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The map label for this gene is lon [H]

Identifier: 238026975

GI number: 238026975

Start: 1484003

End: 1486420

Strand: Direct

Name: lon [H]

Synonym: bglu_1g13520

Alternate gene names: 238026975

Gene position: 1484003-1486420 (Clockwise)

Preceding gene: 238026974

Following gene: 238026976

Centisome position: 37.99

GC content: 64.02

Gene sequence:

>2418_bases
ATGTCAGGCACCCAACTTCTCCCGCCGGAACGCATTACGCTCCCGCTGCTGCCGCTGCGGGATGTCGTCGTTTTCCCGCA
TATGGTGATCCCGCTCTTCGTGGGGCGGCCGAAATCGATCAAGGCCCTCGAGGCCGCGATGGAAGGCGGCAAGCACATCA
TGCTGGTGGCGCAGAAGACCGCCGCGAAGGATGAGCCGACCGAGAAGGACATGTACGAGGTCGGCTGTATCGCCAACATC
CTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTGGTCGAGGGCCTGCAGCGTGCCCAGGCGCTGTCGATCGA
GGAGCAGGAAACCCAGTTCTCGTGCGAAGTGCTGCCGCTCGAACCCGATCATGCCGATAGCGCCGAAACGGAAGCGCTGC
GGCGCGCCATCGTGTCGCAGTTCGATCAGTACGTGAAGCTGAACAAGAAGATCCCGCCGGAGATCCTGACCTCGCTGTCG
GGCATCGACGAGGCCGGGCGTCTGGCCGACACGATCGCGGCGCACCTGCCGCTCAAGCTCGATCAGAAGCAGCACATCCT
CGAGATGTTCCCCGTGATCGAGCGCCTCGAGCATCTGCTTGCGCAGCTCGAGGCCGAGATCGACATCCTGCAGGTGGAAA
AGCGCATCCGCGGGCGCGTCAAGCGCCAGATGGAGAAGAGCCAGCGCGAGTACTATCTGAACGAACAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAGGGCGAGGAAGGCGCCGATCTCGAGGAACTCGAGAAGCGCATCAACGCCGCGCGCATGCCGAA
GGAAGCCAAGAAGAAGGCCGACGCCGAGCTCAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCCGAAGCCACCGTGGTGC
GCAACTACATCGACACGCTGATCGGTCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGATCTGTCGAACGCCGAGCAG
GTGCTCGACGAGGACCACTACGGCCTCGAGAAGGTCAAGGAACGGATTCTCGAGTATCTCGCGGTGCAACAGCGAGTCGA
CAAGGTCAAGGCGCCGATCCTGTGCCTCGTGGGGCCCCCGGGCGTCGGCAAGACCTCGCTCGGCCAGTCGATCGCGCGCG
CGACGAACCGCAAGTTCGTGCGCATGGCGCTCGGCGGCGTGCGTGACGAGGCCGAGATCCGCGGCCATCGCCGCACCTAC
ATCGGGTCGATGCCGGGCAAGATCCTGCAGAGCCTGACCAAGGTCGGCGTGCGCAATCCGCTCTTCCTGCTCGACGAAGT
CGACAAGATGGGCATGGATTTCCGCGGCGATCCTTCGTCTGCGCTGCTCGAAGTCCTCGATCCGGAGCAGAACCATACGT
TCGCCGATCACTACGTCGAGGTCGATTTCGATTTGTCCGACGTGATGTTCGTGGCCACCTCGAACTCGCTGAACATCCCG
CCGCCGCTGCTCGACCGGATGGAAGTGATCCGCCTGTCCGGCTACACGGAGGACGAGAAGGTCAGCATCGCCCAGCGTTA
TCTGCTGCCGAAGCAGAAGAAGAACAACGGGCTCAAGGACGGCGAGATCGCCGTGTCCGAAGAGGCGATCCGCGACATCA
TCCGCTACTACACGCGGGAAGCCGGCGTGCGCTCGCTAGAGCGCGAAGTGTCGAAGATCTGCCGCAAGGTCGTGAAGATG
CTGCTGCTGAAGAAGGCGGCCAGCCCGGTGAAGGTCGACGCGGGCAACCTCGACACCTTCCTCGGCGTGCGCAAGTACGA
CTTCGGCCTCGCCGCGAAGGAGAATCAGGTCGGCCAGGTCACGGGTCTCGCCTGGACGGAAGTCGGCGGCGATCTGCTGA
CCATCGAAGCCGCGGTGATGCCGGGCAAGGGCAACGTGATCCGCACCGGCTCGCTCGGCGACGTGATGAAGGAATCGGTC
GAGGCCGCACGCTCGGTGGTGCGTTCGCGTTCGCGCCGTCTCGGTGTGAAGGACGAGGCGTTCGAGAAGCAGGACATCCA
CATCCACGTGCCGGAAGGCGCGACGCCGAAGGACGGCCCGTCCGCCGGCATCGCGATGACGACGGCGCTGGTGTCGGTGC
TGACCGGCATTCCGGTGCGTGCCGATGTCGCCATGACGGGCGAGATCACGCTGCGCGGCGAAGTGCTGCCGATCGGCGGG
CTGAAGGAGAAGCTGCTCGCGGCGCATCGCGGCGGCATCAAGCTCGTGCTGATTCCGGAAGAGAACGTGAAGGATCTCGC
CGACATTCCGGACAACGTGAAGAACGCGATCGAGATCGTGCCGGTCCGCTGGATCGACAAGGTTCTGGAGCTGGCGCTCG
AACGCGTGCCCGACGTGTTGCCGGAAGAGGAAGCCAAGGCTGCGGCGCCGGTTGCCGAAGCCGCCAAGGACGCCTCGACG
GAAGTCGTCAAGCACTGA

Upstream 100 bases:

>100_bases
GCGAATTTTTTACCGGATATTTCCCACGCGCTGAAGGCTTGCATTCTACTGTGCCGGCCTCAATTACCGAACAATTGATT
CCACTCATGGGGAAATGAAA

Downstream 100 bases:

>100_bases
TCCGAACCCTTTTCGGCACCCAACCCGCGGCAGGTCCGCGGGTTTTTTATTTGTCGGCGTAGGATTTGGGCGAGCATTGC
GTTGCCTCATTCGTATCACT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVLPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIAVSEEAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKAASPVKVDAGNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGVKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERVPDVLPEEEAKAAAPVAEAAKDAST
EVVKH

Sequences:

>Translated_805_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVLPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIAVSEEAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKAASPVKVDAGNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGVKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERVPDVLPEEEAKAAAPVAEAAKDAST
EVVKH
>Mature_804_residues
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANIL
QMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVLPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQV
LDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIAVSEEAIRDIIRYYTREAGVRSLEREVSKICRKVVKML
LLKKAASPVKVDAGNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGVKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERVPDVLPEEEAKAAAPVAEAAKDASTE
VVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=46.9858156028369, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=683, Percent_Identity=40.99560761347, Blast_Score=506, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=70.0910273081925, Blast_Score=1084, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.5953757225434, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=40.9259259259259, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=40.5555555555556, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=704, Percent_Identity=41.6193181818182, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=704, Percent_Identity=41.6193181818182, Blast_Score=517, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88999; Mature: 88868

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVLPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIAVSEEAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCEEECHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKAASPVKVDAGNLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGVKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERVPDVL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PEEEAKAAAPVAEAAKDASTEVVKH
CCHHHHHHCHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAQALSIEEQETQFSCEVLPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIAVSEEAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCEEECHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKAASPVKVDAGNLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGVKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERVPDVL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PEEEAKAAAPVAEAAKDASTEVVKH
CCHHHHHHCHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]