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The map label for this gene is lon [H]

Identifier: 238893388

GI number: 238893388

Start: 1227198

End: 1229660

Strand: Direct

Name: lon [H]

Synonym: KP1_1272

Alternate gene names: 238893388

Gene position: 1227198-1229660 (Clockwise)

Preceding gene: 238893387

Following gene: 238893389

Centisome position: 23.38

GC content: 55.46

Gene sequence:

>2463_bases
TTGAATGTGTGGAATACATCCCCATATACTGGATTACATATTAACGACGATGCAGTGGAGTGTGGCGTCGTCGGCTACCT
GGCGGACTTTAAACTAAGAGAGAGCTCTATGAATCCTGAGCGTTCTGAACGCATTGAAATCCCCGTATTGCCATTGCGCG
ATGTGGTGGTTTATCCGCACATGGTCATACCCCTGTTCGTAGGGCGGGAAAAATCTATCCGTTGCCTCGAAGCGGCCATG
GACCATGATAAAAAAATCATGCTGGTTGCGCAGAAAGAAGCGTCGACGGATGAGCCGGGTGTAAACGATCTTTTCACCGT
TGGAACCGTGGCGTCTATTTTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTGGTCGAAGGGCTGCAGCGTG
CTCGCATTTCTGCGCTGTCTGATAATGGCGAGCATTTCTCGGCGAAAGCGGAGTATCTCGACTCGCCGGCGATTGACGAA
CGCGAGCAGGAAGTGCTGGTTCGCACCGCTATCAGCCAGTTTGAAGGCTATATCAAGCTGAACAAGAAGATCCCACCGGA
AGTGCTGACGTCGCTGAACAGCATCGACGATCCGGCGCGCCTGGCGGATACCATCGCGGCGCACATGCCGCTGAAGCTGG
CTGACAAGCAGTCTGTGCTTGAGATGTCCGACGTTAACGAACGTCTGGAATATCTGATGGCGATGATGGAATCGGAAATC
GATCTGCTGCAGGTTGAGAAGCGCATTCGCAACCGCGTCAAAAAGCAGATGGAGAAATCTCAGCGCGAGTACTATCTGAA
CGAGCAAATGAAAGCGATTCAGAAAGAACTCGGCGAGATGGACGACGCCCCGGACGAAAACGAAGCGCTGAAGCGTAAGA
TCGACGCGGCGAAAATGCCGAAAGAGGCGAAAGAAAAAACCGAAGCGGAACTGCAGAAGCTGAAGATGATGTCGCCGATG
TCAGCGGAAGCGACCGTCGTGCGTGGCTACATCGACTGGATGGTGCAGGTGCCGTGGAATGCGCGCAGTAAGGTCAAAAA
AGACCTGCGTCAGGCCCAGGAGATCCTCGATACCGATCACTATGGCCTGGAGCGCGTGAAGGATCGCATCCTTGAATATC
TCGCGGTGCAGAGCCGGGTGAACAAAATCAAGGGGCCAATCCTTTGTCTGGTGGGACCGCCGGGGGTAGGTAAAACCTCG
CTGGGTCAATCCATCGCCAAAGCGACCGGACGGAAATACGTTCGTATGGCGCTTGGCGGCGTGCGCGATGAAGCGGAAAT
CCGCGGTCATCGTCGGACCTACATTGGCTCGATGCCGGGCAAACTGATCCAGAAAATGGCGAAAGTGGGGGTCAAAAACC
CGCTGTTCCTGTTGGACGAGATCGACAAAATGTCTTCCGACATGCGCGGCGACCCGGCTTCCGCGTTGCTTGAGGTGCTG
GATCCGGAACAGAACGTGGCCTTTAACGACCACTATCTGGAAGTGGATTACGATCTCAGCGACGTGATGTTCGTGGCGAC
TTCCAACTCCATGAACATTCCGGCGCCGCTGCTGGACCGTATGGAAGTGATTCGTCTCTCCGGCTATACCGAAGATGAAA
AACTGAACATCGCCAAACGTCATCTGCTGCCGAAGCAGATCGAACGTAACGCGCTGAAGAAAGGCGAGTTGACCGTCGAC
GATAGCGCCATTATCGGCATTATTCGTTACTACACGCGGGAAGCGGGGGTACGTAGCCTGGAGCGTGAAATCTCCAAGCT
GTGCCGCAAGGCCGTTAAGCAACTGCTGCTGGATAAATCGCTGAAACACATCGAAATTAACGGTGAGAATCTGCATGATT
ATCTCGGCGTACAGCGCTTCGACTATGGCCGCGCCGATAGTGAGAACCGCGTCGGTCAGGTGACCGGTCTGGCGTGGACG
GAAGTGGGCGGCGATCTGCTGACCATCGAAACCGCCTGCGTGCCGGGCAAAGGCAAGCTGACCTACACCGGCTCGCTGGG
CGAGGTGATGCAGGAGTCGATTCAGGCTGCGCTGACGGTGGTACGTTCGCGGGCTGACAAGCTGGGCATTAACGCCGACT
TCTACGAGAAGCGTGACATTCACGTGCACGTGCCGGAAGGGGCGACGCCTAAGGATGGTCCGAGCGCGGGTATTGCCATG
TGCACGGCGCTGGTATCCTGCCTGACCGGTAACCCGGTACGCGCTGATGTGGCGATGACCGGTGAAATCACTCTGCGTGG
TCAGGTGCTGCCGATCGGCGGTCTGAAGGAAAAACTGCTGGCGGCGCATCGCGGCGGCATTAAGACTGTTCTGATTCCTG
ATGAGAACAAACGCGACCTTGAAGAAATTCCGGATAACGTTATCGCCGATTTGGATATCCATCCGGTGAAACGAATCGAG
GAAGTTCTGACACTTGCGCTGCAGAACGAACCGTTCGGCATGCAGGTTGTGACCGCGAAATAG

Upstream 100 bases:

>100_bases
AGCTCAGCAGGCATCTGGTGAATAATTAACCATTTCACTCAAGCAGTTAACAAAAAGGGGGGATTTTATCTCCCCTTTTA
TTTTTCCTGCATTCCCGCCG

Downstream 100 bases:

>100_bases
TGATTCTGCGCAAATTGCGCTAATAAAAATAGGGCTGGTAAGTCATTTCGGACTTGCCAGCCTTTTTTTGTGTAGCTAAC
TTAGATCGCTGGCAGGGGGG

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 820; Mature: 820

Protein sequence:

>820_residues
MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAM
DHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDE
REQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI
DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPM
SAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTS
LGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL
DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVD
DSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWT
EVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM
CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIE
EVLTLALQNEPFGMQVVTAK

Sequences:

>Translated_820_residues
MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAM
DHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDE
REQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI
DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPM
SAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTS
LGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL
DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVD
DSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWT
EVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM
CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIE
EVLTLALQNEPFGMQVVTAK
>Mature_820_residues
MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAM
DHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDE
REQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI
DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPM
SAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTS
LGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL
DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVD
DSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWT
EVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM
CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIE
EVLTLALQNEPFGMQVVTAK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=46.7140319715808, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=41.6267942583732, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=98.469387755102, Blast_Score=1571, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=663, Percent_Identity=40.8748114630468, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=794, Percent_Identity=33.2493702770781, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=863, Percent_Identity=36.3847045191193, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI221513036, Length=628, Percent_Identity=44.5859872611465, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=628, Percent_Identity=44.5859872611465, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91458; Mature: 91458

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS01046 LON_SER ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPH
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHCEEECCCCCHHHHHHCCH
MVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLP
HHHHHEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
DGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKL
CHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEE
NKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI
CCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCH
DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
KEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDH
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCC
YGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGG
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL
CCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKR
CCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
HLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKS
HCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKL
CCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEECEEHHHCCCCEEEEEEEECCCCCCE
TYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHH
CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDL
HHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHH
EEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK
HHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MNVWNTSPYTGLHINDDAVECGVVGYLADFKLRESSMNPERSERIEIPVLPLRDVVVYPH
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHCEEECCCCCHHHHHHCCH
MVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQMLKLP
HHHHHEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
DGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKL
CHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEE
NKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEI
CCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCH
DLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKELGEMDDAPDENEALKRKIDAAKMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
KEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDH
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCC
YGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGG
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVL
CCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
DPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIAKR
CCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
HLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLLLDKS
HCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKL
CCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEECEEHHHCCCCEEEEEEEECCCCCCE
TYTGSLGEVMQESIQAALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAM
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHH
CTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLKEKLLAAHRGGIKTVLIPDENKRDL
HHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHH
EEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK
HHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA