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The map label for this gene is purD [H]

Identifier: 238028184

GI number: 238028184

Start: 3001302

End: 3002579

Strand: Direct

Name: purD [H]

Synonym: bglu_1g26360

Alternate gene names: 238028184

Gene position: 3001302-3002579 (Clockwise)

Preceding gene: 238028183

Following gene: 238028185

Centisome position: 76.83

GC content: 68.31

Gene sequence:

>1278_bases
ATGAAACTACTCGTCGTCGGTTCCGGCGGCCGCGAACACGCGCTCGCCTGGAAACTCGCCCAGTCGCCGCGCGTCCAGAC
CGTCTACGTTGCACCCGGCAACGGCGGCACCGCGCAGGACGCGCGCCTGAAGAACATCGAACTGAGCTCGCTCGACGACC
TGGCCGATTTCGCCGAGGCCGAGCAGGTGGCGTTCACGCTGGTCGGCCCGGAAGCACCGCTGGCCGCCGGCATCGTCAAC
CATTTCCGCTCGCGCGGCCTGAAAGTGTTCGGCCCGACCCGCGAAGCCGCCCAGCTCGAAAGCTCGAAGGACTTCGCCAA
GGCGTTCATGAAGCGCCACGGCATTCCGACCGCCGAATACGAAACCTTCACCGACGCGGCCGCCGCGCACGCCTATCTCG
ACGCCAAGGGCGCGCCGATCGTGGTCAAGGCCGACGGCCTCGCGGCCGGCAAGGGTGTGGTGGTGGCGATGTCGCTGGAA
GAAGCGCACGAGGCGGTCGACATGATGCTGTCGGGCAACAAGCTCGGCGATGCCGGCGCGCGCGTCGTGATCGAGGAATT
CCTCGACGGCGAGGAAGCCAGCTTCATCGTGATGGTGGACGGCAAGCACGCGCTCGCGCTGGCCTCGAGCCAGGACCACA
AGCGCCTGCTCGACGGCGACCGCGGCCCCAACACGGGCGGCATGGGCGCCTATTCGCCGGCCCCGATCATCACGCCGCAG
ATGCATGCGCGCGTGATGCGCGAGATCATCATGCCGACCGTGCGCGGCATGGAGAACGACGGCATCCGCTTCACCGGCTT
CCTGTATGCGGGCCTGATGATCGACAAGGACGGCAATCCGCGCACGCTCGAGTTCAATTGCCGGATGGGCGACCCGGAAA
CGCAGCCGATCATGGCGCGCCTGAAGAGCGACTTCTCGAAGGTGGTCGAGCAGGCGATCGCCGGCACGCTCGACACCGTC
GAGCTCGACTGGGACCGCCGCACCGCGCTCGGCGTGGTGCTGGCCGCGCACGGCTACCCCGACACGCCGCGCAAGGGCGA
CCGGATCAACGGCGTGCCCGAGGAAACCGCGCACGCGGTGACGTTCCACGCCGGCACCAGGTTCGACGGCGACAAGCTCG
TCACCTCGGGCGGCCGCGTGCTGTGCGTGGTCGGGCTGTCCGATTCGGTACGCGGCGCGCAGCAGGCGGCCTACGATGCG
ATCAACCAGATCAACTTCGAGGGCATGCAGTATCGCCGCGACATCGGCCACCGCGCGCTCGCCCGCAAGCAGGGTTGA

Upstream 100 bases:

>100_bases
CCGGTCCGTCTTTCGGGTGAAGGGCGGCCGGCGTCAGGTTTCGCGGCCGGCCCGCCCAAGGCGCGCCGGCCGCCCCATTT
TCTAGCCTGCGGGGAATCCC

Downstream 100 bases:

>100_bases
GGCGCCGAGCCGCCGCCCGGCGCGCCCGCGTGCGCCCGGGCGGCATTTTTCAAGGTGCGCCCGCAAGCCGGGCGCGCCGG
CCGAAAGGTCTACAATCGCG

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKLLVVGSGGREHALAWKLAQSPRVQTVYVAPGNGGTAQDARLKNIELSSLDDLADFAEAEQVAFTLVGPEAPLAAGIVN
HFRSRGLKVFGPTREAAQLESSKDFAKAFMKRHGIPTAEYETFTDAAAAHAYLDAKGAPIVVKADGLAAGKGVVVAMSLE
EAHEAVDMMLSGNKLGDAGARVVIEEFLDGEEASFIVMVDGKHALALASSQDHKRLLDGDRGPNTGGMGAYSPAPIITPQ
MHARVMREIIMPTVRGMENDGIRFTGFLYAGLMIDKDGNPRTLEFNCRMGDPETQPIMARLKSDFSKVVEQAIAGTLDTV
ELDWDRRTALGVVLAAHGYPDTPRKGDRINGVPEETAHAVTFHAGTRFDGDKLVTSGGRVLCVVGLSDSVRGAQQAAYDA
INQINFEGMQYRRDIGHRALARKQG

Sequences:

>Translated_425_residues
MKLLVVGSGGREHALAWKLAQSPRVQTVYVAPGNGGTAQDARLKNIELSSLDDLADFAEAEQVAFTLVGPEAPLAAGIVN
HFRSRGLKVFGPTREAAQLESSKDFAKAFMKRHGIPTAEYETFTDAAAAHAYLDAKGAPIVVKADGLAAGKGVVVAMSLE
EAHEAVDMMLSGNKLGDAGARVVIEEFLDGEEASFIVMVDGKHALALASSQDHKRLLDGDRGPNTGGMGAYSPAPIITPQ
MHARVMREIIMPTVRGMENDGIRFTGFLYAGLMIDKDGNPRTLEFNCRMGDPETQPIMARLKSDFSKVVEQAIAGTLDTV
ELDWDRRTALGVVLAAHGYPDTPRKGDRINGVPEETAHAVTFHAGTRFDGDKLVTSGGRVLCVVGLSDSVRGAQQAAYDA
INQINFEGMQYRRDIGHRALARKQG
>Mature_425_residues
MKLLVVGSGGREHALAWKLAQSPRVQTVYVAPGNGGTAQDARLKNIELSSLDDLADFAEAEQVAFTLVGPEAPLAAGIVN
HFRSRGLKVFGPTREAAQLESSKDFAKAFMKRHGIPTAEYETFTDAAAAHAYLDAKGAPIVVKADGLAAGKGVVVAMSLE
EAHEAVDMMLSGNKLGDAGARVVIEEFLDGEEASFIVMVDGKHALALASSQDHKRLLDGDRGPNTGGMGAYSPAPIITPQ
MHARVMREIIMPTVRGMENDGIRFTGFLYAGLMIDKDGNPRTLEFNCRMGDPETQPIMARLKSDFSKVVEQAIAGTLDTV
ELDWDRRTALGVVLAAHGYPDTPRKGDRINGVPEETAHAVTFHAGTRFDGDKLVTSGGRVLCVVGLSDSVRGAQQAAYDA
INQINFEGMQYRRDIGHRALARKQG

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=428, Percent_Identity=50.2336448598131, Blast_Score=410, Evalue=1e-115,
Organism=Homo sapiens, GI4503915, Length=428, Percent_Identity=50.2336448598131, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI209869995, Length=428, Percent_Identity=50.2336448598131, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI209869993, Length=428, Percent_Identity=50.2336448598131, Blast_Score=410, Evalue=1e-114,
Organism=Escherichia coli, GI1790438, Length=428, Percent_Identity=60.5140186915888, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17567511, Length=423, Percent_Identity=43.9716312056738, Blast_Score=344, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6321203, Length=443, Percent_Identity=43.1151241534989, Blast_Score=355, Evalue=5e-99,
Organism=Drosophila melanogaster, GI62471619, Length=430, Percent_Identity=46.046511627907, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24582400, Length=430, Percent_Identity=46.046511627907, Blast_Score=353, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 45551; Mature: 45551

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVGSGGREHALAWKLAQSPRVQTVYVAPGNGGTAQDARLKNIELSSLDDLADFAEA
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHH
EQVAFTLVGPEAPLAAGIVNHFRSRGLKVFGPTREAAQLESSKDFAKAFMKRHGIPTAEY
HHEEEEEECCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHHHHHHHCCCCCCCC
ETFTDAAAAHAYLDAKGAPIVVKADGLAAGKGVVVAMSLEEAHEAVDMMLSGNKLGDAGA
HHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCHH
RVVIEEFLDGEEASFIVMVDGKHALALASSQDHKRLLDGDRGPNTGGMGAYSPAPIITPQ
HHHHHHHCCCCCCEEEEEECCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHH
MHARVMREIIMPTVRGMENDGIRFTGFLYAGLMIDKDGNPRTLEFNCRMGDPETQPIMAR
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHH
LKSDFSKVVEQAIAGTLDTVELDWDRRTALGVVLAAHGYPDTPRKGDRINGVPEETAHAV
HHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEE
TFHAGTRFDGDKLVTSGGRVLCVVGLSDSVRGAQQAAYDAINQINFEGMQYRRDIGHRAL
EEECCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ARKQG
HHCCC
>Mature Secondary Structure
MKLLVVGSGGREHALAWKLAQSPRVQTVYVAPGNGGTAQDARLKNIELSSLDDLADFAEA
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCEECCCCCCCHHHHHHHHHH
EQVAFTLVGPEAPLAAGIVNHFRSRGLKVFGPTREAAQLESSKDFAKAFMKRHGIPTAEY
HHEEEEEECCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHHHHHHHCCCCCCCC
ETFTDAAAAHAYLDAKGAPIVVKADGLAAGKGVVVAMSLEEAHEAVDMMLSGNKLGDAGA
HHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCHH
RVVIEEFLDGEEASFIVMVDGKHALALASSQDHKRLLDGDRGPNTGGMGAYSPAPIITPQ
HHHHHHHCCCCCCEEEEEECCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHH
MHARVMREIIMPTVRGMENDGIRFTGFLYAGLMIDKDGNPRTLEFNCRMGDPETQPIMAR
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHH
LKSDFSKVVEQAIAGTLDTVELDWDRRTALGVVLAAHGYPDTPRKGDRINGVPEETAHAV
HHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEE
TFHAGTRFDGDKLVTSGGRVLCVVGLSDSVRGAQQAAYDAINQINFEGMQYRRDIGHRAL
EEECCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ARKQG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]