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The map label for this gene is speE [H]

Identifier: 238893106

GI number: 238893106

Start: 936663

End: 937523

Strand: Reverse

Name: speE [H]

Synonym: KP1_0952

Alternate gene names: 238893106

Gene position: 937523-936663 (Counterclockwise)

Preceding gene: 238893107

Following gene: 238893105

Centisome position: 17.86

GC content: 54.59

Gene sequence:

>861_bases
GTGGCCGATAATCCACTGTGGCATGAAACGCTGCATGACCATTTTGGTCAGTATTTTAGCGTTGATAACGTGCTGTACCA
CGAAAAAACCGATCATCAGGATCTGATCATCTTTGATAACCGCGCCTTTGGCCGGGTGATGGCGCTGGATGGCGTCGTAC
AAACCACCGAACGCGACGAGTTCATCTATCACGAAATGATGACCCATGTGCCGCTGCTGGCTCACGGCAACGCGAAGCAT
GTGTTGATCATTGGCGGCGGCGATGGCGCGATGCTGCGCGAAGTCTCTCGTCACCGTAGCATCGAAACCATCACCATGGT
GGAAATCGACGCCGGGGTAGTTTCATTCTCCCGCCAGTACCTGCCGAACCATAACGCCGGCGCCTATGACGATCCGCGCT
TTACGCTGGTGATTGATGATGGCGTCAATTTTGTTAATCAGACGACGCAAACGTTTGACGTGATCATTTCGGACTGTACC
GACCCTATCGGCCCGGGAGAAAGCCTGTTCACCTCGGCTTTTTATGAAGGCTGCAAACGCTGCCTGAACCCGGGTGGGAT
CTTTGTTGCCCAGAACGGCGTCTGCTTCCTGCAACAGGATGAAGCGGTAGGCAGCCATCGCAAGCTAAGCCACTATTTTC
GCGACGTCAGCTTCTACCAGGCGGCAATTCCAACCTATTACGGCGGGATCATGACCTTTGCCTGGGCGAGCGACAATGAG
GCGCTGCGCCATCTCTCCAGCGAAATCATTCAGGCGCGCTTTCACAAAGCCAACCTGACCTGCCGTTACTACAATCCGGC
AATCCATACGGCGGCCTTCGCCTTACCACAATATCTGCATGATGCTCTGTCCGCACCGTGA

Upstream 100 bases:

>100_bases
CATTGCTGCAATAACCGCCGTGCATCCTCATCTATAGTTGTCTATGATGTTGCACTCGTTTTACGGGTGTAACAGATGTT
AACGAAGGAGGAGCCTTATC

Downstream 100 bases:

>100_bases
CGCGAAATAAGGGGGTGAACTAAATTGAAAAAATTGAAGCTGCACGGCTTTAACAACCTGACCAAAAGCCTGAGTTTTTG
TATCTACGATATCTGTTACG

Product: spermidine synthase

Products: NA

Alternate protein names: Putrescine aminopropyltransferase; PAPT; SPDSY [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MADNPLWHETLHDHFGQYFSVDNVLYHEKTDHQDLIIFDNRAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGNAKH
VLIIGGGDGAMLREVSRHRSIETITMVEIDAGVVSFSRQYLPNHNAGAYDDPRFTLVIDDGVNFVNQTTQTFDVIISDCT
DPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEAVGSHRKLSHYFRDVSFYQAAIPTYYGGIMTFAWASDNE
ALRHLSSEIIQARFHKANLTCRYYNPAIHTAAFALPQYLHDALSAP

Sequences:

>Translated_286_residues
MADNPLWHETLHDHFGQYFSVDNVLYHEKTDHQDLIIFDNRAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGNAKH
VLIIGGGDGAMLREVSRHRSIETITMVEIDAGVVSFSRQYLPNHNAGAYDDPRFTLVIDDGVNFVNQTTQTFDVIISDCT
DPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEAVGSHRKLSHYFRDVSFYQAAIPTYYGGIMTFAWASDNE
ALRHLSSEIIQARFHKANLTCRYYNPAIHTAAFALPQYLHDALSAP
>Mature_285_residues
ADNPLWHETLHDHFGQYFSVDNVLYHEKTDHQDLIIFDNRAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGNAKHV
LIIGGGDGAMLREVSRHRSIETITMVEIDAGVVSFSRQYLPNHNAGAYDDPRFTLVIDDGVNFVNQTTQTFDVIISDCTD
PIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEAVGSHRKLSHYFRDVSFYQAAIPTYYGGIMTFAWASDNEA
LRHLSSEIIQARFHKANLTCRYYNPAIHTAAFALPQYLHDALSAP

Specific function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor [H]

COG id: COG0421

COG function: function code E; Spermidine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the spermidine/spermine synthase family [H]

Homologues:

Organism=Homo sapiens, GI63253298, Length=280, Percent_Identity=37.5, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1786312, Length=285, Percent_Identity=88.0701754385965, Blast_Score=539, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25154106, Length=279, Percent_Identity=40.8602150537634, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI212645616, Length=328, Percent_Identity=35.0609756097561, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323175, Length=283, Percent_Identity=38.86925795053, Blast_Score=211, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6325326, Length=272, Percent_Identity=37.1323529411765, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24645443, Length=267, Percent_Identity=38.5767790262172, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21355941, Length=215, Percent_Identity=36.7441860465116, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001045 [H]

Pfam domain/function: PF01564 Spermine_synth [H]

EC number: =2.5.1.16 [H]

Molecular weight: Translated: 32178; Mature: 32047

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01330 SPERMIDINE_SYNTHASE_1 ; PS51006 SPERMIDINE_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNPLWHETLHDHFGQYFSVDNVLYHEKTDHQDLIIFDNRAFGRVMALDGVVQTTERDE
CCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEECCCCCCEEEECCCHHHCCCCHH
FIYHEMMTHVPLLAHGNAKHVLIIGGGDGAMLREVSRHRSIETITMVEIDAGVVSFSRQY
HHHHHHHHHCCEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHHH
LPNHNAGAYDDPRFTLVIDDGVNFVNQTTQTFDVIISDCTDPIGPGESLFTSAFYEGCKR
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
CLNPGGIFVAQNGVCFLQQDEAVGSHRKLSHYFRDVSFYQAAIPTYYGGIMTFAWASDNE
HCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
ALRHLSSEIIQARFHKANLTCRYYNPAIHTAAFALPQYLHDALSAP
HHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADNPLWHETLHDHFGQYFSVDNVLYHEKTDHQDLIIFDNRAFGRVMALDGVVQTTERDE
CCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEECCCCCCEEEECCCHHHCCCCHH
FIYHEMMTHVPLLAHGNAKHVLIIGGGDGAMLREVSRHRSIETITMVEIDAGVVSFSRQY
HHHHHHHHHCCEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHHH
LPNHNAGAYDDPRFTLVIDDGVNFVNQTTQTFDVIISDCTDPIGPGESLFTSAFYEGCKR
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
CLNPGGIFVAQNGVCFLQQDEAVGSHRKLSHYFRDVSFYQAAIPTYYGGIMTFAWASDNE
HCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
ALRHLSSEIIQARFHKANLTCRYYNPAIHTAAFALPQYLHDALSAP
HHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA