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The map label for this gene is (groL2 [H]

Identifier: 238025261

GI number: 238025261

Start: 2404595

End: 2406217

Strand: Reverse

Name: (groL2 [H]

Synonym: bglu_2g19330

Alternate gene names: 238025261

Gene position: 2406217-2404595 (Counterclockwise)

Preceding gene: 238025262

Following gene: 238025260

Centisome position: 85.11

GC content: 66.42

Gene sequence:

>1623_bases
ATGAGTGCAAAAGACGTGAAATTCCATGACAGCGCGCGCGCCCGCATCGTCAAGGGCGTGAACGTGCTGGCCGACGCCGT
CAAGGTCACGCTCGGTCCGAAGGGCCGCAACGTGCTGATCGAACGCAGTTTCGGCGCGCCGACGATGACGAAGGACGGCG
TGTCGGTCGCCAAGGAAATCGAGCTGAAGGACCGCTTCGAGAACATGGGCGCCCAGGTGGTCAAGCAGGTCGCCTCGAAG
ACGGCCGACGTGGCCGGCGACGGCACGACGACGGCCACGGTGCTTGCGCAGGCGATCGTGCAGGAGGGCATGAAGCACGT
CGCCGCCGGCATGAATCCGATGGACCTGAAGCGCGGCATCGACAAGGCGGTGGGCGCCGTGCTCGACCAGCTGCGCACCT
TGTCCAAGCCGATCTCGACCAACAAGGAAATCGCCCAGGTCGGCTCGATCTCGGCGAACTCGGACGAGGCGATCGGCAAG
ATCATCGCCGACGCGATGGAGAAGGTCGGCAAGGAGGGCGTCATCACGGTGGAGGATGGCAAGTCGCTCGACAACGAACT
CGACGTCGTGGAGGGCATGCAGTTCGACCGCGGCTATCTGAGCCCGTACTTCATCAACGACCCGGAAAAGCAGGCGGCCT
ACCTCGACGATGCGCTGATCCTGCTGCACGACAAGAAGATTTCCGCGGTTCGCGACCTGCTGCCGATCCTCGAGGTGGCC
GCCAAGGCCGGCAAGCCGCTGCTGATCGTGGCCGAGGACATCGAGGGCGAAGCGCTGGCCACCCTGGTGGTCAACGCGAT
GCGCGGCATCCTGAAGGTGGTGGCCGTGAAGGCGCCGGGCTTCGGCGATCGCCGCAAGGCGATGCTCGAGGATATCGCCA
TCCTCACGGGCGCCACGGTGATTGCGGAAGAGACCGGCAAGCAGCTCGAAAAAGCCACGCTCGAGGACCTGGGGCAAGCC
AAGCGAGTGGAAGTCCGCAAGGAGGACACGATCATCATCGACGGCGCGGGCGAGGCGAAGCGCATCGAGGCCCGGGTCAA
GCAGATCCGCGCGCAGATCGACGAGGCCACCTCCGACTACGACCGGGAAAAGCTGCAGGAGCGGCTTGCCAAGCTCGCGG
GCGGCGTGGCGGTCATCAAGGTCGGTGCGGCGACCGAGGTCGAGATGAAGGAGAAGAAGGATCGCGTCGACGACGCGTTG
CACGCGACGCGCGCGGCCGTCGAGGAAGGCATCGTGCCGGGCGGCGGGGTGGCGCTGCTGCGGGCTCGCGCCGCGCTGTC
CGGCCTGAAGGGCGCGAACGCCGACCAGGACGCGGGCATTCAGATCGTGCTGCGCGCGCTGGAAGCGCCGCTGCGCGTCA
TCGTGTCGAACGCCGGCGACGAACCGGCGGTCGTGATCGCCAAGGTGCTCGAAGGCAAGGGCAATTTCGGCTACAACGCG
GCCAGCGGCGAATATGGTGACCTGGTGGAAACCGGCGTGGTGGATCCGACCAAGGTGACGCGCACCGCGCTGCAGAACGC
AGCCTCGATCGCCGGTCTGATCCTGACGACCGACGCCACTGTCGCGGAAGCGCCGAAGGACGAGAAGCCGGTGCCGGCGG
CCGCGCCCGAGATGGACTATTGA

Upstream 100 bases:

>100_bases
AGCCGGTTCGGGTCGCGCACGGCGTGCTCGCCTCGTTGGCCACGCTGTTCGCGACGTGTCGAGTCGACACTGAGTCAAGG
ACTTTTCCCGGAGCAACGAC

Downstream 100 bases:

>100_bases
CGGGCGGCCCGGGCCGATCTGGCCCGAGGCGATGCCGGGCCGGGGCAACCGCCTCGCCGGCCCGGCGCCCTCGCCCGCGC
GCCGGCCTGCCACCCGAGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSAKDVKFHDSARARIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTMTKDGVSVAKEIELKDRFENMGAQVVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVGAVLDQLRTLSKPISTNKEIAQVGSISANSDEAIGK
IIADAMEKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINDPEKQAAYLDDALILLHDKKISAVRDLLPILEVA
AKAGKPLLIVAEDIEGEALATLVVNAMRGILKVVAVKAPGFGDRRKAMLEDIAILTGATVIAEETGKQLEKATLEDLGQA
KRVEVRKEDTIIIDGAGEAKRIEARVKQIRAQIDEATSDYDREKLQERLAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARAALSGLKGANADQDAGIQIVLRALEAPLRVIVSNAGDEPAVVIAKVLEGKGNFGYNA
ASGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKDEKPVPAAAPEMDY

Sequences:

>Translated_540_residues
MSAKDVKFHDSARARIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTMTKDGVSVAKEIELKDRFENMGAQVVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVGAVLDQLRTLSKPISTNKEIAQVGSISANSDEAIGK
IIADAMEKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINDPEKQAAYLDDALILLHDKKISAVRDLLPILEVA
AKAGKPLLIVAEDIEGEALATLVVNAMRGILKVVAVKAPGFGDRRKAMLEDIAILTGATVIAEETGKQLEKATLEDLGQA
KRVEVRKEDTIIIDGAGEAKRIEARVKQIRAQIDEATSDYDREKLQERLAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARAALSGLKGANADQDAGIQIVLRALEAPLRVIVSNAGDEPAVVIAKVLEGKGNFGYNA
ASGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKDEKPVPAAAPEMDY
>Mature_539_residues
SAKDVKFHDSARARIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTMTKDGVSVAKEIELKDRFENMGAQVVKQVASKT
ADVAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVGAVLDQLRTLSKPISTNKEIAQVGSISANSDEAIGKI
IADAMEKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINDPEKQAAYLDDALILLHDKKISAVRDLLPILEVAA
KAGKPLLIVAEDIEGEALATLVVNAMRGILKVVAVKAPGFGDRRKAMLEDIAILTGATVIAEETGKQLEKATLEDLGQAK
RVEVRKEDTIIIDGAGEAKRIEARVKQIRAQIDEATSDYDREKLQERLAKLAGGVAVIKVGAATEVEMKEKKDRVDDALH
ATRAAVEEGIVPGGGVALLRARAALSGLKGANADQDAGIQIVLRALEAPLRVIVSNAGDEPAVVIAKVLEGKGNFGYNAA
SGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKDEKPVPAAAPEMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.7878787878788, Blast_Score=562, Evalue=1e-160,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.7878787878788, Blast_Score=562, Evalue=1e-160,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=72.1590909090909, Blast_Score=767, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.3081285444234, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=54.0284360189574, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17564182, Length=553, Percent_Identity=24.0506329113924, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.8022813688213, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322524, Length=537, Percent_Identity=24.2085661080074, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=55.2182163187856, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=55.2182163187856, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=53.3206831119545, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=53.3206831119545, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=53.3206831119545, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=45.6603773584906, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=40.1129943502825, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=40.1129943502825, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56965; Mature: 56834

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDVKFHDSARARIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTMTKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQVVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVGAVLDQLRTLSKPISTNKEIAQVGSISANSDEAIGKIIADAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCC
KSLDNELDVVEGMQFDRGYLSPYFINDPEKQAAYLDDALILLHDKKISAVRDLLPILEVA
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEDIEGEALATLVVNAMRGILKVVAVKAPGFGDRRKAMLEDIAILTGATV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
IAEETGKQLEKATLEDLGQAKRVEVRKEDTIIIDGAGEAKRIEARVKQIRAQIDEATSDY
HHHHHHHHHHHHHHHHHCCHHHEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHH
DREKLQERLAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAALSGLKGANADQDAGIQIVLRALEAPLRVIVSNAGDEPAVVIAKVLEGKGNFGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
ASGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKDEKPVPAAAPEMDY
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCCHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAKDVKFHDSARARIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTMTKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQVVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVGAVLDQLRTLSKPISTNKEIAQVGSISANSDEAIGKIIADAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCC
KSLDNELDVVEGMQFDRGYLSPYFINDPEKQAAYLDDALILLHDKKISAVRDLLPILEVA
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEDIEGEALATLVVNAMRGILKVVAVKAPGFGDRRKAMLEDIAILTGATV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
IAEETGKQLEKATLEDLGQAKRVEVRKEDTIIIDGAGEAKRIEARVKQIRAQIDEATSDY
HHHHHHHHHHHHHHHHHCCHHHEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHH
DREKLQERLAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAALSGLKGANADQDAGIQIVLRALEAPLRVIVSNAGDEPAVVIAKVLEGKGNFGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
ASGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKDEKPVPAAAPEMDY
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCCHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA