Click here to switch to the map view.

The map label for this gene is aceA [H]

Identifier: 238026874

GI number: 238026874

Start: 1358719

End: 1360026

Strand: Reverse

Name: aceA [H]

Synonym: bglu_1g12420

Alternate gene names: 238026874

Gene position: 1360026-1358719 (Counterclockwise)

Preceding gene: 238026875

Following gene: 238026872

Centisome position: 34.81

GC content: 65.14

Gene sequence:

>1308_bases
ATGTCGCGTCAGCAACAGGCGAAGGAACTGCAGCAGCAGTGGGAGAAGGATCCGCGCTGGAAAGGCATCAAGCGCAGCTA
CACGGCAGAAGACGTGGTCCGCCTGCGCGGCTCGCTGGCCGTCGAGCACACCATCGCGAAGCACGGCGCCGAGAAGCTCT
GGAAGCTGATCAACACCGAGCCGTTCGTCAACGCGCTCGGCGCACTGACCGGCAACCAGGCGATGCAGCAGGTCAAGGCC
GGCCTCAAGGCGATCTACCTGTCGGGATGGCAGGTCGCGGGCGATGCCAACGTGGCCGGCGAAATGTATCCGGACCAGTC
GCTTTATCCGGCCAACTCGGTGCCGCTCGTCGTCAAGCGCATCAACAACACGCTCACGCGCGCCGACCAGATCCAGTGGT
CCGAGGGCAAGAATCCCGGCGACGAAGGCTACGTGGACTACTTCGCGCCGATCGTGGCCGACGCGGAAGCCGGCTTCGGG
GGCGTGCTGAATGCGTTCGAGCTGATGAAGGCCATGATCGAAGCCGGTGCCTCGGGCGTGCATTTCGAGGACCAGCTCGC
GTCCGTGAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTGGTGCCGACCCGCGAGAACGTCGCGAAGCTGACGGCCGCGC
GGCTCGCAGCCGACGTGATGGGTGTGCCGGCCGTGCTGATCGCGCGCACCGACGCCGAGGCAGCCGATCTCATCACCTCC
GACATCGACGACAACGACCGGCCGTTCCTGACCGGCGAGCGCACCGTCGAAGGCTTCTTCCGCACCAAGCCCGGCATCGA
CCAGGCGATTTCGCGCGGCCTCGCCTACGCGCCCTATGCCGACCTGGTCTGGTGCGAGACCGGCAAGCCCGACCTCGACT
ACGCCAAGCGCTTCGCCGAGGCGATCCACAAGCAGTTCCCGGACAAGCTGCTCTCCTACAACTGCTCGCCGTCGTTCAAC
TGGAAGAAGAACCTCGATGACGCGACCATCGCGAAGTTCCAGAAGGAGCTGGGCGCGATGGGCTACAAGTTCCAGTTCAT
CACGCTGGCCGGCTTCCATTCGCTGAACTACTCGATGTTCAACCTCGCGCACGGCTATGCACGCACCCAGATGAGCGCGT
TCGTCGAGTTGCAGCAGGCCGAGTTCGCGGCGGCCGAGAAGGGCTTCACCGCCGTCAAGCACCAGCGCGAAGTGGGCACC
GGCTACTTCGACGCCGTCACGCAGACCGTCGAGCGCGAAGCGTCGACCACGGCACTGCACGGCTCGACCGAGGACGAACA
GTTCTTCGACGGCCAGAAGGTGGCCTGA

Upstream 100 bases:

>100_bases
GTTCACGAAACGCGGCGCCGGGCGCCAGGCTCCCCACGCTTCGTGATTCGCCGATTCGCGTCACTCAACGATTCACGTTC
AATCCATCAAGGAGCTCATC

Downstream 100 bases:

>100_bases
GGCACCGGGCGACACGACAGGCAGGGCCGCGTCGCGCCAGCCCCTTGCGATGCGGCCAAGGGGCGCCTCGGCCGGTCCGC
CGGTGCGCCCCACAGGGAGT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSRQQQAKELQQQWEKDPRWKGIKRSYTAEDVVRLRGSLAVEHTIAKHGAEKLWKLINTEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFG
GVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVMGVPAVLIARTDAEAADLITS
DIDDNDRPFLTGERTVEGFFRTKPGIDQAISRGLAYAPYADLVWCETGKPDLDYAKRFAEAIHKQFPDKLLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHSLNYSMFNLAHGYARTQMSAFVELQQAEFAAAEKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA

Sequences:

>Translated_435_residues
MSRQQQAKELQQQWEKDPRWKGIKRSYTAEDVVRLRGSLAVEHTIAKHGAEKLWKLINTEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFG
GVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVMGVPAVLIARTDAEAADLITS
DIDDNDRPFLTGERTVEGFFRTKPGIDQAISRGLAYAPYADLVWCETGKPDLDYAKRFAEAIHKQFPDKLLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHSLNYSMFNLAHGYARTQMSAFVELQQAEFAAAEKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA
>Mature_434_residues
SRQQQAKELQQQWEKDPRWKGIKRSYTAEDVVRLRGSLAVEHTIAKHGAEKLWKLINTEPFVNALGALTGNQAMQQVKAG
LKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFGG
VLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVMGVPAVLIARTDAEAADLITSD
IDDNDRPFLTGERTVEGFFRTKPGIDQAISRGLAYAPYADLVWCETGKPDLDYAKRFAEAIHKQFPDKLLSYNCSPSFNW
KKNLDDATIAKFQKELGAMGYKFQFITLAGFHSLNYSMFNLAHGYARTQMSAFVELQQAEFAAAEKGFTAVKHQREVGTG
YFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=69.7459584295612, Blast_Score=623, Evalue=1e-180,
Organism=Escherichia coli, GI1786525, Length=258, Percent_Identity=27.1317829457364, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17561814, Length=418, Percent_Identity=63.1578947368421, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71982926, Length=418, Percent_Identity=63.1578947368421, Blast_Score=541, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320908, Length=289, Percent_Identity=36.3321799307958, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=250, Percent_Identity=35.6, Blast_Score=150, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47870; Mature: 47739

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQQQAKELQQQWEKDPRWKGIKRSYTAEDVVRLRGSLAVEHTIAKHGAEKLWKLINTE
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
HHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFGGVLNAFELMKAMIEAGASGV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVMGVPAVLIARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHH
DIDDNDRPFLTGERTVEGFFRTKPGIDQAISRGLAYAPYADLVWCETGKPDLDYAKRFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPDKLLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHSLNYSMF
HHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECHHHCCHHHH
NLAHGYARTQMSAFVELQQAEFAAAEKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGQKVA
CCCCCHHHCCCCCCC
>Mature Secondary Structure 
SRQQQAKELQQQWEKDPRWKGIKRSYTAEDVVRLRGSLAVEHTIAKHGAEKLWKLINTE
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
HHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDYFAPIVADAEAGFGGVLNAFELMKAMIEAGASGV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTRENVAKLTAARLAADVMGVPAVLIARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHH
DIDDNDRPFLTGERTVEGFFRTKPGIDQAISRGLAYAPYADLVWCETGKPDLDYAKRFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPDKLLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHSLNYSMF
HHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECHHHCCHHHH
NLAHGYARTQMSAFVELQQAEFAAAEKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGQKVA
CCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]