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The map label for this gene is ybiC [C]

Identifier: 238892924

GI number: 238892924

Start: 732293

End: 733309

Strand: Direct

Name: ybiC [C]

Synonym: KP1_0749

Alternate gene names: 238892924

Gene position: 732293-733309 (Clockwise)

Preceding gene: 238892923

Following gene: 238892926

Centisome position: 13.95

GC content: 64.9

Gene sequence:

>1017_bases
ATGGAGTCGGTAACTCTATCGTTACCTGAAGCTTATGACCTGGCGCTGGAGGTACTCAGCGCCAATGGATTTAGCGCCGA
CCACGCGGCGGCGATTGCCCGCAATGTGACCGCCGGGGAGCGCGACGGCTGCGCTTCCCACGGCCTGTGGCGGCTGTTGG
GCATTGTCGATACCCTGCGCAAAGGTAAGGTATCGCCCGATGCCGAGCCGCAGATCCATGACCAGGCGCCGGGGATTGCG
CGGGCGGACGCCGGGGGCGCTTTTTCACTGCTGGCCTACGAGCGCGCGCTGCCGCTGCTGCTGGAGAAGGCGCGCCACAA
TGGCATTGCGGCGCTGGCAATTAATCGCTGCGTTCATTTTTCCGCGCTGTTTGCCGATATTGAGCCGTTGACCGAGGCAG
GGCTGGTAGGGCTAGCCTGTACGCCAAGCCACGCCTGGGTCGCCCCGGCGGGCGGCACACGTCCGCTGTTCGGCACCAAC
CCCATCGCCTTCGGCTGGCCGCGGCAGGATAAGCCGCCATTTATTGTTGATATGGCGACCAGCGCTGCGGCGCGCGGCGA
GATCCAGCTGCATCAGCGCAGCGGCAAAGCGCTACCGGAAGGCTGGGGAATCGACAGTCAGGGACAGCCAACGACCGATG
CCGCAGAGGTGCTGAACGGCGCGATGTTGACTTTCGGCGGCCATAAGGGCTCGGCGCTGGCGGCAATGGTTGAGCTGTTG
GCCGGGCCGCTTATCGGCGATATGACCAGCGCCGAATCGCTGGCGTGGGATAACGGCGCGGGCGGTCTCCCCTACGGCGG
CGAGCTGATTCTGGCGCTGGATCCGCAGCGTTTTCTCGGCGCGCAGGCACCAGAGCAGCTGGCGCGCGCCGAAACGCTGT
TCATGGGTATGCAGGAACAAGGGGCGCGTCTACCGGGCGAGCGGCGTTTTGCCTGCCGCCAGCAGAGTGAACGGCAGGGG
GTCATTATCAGTCGTTCATTGCATGATGAGATTTGCGCCTTGCGCCGGGGCGGGTAA

Upstream 100 bases:

>100_bases
GGATGGCGGCGATGTCGTAGGGGATTTACTACTGGGGCGCGCGCAGCTGCCTGCCGCAGGCTAACTTTAGCGGAGACGAA
GAAGAGTAAAGGAGAACAGT

Downstream 100 bases:

>100_bases
GGCGCGAAGCGCCGCTACCCGGATGCCTGTCAAAACAGCGTGTCGAGCTCGTCCAGCACGTTGTAGTCGTCATCGACCAG
CAGCAACGTCTTCCACTTAT

Product: putative dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MESVTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLRKGKVSPDAEPQIHDQAPGIA
RADAGGAFSLLAYERALPLLLEKARHNGIAALAINRCVHFSALFADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTN
PIAFGWPRQDKPPFIVDMATSAAARGEIQLHQRSGKALPEGWGIDSQGQPTTDAAEVLNGAMLTFGGHKGSALAAMVELL
AGPLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLGAQAPEQLARAETLFMGMQEQGARLPGERRFACRQQSERQG
VIISRSLHDEICALRRGG

Sequences:

>Translated_338_residues
MESVTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLRKGKVSPDAEPQIHDQAPGIA
RADAGGAFSLLAYERALPLLLEKARHNGIAALAINRCVHFSALFADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTN
PIAFGWPRQDKPPFIVDMATSAAARGEIQLHQRSGKALPEGWGIDSQGQPTTDAAEVLNGAMLTFGGHKGSALAAMVELL
AGPLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLGAQAPEQLARAETLFMGMQEQGARLPGERRFACRQQSERQG
VIISRSLHDEICALRRGG
>Mature_338_residues
MESVTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLRKGKVSPDAEPQIHDQAPGIA
RADAGGAFSLLAYERALPLLLEKARHNGIAALAINRCVHFSALFADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTN
PIAFGWPRQDKPPFIVDMATSAAARGEIQLHQRSGKALPEGWGIDSQGQPTTDAAEVLNGAMLTFGGHKGSALAAMVELL
AGPLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLGAQAPEQLARAETLFMGMQEQGARLPGERRFACRQQSERQG
VIISRSLHDEICALRRGG

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=330, Percent_Identity=29.6969696969697, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786727, Length=276, Percent_Identity=27.8985507246377, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790000, Length=326, Percent_Identity=24.8466257668712, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17507179, Length=287, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17536633, Length=284, Percent_Identity=26.056338028169, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667904, Length=283, Percent_Identity=28.9752650176678, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667908, Length=283, Percent_Identity=28.9752650176678, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45553211, Length=283, Percent_Identity=28.9752650176678, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667912, Length=283, Percent_Identity=28.9752650176678, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24648360, Length=283, Percent_Identity=29.6819787985866, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24658010, Length=308, Percent_Identity=24.025974025974, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 35548; Mature: 35548

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLR
CCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KGKVSPDAEPQIHDQAPGIARADAGGAFSLLAYERALPLLLEKARHNGIAALAINRCVHF
HCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
SALFADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTNPIAFGWPRQDKPPFIVDMAT
HHHHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCEEEEECC
SAAARGEIQLHQRSGKALPEGWGIDSQGQPTTDAAEVLNGAMLTFGGHKGSALAAMVELL
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHHH
AGPLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLGAQAPEQLARAETLFMGMQEQ
HCCHHCCCCCHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHCHHHH
GARLPGERRFACRQQSERQGVIISRSLHDEICALRRGG
CCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCC
>Mature Secondary Structure
MESVTLSLPEAYDLALEVLSANGFSADHAAAIARNVTAGERDGCASHGLWRLLGIVDTLR
CCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KGKVSPDAEPQIHDQAPGIARADAGGAFSLLAYERALPLLLEKARHNGIAALAINRCVHF
HCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
SALFADIEPLTEAGLVGLACTPSHAWVAPAGGTRPLFGTNPIAFGWPRQDKPPFIVDMAT
HHHHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCEEEEECC
SAAARGEIQLHQRSGKALPEGWGIDSQGQPTTDAAEVLNGAMLTFGGHKGSALAAMVELL
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHHH
AGPLIGDMTSAESLAWDNGAGGLPYGGELILALDPQRFLGAQAPEQLARAETLFMGMQEQ
HCCHHCCCCCHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHCHHHH
GARLPGERRFACRQQSERQGVIISRSLHDEICALRRGG
CCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]