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The map label for this gene is thyA [H]

Identifier: 238025095

GI number: 238025095

Start: 2196872

End: 2197861

Strand: Reverse

Name: thyA [H]

Synonym: bglu_2g17520

Alternate gene names: 238025095

Gene position: 2197861-2196872 (Counterclockwise)

Preceding gene: 238025096

Following gene: 238025094

Centisome position: 77.74

GC content: 66.87

Gene sequence:

>990_bases
ATGCGCGCCCGCTTCGCGAATCTCGACGAGCTCTACCTCGCCACGCTGCGCGACGTCTGCACCGCCTACGAATACCGCAA
CGCGCCGCGCGGGCAGGCCGAGCGCGAAATCATCGGCTACAGCGCGCGGATCGAGGATCCGCGCGCGCGCTTCTGCCGCC
ATGCCTCGCGCAAGCAGAACGTGGTGTTCAACTATGCCGAGGCGCTCTGGTATCTGTCGGGGCGCAACGACCTCGCGTTC
ATCGAGTACTACGCGCCGTCGATGGCGCGCTACAGCCCCGATGGCAAGACGCTGCCGGGCACCGGCTACGGCGCGCGGCT
GCTGCATTTCGGCGACGACGGCATCGACCAGATCGAACGTGCGATCGACATCCTCAAGCGTGACGATGCCGAGAGCAAAC
GCGTCGTGCTGCAGATCTTCGACGCTCGCGAGGACCTTTACAAGCGCAACATCGACGTGTCGTGCACGCTCGGCCTGCAA
CTGCTGCTGCGCGACGGGCGCCTCAACATGGTGGCCTTCATGCGCGCCAACGATGCCTACGTCGGCCTGCTCAACGACGT
GTTCTCGTTTACGTTCCTGCAGGAATACCTCGCCTCGGCGATCGGCTGCGAGCTCGGCACCTATACGCACCACGTCGGCT
CGGTCCACATCTACGACCAGAATCTGCTGCAGGCCGAGGCGCTGCTCGGGCCGCCCGGCACGGCCGTCACGGCAGTGGCG
CCGCCGCGCATGCCCCCCGGCTGCGGGAGCGCCACGATCCGCCGCGTGCTGGAGGAGGAGGCGCGCATCCGCGCGGGGCG
GGTCTCGTTCGCGGCGCTGCAGGACATCGACCTCGACCCGTACTGGCGCGACATTCTCGGACTCTTCTGGGTGTACCGGC
AGATCCGCTCCGGCGCGCCCGTTCCCGATCGTTCACTGAGCTTCCTCCATCCGTTCCATCGCGACTATCTGGTCAACCGC
TGGGGCGAGACGCTGGCATTGCTGCACTGA

Upstream 100 bases:

>100_bases
ATCAGGTCACGCGCCTCGAGCGCGTGGAGTATCGGGCCGGCGATCTCGATCCGGGCGCGATCGAGGCGGCCATCGCGCGC
CTCGAGGGCGGGCGCTGATC

Downstream 100 bases:

>100_bases
CAGGGCATACACGATGAAAACCGATTGGACCGAGGATCAGGTCTCGCGCCTGTTCGACGCCTACGACGATCGCGTGGAAG
CGCACTTCGGCTACCGGCCG

Product: Thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRARFANLDELYLATLRDVCTAYEYRNAPRGQAEREIIGYSARIEDPRARFCRHASRKQNVVFNYAEALWYLSGRNDLAF
IEYYAPSMARYSPDGKTLPGTGYGARLLHFGDDGIDQIERAIDILKRDDAESKRVVLQIFDAREDLYKRNIDVSCTLGLQ
LLLRDGRLNMVAFMRANDAYVGLLNDVFSFTFLQEYLASAIGCELGTYTHHVGSVHIYDQNLLQAEALLGPPGTAVTAVA
PPRMPPGCGSATIRRVLEEEARIRAGRVSFAALQDIDLDPYWRDILGLFWVYRQIRSGAPVPDRSLSFLHPFHRDYLVNR
WGETLALLH

Sequences:

>Translated_329_residues
MRARFANLDELYLATLRDVCTAYEYRNAPRGQAEREIIGYSARIEDPRARFCRHASRKQNVVFNYAEALWYLSGRNDLAF
IEYYAPSMARYSPDGKTLPGTGYGARLLHFGDDGIDQIERAIDILKRDDAESKRVVLQIFDAREDLYKRNIDVSCTLGLQ
LLLRDGRLNMVAFMRANDAYVGLLNDVFSFTFLQEYLASAIGCELGTYTHHVGSVHIYDQNLLQAEALLGPPGTAVTAVA
PPRMPPGCGSATIRRVLEEEARIRAGRVSFAALQDIDLDPYWRDILGLFWVYRQIRSGAPVPDRSLSFLHPFHRDYLVNR
WGETLALLH
>Mature_329_residues
MRARFANLDELYLATLRDVCTAYEYRNAPRGQAEREIIGYSARIEDPRARFCRHASRKQNVVFNYAEALWYLSGRNDLAF
IEYYAPSMARYSPDGKTLPGTGYGARLLHFGDDGIDQIERAIDILKRDDAESKRVVLQIFDAREDLYKRNIDVSCTLGLQ
LLLRDGRLNMVAFMRANDAYVGLLNDVFSFTFLQEYLASAIGCELGTYTHHVGSVHIYDQNLLQAEALLGPPGTAVTAVA
PPRMPPGCGSATIRRVLEEEARIRAGRVSFAALQDIDLDPYWRDILGLFWVYRQIRSGAPVPDRSLSFLHPFHRDYLVNR
WGETLALLH

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 37372; Mature: 37372

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARFANLDELYLATLRDVCTAYEYRNAPRGQAEREIIGYSARIEDPRARFCRHASRKQN
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCC
VVFNYAEALWYLSGRNDLAFIEYYAPSMARYSPDGKTLPGTGYGARLLHFGDDGIDQIER
HHEEEHHHHEEECCCCCEEEEEEECCHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHH
AIDILKRDDAESKRVVLQIFDAREDLYKRNIDVSCTLGLQLLLRDGRLNMVAFMRANDAY
HHHHHHCCCCCHHEEHHHHHHHHHHHHHCCCCEEEHHCHHEEHCCCCCCEEEEEECCCCH
VGLLNDVFSFTFLQEYLASAIGCELGTYTHHVGSVHIYDQNLLQAEALLGPPGTAVTAVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCHHHHHHHHCCCCCCEEEEEC
PPRMPPGCGSATIRRVLEEEARIRAGRVSFAALQDIDLDPYWRDILGLFWVYRQIRSGAP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
VPDRSLSFLHPFHRDYLVNRWGETLALLH
CCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRARFANLDELYLATLRDVCTAYEYRNAPRGQAEREIIGYSARIEDPRARFCRHASRKQN
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCC
VVFNYAEALWYLSGRNDLAFIEYYAPSMARYSPDGKTLPGTGYGARLLHFGDDGIDQIER
HHEEEHHHHEEECCCCCEEEEEEECCHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHH
AIDILKRDDAESKRVVLQIFDAREDLYKRNIDVSCTLGLQLLLRDGRLNMVAFMRANDAY
HHHHHHCCCCCHHEEHHHHHHHHHHHHHCCCCEEEHHCHHEEHCCCCCCEEEEEECCCCH
VGLLNDVFSFTFLQEYLASAIGCELGTYTHHVGSVHIYDQNLLQAEALLGPPGTAVTAVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCHHHHHHHHCCCCCCEEEEEC
PPRMPPGCGSATIRRVLEEEARIRAGRVSFAALQDIDLDPYWRDILGLFWVYRQIRSGAP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
VPDRSLSFLHPFHRDYLVNRWGETLALLH
CCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]