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The map label for this gene is pdxA [H]

Identifier: 238893025

GI number: 238893025

Start: 838157

End: 839146

Strand: Reverse

Name: pdxA [H]

Synonym: KP1_0862

Alternate gene names: 238893025

Gene position: 839146-838157 (Counterclockwise)

Preceding gene: 238893026

Following gene: 238893024

Centisome position: 15.99

GC content: 58.79

Gene sequence:

>990_bases
ATGCCTGAAACCCGTAAAGTTGTTATCACTCCCGGCGAACCCGCCGGGATTGGCCCTGACCTGGTCGTGCAGCTTGCCCA
GCGCGACTGGCCAGTTGAGCTGGTGATTTGCGCCGATGGCGCCCTGTTAACTGACCGAGCCAAGCGGCTCGGTCTTCCTT
TATCTCTCCTCCCTTACGATCCCGCGCAACCTCCTGTTCCTCAGCGCACCGGTACCCTGACGCTGCTGAACGTGCCGCTA
AACGTCCCGGCGGAGCCCGGCGTGCTGAATGTGCAAAACGGCGCCTACGTAGTGGAGACGCTGGCGCGCGCCTGCGACGG
TTGCCTTAGCGGCGAGTTTGCGGCGTTAGTGACCGGCCCGGTGCATAAAGGCAACATCAACGACGCCGGTATCGCCTTTA
CCGGTCATACCGAGTTCTTTGAAGAGCGCGCGAAGGCCAGCAAAGTGGTGATGATGTTGGCGACCGAGGAGCTGCGGGTG
GCGCTGGTCACCACCCATCTGCCGTTGAAAGCCATCAGCGAAGCGATTACCCCCGAGCTACTGCGCGAGATCATCACCAT
TCTCGATCACGACCTGCGCACGAAATTTGGCATTGCCCAGCCGCATGTGCTGGTTTGCGGGCTTAACCCGCACGCTGGCG
AAGGCGGCCATATGGGAACAGAAGAGATAGACACCATCATTCCGGTGCTGGAAGAGATGCGCGCAAAGGGGATGAACCTC
AGCGGTCCGCTGCCGGCAGACACCCTCTTTCAGCCGAAATATCTTGATCATGCCGATGCGGTACTCGCGATGTACCACGA
TCAGGGCCTGCCCGTGCTAAAATACCAGGGCTTTGGCCGCGGCGTGAACATTACGCTCGGTTTACCTTTTATTCGTACCT
CCGTCGACCACGGCACCGCACTGGAATTAGCGGGTCAGGGAAAAGCGGACGTCGGCAGTTTTATCACGGCGCTTAATCTC
GCCATCAAAATGATTGTTAATACCCAATGA

Upstream 100 bases:

>100_bases
ACCGCATGCTGATGAACCGCAAATTCTCTGAAGAAGCGGCAACCTGGATGCAGGAACAGCGCGCCAGTGCGTATGTTAAA
ATTCTGAGCAACTAATATCG

Downstream 100 bases:

>100_bases
ATAATCGAGTCCATCAGGGCCATTTAGCCCGTAAACGCTTCGGGCAGAACTTCCTCAACGATCAGTTTGTGATCGACAGC
ATCGTCTCGGCGATTAACCC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MPETRKVVITPGEPAGIGPDLVVQLAQRDWPVELVICADGALLTDRAKRLGLPLSLLPYDPAQPPVPQRTGTLTLLNVPL
NVPAEPGVLNVQNGAYVVETLARACDGCLSGEFAALVTGPVHKGNINDAGIAFTGHTEFFEERAKASKVVMMLATEELRV
ALVTTHLPLKAISEAITPELLREIITILDHDLRTKFGIAQPHVLVCGLNPHAGEGGHMGTEEIDTIIPVLEEMRAKGMNL
SGPLPADTLFQPKYLDHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGQGKADVGSFITALNL
AIKMIVNTQ

Sequences:

>Translated_329_residues
MPETRKVVITPGEPAGIGPDLVVQLAQRDWPVELVICADGALLTDRAKRLGLPLSLLPYDPAQPPVPQRTGTLTLLNVPL
NVPAEPGVLNVQNGAYVVETLARACDGCLSGEFAALVTGPVHKGNINDAGIAFTGHTEFFEERAKASKVVMMLATEELRV
ALVTTHLPLKAISEAITPELLREIITILDHDLRTKFGIAQPHVLVCGLNPHAGEGGHMGTEEIDTIIPVLEEMRAKGMNL
SGPLPADTLFQPKYLDHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGQGKADVGSFITALNL
AIKMIVNTQ
>Mature_328_residues
PETRKVVITPGEPAGIGPDLVVQLAQRDWPVELVICADGALLTDRAKRLGLPLSLLPYDPAQPPVPQRTGTLTLLNVPLN
VPAEPGVLNVQNGAYVVETLARACDGCLSGEFAALVTGPVHKGNINDAGIAFTGHTEFFEERAKASKVVMMLATEELRVA
LVTTHLPLKAISEAITPELLREIITILDHDLRTKFGIAQPHVLVCGLNPHAGEGGHMGTEEIDTIIPVLEEMRAKGMNLS
GPLPADTLFQPKYLDHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGQGKADVGSFITALNLA
IKMIVNTQ

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=82.370820668693, Blast_Score=551, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35134; Mature: 35003

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETRKVVITPGEPAGIGPDLVVQLAQRDWPVELVICADGALLTDRAKRLGLPLSLLPYD
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCEEECCCC
PAQPPVPQRTGTLTLLNVPLNVPAEPGVLNVQNGAYVVETLARACDGCLSGEFAALVTGP
CCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCHHCCCCEEEEEECC
VHKGNINDAGIAFTGHTEFFEERAKASKVVMMLATEELRVALVTTHLPLKAISEAITPEL
CCCCCCCCCCEEEECCHHHHHHHHHHHEEEEEEECCCEEEEEEEECCCHHHHHHHCCHHH
LREIITILDHDLRTKFGIAQPHVLVCGLNPHAGEGGHMGTEEIDTIIPVLEEMRAKGMNL
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
SGPLPADTLFQPKYLDHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA
CCCCCCCCCCCCCCCCCHHHEEEEEECCCCCEEEECCCCCCEEEEEECCHHEECCCCCCE
LELAGQGKADVGSFITALNLAIKMIVNTQ
EEECCCCCCHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
PETRKVVITPGEPAGIGPDLVVQLAQRDWPVELVICADGALLTDRAKRLGLPLSLLPYD
CCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCEEECCCC
PAQPPVPQRTGTLTLLNVPLNVPAEPGVLNVQNGAYVVETLARACDGCLSGEFAALVTGP
CCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCHHCCCCEEEEEECC
VHKGNINDAGIAFTGHTEFFEERAKASKVVMMLATEELRVALVTTHLPLKAISEAITPEL
CCCCCCCCCCEEEECCHHHHHHHHHHHEEEEEEECCCEEEEEEEECCCHHHHHHHCCHHH
LREIITILDHDLRTKFGIAQPHVLVCGLNPHAGEGGHMGTEEIDTIIPVLEEMRAKGMNL
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
SGPLPADTLFQPKYLDHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA
CCCCCCCCCCCCCCCCCHHHEEEEEECCCCCEEEECCCCCCEEEEEECCHHEECCCCCCE
LELAGQGKADVGSFITALNLAIKMIVNTQ
EEECCCCCCHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA