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The map label for this gene is zraS [H]

Identifier: 238025419

GI number: 238025419

Start: 2608520

End: 2610001

Strand: Reverse

Name: zraS [H]

Synonym: bglu_2g21080

Alternate gene names: 238025419

Gene position: 2610001-2608520 (Counterclockwise)

Preceding gene: 238025420

Following gene: 238025418

Centisome position: 92.31

GC content: 73.01

Gene sequence:

>1482_bases
ATGCCGAGACTTCCGTTTTCCACTCAGATCGTCGCGCTCTGGATTCTGGTCGCGGTCCTCTGCAGCCTGCTCACGGCTGC
GGTGTGGCTGATGCTGTCGTCGGCGCTCGGCGAGCGCGTGGCGCTCGGCACGCAGCAGGCTTCGGCGGCCTGCGCGACGG
TCGCCTCGCGATACGACCTGTCGATGCAACGCGCGAACGAAGCAAACGTGGATCTCATGCACGCCGTGCTCGATCTCGTG
CTGAGCCGCAGCGAGGGCATCGAAGGCGGCTTCTGGCTGCGCGGGTCCGCGGCCGCGGCGGGCGGCTTCCAGGCCTACGC
GTTCCCGACCTACGACGGCAGCGGCGTGAAGCGCGACATTCCCGAGGCGGAAACGCCGCTGATCCTGCGCGCGCTGGCGG
ACACGGCAGCCGCGGGCCGGACGCGCTCGCATGTGGTGTCGAGCGGCGCGGATGCGGTGATCGCCGTGGGCTGCCCCGTG
CCGCATCACGAGGCCTTGTTCGCCTGGACGCTGACGCGCGCGCATCCGCCGCTCGGCCCGCGCGGCGAAAGCGCCGCGCA
GGTGCTGGCGGCCATGCTCGCGATCATCCTCGTGCTGGCCGTGTTCCTGGCGCTGGCGCTGCGGCGCTGGCGGCGCGACC
TGACGCGGCTGGAGCGGGCGCTCGCCCCGGCCGGCGCGTTCGAGCGCGGCGAGCGGCTGGCGCCGCTCGGGGAGCGCGAT
CTCGACCAGATCGTCGATGCGCTGAACCGCTACGCCGAGCGCGCCGCGACGCTGCAGCGCGAGACACGGGCGCTCAGCGA
GCAGCTCGCGCAGGCGCAGCGGTTCAGCACCCTGGGCAAGCTGGCCGCGCAGGTCGCCCACGAGATCCGGAATCCGGCCG
GCGCCATGCGCCTGAAGGCGGAAAACGCGCTCGCCGGCGACGATGCCCGCCGCGAGGCGGCGCTGCGTACCATCATCGTG
CAGCTCGGGCGCATCGAGACGCAGGTCGCCAGCCTGCTGGCCCTGACGCGGCCGGTGACGGTCCAGGCCTGCGAGGTCGA
TCTGCCGGCCTGGCTTGCCGACATCGTGCATACCCACGAACCGAACGCCGAGCGGCGCGGCCTGAAGCTGACCGTCGAGG
CCGCACCCGGCACGTCGCGGCCGGTGTTCGATCCCGCCCAGCTTGCTCGCGCGCTCGACAATCTGATCCTCAACGCACTG
CGCCACGCGTCGCCCGGCGGCCAGGTGTCGGTGCGCGCGCTTGCCGCGCAGGCGCCCGAGGGCGAACGGCTCCGGCTGGA
GGTGAGCGACGACGGGCCGGGCGTCGGCGCCGCCGAGCGCGACCGGATCTTCGAGCCGTTCGTGACGGCCCGCCCCGACG
GGGCCGGCCTCGGCCTCGTCGTCGTGCGGGAAATCGCTGCGGCGCACGGCGGCCGTGCCTGGCTCGCCAGCGACGCGAAC
CCCACCTGCTTCGTGATCGAACTGCCATGGCGACCATACTGA

Upstream 100 bases:

>100_bases
CGGCGTCCGGGCCGGCCGATTCACGGCGCGCACCGCCGCCGGCCAACGGGACGGAGGCCGCCGCGAGGCCTCGCCAACCG
CTTCTTTTCACAGGCCGCCC

Downstream 100 bases:

>100_bases
TCATCGACGACGACGATGCGTTTCGCGAAGGCCTCGCCGAAACCATCGAGGACCTCGGCCACGTTCCGCTCGAGGCCGGC
TCCGGCGACGAGGCGTTCGC

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MPRLPFSTQIVALWILVAVLCSLLTAAVWLMLSSALGERVALGTQQASAACATVASRYDLSMQRANEANVDLMHAVLDLV
LSRSEGIEGGFWLRGSAAAAGGFQAYAFPTYDGSGVKRDIPEAETPLILRALADTAAAGRTRSHVVSSGADAVIAVGCPV
PHHEALFAWTLTRAHPPLGPRGESAAQVLAAMLAIILVLAVFLALALRRWRRDLTRLERALAPAGAFERGERLAPLGERD
LDQIVDALNRYAERAATLQRETRALSEQLAQAQRFSTLGKLAAQVAHEIRNPAGAMRLKAENALAGDDARREAALRTIIV
QLGRIETQVASLLALTRPVTVQACEVDLPAWLADIVHTHEPNAERRGLKLTVEAAPGTSRPVFDPAQLARALDNLILNAL
RHASPGGQVSVRALAAQAPEGERLRLEVSDDGPGVGAAERDRIFEPFVTARPDGAGLGLVVVREIAAAHGGRAWLASDAN
PTCFVIELPWRPY

Sequences:

>Translated_493_residues
MPRLPFSTQIVALWILVAVLCSLLTAAVWLMLSSALGERVALGTQQASAACATVASRYDLSMQRANEANVDLMHAVLDLV
LSRSEGIEGGFWLRGSAAAAGGFQAYAFPTYDGSGVKRDIPEAETPLILRALADTAAAGRTRSHVVSSGADAVIAVGCPV
PHHEALFAWTLTRAHPPLGPRGESAAQVLAAMLAIILVLAVFLALALRRWRRDLTRLERALAPAGAFERGERLAPLGERD
LDQIVDALNRYAERAATLQRETRALSEQLAQAQRFSTLGKLAAQVAHEIRNPAGAMRLKAENALAGDDARREAALRTIIV
QLGRIETQVASLLALTRPVTVQACEVDLPAWLADIVHTHEPNAERRGLKLTVEAAPGTSRPVFDPAQLARALDNLILNAL
RHASPGGQVSVRALAAQAPEGERLRLEVSDDGPGVGAAERDRIFEPFVTARPDGAGLGLVVVREIAAAHGGRAWLASDAN
PTCFVIELPWRPY
>Mature_492_residues
PRLPFSTQIVALWILVAVLCSLLTAAVWLMLSSALGERVALGTQQASAACATVASRYDLSMQRANEANVDLMHAVLDLVL
SRSEGIEGGFWLRGSAAAAGGFQAYAFPTYDGSGVKRDIPEAETPLILRALADTAAAGRTRSHVVSSGADAVIAVGCPVP
HHEALFAWTLTRAHPPLGPRGESAAQVLAAMLAIILVLAVFLALALRRWRRDLTRLERALAPAGAFERGERLAPLGERDL
DQIVDALNRYAERAATLQRETRALSEQLAQAQRFSTLGKLAAQVAHEIRNPAGAMRLKAENALAGDDARREAALRTIIVQ
LGRIETQVASLLALTRPVTVQACEVDLPAWLADIVHTHEPNAERRGLKLTVEAAPGTSRPVFDPAQLARALDNLILNALR
HASPGGQVSVRALAAQAPEGERLRLEVSDDGPGVGAAERDRIFEPFVTARPDGAGLGLVVVREIAAAHGGRAWLASDANP
TCFVIELPWRPY

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=32.3404255319149, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=27.6859504132231, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=290, Percent_Identity=28.2758620689655, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790300, Length=245, Percent_Identity=30.6122448979592, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=310, Percent_Identity=26.7741935483871, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=29.0598290598291, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=254, Percent_Identity=27.5590551181102, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=28.3185840707965, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=29.0748898678414, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=356, Percent_Identity=28.3707865168539, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082128, Length=241, Percent_Identity=26.1410788381743, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52648; Mature: 52517

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLPFSTQIVALWILVAVLCSLLTAAVWLMLSSALGERVALGTQQASAACATVASRYDL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SMQRANEANVDLMHAVLDLVLSRSEGIEGGFWLRGSAAAAGGFQAYAFPTYDGSGVKRDI
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCC
PEAETPLILRALADTAAAGRTRSHVVSSGADAVIAVGCPVPHHEALFAWTLTRAHPPLGP
CCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCHHEEEEEHHCCCCCCC
RGESAAQVLAAMLAIILVLAVFLALALRRWRRDLTRLERALAPAGAFERGERLAPLGERD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCH
LDQIVDALNRYAERAATLQRETRALSEQLAQAQRFSTLGKLAAQVAHEIRNPAGAMRLKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEC
ENALAGDDARREAALRTIIVQLGRIETQVASLLALTRPVTVQACEVDLPAWLADIVHTHE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCC
PNAERRGLKLTVEAAPGTSRPVFDPAQLARALDNLILNALRHASPGGQVSVRALAAQAPE
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCC
GERLRLEVSDDGPGVGAAERDRIFEPFVTARPDGAGLGLVVVREIAAAHGGRAWLASDAN
CCEEEEEECCCCCCCCCHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCC
PTCFVIELPWRPY
CEEEEEECCCCCC
>Mature Secondary Structure 
PRLPFSTQIVALWILVAVLCSLLTAAVWLMLSSALGERVALGTQQASAACATVASRYDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SMQRANEANVDLMHAVLDLVLSRSEGIEGGFWLRGSAAAAGGFQAYAFPTYDGSGVKRDI
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCC
PEAETPLILRALADTAAAGRTRSHVVSSGADAVIAVGCPVPHHEALFAWTLTRAHPPLGP
CCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCHHEEEEEHHCCCCCCC
RGESAAQVLAAMLAIILVLAVFLALALRRWRRDLTRLERALAPAGAFERGERLAPLGERD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCH
LDQIVDALNRYAERAATLQRETRALSEQLAQAQRFSTLGKLAAQVAHEIRNPAGAMRLKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEC
ENALAGDDARREAALRTIIVQLGRIETQVASLLALTRPVTVQACEVDLPAWLADIVHTHE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCC
PNAERRGLKLTVEAAPGTSRPVFDPAQLARALDNLILNALRHASPGGQVSVRALAAQAPE
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCC
GERLRLEVSDDGPGVGAAERDRIFEPFVTARPDGAGLGLVVVREIAAAHGGRAWLASDAN
CCEEEEEECCCCCCCCCHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCC
PTCFVIELPWRPY
CEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]