Click here to switch to the map view.

The map label for this gene is fimB [H]

Identifier: 238892790

GI number: 238892790

Start: 587739

End: 588329

Strand: Direct

Name: fimB [H]

Synonym: KP1_0596

Alternate gene names: 238892790

Gene position: 587739-588329 (Clockwise)

Preceding gene: 238892786

Following gene: 238892791

Centisome position: 11.2

GC content: 54.82

Gene sequence:

>591_bases
ATGCCAGTAAAACGAAAACACCTTACACGCCAGGAAGTGGGGCAGATACTGCTTGCAGCGGACCGAGGGATCCATTTCGA
GCGCGATTACTGCCTCATCCAGATGTGTTTTTTACACGGTCTGCGCGTCAGTGAGCTGTGTGGAATGCGCCTGTCGGATA
TCGATTTGGTCGGACGCTCGGTGTATATCAGGCGACTCAAAAACAGCCTGTCCACGCAGCATCCGCTGTTCGATGCTGAA
CTGCCCGCGTTGATGCGTTGGCTAAAGGTGCGCCGCCGCTGGCGGGAGGCAGACAGCGACTGGCTTTTTTTGTCGCAGAA
AGGGGGTCCACTGTCGCGCCATCAGGTCAGGTTATTGCTCAGACGTTACGGCGAACTGGGTGGGATCAGCATTCCCGCGT
ATCCGCATATGCTGAGACACGGATGCGGTTACGCGCTGGCGGACCTGGGGCGTGATACCCGTCTGATACAGGATTATCTG
GGGCACCGGAACATCCGGCATACGGTGATTTATACGGCGACAAATACGCAGAGGTTTATGAATGTCTGGGGGAACATGAG
AGAAAACCACACAATTAGTGCCAGAATGTAA

Upstream 100 bases:

>100_bases
TTGGGCTTTCTGGTAGTATTCTCTGGTCCAGGCCGGGCTACGAAAGTGGTTCCGGCCTGTTTTTTTCTTCATTGTTTATT
GTGTTTAAGGAGCAAGGCTT

Downstream 100 bases:

>100_bases
AGTAGTATCAGAAAAATTTAGCAAAGTGTCAAAATTTTTCTGAGACCCCTTTAGGTTACGGATTATCTCGCTGTTTTTAA
ATAATTTATCTGCGCGAATA

Product: recombinase involved in phase variation

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MPVKRKHLTRQEVGQILLAADRGIHFERDYCLIQMCFLHGLRVSELCGMRLSDIDLVGRSVYIRRLKNSLSTQHPLFDAE
LPALMRWLKVRRRWREADSDWLFLSQKGGPLSRHQVRLLLRRYGELGGISIPAYPHMLRHGCGYALADLGRDTRLIQDYL
GHRNIRHTVIYTATNTQRFMNVWGNMRENHTISARM

Sequences:

>Translated_196_residues
MPVKRKHLTRQEVGQILLAADRGIHFERDYCLIQMCFLHGLRVSELCGMRLSDIDLVGRSVYIRRLKNSLSTQHPLFDAE
LPALMRWLKVRRRWREADSDWLFLSQKGGPLSRHQVRLLLRRYGELGGISIPAYPHMLRHGCGYALADLGRDTRLIQDYL
GHRNIRHTVIYTATNTQRFMNVWGNMRENHTISARM
>Mature_195_residues
PVKRKHLTRQEVGQILLAADRGIHFERDYCLIQMCFLHGLRVSELCGMRLSDIDLVGRSVYIRRLKNSLSTQHPLFDAEL
PALMRWLKVRRRWREADSDWLFLSQKGGPLSRHQVRLLLRRYGELGGISIPAYPHMLRHGCGYALADLGRDTRLIQDYLG
HRNIRHTVIYTATNTQRFMNVWGNMRENHTISARM

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=184, Percent_Identity=53.2608695652174, Blast_Score=214, Evalue=4e-57,
Organism=Escherichia coli, GI1790768, Length=181, Percent_Identity=49.7237569060773, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1789261, Length=180, Percent_Identity=32.7777777777778, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790244, Length=156, Percent_Identity=30.1282051282051, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 22962; Mature: 22831

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKRKHLTRQEVGQILLAADRGIHFERDYCLIQMCFLHGLRVSELCGMRLSDIDLVGRS
CCCCHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHH
VYIRRLKNSLSTQHPLFDAELPALMRWLKVRRRWREADSDWLFLSQKGGPLSRHQVRLLL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
RRYGELGGISIPAYPHMLRHGCGYALADLGRDTRLIQDYLGHRNIRHTVIYTATNTQRFM
HHHCCCCCCCCCCHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHH
NVWGNMRENHTISARM
HHHCCCCCCCEEECCC
>Mature Secondary Structure 
PVKRKHLTRQEVGQILLAADRGIHFERDYCLIQMCFLHGLRVSELCGMRLSDIDLVGRS
CCCHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHH
VYIRRLKNSLSTQHPLFDAELPALMRWLKVRRRWREADSDWLFLSQKGGPLSRHQVRLLL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHH
RRYGELGGISIPAYPHMLRHGCGYALADLGRDTRLIQDYLGHRNIRHTVIYTATNTQRFM
HHHCCCCCCCCCCHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHH
NVWGNMRENHTISARM
HHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]