMPEEQKKAMVQGITQNNAQIAFEALMSNLRKAAKIKLGDSIDQQQ
>Mature_624_residues
MMDNLRTAANSVVLKIIFGIIIVSFILTGVSGYLIGGGKNYAAKVNGQEIGRGQFENAVASERNRMQQQLGDQFSELAAN
ENYMKTMRQQVLNRLIDESLLDQYARELGLSISDEQVKQAIFQTQAFQTNGKFDNQRFSGIVAQMGMTTDQYAQALRNQL
TTQQLINAIAGTDFMLPGESDQLAALVSQQRVVREATINVNALAAKQTASDEEINAFWQQNQARFMAPEQFRVSYIKMDA
ASMQESASDEEIQSWYDQHKDQFTQPQRNRYSVIQTKTEADAKAVLAELQKGADFATLAKEKSTDIISARNGGDMGWMED
ASTVPELKDAGLKEKGQLSGVIKSSVGFLVARLDDVQPAQVKPLADVRNDIAAKVKQEKALDAYYALQQKVSDAASNDNE
SLASAAQVAGLKVVETGWFGRDNLPEELNFKPVADAIFNGGLVGENGAPGSNSDIITVDGDRAFVLRISEHKAEAVKPLA
EVKAQVSDIVKHNKAEQQAKLEADKLLAALKDGKGDEAMKAAGLSFGAPQTLSRTGQDPLSQLAFTLPLPQQGKPVYGVG
SNMQGDVVLVALDEVKAGSMPEEQKKAMVQGITQNNAQIAFEALMSNLRKAAKIKLGDSIDQQQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=623, Percent_Identity=79.1332263242376, Blast_Score=1015, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 67836; Mature: 67836

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDNLRTAANSVVLKIIFGIIIVSFILTGVSGYLIGGGKNYAAKVNGQEIGRGQFENAVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCHHCCCCHHHHHHH
SERNRMQQQLGDQFSELAANENYMKTMRQQVLNRLIDESLLDQYARELGLSISDEQVKQA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IFQTQAFQTNGKFDNQRFSGIVAQMGMTTDQYAQALRNQLTTQQLINAIAGTDFMLPGES
HHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
DQLAALVSQQRVVREATINVNALAAKQTASDEEINAFWQQNQARFMAPEQFRVSYIKMDA
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHEEECH
ASMQESASDEEIQSWYDQHKDQFTQPQRNRYSVIQTKTEADAKAVLAELQKGADFATLAK
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEECHHHHHHHHHHHHHHCCCHHHHHH
EKSTDIISARNGGDMGWMEDASTVPELKDAGLKEKGQLSGVIKSSVGFLVARLDDVQPAQ
HHCCCEEECCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
VKPLADVRNDIAAKVKQEKALDAYYALQQKVSDAASNDNESLASAAQVAGLKVVETGWFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCC
RDNLPEELNFKPVADAIFNGGLVGENGAPGSNSDIITVDGDRAFVLRISEHKAEAVKPLA
CCCCCCCCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEEEEECHHHHHHHHHHH
EVKAQVSDIVKHNKAEQQAKLEADKLLAALKDGKGDEAMKAAGLSFGAPQTLSRTGQDPL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHCCCCHH
SQLAFTLPLPQQGKPVYGVGSNMQGDVVLVALDEVKAGSMPEEQKKAMVQGITQNNAQIA
HHHEEECCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHH
FEALMSNLRKAAKIKLGDSIDQQQ
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMDNLRTAANSVVLKIIFGIIIVSFILTGVSGYLIGGGKNYAAKVNGQEIGRGQFENAVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCHHCCCCHHHHHHH
SERNRMQQQLGDQFSELAANENYMKTMRQQVLNRLIDESLLDQYARELGLSISDEQVKQA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IFQTQAFQTNGKFDNQRFSGIVAQMGMTTDQYAQALRNQLTTQQLINAIAGTDFMLPGES
HHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
DQLAALVSQQRVVREATINVNALAAKQTASDEEINAFWQQNQARFMAPEQFRVSYIKMDA
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHEEECH
ASMQESASDEEIQSWYDQHKDQFTQPQRNRYSVIQTKTEADAKAVLAELQKGADFATLAK
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEECHHHHHHHHHHHHHHCCCHHHHHH
EKSTDIISARNGGDMGWMEDASTVPELKDAGLKEKGQLSGVIKSSVGFLVARLDDVQPAQ
HHCCCEEECCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
VKPLADVRNDIAAKVKQEKALDAYYALQQKVSDAASNDNESLASAAQVAGLKVVETGWFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCC
RDNLPEELNFKPVADAIFNGGLVGENGAPGSNSDIITVDGDRAFVLRISEHKAEAVKPLA
CCCCCCCCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEEEEECHHHHHHHHHHH
EVKAQVSDIVKHNKAEQQAKLEADKLLAALKDGKGDEAMKAAGLSFGAPQTLSRTGQDPL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHCCCCHH
SQLAFTLPLPQQGKPVYGVGSNMQGDVVLVALDEVKAGSMPEEQKKAMVQGITQNNAQIA
HHHEEECCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHH
FEALMSNLRKAAKIKLGDSIDQQQ
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]