Click here to switch to the map view.

The map label for this gene is melR [H]

Identifier: 238892592

GI number: 238892592

Start: 378321

End: 379259

Strand: Reverse

Name: melR [H]

Synonym: KP1_0370

Alternate gene names: 238892592

Gene position: 379259-378321 (Counterclockwise)

Preceding gene: 238892597

Following gene: 238892590

Centisome position: 7.23

GC content: 58.57

Gene sequence:

>939_bases
ATGGAACACCGCTTCACCTCTCTGCCCCCCGATCCCTTTATGTGCAGCAGCGACGAAAAGCAGAGCCGCAGCCCGCTGGC
GCTCTACTCCGAGTATCAGCGTATGGATATCGAACTGCGCCCGCCGCACGCCATGCCCACCAGCCACTGGCACGGCCAGG
TGGAGGTCAACGTGCCGTTCGATGGCGACGTGGAGTATTTGATTAATAACGAAGTGGTGCGCATTGAGAAAGGCTATATC
ACTCTGTTCTGGGCCTGTACGCCGCATCAGCTGACCCGCCCCGGCGATTGCCAGCAGATGGCGATATTCAACCTACCGAT
GCATCTGTTTCTCTCATGGCCGCTGGACCGGGAGCTTATCAACCACGTCACCCATGGGATGGTGATTAAATCCCTCGCTG
CGCAGCAGTTGAGCGCCTTCGAAGTGCGCCGCTGGCAGCAGGAACTGAGCCACGAGAATGAACAGATACGCCAGCTGGCG
ATCGATGAAATCGCCCTGATGCTGAAGCGGCTGAGCCTCGCCGGCTGGCAGCCGATTCTGGTCAATAAAACCTCACGCAC
CCACAAGAACAGCGTCTCGCGCCACGCGCAGTTTTATGTCAGCCAGATGCTGGAGTTTATCGCTGCCCACTACGACCAGG
CGCTGACCGTCAATGCCGTTGCCGAGCACGTGAAGCTCAACCCGAACTATGCGATGGGGGTCTTTCAGCGGGTGATGCAG
CAGACCATGAAGCAGTACATTACCGCCATGCGTATCAATCATGTGCGGGCGCTGCTGAGCGATACCGACAAGACCATCCT
GGATATTGCCCTTACCGCCGGTTTTCGCTCCAGCAGCCGCTTCTACAGCACCTTTACCCGTTACGTGGGCATGCCGCCGC
AGCAGTACCGTAAACTCAGCCAGCAGCGGCGTCACGGCCTGGCCTTGCCGAAGGCATAA

Upstream 100 bases:

>100_bases
TTGAGCAAAAAGGAGAGAAAATGGGCCGATTCTTCCGCTAAGCTGTCGTCAGTTCTGGCGAAAAATGCAGCCACTCTGAC
AATTCAGGAATACGCTAACG

Downstream 100 bases:

>100_bases
AAAATGCCGCCGGGGTTTCCCCAGGCGGCATGATTAACAGTGAAAACGGTTAGTCGTTGATACGCGGATGCTGCTGCACC
AGACGCGACCGTTTTGCCTG

Product: DNA-binding transcriptional regulator MelR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEHRFTSLPPDPFMCSSDEKQSRSPLALYSEYQRMDIELRPPHAMPTSHWHGQVEVNVPFDGDVEYLINNEVVRIEKGYI
TLFWACTPHQLTRPGDCQQMAIFNLPMHLFLSWPLDRELINHVTHGMVIKSLAAQQLSAFEVRRWQQELSHENEQIRQLA
IDEIALMLKRLSLAGWQPILVNKTSRTHKNSVSRHAQFYVSQMLEFIAAHYDQALTVNAVAEHVKLNPNYAMGVFQRVMQ
QTMKQYITAMRINHVRALLSDTDKTILDIALTAGFRSSSRFYSTFTRYVGMPPQQYRKLSQQRRHGLALPKA

Sequences:

>Translated_312_residues
MEHRFTSLPPDPFMCSSDEKQSRSPLALYSEYQRMDIELRPPHAMPTSHWHGQVEVNVPFDGDVEYLINNEVVRIEKGYI
TLFWACTPHQLTRPGDCQQMAIFNLPMHLFLSWPLDRELINHVTHGMVIKSLAAQQLSAFEVRRWQQELSHENEQIRQLA
IDEIALMLKRLSLAGWQPILVNKTSRTHKNSVSRHAQFYVSQMLEFIAAHYDQALTVNAVAEHVKLNPNYAMGVFQRVMQ
QTMKQYITAMRINHVRALLSDTDKTILDIALTAGFRSSSRFYSTFTRYVGMPPQQYRKLSQQRRHGLALPKA
>Mature_312_residues
MEHRFTSLPPDPFMCSSDEKQSRSPLALYSEYQRMDIELRPPHAMPTSHWHGQVEVNVPFDGDVEYLINNEVVRIEKGYI
TLFWACTPHQLTRPGDCQQMAIFNLPMHLFLSWPLDRELINHVTHGMVIKSLAAQQLSAFEVRRWQQELSHENEQIRQLA
IDEIALMLKRLSLAGWQPILVNKTSRTHKNSVSRHAQFYVSQMLEFIAAHYDQALTVNAVAEHVKLNPNYAMGVFQRVMQ
QTMKQYITAMRINHVRALLSDTDKTILDIALTAGFRSSSRFYSTFTRYVGMPPQQYRKLSQQRRHGLALPKA

Specific function: Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790559, Length=294, Percent_Identity=86.734693877551, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI171474011, Length=276, Percent_Identity=22.1014492753623, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008917
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 36190; Mature: 36190

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHRFTSLPPDPFMCSSDEKQSRSPLALYSEYQRMDIELRPPHAMPTSHWHGQVEVNVPF
CCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCEEEEECCC
DGDVEYLINNEVVRIEKGYITLFWACTPHQLTRPGDCQQMAIFNLPMHLFLSWPLDRELI
CCCCCEEECCCEEEEECCEEEEEEEECCCCCCCCCCCCHHHHHCCCHHHEEECCCCHHHH
NHVTHGMVIKSLAAQQLSAFEVRRWQQELSHENEQIRQLAIDEIALMLKRLSLAGWQPIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VNKTSRTHKNSVSRHAQFYVSQMLEFIAAHYDQALTVNAVAEHVKLNPNYAMGVFQRVMQ
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHH
QTMKQYITAMRINHVRALLSDTDKTILDIALTAGFRSSSRFYSTFTRYVGMPPQQYRKLS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
QQRRHGLALPKA
HHHHCCCCCCCC
>Mature Secondary Structure
MEHRFTSLPPDPFMCSSDEKQSRSPLALYSEYQRMDIELRPPHAMPTSHWHGQVEVNVPF
CCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCEEEEECCC
DGDVEYLINNEVVRIEKGYITLFWACTPHQLTRPGDCQQMAIFNLPMHLFLSWPLDRELI
CCCCCEEECCCEEEEECCEEEEEEEECCCCCCCCCCCCHHHHHCCCHHHEEECCCCHHHH
NHVTHGMVIKSLAAQQLSAFEVRRWQQELSHENEQIRQLAIDEIALMLKRLSLAGWQPIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VNKTSRTHKNSVSRHAQFYVSQMLEFIAAHYDQALTVNAVAEHVKLNPNYAMGVFQRVMQ
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHH
QTMKQYITAMRINHVRALLSDTDKTILDIALTAGFRSSSRFYSTFTRYVGMPPQQYRKLS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
QQRRHGLALPKA
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]