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The map label for this gene is Hgd [H]

Identifier: 238025226

GI number: 238025226

Start: 2367347

End: 2368219

Strand: Reverse

Name: Hgd [H]

Synonym: bglu_2g18970

Alternate gene names: 238025226

Gene position: 2368219-2367347 (Counterclockwise)

Preceding gene: 238025229

Following gene: 238025225

Centisome position: 83.76

GC content: 74.34

Gene sequence:

>873_bases
ATGAAAACGGTAGGCGTGATCGGCTTGGGCAACATGGGGCGCGGCATGGCCGGCTCGCTGCGGCGCGGCGGCCATCGGGT
GCTCGGCTACGACGCGGCGCCCGGCGTGGCGGCCGCGCTGGCCGCCGAGGGCGTGATCGAGGCACGCGAGTCGGTGGCCG
CGATCGCGCGCGAGGCGGAGCTGCTGCTGCTGTCGCTGCCCACCTCGGCGGTGGTCGAGGCGGTGGTGCTGGGCGAGGAC
GGCGTGCTGGCCCATGCGCGGCGCGGCACGATCGTGGTGGACACCACCACGGCCGACCCGGACAGCACGCGGCGCGTGGC
GGCGGCGCTGGCCGAGCGCGGCATCGGCTTCGTCGACGGCCCGGTCAGCGGCGGCCCGAAGGGCGCGGCCACGGCCACCA
TGACGATGGTGCTCGGCGGCGCGCAGGCCGACGTCGACGCGGTCGAGCCGGTGCTCGCCGCGATCAGCGCCAAGCGCGTC
CACGTCGGGCCGGTGGGCGCCGGACACGTCACCAAGCTGCTCAACAACCTGCTGACCGGCATCCACCTGCTGGCCGCGAG
CGAAGCGGTGCGTGCCGCGCGCGCGGCCGGCGTGGACCCGGAAAAGCTGGTGGAGGCGCTCAACGGCGGCTCGGGCCGCA
ACAGCGCCACGCTCGTCAACTACCCGACCTGGATCTTCAACGGCGCGTTCGATTCGGGCTTCACGATGAAGCTGATGCGC
AAGGACGTGCGGCTCGCGCTCGGCCTGCTCGACCAGCAGGGCGGCGCGGCGCCCGTGGCGCGCGAGGCCGCGCGCCTGTG
GGCCGCGAGCGAGGCCGTGATCGGCGACGCCGAGGATTTCAACCGCATCGTCGAACTGCTCGACCGCGCCTGA

Upstream 100 bases:

>100_bases
ATTGATTATACGAGTCCGCCGCCGCAACATCGCATCGACATGCGGTGCCGGCACGGCTCGACGAGGCGGCCCGCTCCATT
TCATATCGGGAGTGCTTCTG

Downstream 100 bases:

>100_bases
GCGGCGCGCGCCTTCGACTTCGCCTCCTGACACCGGAACCCATTCCATGACCCAGCACGCAGACCAGCTTCTCGCCGCGT
TCGCCCATTTCTTCCCCGAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKTVGVIGLGNMGRGMAGSLRRGGHRVLGYDAAPGVAAALAAEGVIEARESVAAIAREAELLLLSLPTSAVVEAVVLGED
GVLAHARRGTIVVDTTTADPDSTRRVAAALAERGIGFVDGPVSGGPKGAATATMTMVLGGAQADVDAVEPVLAAISAKRV
HVGPVGAGHVTKLLNNLLTGIHLLAASEAVRAARAAGVDPEKLVEALNGGSGRNSATLVNYPTWIFNGAFDSGFTMKLMR
KDVRLALGLLDQQGGAAPVAREAARLWAASEAVIGDAEDFNRIVELLDRA

Sequences:

>Translated_290_residues
MKTVGVIGLGNMGRGMAGSLRRGGHRVLGYDAAPGVAAALAAEGVIEARESVAAIAREAELLLLSLPTSAVVEAVVLGED
GVLAHARRGTIVVDTTTADPDSTRRVAAALAERGIGFVDGPVSGGPKGAATATMTMVLGGAQADVDAVEPVLAAISAKRV
HVGPVGAGHVTKLLNNLLTGIHLLAASEAVRAARAAGVDPEKLVEALNGGSGRNSATLVNYPTWIFNGAFDSGFTMKLMR
KDVRLALGLLDQQGGAAPVAREAARLWAASEAVIGDAEDFNRIVELLDRA
>Mature_290_residues
MKTVGVIGLGNMGRGMAGSLRRGGHRVLGYDAAPGVAAALAAEGVIEARESVAAIAREAELLLLSLPTSAVVEAVVLGED
GVLAHARRGTIVVDTTTADPDSTRRVAAALAERGIGFVDGPVSGGPKGAATATMTMVLGGAQADVDAVEPVLAAISAKRV
HVGPVGAGHVTKLLNNLLTGIHLLAASEAVRAARAAGVDPEKLVEALNGGSGRNSATLVNYPTWIFNGAFDSGFTMKLMR
KDVRLALGLLDQQGGAAPVAREAARLWAASEAVIGDAEDFNRIVELLDRA

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=251, Percent_Identity=32.6693227091633, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI40556376, Length=272, Percent_Identity=25.7352941176471, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI145693186, Length=244, Percent_Identity=34.4262295081967, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1786719, Length=244, Percent_Identity=32.3770491803279, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1790315, Length=286, Percent_Identity=26.9230769230769, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=30.0699300699301, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17557316, Length=299, Percent_Identity=32.7759197324415, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=30.8724832214765, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=30.8724832214765, Blast_Score=150, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 29489; Mature: 29489

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGVIGLGNMGRGMAGSLRRGGHRVLGYDAAPGVAAALAAEGVIEARESVAAIAREAE
CCCEEEEECCCCCCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCE
LLLLSLPTSAVVEAVVLGEDGVLAHARRGTIVVDTTTADPDSTRRVAAALAERGIGFVDG
EEEEECCHHHHHEEHEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEECC
PVSGGPKGAATATMTMVLGGAQADVDAVEPVLAAISAKRVHVGPVGAGHVTKLLNNLLTG
CCCCCCCCCHHHEEHHEECCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHH
IHLLAASEAVRAARAAGVDPEKLVEALNGGSGRNSATLVNYPTWIFNGAFDSGFTMKLMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHH
KDVRLALGLLDQQGGAAPVAREAARLWAASEAVIGDAEDFNRIVELLDRA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTVGVIGLGNMGRGMAGSLRRGGHRVLGYDAAPGVAAALAAEGVIEARESVAAIAREAE
CCCEEEEECCCCCCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCE
LLLLSLPTSAVVEAVVLGEDGVLAHARRGTIVVDTTTADPDSTRRVAAALAERGIGFVDG
EEEEECCHHHHHEEHEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEECC
PVSGGPKGAATATMTMVLGGAQADVDAVEPVLAAISAKRVHVGPVGAGHVTKLLNNLLTG
CCCCCCCCCHHHEEHHEECCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHH
IHLLAASEAVRAARAAGVDPEKLVEALNGGSGRNSATLVNYPTWIFNGAFDSGFTMKLMR
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHH
KDVRLALGLLDQQGGAAPVAREAARLWAASEAVIGDAEDFNRIVELLDRA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA