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The map label for this gene is hemF [H]

Identifier: 238028185

GI number: 238028185

Start: 3002743

End: 3003666

Strand: Direct

Name: hemF [H]

Synonym: bglu_1g26370

Alternate gene names: 238028185

Gene position: 3002743-3003666 (Clockwise)

Preceding gene: 238028184

Following gene: 238028186

Centisome position: 76.87

GC content: 69.81

Gene sequence:

>924_bases
ATGACCAGCGATTCGAATTTCGACGTCAACCGTGTGCGCGCCTACCTCGAGGCGCTGCAAACCCGCATCGCCGACGCGCT
CGGCGCATTCGACGGCATCCCGCTCGCCAGCCACGCCTGGCAGCGCGGGCCCGAGGAGCGCCTGCGCGGCGGCGGCTGCA
CGCGCATTCTCGAGAACGGCCGGTTCTTCGAGCGTGCCGGGATCGGCTTCTCGGCCGTGGCCGGCGACGCGCTGCCGCCG
TCCGCGAGCGCGGCGCGCCCGCAGCTCGCGGGGCGCGGCTTCGAGGCGCTCGGCGTGTCGCTGGTGCTGCATCCGCGCAA
TCCGTACTGCCCCACCGTCCACATGAACGTGCGCATGTTCGTGGCGACCAAGGCCGGCGAGGCGCCGGTGTTCTGGTTCG
GCGGCGGCATGGACCTGACGCCGTTCTATCCCGACGAGGACGACGCGCGCCACTTCCACCGCGCTTGCCGCGACGCGCTC
GCACCGTTCGGCGCCGAGCTCTATCCGCGCTACAAAGCGTGGTGCGACGAGTATTTCTTCCTCAAGCACCGCAACGAGAC
GCGCGGCATCGGCGGAATCTTCTTCGACGATCTGTCGGAGCCGGGCTTCGAGCGCTCGTTCGCGTTGATGCAAAGCGTCG
GCGACGCCTTCTTGGGCGCCTATCTGCCGATCGTCGAACGCCACCGCGACACGCCGTATGGCGAGCGCGAGCGCGACTTC
CAGGCTTACCGGCGCGGCCGCTACGTCGAATTCAACCTGGTGTTCGACCGCGGCACGCTGTTCGGCCTGCAAAGCGGCGG
GCGCACCGAGTCGATCCTGATGTCGATGCCGCCCGCCGCGAGCTGGCGCTACGACTGGCAGCCCGAGCCGGGCACGCCCG
AGGCGCGCCTCGGCGAATTCCTGGTGCCGCGCGAATGGCTGTGA

Upstream 100 bases:

>100_bases
CAAGCCGGGCGCGCCGGCCGAAAGGTCTACAATCGCGGCAATCGGCCCGAGCCGGAGCCGACCGAGCCAGCAGACATCAG
CGCGCCCTCTTTCCGACCCC

Downstream 100 bases:

>100_bases
GCCGCCCGCCGGCGCCCGCTGGCGCCGGCTTCGACCCGAAGGAACGCGATCTGGACACGCAAGCCCGACCGACCCCGCTG
GCGCGCCGCATCGGCATCCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTSDSNFDVNRVRAYLEALQTRIADALGAFDGIPLASHAWQRGPEERLRGGGCTRILENGRFFERAGIGFSAVAGDALPP
SASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMFVATKAGEAPVFWFGGGMDLTPFYPDEDDARHFHRACRDAL
APFGAELYPRYKAWCDEYFFLKHRNETRGIGGIFFDDLSEPGFERSFALMQSVGDAFLGAYLPIVERHRDTPYGERERDF
QAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPAASWRYDWQPEPGTPEARLGEFLVPREWL

Sequences:

>Translated_307_residues
MTSDSNFDVNRVRAYLEALQTRIADALGAFDGIPLASHAWQRGPEERLRGGGCTRILENGRFFERAGIGFSAVAGDALPP
SASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMFVATKAGEAPVFWFGGGMDLTPFYPDEDDARHFHRACRDAL
APFGAELYPRYKAWCDEYFFLKHRNETRGIGGIFFDDLSEPGFERSFALMQSVGDAFLGAYLPIVERHRDTPYGERERDF
QAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPAASWRYDWQPEPGTPEARLGEFLVPREWL
>Mature_306_residues
TSDSNFDVNRVRAYLEALQTRIADALGAFDGIPLASHAWQRGPEERLRGGGCTRILENGRFFERAGIGFSAVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMFVATKAGEAPVFWFGGGMDLTPFYPDEDDARHFHRACRDALA
PFGAELYPRYKAWCDEYFFLKHRNETRGIGGIFFDDLSEPGFERSFALMQSVGDAFLGAYLPIVERHRDTPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPAASWRYDWQPEPGTPEARLGEFLVPREWL

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=312, Percent_Identity=42.9487179487179, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1788777, Length=300, Percent_Identity=62, Blast_Score=387, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320249, Length=319, Percent_Identity=44.2006269592476, Blast_Score=266, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17864388, Length=312, Percent_Identity=44.5512820512821, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34547; Mature: 34416

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDSNFDVNRVRAYLEALQTRIADALGAFDGIPLASHAWQRGPEERLRGGGCTRILENG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCCHHHHHHCC
RFFERAGIGFSAVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMF
CEEECCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEE
VATKAGEAPVFWFGGGMDLTPFYPDEDDARHFHRACRDALAPFGAELYPRYKAWCDEYFF
EEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
LKHRNETRGIGGIFFDDLSEPGFERSFALMQSVGDAFLGAYLPIVERHRDTPYGERERDF
EEECCCCCCCCCEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
QAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPAASWRYDWQPEPGTPEARLGEF
HHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCC
LVPREWL
CCCCCCC
>Mature Secondary Structure 
TSDSNFDVNRVRAYLEALQTRIADALGAFDGIPLASHAWQRGPEERLRGGGCTRILENG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCCHHHHHHCC
RFFERAGIGFSAVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMF
CEEECCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEE
VATKAGEAPVFWFGGGMDLTPFYPDEDDARHFHRACRDALAPFGAELYPRYKAWCDEYFF
EEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
LKHRNETRGIGGIFFDDLSEPGFERSFALMQSVGDAFLGAYLPIVERHRDTPYGERERDF
EEECCCCCCCCCEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
QAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPAASWRYDWQPEPGTPEARLGEF
HHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCC
LVPREWL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA