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The map label for this gene is folP [H]

Identifier: 238026785

GI number: 238026785

Start: 1254585

End: 1255448

Strand: Direct

Name: folP [H]

Synonym: bglu_1g11430

Alternate gene names: 238026785

Gene position: 1254585-1255448 (Clockwise)

Preceding gene: 238026784

Following gene: 238026786

Centisome position: 32.12

GC content: 71.41

Gene sequence:

>864_bases
ATGCCCGCGCCGCTGCAATGCGGCCGCTTCACGCTGACGTTCGAGCGCCCGCTCGTGATGGGCATCCTCAACGTCACCCC
CGACTCGTTTTCCGACGGCGGTCGCTACGTGGCCCGTGACGCCGCGCTGCGCCAGGCCGAACGCATGCTTGCCGACGGCG
CCGACCTGATCGACATCGGTGGCGAGTCGACGCGGCCCGGCGCGCCGCCCGTGCCGCTCGACGAGGAACTGTCACGCGTG
CTCCCCGTCGTCGAGGCCTTGCAGGCGATGCGCGTGCCGCTGTCGATCGACACCTACAAGCCTGCGGTGATGCGCGCCGC
GCTCGCGGCCGGTGCCGATCTGATCAATGACATCTGGGGCTTTCGCCAGCCCGGCGCCCTCGAGGCGGTGAGCGGCTCGA
ATTGCGGGCTCTGCGCGATGCACATGCTCGGCGAACCGAGGACGATGCAACTCGGCGAACCCGATTACCTCGACGTGGTG
GCCGAGGTGCGCGGCTTTCTCGCCGATCGCGCGGCCGCGCTCGTTTCGGCCGGCATCGCGCCGCAGCGAATCAGCGTCGA
TCCCGGCTTCGGCTTCGGCAAGGCCACGGTCGAACACAACTACGCGCTGCTGGCGAAGCTGGCCGACACCGCGCCGGCGC
GCCCGGACGGCGCGCGCTATCCGATTCTCGCCGGCATGTCGCGCAAGTCGATGCTCGGTGTGCTGATCGGCCGGCCGGCG
GCCGAGCGCGTCGCCGCGAGCGTGGCGGCGGCGGTCTGCGCGGCCGAACGCGGCGCGGCCATCATTCGCGTGCACGACGT
CGCGCCGACGGTCGACGCATTGAAGATCTGGGGCGCCGTGCGGGCCGCGGCGCAAGACGCATAG

Upstream 100 bases:

>100_bases
GCGCGATCGAGTTGACGGGCTGGTGTGAATCACACCGGCCCGTTTTGTTTCCGGCTTGCCCCAGATTTTCGTTGACGTGC
CGACCTTCATCGATCATTTC

Downstream 100 bases:

>100_bases
CAACGGACGGACAGACAAGGAGGAATCGTTCCATGGGACGTCGTTATTTCGGTACGGACGGGATTCGCGGCGAGGTCGGC
GTGGCGCCGATCAGCCCCGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALRQAERMLADGADLIDIGGESTRPGAPPVPLDEELSRV
LPVVEALQAMRVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGALEAVSGSNCGLCAMHMLGEPRTMQLGEPDYLDVV
AEVRGFLADRAAALVSAGIAPQRISVDPGFGFGKATVEHNYALLAKLADTAPARPDGARYPILAGMSRKSMLGVLIGRPA
AERVAASVAAAVCAAERGAAIIRVHDVAPTVDALKIWGAVRAAAQDA

Sequences:

>Translated_287_residues
MPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALRQAERMLADGADLIDIGGESTRPGAPPVPLDEELSRV
LPVVEALQAMRVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGALEAVSGSNCGLCAMHMLGEPRTMQLGEPDYLDVV
AEVRGFLADRAAALVSAGIAPQRISVDPGFGFGKATVEHNYALLAKLADTAPARPDGARYPILAGMSRKSMLGVLIGRPA
AERVAASVAAAVCAAERGAAIIRVHDVAPTVDALKIWGAVRAAAQDA
>Mature_286_residues
PAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALRQAERMLADGADLIDIGGESTRPGAPPVPLDEELSRVL
PVVEALQAMRVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGALEAVSGSNCGLCAMHMLGEPRTMQLGEPDYLDVVA
EVRGFLADRAAALVSAGIAPQRISVDPGFGFGKATVEHNYALLAKLADTAPARPDGARYPILAGMSRKSMLGVLIGRPAA
ERVAASVAAAVCAAERGAAIIRVHDVAPTVDALKIWGAVRAAAQDA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=277, Percent_Identity=49.0974729241877, Blast_Score=253, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6324073, Length=322, Percent_Identity=27.639751552795, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30017; Mature: 29886

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALRQAERMLADGADLIDIG
CCCCCCCCCEEEEECCCCEEHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECC
GESTRPGAPPVPLDEELSRVLPVVEALQAMRVPLSIDTYKPAVMRAALAAGADLINDIWG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
FRQPGALEAVSGSNCGLCAMHMLGEPRTMQLGEPDYLDVVAEVRGFLADRAAALVSAGIA
CCCCCCEEECCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PQRISVDPGFGFGKATVEHNYALLAKLADTAPARPDGARYPILAGMSRKSMLGVLIGRPA
CCEEECCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHCCCH
AERVAASVAAAVCAAERGAAIIRVHDVAPTVDALKIWGAVRAAAQDA
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALRQAERMLADGADLIDIG
CCCCCCCCEEEEECCCCEEHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECC
GESTRPGAPPVPLDEELSRVLPVVEALQAMRVPLSIDTYKPAVMRAALAAGADLINDIWG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
FRQPGALEAVSGSNCGLCAMHMLGEPRTMQLGEPDYLDVVAEVRGFLADRAAALVSAGIA
CCCCCCEEECCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PQRISVDPGFGFGKATVEHNYALLAKLADTAPARPDGARYPILAGMSRKSMLGVLIGRPA
CCEEECCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHCCCH
AERVAASVAAAVCAAERGAAIIRVHDVAPTVDALKIWGAVRAAAQDA
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]