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The map label for this gene is gyaR [H]

Identifier: 238026587

GI number: 238026587

Start: 1009525

End: 1010514

Strand: Direct

Name: gyaR [H]

Synonym: bglu_1g09330

Alternate gene names: 238026587

Gene position: 1009525-1010514 (Clockwise)

Preceding gene: 238026586

Following gene: 238026588

Centisome position: 25.84

GC content: 71.21

Gene sequence:

>990_bases
ATGCAGAAAATCCTGGTGGCGCGTGCGATCTTTCCGGACGTGATCGAGCGCCTGAGGCAGTATTTCGACGTGGACTGGAA
CGACGGCGACGCGCTCGCGCCCGACGCGCTTCATGCGCGCCTCGCCGACAAGGACGGCGCGCTCACCGCGGGCGACCCGA
TCGGCGCGGCGGCGCTCGCGGCGGCGCCGAAGCTGCGTGCGGTCGCGAACATGGCGGTCGGCTACAACAACTTCGACATG
GCGGCGTTCGACGCCGCCAACGTGCTCGCCACCAACACGCCGGACGTGCTGAACGAGACCACCGCCGATTTCGGCTGGGC
GCTGATGATGGCCGCCGCGCGGCGCATCGCCGAGTCGGAACACTGGCTGCGCGCGGGCCGCTGGCAGAAATGGTCGTTCG
ACAGCTTTCTCGGCGCCGACCTCCACGGCACGACGCTCGGCGTGATCGGCATGGGCCGCATCGGCCAGGCGATCGCGCGC
CGCGCGCGCGGCTTCAACATGCGCGTCGTCTATCACAACCGCTCGCGCGTGGCGGCCGGCATCGAGGCCGAGCTGAACGC
CGAATATCTGTCGAAGGAAGCCCTGCTGCGGCAGGCCGACCACGTGGTGCTGGTGCTGCCCTACACGAAGGAGAGCCACC
ATACGATCGGCGCGGCCGAGCTCGCGCTGATGAAGCCCAGCGCGACGCTGACCAACATCGCGCGCGGCGGCATCGTCGAC
GACGCGGCGCTGGCCGCCGCGCTGCGCGAGCGCCGCATCGCGGCGGCCGGGCTCGACGTGTTCGAGGGCGAGCCGAGCGT
GCTGCCGGCGCTGCTGGAGGTGCCCAACGTCGTGCTCACGCCGCATATCGCGAGCGCGAGCGAGGCCACGCGTCGCGCGA
TGGCCAACCTCGCCGCCGACAATCTGATCGCGGCGCTTGGCGAAGGCCCGCGCGCCGGCCGGCCGCCGAACCCGATCAAT
CCCGACGTGCTCGGCAGGGCGCGCGCATGA

Upstream 100 bases:

>100_bases
TGAACGGGCGGGTTTCGGCAGGTGTGGGCTGCGTGCCGCGGCCCGGTGGGGCCGCGAGGCGCCGTCCCACCGGGCCGCGC
ACGCTCGACGGAGACGGCTT

Downstream 100 bases:

>100_bases
CGCCGTGGCTGCTCGGCGCGGTCGCGCTGCTCGCGGCCGCGCTCGCGATCGCGCTGGGGGTGATCTGGCGCGGCGCGAGC
CATGCCGGTGACGGCATCGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARAIFPDVIERLRQYFDVDWNDGDALAPDALHARLADKDGALTAGDPIGAAALAAAPKLRAVANMAVGYNNFDM
AAFDAANVLATNTPDVLNETTADFGWALMMAAARRIAESEHWLRAGRWQKWSFDSFLGADLHGTTLGVIGMGRIGQAIAR
RARGFNMRVVYHNRSRVAAGIEAELNAEYLSKEALLRQADHVVLVLPYTKESHHTIGAAELALMKPSATLTNIARGGIVD
DAALAAALRERRIAAAGLDVFEGEPSVLPALLEVPNVVLTPHIASASEATRRAMANLAADNLIAALGEGPRAGRPPNPIN
PDVLGRARA

Sequences:

>Translated_329_residues
MQKILVARAIFPDVIERLRQYFDVDWNDGDALAPDALHARLADKDGALTAGDPIGAAALAAAPKLRAVANMAVGYNNFDM
AAFDAANVLATNTPDVLNETTADFGWALMMAAARRIAESEHWLRAGRWQKWSFDSFLGADLHGTTLGVIGMGRIGQAIAR
RARGFNMRVVYHNRSRVAAGIEAELNAEYLSKEALLRQADHVVLVLPYTKESHHTIGAAELALMKPSATLTNIARGGIVD
DAALAAALRERRIAAAGLDVFEGEPSVLPALLEVPNVVLTPHIASASEATRRAMANLAADNLIAALGEGPRAGRPPNPIN
PDVLGRARA
>Mature_329_residues
MQKILVARAIFPDVIERLRQYFDVDWNDGDALAPDALHARLADKDGALTAGDPIGAAALAAAPKLRAVANMAVGYNNFDM
AAFDAANVLATNTPDVLNETTADFGWALMMAAARRIAESEHWLRAGRWQKWSFDSFLGADLHGTTLGVIGMGRIGQAIAR
RARGFNMRVVYHNRSRVAAGIEAELNAEYLSKEALLRQADHVVLVLPYTKESHHTIGAAELALMKPSATLTNIARGGIVD
DAALAAALRERRIAAAGLDVFEGEPSVLPALLEVPNVVLTPHIASASEATRRAMANLAADNLIAALGEGPRAGRPPNPIN
PDVLGRARA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=36, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=28.476821192053, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI145580578, Length=268, Percent_Identity=34.7014925373134, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI4557499, Length=268, Percent_Identity=34.7014925373134, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=33.9483394833948, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=33.9483394833948, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=35.3413654618474, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=42.7692307692308, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1789279, Length=310, Percent_Identity=28.0645161290323, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=28.2352941176471, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87081824, Length=171, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=30.4918032786885, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=26.171875, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=247, Percent_Identity=34.0080971659919, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=269, Percent_Identity=27.1375464684015, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=322, Percent_Identity=25.4658385093168, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=32.6388888888889, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=166, Percent_Identity=29.5180722891566, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=270, Percent_Identity=39.2592592592593, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24585514, Length=270, Percent_Identity=39.2592592592593, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574282, Length=270, Percent_Identity=39.2592592592593, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574284, Length=270, Percent_Identity=39.2592592592593, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45551003, Length=270, Percent_Identity=39.2592592592593, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574286, Length=303, Percent_Identity=35.973597359736, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571528, Length=316, Percent_Identity=36.7088607594937, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24585516, Length=269, Percent_Identity=34.2007434944238, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19921140, Length=333, Percent_Identity=30.6306306306306, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=32.8413284132841, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=32.8413284132841, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=32.8413284132841, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=32.8413284132841, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=33.469387755102, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35083; Mature: 35083

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARAIFPDVIERLRQYFDVDWNDGDALAPDALHARLADKDGALTAGDPIGAAALA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCEECCCCCCHHHHH
AAPKLRAVANMAVGYNNFDMAAFDAANVLATNTPDVLNETTADFGWALMMAAARRIAESE
HCHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HWLRAGRWQKWSFDSFLGADLHGTTLGVIGMGRIGQAIARRARGFNMRVVYHNRSRVAAG
HHHHCCCCCCCCCHHHHCCCCCCCEEEEEECHHHHHHHHHHHCCCEEEEEEECCCCEEEC
IEAELNAEYLSKEALLRQADHVVLVLPYTKESHHTIGAAELALMKPSATLTNIARGGIVD
CCHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHCCCCCH
DAALAAALRERRIAAAGLDVFEGEPSVLPALLEVPNVVLTPHIASASEATRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
NLIAALGEGPRAGRPPNPINPDVLGRARA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARAIFPDVIERLRQYFDVDWNDGDALAPDALHARLADKDGALTAGDPIGAAALA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCEECCCCCCHHHHH
AAPKLRAVANMAVGYNNFDMAAFDAANVLATNTPDVLNETTADFGWALMMAAARRIAESE
HCHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HWLRAGRWQKWSFDSFLGADLHGTTLGVIGMGRIGQAIARRARGFNMRVVYHNRSRVAAG
HHHHCCCCCCCCCHHHHCCCCCCCEEEEEECHHHHHHHHHHHCCCEEEEEEECCCCEEEC
IEAELNAEYLSKEALLRQADHVVLVLPYTKESHHTIGAAELALMKPSATLTNIARGGIVD
CCHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHCCCCCH
DAALAAALRERRIAAAGLDVFEGEPSVLPALLEVPNVVLTPHIASASEATRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
NLIAALGEGPRAGRPPNPINPDVLGRARA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA