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The map label for this gene is cpxA [H]

Identifier: 238025043

GI number: 238025043

Start: 2131120

End: 2132217

Strand: Reverse

Name: cpxA [H]

Synonym: bglu_2g17000

Alternate gene names: 238025043

Gene position: 2132217-2131120 (Counterclockwise)

Preceding gene: 238025044

Following gene: 238025042

Centisome position: 75.41

GC content: 70.22

Gene sequence:

>1098_bases
ATGAATGGAATGACTCACACGAACTACGCATCGGATTCTTACGAATCCGGCATCTCTGTGCTGCTCGTCGACGACCAGGC
CTTCGTCGGCGAGGTGATCCGCCGGCTGCTGGCCGCCGAGACCGACATCGCGCTGCATGTCTGCGGCGATGCCGGCAGCG
CGCTCGAACTGGGCCGCACGCTGCGCCCCACCGTGATCCTGCAGGATCTGGTGATGCCCGGCGTCGACGGGCTGGAGCTG
GTGCGCGCCTGGCGCGCCGAGGCGGCCACCGCGCAGGTGCCGATCATCGTGCTGTCGATCAACGACGATCCGCTCGCCAA
GCGCGAGGCATTCGTGGCCGGCGCGAACGACTACCTCGTGAAGCTGCCGGACCCGATCGAGATGATCGCGCGGATCCGCT
ACCACTCGAACTCGTACCACATGCTGCGCCAGCGCGACGAGGTGCTCGACTTCCTCTCGCACGACATGCGCGCGCCGCAG
GCCTCGATCCTCTCGCTGCTGGAGGGCTATCGCGCGACGCACGGCGAGATGCCGATGCTGCTCGAGCGCATCGAGGTGCA
TGCGCGGCGCGCGCTCGCGCTGGCCGACGGCTTCATCCAGCTCACGCGCGCGCAGTCGGAGAAGCGGCCGAGCGAGCTGG
TGTGCCTCAACGAGGTGCTGCTCGACGCGGCCGACCAGCTCTGGGAGAAGGCGGCCGCCACCGGCAGCCGCGTGAAGGTG
GTGCTTCCGGAGGCCGAGTGTCTCTGCGTCGGGGACCGGATGATGCTCACGCGCGCGCTGGCGAACCTGATCGACAACGC
GCTGAAGTACGCGCCGCCCGCCTCCGAGGTGCGCGGCCTGATCGCCGACGACGGCGAGCGCTGGCTGATCGGCGTGGAGG
ACGAGGGCGAGGGGATCGCGCCGGCGCAGCGCGCGAGCGCCACCGAATCGTTCGTGCGGCTCACGCACGGCCCGGACTCG
CAGAAGGGCGGCTTCGGGCTCGGCCTCGCGTTCGTGCGCGCCACCGCCACGAAGCACGGCGGCGCACTGCTGATGCGCTA
CACGCCGCGCGGTTTCATGGCCGGGCTGGGGCTGCCCAAGGCGCGTGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
TAACCGGGGATGCGCTAGCAAGGACGTCGGCGGTGCGGGTGCCCGCGCCCGGCGAACCCGCCGTCTGCCGCGGCCGCAAG
GCGATGGCATTCGCGATGCG

Downstream 100 bases:

>100_bases
GCCGGCGCCGGGCGGCCGGGCCGCGCGCCGGCGGCCGCAGGCGCGCGGTCGGTGCGCGTGGGTGGCGGCAGGTGGTGGCG
GGTGGTGGCGGGTGGCCGGT

Product: response regulator/sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNGMTHTNYASDSYESGISVLLVDDQAFVGEVIRRLLAAETDIALHVCGDAGSALELGRTLRPTVILQDLVMPGVDGLEL
VRAWRAEAATAQVPIIVLSINDDPLAKREAFVAGANDYLVKLPDPIEMIARIRYHSNSYHMLRQRDEVLDFLSHDMRAPQ
ASILSLLEGYRATHGEMPMLLERIEVHARRALALADGFIQLTRAQSEKRPSELVCLNEVLLDAADQLWEKAAATGSRVKV
VLPEAECLCVGDRMMLTRALANLIDNALKYAPPASEVRGLIADDGERWLIGVEDEGEGIAPAQRASATESFVRLTHGPDS
QKGGFGLGLAFVRATATKHGGALLMRYTPRGFMAGLGLPKARAAR

Sequences:

>Translated_365_residues
MNGMTHTNYASDSYESGISVLLVDDQAFVGEVIRRLLAAETDIALHVCGDAGSALELGRTLRPTVILQDLVMPGVDGLEL
VRAWRAEAATAQVPIIVLSINDDPLAKREAFVAGANDYLVKLPDPIEMIARIRYHSNSYHMLRQRDEVLDFLSHDMRAPQ
ASILSLLEGYRATHGEMPMLLERIEVHARRALALADGFIQLTRAQSEKRPSELVCLNEVLLDAADQLWEKAAATGSRVKV
VLPEAECLCVGDRMMLTRALANLIDNALKYAPPASEVRGLIADDGERWLIGVEDEGEGIAPAQRASATESFVRLTHGPDS
QKGGFGLGLAFVRATATKHGGALLMRYTPRGFMAGLGLPKARAAR
>Mature_365_residues
MNGMTHTNYASDSYESGISVLLVDDQAFVGEVIRRLLAAETDIALHVCGDAGSALELGRTLRPTVILQDLVMPGVDGLEL
VRAWRAEAATAQVPIIVLSINDDPLAKREAFVAGANDYLVKLPDPIEMIARIRYHSNSYHMLRQRDEVLDFLSHDMRAPQ
ASILSLLEGYRATHGEMPMLLERIEVHARRALALADGFIQLTRAQSEKRPSELVCLNEVLLDAADQLWEKAAATGSRVKV
VLPEAECLCVGDRMMLTRALANLIDNALKYAPPASEVRGLIADDGERWLIGVEDEGEGIAPAQRASATESFVRLTHGPDS
QKGGFGLGLAFVRATATKHGGALLMRYTPRGFMAGLGLPKARAAR

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG3706

COG function: function code T; Response regulator containing a CheY-like receiver domain and a GGDEF domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=212, Percent_Identity=28.7735849056604, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=31.7972350230415, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=218, Percent_Identity=31.1926605504587, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=92, Percent_Identity=42.3913043478261, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=25.3218884120172, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI1786600, Length=203, Percent_Identity=30.0492610837438, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39685; Mature: 39685

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGMTHTNYASDSYESGISVLLVDDQAFVGEVIRRLLAAETDIALHVCGDAGSALELGRT
CCCCCCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCC
LRPTVILQDLVMPGVDGLELVRAWRAEAATAQVPIIVLSINDDPLAKREAFVAGANDYLV
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHEEECCCCEEE
KLPDPIEMIARIRYHSNSYHMLRQRDEVLDFLSHDMRAPQASILSLLEGYRATHGEMPML
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
LERIEVHARRALALADGFIQLTRAQSEKRPSELVCLNEVLLDAADQLWEKAAATGSRVKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VLPEAECLCVGDRMMLTRALANLIDNALKYAPPASEVRGLIADDGERWLIGVEDEGEGIA
EECCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHCCCCCEEEEEECCCCCCCC
PAQRASATESFVRLTHGPDSQKGGFGLGLAFVRATATKHGGALLMRYTPRGFMAGLGLPK
CHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCC
ARAAR
CCCCC
>Mature Secondary Structure
MNGMTHTNYASDSYESGISVLLVDDQAFVGEVIRRLLAAETDIALHVCGDAGSALELGRT
CCCCCCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCC
LRPTVILQDLVMPGVDGLELVRAWRAEAATAQVPIIVLSINDDPLAKREAFVAGANDYLV
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHEEECCCCEEE
KLPDPIEMIARIRYHSNSYHMLRQRDEVLDFLSHDMRAPQASILSLLEGYRATHGEMPML
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
LERIEVHARRALALADGFIQLTRAQSEKRPSELVCLNEVLLDAADQLWEKAAATGSRVKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VLPEAECLCVGDRMMLTRALANLIDNALKYAPPASEVRGLIADDGERWLIGVEDEGEGIA
EECCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHCCCCCEEEEEECCCCCCCC
PAQRASATESFVRLTHGPDSQKGGFGLGLAFVRATATKHGGALLMRYTPRGFMAGLGLPK
CHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCC
ARAAR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]