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The map label for this gene is trxA [H]

Identifier: 238024921

GI number: 238024921

Start: 1989395

End: 1990633

Strand: Reverse

Name: trxA [H]

Synonym: bglu_2g15660

Alternate gene names: 238024921

Gene position: 1990633-1989395 (Counterclockwise)

Preceding gene: 238024923

Following gene: 238024917

Centisome position: 70.41

GC content: 64.65

Gene sequence:

>1239_bases
ATGAGCAGCTTGAAAAGTGTGACCGAAGCGAGCTTCGAGGCCGATGTGACGCTGAACAGCCGTCCGGTGCTGATCGACTT
CTGGGCGGAATGGTGCGGGCCGTGCAAGGCGCTGGCGCCGACGCTCGAGAAAGTGGCGCGGAACTTCGAAGGCAAGGTCG
ACATCGTCAAGGTCAACGTCGACGAGCATCCTGGCCTGCGCGAGCGCTTTGGCGTGCGCGGCATCCCCGCGCTGGTGCTG
ATGAACGGTGCCAACGAGGCGGGCCGCATCGTGGGGAACCGCACCGCCACGCAGCTCGCGAGCTACCTGGATGCGCACCT
GGGAACCGTGACGCAACTGGCGCGCCCGGAAGTGACGCTGTCCGCGTTCGGCGGCGATGCGCAGGCGAAAGCGGACCGTA
TCGCTCGATTGCGCGACTACCTCGAACGCAAGCAGGCCGATCCGAATACGCCCATGTGGCCGGAAAAGGTCACCGGTGCG
CTCGCCTACGTGGCCGGCTCGTCCGATCCGGACGATTGCGCAGTCGCGCTGGGTATCCCGAGCGCCGTGGTCGAGGTCGT
GAACTCGTTGTTTACCTATAGGGGAACCAATTTCAATGCTGCGCTGTTCGTGGCCGATTGGCTGGAAAGCGTACCGGTGG
GCGCCGACCTTTCCAAGCTGCCGGGTCAGCTGCTGACTTCGATTCTGGCAGGCCCCATCGTCTCGGAAACCCTGAACGGG
GAGCCGAGGTTGCTGGCGATTCGCGACGCGCTGGTTTCTCTCCACGCGGCCGAAACGAACGGCTCCCCGGTGGGTGACGC
GAGCTGGGCGGAGCACAAGCAGGCTTGTCAGGCGGTGGCAGCCGGGCTCGGAGAGGGTAACGCCGCCAGGGCAGCCGCCG
TGCTGGAGGTGGCCGCGTCCTCTGCGGCCAAGAATCCTGACATGTTGAGGGGCTTCGTGGCCGCTGTTTGCGGTTTCGTC
CGGAAGTGCCGGCAGGCCGAGTGCAATTGGAGCCCGGAGGACGATTCCCGCTTTTCCAGCATCGCAAAAGGGATTTACAA
GCATGCGATCGAGACCGGTGCCGAGCCTCCCATGGGCGATGCGATGCGTAAGCGGATAGCGGAAGTCGATCCGGAACTCG
TGGCGCGCTTCAAGTTTCATTACGACGAAGGCTGGCGCAGCGCGCAGGAGCGCGGCACGGCGTTCGGCGACCTGCTGATC
GCGCTCACCAGGCAGACTGAAGTGGCTTCGCCAGTTTAG

Upstream 100 bases:

>100_bases
GTCCGCGTATCCTGCATGACCCCGCGATGGCGTCGCGACGATGCCGGTGGGTCGGTCGGGCAAGGCCCGACGAGATAGAA
CTTGTAAACAGGGAACTGAA

Downstream 100 bases:

>100_bases
ACGGTGGGAAAGGCGCCGCGCTGCACCTATCACCGATGAGCGGCGTGCGGCTGGCGCCGGCGGCCGGCGACGCGGCGCTG
CAGCCGCGCGCGCGGGCGCC

Product: Thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNVDEHPGLRERFGVRGIPALVL
MNGANEAGRIVGNRTATQLASYLDAHLGTVTQLARPEVTLSAFGGDAQAKADRIARLRDYLERKQADPNTPMWPEKVTGA
LAYVAGSSDPDDCAVALGIPSAVVEVVNSLFTYRGTNFNAALFVADWLESVPVGADLSKLPGQLLTSILAGPIVSETLNG
EPRLLAIRDALVSLHAAETNGSPVGDASWAEHKQACQAVAAGLGEGNAARAAAVLEVAASSAAKNPDMLRGFVAAVCGFV
RKCRQAECNWSPEDDSRFSSIAKGIYKHAIETGAEPPMGDAMRKRIAEVDPELVARFKFHYDEGWRSAQERGTAFGDLLI
ALTRQTEVASPV

Sequences:

>Translated_412_residues
MSSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNVDEHPGLRERFGVRGIPALVL
MNGANEAGRIVGNRTATQLASYLDAHLGTVTQLARPEVTLSAFGGDAQAKADRIARLRDYLERKQADPNTPMWPEKVTGA
LAYVAGSSDPDDCAVALGIPSAVVEVVNSLFTYRGTNFNAALFVADWLESVPVGADLSKLPGQLLTSILAGPIVSETLNG
EPRLLAIRDALVSLHAAETNGSPVGDASWAEHKQACQAVAAGLGEGNAARAAAVLEVAASSAAKNPDMLRGFVAAVCGFV
RKCRQAECNWSPEDDSRFSSIAKGIYKHAIETGAEPPMGDAMRKRIAEVDPELVARFKFHYDEGWRSAQERGTAFGDLLI
ALTRQTEVASPV
>Mature_411_residues
SSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNVDEHPGLRERFGVRGIPALVLM
NGANEAGRIVGNRTATQLASYLDAHLGTVTQLARPEVTLSAFGGDAQAKADRIARLRDYLERKQADPNTPMWPEKVTGAL
AYVAGSSDPDDCAVALGIPSAVVEVVNSLFTYRGTNFNAALFVADWLESVPVGADLSKLPGQLLTSILAGPIVSETLNGE
PRLLAIRDALVSLHAAETNGSPVGDASWAEHKQACQAVAAGLGEGNAARAAAVLEVAASSAAKNPDMLRGFVAAVCGFVR
KCRQAECNWSPEDDSRFSSIAKGIYKHAIETGAEPPMGDAMRKRIAEVDPELVARFKFHYDEGWRSAQERGTAFGDLLIA
LTRQTEVASPV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI21361657, Length=130, Percent_Identity=32.3076923076923, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=43.1372549019608, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788936, Length=86, Percent_Identity=40.6976744186046, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17556044, Length=116, Percent_Identity=30.1724137931034, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=33.695652173913, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=41.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639826, Length=95, Percent_Identity=36.8421052631579, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 43954; Mature: 43823

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNV
CCCHHHHHHHCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
DEHPGLRERFGVRGIPALVLMNGANEAGRIVGNRTATQLASYLDAHLGTVTQLARPEVTL
CCCCCHHHHCCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
SAFGGDAQAKADRIARLRDYLERKQADPNTPMWPEKVTGALAYVAGSSDPDDCAVALGIP
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEECCCCCCCCEEEECCH
SAVVEVVNSLFTYRGTNFNAALFVADWLESVPVGADLSKLPGQLLTSILAGPIVSETLNG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHCCC
EPRLLAIRDALVSLHAAETNGSPVGDASWAEHKQACQAVAAGLGEGNAARAAAVLEVAAS
CCCEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SAAKNPDMLRGFVAAVCGFVRKCRQAECNWSPEDDSRFSSIAKGIYKHAIETGAEPPMGD
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
AMRKRIAEVDPELVARFKFHYDEGWRSAQERGTAFGDLLIALTRQTEVASPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNV
CCHHHHHHHCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
DEHPGLRERFGVRGIPALVLMNGANEAGRIVGNRTATQLASYLDAHLGTVTQLARPEVTL
CCCCCHHHHCCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
SAFGGDAQAKADRIARLRDYLERKQADPNTPMWPEKVTGALAYVAGSSDPDDCAVALGIP
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEECCCCCCCCEEEECCH
SAVVEVVNSLFTYRGTNFNAALFVADWLESVPVGADLSKLPGQLLTSILAGPIVSETLNG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHCCC
EPRLLAIRDALVSLHAAETNGSPVGDASWAEHKQACQAVAAGLGEGNAARAAAVLEVAAS
CCCEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SAAKNPDMLRGFVAAVCGFVRKCRQAECNWSPEDDSRFSSIAKGIYKHAIETGAEPPMGD
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
AMRKRIAEVDPELVARFKFHYDEGWRSAQERGTAFGDLLIALTRQTEVASPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]