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The map label for this gene is mdtG [H]

Identifier: 238893307

GI number: 238893307

Start: 1149924

End: 1151123

Strand: Direct

Name: mdtG [H]

Synonym: KP1_1184

Alternate gene names: 238893307

Gene position: 1149924-1151123 (Clockwise)

Preceding gene: 238893306

Following gene: 238893308

Centisome position: 21.91

GC content: 59.0

Gene sequence:

>1200_bases
ATGGAATCCTGGAAGGTTAATCTCATCTCCGTCTGGTTTGGTTGCTTTTTTACCGGCCTGGCGATCAGTCAAATTCTCCC
CTTTTTACCCCTCTACGTCTCCCAGCTCGGCGTCACCTCGCATGAAGCGCTATCGATGTGGTCGGGGCTGACCTTCAGCG
TCACTTTTCTTGTCTCGGCGATCGTCTCGCCAATGTGGGGAAGCCTGGCGGACCGTAAAGGCCGCAAGCTCATGCTGCTG
CGCGCCTCGTTGGGGATGGCGATTGCCATTTTACTGCAGGCTTTCGCCACCAACGTCTGGCAGCTGTTTATCCTGCGGGC
GATCATGGGCTTAACCTCCGGTTATATTCCCAACGCCATGGCGCTGGTGGCCTCCCAGGTGCCGCGCGAGCGCAGCGGCT
GGGCGCTAAGCACGCTGTCGACGGCGCAAATTAGCGGGGTGATCGGCGGTCCGCTGCTGGGCGGTTTCCTGGCGGACCAC
GTCGGGCTGCGGATGGTCTTTTTTATTACGGCGATCCTGCTGACCATCAGTTTTCTGGTGACCCTGTTTCTGATTAAAGA
GGGCGTTCGCCCGCAGGTCAGCAAAAGCGAGCGTCTCACCGGGAAACAAGTCTTTGCCTCTTTGCCCTATCCGGGGCTGG
TGATCAGCCTGTTCTTCACCACCCTGGTGATCCAATTGTGCAACGGCTCAATCGGCCCGATTCTGGCGCTGTTTATTAAG
TCGATGGCGCCGGACAGCAACAATATCGCTTTTCTGGCCGGGATGATCGCCGCGGTGCCCGGCGTGTCGGCACTGATTTC
TGCGCCACGGTTGGGTAAGCTTGGCGACCGCATCGGCACCTCGCGGATCCTGCTGGCGACGCTCTGCTGCGCGGTGGTGA
TGTTCTTCGCCATGTCCTTTGTCACCACCCCGCTGCAATTGGGTACGCTGCGTTTTCTGCTCGGCTTTGCCGATGGCGCG
ATGCTCCCGGCGGTGCAGACCTTATTGCTGAAGTACAGCAGCGACAGCGTCACCGGGCGTATCTTTGGCTATAACCAGTC
GTTTATGTATCTGGGCAACGTCGCCGGGCCGCTAATTGGCGCCTCTGTGTCAGCCATGGCCGGCTTCCGCTGGGTGTTTA
TTGCCACCGCCATTATCGTTTTCATTAACCTCTGGCAACTGGCGTGGATGCTGCGCCAAACCCGCCGGGCTAACGCCTGA

Upstream 100 bases:

>100_bases
ACACCAAACTCACCGCCAGCGCATCTATGGTAGTACACCAGTGGGATGAAATTGCTAAGCTAGATAATAATTGGCAAATC
ATTAATGAATACGCGTAGTT

Downstream 100 bases:

>100_bases
ACCTCTGCTGGCGGTATTTATTGCGATACCGTCAGCATTATTCGCCGTCAGCGGATTTACTATTACTTTTTGTTATCGTC
ATGGCGTGAACGCTATTCCA

Product: putative permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MESWKVNLISVWFGCFFTGLAISQILPFLPLYVSQLGVTSHEALSMWSGLTFSVTFLVSAIVSPMWGSLADRKGRKLMLL
RASLGMAIAILLQAFATNVWQLFILRAIMGLTSGYIPNAMALVASQVPRERSGWALSTLSTAQISGVIGGPLLGGFLADH
VGLRMVFFITAILLTISFLVTLFLIKEGVRPQVSKSERLTGKQVFASLPYPGLVISLFFTTLVIQLCNGSIGPILALFIK
SMAPDSNNIAFLAGMIAAVPGVSALISAPRLGKLGDRIGTSRILLATLCCAVVMFFAMSFVTTPLQLGTLRFLLGFADGA
MLPAVQTLLLKYSSDSVTGRIFGYNQSFMYLGNVAGPLIGASVSAMAGFRWVFIATAIIVFINLWQLAWMLRQTRRANA

Sequences:

>Translated_399_residues
MESWKVNLISVWFGCFFTGLAISQILPFLPLYVSQLGVTSHEALSMWSGLTFSVTFLVSAIVSPMWGSLADRKGRKLMLL
RASLGMAIAILLQAFATNVWQLFILRAIMGLTSGYIPNAMALVASQVPRERSGWALSTLSTAQISGVIGGPLLGGFLADH
VGLRMVFFITAILLTISFLVTLFLIKEGVRPQVSKSERLTGKQVFASLPYPGLVISLFFTTLVIQLCNGSIGPILALFIK
SMAPDSNNIAFLAGMIAAVPGVSALISAPRLGKLGDRIGTSRILLATLCCAVVMFFAMSFVTTPLQLGTLRFLLGFADGA
MLPAVQTLLLKYSSDSVTGRIFGYNQSFMYLGNVAGPLIGASVSAMAGFRWVFIATAIIVFINLWQLAWMLRQTRRANA
>Mature_399_residues
MESWKVNLISVWFGCFFTGLAISQILPFLPLYVSQLGVTSHEALSMWSGLTFSVTFLVSAIVSPMWGSLADRKGRKLMLL
RASLGMAIAILLQAFATNVWQLFILRAIMGLTSGYIPNAMALVASQVPRERSGWALSTLSTAQISGVIGGPLLGGFLADH
VGLRMVFFITAILLTISFLVTLFLIKEGVRPQVSKSERLTGKQVFASLPYPGLVISLFFTTLVIQLCNGSIGPILALFIK
SMAPDSNNIAFLAGMIAAVPGVSALISAPRLGKLGDRIGTSRILLATLCCAVVMFFAMSFVTTPLQLGTLRFLLGFADGA
MLPAVQTLLLKYSSDSVTGRIFGYNQSFMYLGNVAGPLIGASVSAMAGFRWVFIATAIIVFINLWQLAWMLRQTRRANA

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=394, Percent_Identity=59.8984771573604, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI87082404, Length=366, Percent_Identity=24.8633879781421, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319871, Length=155, Percent_Identity=28.3870967741935, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43013; Mature: 43013

Theoretical pI: Translated: 10.95; Mature: 10.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESWKVNLISVWFGCFFTGLAISQILPFLPLYVSQLGVTSHEALSMWSGLTFSVTFLVSA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
IVSPMWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFILRAIMGLTSGYIPNAM
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALVASQVPRERSGWALSTLSTAQISGVIGGPLLGGFLADHVGLRMVFFITAILLTISFLV
HHHHHHCCCCCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFLIKEGVRPQVSKSERLTGKQVFASLPYPGLVISLFFTTLVIQLCNGSIGPILALFIK
HHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SMAPDSNNIAFLAGMIAAVPGVSALISAPRLGKLGDRIGTSRILLATLCCAVVMFFAMSF
HHCCCCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VTTPLQLGTLRFLLGFADGAMLPAVQTLLLKYSSDSVTGRIFGYNQSFMYLGNVAGPLIG
HHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHH
ASVSAMAGFRWVFIATAIIVFINLWQLAWMLRQTRRANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MESWKVNLISVWFGCFFTGLAISQILPFLPLYVSQLGVTSHEALSMWSGLTFSVTFLVSA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
IVSPMWGSLADRKGRKLMLLRASLGMAIAILLQAFATNVWQLFILRAIMGLTSGYIPNAM
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ALVASQVPRERSGWALSTLSTAQISGVIGGPLLGGFLADHVGLRMVFFITAILLTISFLV
HHHHHHCCCCCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLFLIKEGVRPQVSKSERLTGKQVFASLPYPGLVISLFFTTLVIQLCNGSIGPILALFIK
HHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SMAPDSNNIAFLAGMIAAVPGVSALISAPRLGKLGDRIGTSRILLATLCCAVVMFFAMSF
HHCCCCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VTTPLQLGTLRFLLGFADGAMLPAVQTLLLKYSSDSVTGRIFGYNQSFMYLGNVAGPLIG
HHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHH
ASVSAMAGFRWVFIATAIIVFINLWQLAWMLRQTRRANA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA