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The map label for this gene is envZ [H]

Identifier: 238026959

GI number: 238026959

Start: 1462545

End: 1463909

Strand: Reverse

Name: envZ [H]

Synonym: bglu_1g13350

Alternate gene names: 238026959

Gene position: 1463909-1462545 (Counterclockwise)

Preceding gene: 238026960

Following gene: 238026956

Centisome position: 37.47

GC content: 69.82

Gene sequence:

>1365_bases
ATGCGCATCGACCGGCGCCTCCTGACGCTCGTTTTCGGCGGCTTGTTCTGGCGCACCTTCCTGCTGATCGCGCTGCTGAT
CGCGGTCAGCCTCGCCGCGTGGTTCCAGAGCTTTCGCGTGATCGAGCGCGAGCCGCGCGCGCAACGCGTGGCGCTGCAGC
TCGTGGCCGTGGTCAAGCTCACGCGCACCGCCCTGCTCTATTCCGATCCCGACCTGCGCCGCGCGCTGCTGCAGGATCTC
GAAAGCAACGAGGGCGTGCGCGTCTACCCGCGCGAGTCCACCGACAAGTTCAAGCTGCAGCCCGACGAGTCGCTCAATCG
TCTGATCGAACACGACATCCGCAGCCGGCTCGGCGACGACACCGTGATCGCGCAGTCGGTCAACGGCATCCCTGGCGTGT
GGATCAGCTTCAAGATCGACGACGACGATTACTGGGTCGCGCTCGACCGCGACCAGCTCGACACCGTCACGGGCCTGCAA
TGGGCCGGCTGGGGGCTGTTCGCGCTGGCGCTGTCGCTGCTCGGCTCGGCGTTCATCACGAGCCTGGTGAACCAGCCGTT
CTCGCGGCTCGCGCACGCGGCGCGCAAGGTCGGCGCGGGGCAGATGCCCGAGCCGCTGCCCGAGCGCGGCATGGGCGTGG
CGGCCGAGACGAACCGCAGCTTCAACCAGATGGTGCGCGATCTCGAACAGCTCGACGCCGATCGCGCGCTGATGCTCGCG
GGGATCTCGCACGACCTGCGCACGCCGCTCGCGCGGCTGCGGCTCGAGACCGAGATGAGCCCGTCCGATCAGGCCACCAA
GGACGCCATGGTGGACGACATCGAACAGATGGACCGCATCATCGCCGCGTTCATCGACTACGCGCGGCCGCTCCAGCAGC
GCGCGCCGGAGCCCGTGGACCTGTCGCTGATCGCGCACGACGTGGGCGCGCGGCTGGCCAACGAGGACGGCGTGCAGATC
ACCACGCAGCTCGCGCCGGCCGCCGTGGTGGAAGCCGACGAGACCGACATGCGCCGCGTGATCGGCAACCTGGTGGAGAA
CGCGCGCAAGTACGGCCTGAGCCAGGCCGACGGCATTGCCCGCATCACGATCGAGACGCGCGTCTCGCATGCGCGCGTCG
AGGTGGTGGTGCGCGACGAAGGCCCCGGCATTCCCGACGACCAGCTGCCGCTCGTGATGCGCCCGTTCTATCGCGTCGAC
GCCGCGCGCAGCAAGGCGGACGGCACCGGCCTCGGGATGGCGATTGTGCTGCGGCTGGTGGGCCGCTATCGCGGCACGCT
GAAGCTGCGCAACCGCACGCCGGAGCCGGGCCTCGAGGTGTCGCTCGACTTCCCGACCGGCAAGGGCACGCGCCCGCCCG
CCTGA

Upstream 100 bases:

>100_bases
CTTCATCCCGGACGGCGCCGCCTGACGCGGCTTCCGCGGACCGCGCGAGCCGCGCGTCCGCGGGCTTCCCTTCGCCCTGC
CACCGAGACAGTCCGCTCCT

Downstream 100 bases:

>100_bases
GCCGGGCAGCGCACGACGGCGCCGGCGCGGGGCGCCCGGAACGGCAGTCGCCGGTACCGGGCGGCGCCGCCGCGCGGGCA
GCCCGCGCGGCGTCATCTTG

Product: putative oxidative stress related two component system, sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MRIDRRLLTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAVVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPRESTDKFKLQPDESLNRLIEHDIRSRLGDDTVIAQSVNGIPGVWISFKIDDDDYWVALDRDQLDTVTGLQ
WAGWGLFALALSLLGSAFITSLVNQPFSRLAHAARKVGAGQMPEPLPERGMGVAAETNRSFNQMVRDLEQLDADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPLQQRAPEPVDLSLIAHDVGARLANEDGVQI
TTQLAPAAVVEADETDMRRVIGNLVENARKYGLSQADGIARITIETRVSHARVEVVVRDEGPGIPDDQLPLVMRPFYRVD
AARSKADGTGLGMAIVLRLVGRYRGTLKLRNRTPEPGLEVSLDFPTGKGTRPPA

Sequences:

>Translated_454_residues
MRIDRRLLTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAVVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPRESTDKFKLQPDESLNRLIEHDIRSRLGDDTVIAQSVNGIPGVWISFKIDDDDYWVALDRDQLDTVTGLQ
WAGWGLFALALSLLGSAFITSLVNQPFSRLAHAARKVGAGQMPEPLPERGMGVAAETNRSFNQMVRDLEQLDADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPLQQRAPEPVDLSLIAHDVGARLANEDGVQI
TTQLAPAAVVEADETDMRRVIGNLVENARKYGLSQADGIARITIETRVSHARVEVVVRDEGPGIPDDQLPLVMRPFYRVD
AARSKADGTGLGMAIVLRLVGRYRGTLKLRNRTPEPGLEVSLDFPTGKGTRPPA
>Mature_454_residues
MRIDRRLLTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAVVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPRESTDKFKLQPDESLNRLIEHDIRSRLGDDTVIAQSVNGIPGVWISFKIDDDDYWVALDRDQLDTVTGLQ
WAGWGLFALALSLLGSAFITSLVNQPFSRLAHAARKVGAGQMPEPLPERGMGVAAETNRSFNQMVRDLEQLDADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPLQQRAPEPVDLSLIAHDVGARLANEDGVQI
TTQLAPAAVVEADETDMRRVIGNLVENARKYGLSQADGIARITIETRVSHARVEVVVRDEGPGIPDDQLPLVMRPFYRVD
AARSKADGTGLGMAIVLRLVGRYRGTLKLRNRTPEPGLEVSLDFPTGKGTRPPA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=427, Percent_Identity=32.0843091334895, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787894, Length=255, Percent_Identity=32.156862745098, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=29.3286219081272, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=30.4932735426009, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=27.6859504132231, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=26.4084507042254, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=322, Percent_Identity=24.5341614906832, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=30.2127659574468, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=234, Percent_Identity=29.0598290598291, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=208, Percent_Identity=27.4038461538462, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=27.6094276094276, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=25.6302521008403, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=28.5106382978723, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50469; Mature: 50469

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDRRLLTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAVVKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPRESTDKFKLQPDESLNRLIEHDIRSRLGDD
HHHHHEECCHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHCCCC
TVIAQSVNGIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFALALSLLGSAFIT
HHHHHHCCCCCCEEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SLVNQPFSRLAHAARKVGAGQMPEPLPERGMGVAAETNRSFNQMVRDLEQLDADRALMLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCEEHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPLQQRAPEPVD
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSLIAHDVGARLANEDGVQITTQLAPAAVVEADETDMRRVIGNLVENARKYGLSQADGIA
HHHHHHHHHHHHCCCCCCEEEEECCCHHEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEE
RITIETRVSHARVEVVVRDEGPGIPDDQLPLVMRPFYRVDAARSKADGTGLGMAIVLRLV
EEEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GRYRGTLKLRNRTPEPGLEVSLDFPTGKGTRPPA
HHHCCEEEECCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRIDRRLLTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAVVKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPRESTDKFKLQPDESLNRLIEHDIRSRLGDD
HHHHHEECCHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHCCCC
TVIAQSVNGIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFALALSLLGSAFIT
HHHHHHCCCCCCEEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SLVNQPFSRLAHAARKVGAGQMPEPLPERGMGVAAETNRSFNQMVRDLEQLDADRALMLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCEEHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPLQQRAPEPVD
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSLIAHDVGARLANEDGVQITTQLAPAAVVEADETDMRRVIGNLVENARKYGLSQADGIA
HHHHHHHHHHHHCCCCCCEEEEECCCHHEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEE
RITIETRVSHARVEVVVRDEGPGIPDDQLPLVMRPFYRVDAARSKADGTGLGMAIVLRLV
EEEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
GRYRGTLKLRNRTPEPGLEVSLDFPTGKGTRPPA
HHHCCEEEECCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]